Journal of Advanced Pharmaceutical Technology & Research

ORIGINAL ARTICLE
Year
: 2018  |  Volume : 9  |  Issue : 3  |  Page : 113--118

Levothyroxine improves Paraoxonase (PON-1) serum levels in patients with primary hypothyroidism: Case–control study


Marwa S Al-Naimi1, Nawar R Hussien1, Huda A Rasheed1, Hayder M Al-kuraishy2, Ali I Al-Gareeb2 
1 Department of Clinical Pharmacology, College of Medicine, Al-Mustansiriya University, Baghdad, Iraq
2 Department of Clinical Pharmacology and Therapeutic, Medical Faculty, College of Medicine, Al-Mustansiriya University, Baghdad, Iraq

Correspondence Address:
Dr. Hayder M Al-kuraishy
Department of Clinical Pharmacology and Therapeutic, Medical Faculty College of Medicine, Al-Mustansiriya University, Baghdad
Iraq

Primary hypothyroidism is associated with oxidative stress and insufficient antioxidant capacity. This study was conducted to evaluate the effects of levothyroxine replacement therapy on paraoxonase 1 (PON-1) serum levels in a patients with primary hypothyroidism. Thirty-one patients with primary hypothyroidism compared to 20 healthy controls were recruited from. A venous blood sample were taken after an overnight fasting for biochemical parameters, before and after starting levothyroxine therapy (100 μ g/day) for 3 months duration. The biochemical variables were PON-1 serum levels, lipid profiles, triiodothyronine (T3), thyroxin (T4), and thyroid stimulating hormone (TSH) serum levels. Levothyroxine replacement therapy leads to a significant amelioration of thyroid functions, lipid profile, cardiometabolic measures P < 0.05 in patients with primary hypothyroidism. Levothyroxine leads to significant elevation in PON-1 serum levels from 188.42 ± 19.81 (U/mL) to 361.23 ± 33.62 (U/mL) P < 0.0001. This study concluded that levothyroxine replacement therapy significantly increases PON-1 serum levels in patients with primary hypothyroidism and attenuating hypothyroidism-induced oxidative stress.


How to cite this article:
Al-Naimi MS, Hussien NR, Rasheed HA, Al-kuraishy HM, Al-Gareeb AI. Levothyroxine improves Paraoxonase (PON-1) serum levels in patients with primary hypothyroidism: Case–control study.J Adv Pharm Technol Res 2018;9:113-118


How to cite this URL:
Al-Naimi MS, Hussien NR, Rasheed HA, Al-kuraishy HM, Al-Gareeb AI. Levothyroxine improves Paraoxonase (PON-1) serum levels in patients with primary hypothyroidism: Case–control study. J Adv Pharm Technol Res [serial online] 2018 [cited 2021 Nov 29 ];9:113-118
Available from: https://www.japtr.org/article.asp?issn=2231-4040;year=2018;volume=9;issue=3;spage=113;epage=118;aulast=Al-Naimi;type=0