Journal of Advanced Pharmaceutical Technology & Research

ORIGINAL ARTICLE
Year
: 2020  |  Volume : 11  |  Issue : 4  |  Page : 202--206

Effect of implantation Ti-6Al-4V ELI in femoral bone defect regeneration of Sprague Dawley rat


I Nyoman Jujur1, Damisih1, Kartika Devy2, Shovy Suha2, Boy Muchlis Bachtiar3, Endang Winiati Bachtiar3 
1 Center for Materials Technology, Agency for the Assessment and Application of Technology (BPPT), Tangerang Selatan, Indonesia
2 Departement of Oral Biology, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia
3 Department of Oral Biology, Faculty of Dentistry, Oral Science Research Center, Universitas Indonesia, Jakarta, Indonesia

Correspondence Address:
Prof. Endang Winiati Bachtiar
Department of Oral Biology, Faculty of Dentistry, Oral Science Research Center, Bahasa Indonesia, Salemba Raya 4, Jakarta 10430
Indonesia

Ti-6Al-4V ELI is one of the most commonly used dental implant restore function. The solution treatment temperature variation can significantly increase the strength, but it is not yet known the effect of these temperature variations on the alloy's biocompatibility properties. Twelve female Sprague Dawley rats were divided into six groups as follows: the treated group, the control group, and the defect group without implant material. In the treated group, the femur bone defect was implanted with as-cast Ti-6Al-4V ELI, 850°C, 950°C, and 1050°C heat-treated Ti-6Al-4V ELI implant material. The rats were euthanized after 30 days postimplantation and evaluated histologically. The results show that the histological scoring of the specimen for femur defect without implant material is 2 (fibrous union and fibrocartilaginous), score with implant as-cast is 2.5, the sample with 850°C heat treatment material is 2.5, 950°C is 2.5, and the temperature at 1050°C is 2.5. The score of 2.5 is between score 2 and score 3: hemorrhage, fibrous union, fibrocartilaginous microhemorrhage, and mineralized cartilage union. In conclusion, there is no effect of different heat treatment temperatures for Ti-6Al-4V ELI implant material in rat bone regeneration's maturation level.


How to cite this article:
Jujur I N, Damisih, Devy K, Suha S, Bachtiar BM, Bachtiar EW. Effect of implantation Ti-6Al-4V ELI in femoral bone defect regeneration of Sprague Dawley rat.J Adv Pharm Technol Res 2020;11:202-206


How to cite this URL:
Jujur I N, Damisih, Devy K, Suha S, Bachtiar BM, Bachtiar EW. Effect of implantation Ti-6Al-4V ELI in femoral bone defect regeneration of Sprague Dawley rat. J Adv Pharm Technol Res [serial online] 2020 [cited 2020 Dec 5 ];11:202-206
Available from: https://www.japtr.org/article.asp?issn=2231-4040;year=2020;volume=11;issue=4;spage=202;epage=206;aulast=Jujur;type=0