Journal of Advanced Pharmaceutical Technology & Research

ORIGINAL ARTICLE
Year
: 2021  |  Volume : 12  |  Issue : 3  |  Page : 232--235

Antimutagenic activity of nanoparticles of Rhaphidophora pinnata leaves in mice using micronucleus assay


Masfria Masfria1, Marianne Marianne2, Yade Metri Permata3, Steven Octavio3, Sri Mulyani3 
1 Department of Pharmaceutical Chemistry, Universitas Sumatera Utara; Nanomedicine Centre, Universitas Sumatera Utara, Medan, 20155, Indonesia
2 Nanomedicine Centre; Department of Pharmacology Pharmacy Faculty of Pharmacy, Universitas Sumatera Utara, Medan, 20155, Indonesia
3 Department of Pharmaceutical Chemistry, Universitas Sumatera Utara, Medan, 20155, Indonesia

Correspondence Address:
Prof. Masfria Masfria
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Sumatera Utara, Medan 20155
Indonesia

Cancer is one of the deadliest diseases in the world. Cancer may occur due to gene mutation. Rhaphidophora pinnata is a plant that has many benefits, especially in the leaves which have been used traditionally to treat cancer. The aim of this research is to test the antimutagenic activity of nanoparticles R. pinnata using the micronucleus method. The mice were induced with cyclophosphamide and then followed with the administration of nanoparticles of R. pinnata at the doses of 50, 100, 200 mg/kg for 7 days. The antimutagenic activity was evaluated at the decrease in the number of micronucleus in 200 polychromatic erythrocytes (PCE) cells of mice bone marrow. The result showed that the reduction of amount of micronucleus in PCE of a negative control group, treatment groups, and normal group is 22.65%, 60.3%, 79.6%, 93.8%, and 100%. These results indicate that the antimutagenic activity of nanoparticle of R. pinnata increases proportionally as the doses were increased. It can be concluded that nanoparticles R. pinnata at the doses of 50, 100, and 200 mg/kg have antimutagenic activity.


How to cite this article:
Masfria M, Marianne M, Permata YM, Octavio S, Mulyani S. Antimutagenic activity of nanoparticles of Rhaphidophora pinnata leaves in mice using micronucleus assay.J Adv Pharm Technol Res 2021;12:232-235


How to cite this URL:
Masfria M, Marianne M, Permata YM, Octavio S, Mulyani S. Antimutagenic activity of nanoparticles of Rhaphidophora pinnata leaves in mice using micronucleus assay. J Adv Pharm Technol Res [serial online] 2021 [cited 2021 Jul 30 ];12:232-235
Available from: https://www.japtr.org/article.asp?issn=2231-4040;year=2021;volume=12;issue=3;spage=232;epage=235;aulast=Masfria;type=0