Journal of Advanced Pharmaceutical Technology & Research

ORIGINAL ARTICLE
Year
: 2022  |  Volume : 13  |  Issue : 2  |  Page : 83--88

Antihyperlipidemic, anti-inflammatory, analgesic, and antipyretic activities of “dimethyl dimethoxy biphenyl dicarboxylate” in male Wistar rats


Heba M. I. Abdallah1, Gihan F Asaad1, Mahmoud S Arbid1, Yousra A Nomier2 
1 Department of Pharmacology, Division of Medical Sciences, National Research Centre, Dokki, Giza, Egypt
2 Department of Pharmacology and Toxicology, Pharmacy College, Jazan University, Jazan, Saudi Arabia

Correspondence Address:
Dr. Yousra A Nomier
Department of Pharmacology and Toxicology, Pharmacy College, Jazan University, P O Box 114, Jizan 45142
Saudi Arabia

Dimethyl dimethoxy biphenyl (DDB) dicarboxylate has been applied as a therapeutic modality for curing liver diseases, particularly hepatitis virus. The objective of this study was to assess the protective potential against Triton X-100 induced abnormal fat metabolism in addition to anti-inflammatory, analgesic, and antipyretic effects of DDB. The anti-inflammatory, antinociceptive, and antipyretic of DDB were investigated through induction of paw edema, pain, and fever in experimental rats. DDB decreased cholesterol and triglyceride contents. DDB resulted in inhibition of inflammation, nociception, and fever in the experimental models. DDB improved lipid profile, as evidence of hypolipidemic potential. It also showed anti-inflammatory, analgesic, and antipyretic properties.


How to cite this article:
Abdallah HM, Asaad GF, Arbid MS, Nomier YA. Antihyperlipidemic, anti-inflammatory, analgesic, and antipyretic activities of “dimethyl dimethoxy biphenyl dicarboxylate” in male Wistar rats.J Adv Pharm Technol Res 2022;13:83-88


How to cite this URL:
Abdallah HM, Asaad GF, Arbid MS, Nomier YA. Antihyperlipidemic, anti-inflammatory, analgesic, and antipyretic activities of “dimethyl dimethoxy biphenyl dicarboxylate” in male Wistar rats. J Adv Pharm Technol Res [serial online] 2022 [cited 2022 May 22 ];13:83-88
Available from: https://www.japtr.org/article.asp?issn=2231-4040;year=2022;volume=13;issue=2;spage=83;epage=88;aulast=Abdallah;type=0