Journal of Advanced Pharmaceutical Technology & Research

ORIGINAL ARTICLE
Year
: 2020  |  Volume : 11  |  Issue : 4  |  Page : 157--162

The coronavirus disease 2019 main protease inhibitor from Andrographis paniculata (Burm.f) Ness


Sukardiman1, Martha Ervina2, Mohammad Rizki Fadhil Pratama3, Hadi Poerwono4, Siswandono Siswodihardjo4 
1 Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia
2 Doctoral Program of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga; Department of Pharmaceutical Biology, Faculty of Pharmacy, Widya Mandala Catholic University, Surabaya, Indonesia
3 Doctoral Program of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Surabaya; Department of Pharmacy, Faculty of Health Sciences, Universitas Muhammadiyah Palangkaraya, Palangkaraya, Indonesia
4 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia

Correspondence Address:
Prof. DR. Sukardiman
Faculty of Pharmacy, Universitas Airlangga, Campus C Unair Jl. DR. Ir. H. Soekarno Mulyorejo, Surabaya 60115
Indonesia

The coronavirus disease 2019 (COVID-19) pandemic has attracted worldwide attention. Andrographis paniculata (Burm. f) Ness (AP) is naturally used to treat various diseases, including infectious diseases. Its Andrographolide has been clinically observed for anti-HIV and has also in silico tested for COVID-19 main protease inhibitors. Meanwhile, the AP phytochemicals content also provides insight into the molecular structures diversity for the bioactive discovery. This study aims to find COVID-19 main protease inhibitor from AP by the molecular docking method and determine the toxicity profile of the compounds. The results obtained two compounds consisting of flavonoid glycosides 5,4'-dihydroxy-7-O-β -D-pyran-glycuronate butyl ester and andrographolide glycoside 3-O-D-glucopyranosyl-andrographolide have lower free binding energy and highest similarity in types of interaction with amino acid residues compared to its co-crystal ligands (6LU7) and Indinavir or Remdesivir. The toxicity prediction of the compounds also reveals their safety. These results confirm the probability of using AP phytochemical compounds as COVID-19 main protease inhibitors, although further research must be carried out.


How to cite this article:
Sukardiman, Ervina M, Fadhil Pratama MR, Poerwono H, Siswodihardjo S. The coronavirus disease 2019 main protease inhibitor from Andrographis paniculata (Burm.f) Ness.J Adv Pharm Technol Res 2020;11:157-162


How to cite this URL:
Sukardiman, Ervina M, Fadhil Pratama MR, Poerwono H, Siswodihardjo S. The coronavirus disease 2019 main protease inhibitor from Andrographis paniculata (Burm.f) Ness. J Adv Pharm Technol Res [serial online] 2020 [cited 2020 Oct 27 ];11:157-162
Available from: https://www.japtr.org/article.asp?issn=2231-4040;year=2020;volume=11;issue=4;spage=157;epage=162;aulast=Sukardiman,;type=0