Journal of Advanced Pharmaceutical Technology & Research

ORIGINAL ARTICLE
Year
: 2019  |  Volume : 10  |  Issue : 2  |  Page : 63--67

Antibacterial activity of cinnamon essential oils and their synergistic potential with antibiotics


Yassine El Atki1, Imane Aouam1, Fatima El Kamari1, Amal Taroq1, Kaotar Nayme2, Mohammed Timinouni2, Badiaa Lyoussi1, Abdelfattah Abdellaoui1 
1 Department of Biology, Laboratory of Physiology Pharmacology and Environmental Health, Faculty of Sciences Dhar Mehraz, Sidi Mohamed Ben Abdellah University, Fez, Morocco
2 Molecular Bacteriology Laboratory, Pasteur Institute of Morocco, Casablanca, Morocco

Correspondence Address:
Yassine El Atki
No. 196, Lots Alhadika Q4, Quartier Tghat, Fez 30090
Morocco

The objective of this study was to evaluate the antibacterial activity of Cinnamomum cassia (cinnamon) essential oil (EO) alone and in combination with some classical antibiotics against three multidrug-resistant bacteria, Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa, to search a possible synergy. The antibacterial activity of all tested compounds was determined by agar disc diffusion and minimum inhibitory concentration assays. The checkerboard method was used to quantify the efficacy of cinnamon EO in combination with these antibiotics. Fractional inhibitory concentrations were calculated and interpreted as synergy, addition, indifferent, or antagonism. A synergistic interaction was shown against S. aureus with the combination cinnamon EO and ampicillin or chloramphenicol and against E. coli when cinnamon EO was combined with chloramphenicol. However, the combination of cinnamon oil and streptomycin displayed additive effects against all bacteria stains. The combinations of cinnamon EO and antibiotics can be used as an alternative therapeutic application, which can decrease the minimum effective dose of the drugs, thus reducing their possible adverse effects and the costs of treatment.


How to cite this article:
El Atki Y, Aouam I, El Kamari F, Taroq A, Nayme K, Timinouni M, Lyoussi B, Abdellaoui A. Antibacterial activity of cinnamon essential oils and their synergistic potential with antibiotics.J Adv Pharm Technol Res 2019;10:63-67


How to cite this URL:
El Atki Y, Aouam I, El Kamari F, Taroq A, Nayme K, Timinouni M, Lyoussi B, Abdellaoui A. Antibacterial activity of cinnamon essential oils and their synergistic potential with antibiotics. J Adv Pharm Technol Res [serial online] 2019 [cited 2022 May 27 ];10:63-67
Available from: https://www.japtr.org/article.asp?issn=2231-4040;year=2019;volume=10;issue=2;spage=63;epage=67;aulast=El;type=0