Journal of Advanced Pharmaceutical Technology & Research

ORIGINAL ARTICLE
Year
: 2017  |  Volume : 8  |  Issue : 3  |  Page : 102--107

Chemopreventive effect of artesunate in 1,2-dimethylhydrazine-induced rat colon carcinogenesis


Sazal Patyar1, Rakesh Raman Patyar2, Bikash Medhi1, Krishan Lal Khanduja3 
1 Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
2 Department of Cardiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
3 Department of Biophysics, Postgraduate Institute of Medical Education and Research, Chandigarh, India

Correspondence Address:
Sazal Patyar
Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh
India

Artesunate (ART) is a semisynthetic derivative of artemisinin. Artemisinin and its derivatives have shown profound cytotoxicity and antitumor activity in addition to antimalarial activity in various studies. As the in vivo chemopreventive efficacy of ART in colon carcinogenesis has not been investigated so far, the aim of the current study was to study the chemopreventive effect of ART in 1,2-dimethylhydrazine (DMH)-induced rat colon carcinogenesis. Animals were divided into four groups (n = 6): Group I - vehicle (1 mM ethylenediaminetetraacetic acid), Group II - DMH (20 mg/kg), Group III - DMH + 5-fluorouracil (81 mg/kg), Group IV - DMH + ART (6.7 mg/kg). After completion of 15 weeks of treatment, rats were sacrificed under ether anesthesia by cervical dislocation for assessment of lipid peroxidation (LPO), antioxidant status, average number of aberrant crypt foci (ACF), and cytokine levels. ART administration significantly decreased the average number of ACF/microscopic field. Similarly, LPO level was decreased and antioxidant activities were enhanced after ART treatment. ART decreased the levels of proinflammatory cytokines and induced apoptosis in the colons of DMH-treated rats. The results of this study suggest that ART has a beneficial effect against chemically induced colonic preneoplastic progression in rats.


How to cite this article:
Patyar S, Patyar RR, Medhi B, Khanduja KL. Chemopreventive effect of artesunate in 1,2-dimethylhydrazine-induced rat colon carcinogenesis.J Adv Pharm Technol Res 2017;8:102-107


How to cite this URL:
Patyar S, Patyar RR, Medhi B, Khanduja KL. Chemopreventive effect of artesunate in 1,2-dimethylhydrazine-induced rat colon carcinogenesis. J Adv Pharm Technol Res [serial online] 2017 [cited 2021 Dec 6 ];8:102-107
Available from: https://www.japtr.org/article.asp?issn=2231-4040;year=2017;volume=8;issue=3;spage=102;epage=107;aulast=Patyar;type=0