Journal of Advanced Pharmaceutical Technology & Research

ORIGINAL ARTICLE
Year
: 2014  |  Volume : 5  |  Issue : 1  |  Page : 41--47

Synthesis and antinociceptive activity of novel mannich base derivatives of some new fused 3,5-pyrazolidinedione


Abhishek Tiwari1, Anita Singh2 
1 Department of Pharmaceutical Chemistry, Devsthali Vidyapeeth College of Pharmacy, Lalpur, Rudrapur (U.S. Nagar), India
2 Department of Pharmacy, Bhimtal Campus, Kaumaun University, Nainital, Bhimtal, Uttrakhand, India

Correspondence Address:
Abhishek Tiwari
Assistant Professor, Devsthali Vidyapeeth College of Pharmacy, Kachhi Khamaria, Kichha Road, Lalpur, Rudrapur (U.S. Nagar), Uttarakhand - 263 148
India

In the present study, a novel series of mannich bases 1-((1-substituted ethyl-1H-benzo[d] imidazol-2-yl) methyl)-2-substituted phenylpyrazolidine-3,5-dione 3(a-l) were synthesized and evaluated as antinociceptive agents in mice by Eddy«SQ»s hot plate and acetic acid-induced writhing models. The structures attributed to compounds 3a-3l were elucidated by using IR, 1H-NMR, and Mass spectroscopic techniques. Some compounds showed promising analgesic activity when compared with the standard drug Diclofenac sodium. Results of analgesic activity via hot plate model showed that compounds 3d and 3f were found to be more active than standard drug. Results of analgesic activity via acetic acid-induced writhing model showed that compounds 3a, 3c, 3k, and 3l showed activity which is comparable with the standard drug.


How to cite this article:
Tiwari A, Singh A. Synthesis and antinociceptive activity of novel mannich base derivatives of some new fused 3,5-pyrazolidinedione.J Adv Pharm Technol Res 2014;5:41-47


How to cite this URL:
Tiwari A, Singh A. Synthesis and antinociceptive activity of novel mannich base derivatives of some new fused 3,5-pyrazolidinedione. J Adv Pharm Technol Res [serial online] 2014 [cited 2022 Aug 10 ];5:41-47
Available from: https://www.japtr.org/article.asp?issn=2231-4040;year=2014;volume=5;issue=1;spage=41;epage=47;aulast=Tiwari;type=0