Journal of Advanced Pharmaceutical Technology & Research

ORIGINAL ARTICLE
Year
: 2015  |  Volume : 6  |  Issue : 3  |  Page : 136--140

Comparison of the efficacy of cardamom (Elettaria cardamomum) with pioglitazone on dexamethasone-induced hepatic steatosis, dyslipidemia, and hyperglycemia in albino rats


GM Nitasha Bhat1, Nagendra Nayak1, K Vinodraj1, N Chandralekha1, Paul Mathai1, J Cherian2 
1 Department of Pharmacology, KS Hegde Medical Academy, Deralakatte, Mangalore, Karnataka, India
2 Medical Advisor, Onco and Nephro Division, Sun Pharma, Mumbai, Maharashtra, India

Correspondence Address:
G M Nitasha Bhat
Department of Pharmacology, KS Hegde Medical Academy, Deralakatte, Mangalore, Karnataka
India

To evaluate the efficacy of cardamom with pioglitazone on dexamethasone-induced hepatic steatosis, dyslipidemia, and hyperglycemia in albino rats. There were four groups of 6 rats each. First group received dexamethasone alone in a dose of 8 mg/kg intraperitoneally for 6 days to induce metabolic changes and considered as dexamethasone control. Second group received cardamom suspension 1 g/kg/10 mL of 2% gum acacia orally 6 days before dexamethasone and 6 days during dexamethasone administration. Third group received pioglitazone 45 mg/kg orally 6 days before dexamethasone and 6 days during dexamethasone administration. Fourth group did not receive any medication and was considered as normal control. Fasting blood sugar, lipid profile, blood sugar 2 h after glucose load, liver weight, liver volume were recorded, and histopathological analysis was done. The effects of cardamom were compared with that of pioglitazone. Dexamethasone caused hepatomegaly, dyslipidemia and hyperglycemia. Both pioglitazone and cardamom significantly reduced hepatomegaly, dyslipidemia, and hyperglycemia (P < 0.01). Reduction of blood sugar levels after glucose load was significant with pioglitazone in comparison to cardamom (P < 0.01). Cardamom has comparable efficacy to pioglitazone in preventing dexamethasone-induced hepatomegaly, dyslipidemia, and fasting hyperglycemia.


How to cite this article:
Nitasha Bhat G M, Nayak N, Vinodraj K, Chandralekha N, Mathai P, Cherian J. Comparison of the efficacy of cardamom (Elettaria cardamomum) with pioglitazone on dexamethasone-induced hepatic steatosis, dyslipidemia, and hyperglycemia in albino rats.J Adv Pharm Technol Res 2015;6:136-140


How to cite this URL:
Nitasha Bhat G M, Nayak N, Vinodraj K, Chandralekha N, Mathai P, Cherian J. Comparison of the efficacy of cardamom (Elettaria cardamomum) with pioglitazone on dexamethasone-induced hepatic steatosis, dyslipidemia, and hyperglycemia in albino rats. J Adv Pharm Technol Res [serial online] 2015 [cited 2021 Dec 7 ];6:136-140
Available from: https://www.japtr.org/article.asp?issn=2231-4040;year=2015;volume=6;issue=3;spage=136;epage=140;aulast=Nitasha;type=0