Journal of Advanced Pharmaceutical Technology & Research

ORIGINAL ARTICLE
Year
: 2017  |  Volume : 8  |  Issue : 4  |  Page : 116--119

Evaluation of the anesthetic effect of nasal mucosa with tetracaine 0.5% on hemodynamic changes and postoperative pain of septoplasty: A randomized controlled trial


Hossein Madineh1, Soroush Amani2, Majid Kabiri1, Behnam Karimi3 
1 Department of Anesthesiology, Shahrekord University of Medical Sciences, Shahrekord, Iran
2 Department of Otolaryngology, Shahrekord University of Medical Sciences, Shahrekord, Iran
3 Department of Nurse of Anaesthesia of Kashani Hospital, Shahrekord University of Medical Sciences, Shahrekord, Iran

Correspondence Address:
Soroush Amani
Department of Otolaryngology, Shahrekord University of Medical Sciences, Rahmatiyeh, Shahrekord
Iran

The nasal septum repair surgery is the dangerous operations that any stimulation of this area causes a large change in the rhythm of the heartbeat and blood pressure. This study aimed to determine the effects of tetracaine 0.5% on changes in heartbeat and heart rhythm, hemodynamic changes during surgery, intraoperative bleeding, and pain after septoplasty surgery. The irregular double-blind clinical trial registry of clinical trials Iran with the code number (IRCT: 20150526625N8) in the first half of 2013 on 86 patients in Kashani hospital of Shahrekord. Having selected and matched the patients were divided into two groups. Case group was dropped tetracaine 0.5% in each of the nasal cavity 15 min before the beginning of the operation. The control group was dropped distilled water 15 min preoperation in each of the nasal cavity. The surgery lasted about 30–60 min. Clinical symptoms were evaluated after anesthetic induction as well as pain using the visual analog scale after the operation, in the recovery room. The collected data were analyzed using SPSS version software 17 through independent t-test, Chi-square, and repeated measures variance analysis. Postoperative pain intensity in the experimental group compared to the control group was significantly lower than the control group (P < 0.05); however, blood pressure and heart rate during anesthesia, there was no difference between groups (P > 0.05). Based on the findings, intake of tetracaine drop 0.5% has no impact on some hemodynamic changes during septoplasty operation. However, compared with the control group, pain was significantly reduced.


How to cite this article:
Madineh H, Amani S, Kabiri M, Karimi B. Evaluation of the anesthetic effect of nasal mucosa with tetracaine 0.5% on hemodynamic changes and postoperative pain of septoplasty: A randomized controlled trial.J Adv Pharm Technol Res 2017;8:116-119


How to cite this URL:
Madineh H, Amani S, Kabiri M, Karimi B. Evaluation of the anesthetic effect of nasal mucosa with tetracaine 0.5% on hemodynamic changes and postoperative pain of septoplasty: A randomized controlled trial. J Adv Pharm Technol Res [serial online] 2017 [cited 2022 Jun 30 ];8:116-119
Available from: https://www.japtr.org/article.asp?issn=2231-4040;year=2017;volume=8;issue=4;spage=116;epage=119;aulast=Madineh;type=0