Journal of Advanced Pharmaceutical Technology & Research

ORIGINAL ARTICLE
Year
: 2022  |  Volume : 13  |  Issue : 2  |  Page : 95--99

The expression of interleukin-1β and nuclear factor erythroid-2 in the periodontitis after treatment of liquid smoke rice hull


Ira Arundina1, Theresia Indah Budhy2, Wisnu Setyari Juliastuti1, Meircurius Dwi Condro Surboyo3, Anisa Nur Halimah4, Putrisa Lestari4 
1 Department of Oral Biology, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia
2 Department of Oral Pathology Maxillofacial, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia
3 Department of Oral Medicine, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia
4 Department of Master of Dental Science Program, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia

Correspondence Address:
Dr. Ira Arundina
Department of Oral Biology, Faculty of Dental Medicine, Universitas Airlangga Jln, Prof. Dr. Moestopo 47, Surabaya 60132
Indonesia

Nonsurgical treatment such as scaling and root planing has been the main therapy of periodontal management. However, some individuals are nonresponsive with only mechanical therapy. Rice hull liquid smoke (RH-LS) with higher of phenolic compound supposed to interfere with inflammation process. Thus, the purpose of this study is to investigate the anti-inflammation properties of RH-LS for chronic periodontitis adjunct therapy by observing the expression of nuclear factor erythroid-2 (Nrf-2) and interleukin-1β (IL-1β). Two groups of Wistar rats were used. Control group was induced by 1 × 109 colony-forming unit (CFU)/ml Porphyromonas gingivalis (PG) and treated with aquadest for 2 and 7 days. Meanwhile, the other group was induced by 1 × 109 CFU/ml PG and treated with RH-LS for 2 and 7 days. Two central incisive/mandibulae were dissected and stained with immunohistochemistry for analyzed the expression of Nrf-2 and IL-1β. Data were then analyzed statistically using independent t-test (P = 0.05). Treatment with RH-LS for 7 days showed lower expression of IL-1β (4.00 ± 1.58) than control group (13.60 ± 2.70) and showed higher expression of Nrf-2 (11.60 ± 1.95) than control group (4.20 ± 1.64) (P = 0.000) (P < 0.05). Treatment of RH-LS for 2 days showed higher expression of Nrf-2 (2.20 ± 1.31) than control group (6.80 ± 1.92) (P = 0.003) (P < 0.05). RH-LS showed anti-inflammation properties by elevating the expression of Nrf-2 and depressing expression of IL-1β in periodontitis induced by PG.


How to cite this article:
Arundina I, Budhy TI, Juliastuti WS, Surboyo MD, Halimah AN, Lestari P. The expression of interleukin-1β and nuclear factor erythroid-2 in the periodontitis after treatment of liquid smoke rice hull.J Adv Pharm Technol Res 2022;13:95-99


How to cite this URL:
Arundina I, Budhy TI, Juliastuti WS, Surboyo MD, Halimah AN, Lestari P. The expression of interleukin-1β and nuclear factor erythroid-2 in the periodontitis after treatment of liquid smoke rice hull. J Adv Pharm Technol Res [serial online] 2022 [cited 2022 May 17 ];13:95-99
Available from: https://www.japtr.org/article.asp?issn=2231-4040;year=2022;volume=13;issue=2;spage=95;epage=99;aulast=Arundina;type=0