Journal of Advanced Pharmaceutical Technology & Research

ORIGINAL ARTICLE
Year
: 2016  |  Volume : 7  |  Issue : 1  |  Page : 6--12

Thermodynamics of dissolution and infrared-spectroscopy of solid dispersions of phenacetin


Alexander V Gerasimov, Mikhail A Varfolomeev, Marat A Ziganshin, Valery V Gorbatchuk, Il'naz T Rakipov, Alexander E Klimovitskii, Liana S Usmanova 
 Department of Physical Chemistry, Butlerov Institute of Chemistry, Kazan Federal University, Kremlevskaya 18, Kazan 420008, Russia

Correspondence Address:
Alexander V Gerasimov
Department of Physical Chemistry, Butlerov Institute of Chemistry, Kazan Federal University, Kremlevskaya 18, Kazan 420008
Russia

In this work enthalpies of dissolution in water of polyethylene glycols (PEGs) having an average molecular weight of 1000 and 1400, Pluronic-F127, phenacetin as well as the composites prepared from them were measured using solution calorimetry at 298.15 K. Intermolecular interaction energies of polymer-phenacetin were calculated on the basis of an additive scheme. It was shown that for mixtures with high content of polymer (>90 wt%) Pluronic-F127 has the highest solubilizing effect, while for mixtures with (4–6):1 polymer: phenacetin ratio the best solubilizing agent is PEG-1400. Infrared-spectra showed a decrease of the number of self-associated molecules of phenacetin with increasing of polymer content in the composites. The obtained results enabled us to identify the features of intermolecular interactions of polymers with a model hydrophobic drug and may be used for optimizing the conditions for preparing solid dispersions based on hydrophilic polymers.


How to cite this article:
Gerasimov AV, Varfolomeev MA, Ziganshin MA, Gorbatchuk VV, Rakipov IT, Klimovitskii AE, Usmanova LS. Thermodynamics of dissolution and infrared-spectroscopy of solid dispersions of phenacetin.J Adv Pharm Technol Res 2016;7:6-12


How to cite this URL:
Gerasimov AV, Varfolomeev MA, Ziganshin MA, Gorbatchuk VV, Rakipov IT, Klimovitskii AE, Usmanova LS. Thermodynamics of dissolution and infrared-spectroscopy of solid dispersions of phenacetin. J Adv Pharm Technol Res [serial online] 2016 [cited 2022 Sep 28 ];7:6-12
Available from: https://www.japtr.org/article.asp?issn=2231-4040;year=2016;volume=7;issue=1;spage=6;epage=12;aulast=Gerasimov;type=0