Journal of Advanced Pharmaceutical Technology & Research

ORIGINAL ARTICLE
Year
: 2014  |  Volume : 5  |  Issue : 1  |  Page : 21--27

Synthesis, characterization and antimicrobial activity of some novel benzimidazole derivatives


Immadisetty Sri Krishnanjaneyulu, Govindaraj Saravanan, Janga Vamsi, Pamidipamula Supriya, Jarugula Udaya Bhavana, Mittineni Venkata Sunil Kumar 
 Department of Pharmaceutical Chemistry, Bapatla College of Pharmacy, Bapatla, Andra Pradesh, India

Correspondence Address:
Immadisetty Sri Krishnanjaneyulu
Department of Pharmaceutical Chemistry, Bapatla College of Pharmacy, Bapatla - 522 101, Andra Pradesh
India

A series of novel N-((1H-benzoimidazol-1-yl) methyl)-4-(1-phenyl-5-substituted-4, 5-dihydro-1-benzoimidazol-1-yl) methyl)-4-(1-phenyl-5-substituted-4, 5-dihydro-1H-pyrazol-3-yl) benzenamine were synthesized by treating various 1-(4-((1H-benzoimidazol-1-yl) methylamino) phenyl)-3-substitutedprop-2-en-1-one with phenyl hydrazine in the presence of sodium acetate through a simple ring closure reaction. The starting material, 1-(4-((1H-benzoimidazol-1-yl) methylamino) phenyl)-3-substitutedprop-2-en-1-one,-benzoimidazol-1-yl) methylamino) phenyl)-3-substitutedprop-2-en-1-one, was synthesized from o-phenylenediamine by a multistep synthesis. All the synthesized compounds were characterized by spectroscopic means and elemental analyses. The title compounds were investigated for in vitro antibacterial and antifungal properties against some human pathogenic microorganisms by employing the agar streak dilution method using Ciprofloxacin and Ketoconazole as standard drugs. All title compounds showed activity against the entire strains of microorganism. Structural activity relationship studies reveal that compounds possessing an electron-withdrawing group display better activity than the compounds containing electron-donating groups, whereas the unsubstituted derivatives display moderate activity. Based on the results obtained, N-((1H-benzoimidazol-1-yl) methyl)-4-(1-phenyl-5-(4-(trifluoromethyl) phenyl)-4,5-dihydro-1H-pyrazol-3-yl) benzenamine 5i was found to be very active compared with the rest of the compounds and standard drugs that were subjected to antimicrobial assay.


How to cite this article:
Krishnanjaneyulu IS, Saravanan G, Vamsi J, Supriya P, Bhavana JU, Sunil Kumar MV. Synthesis, characterization and antimicrobial activity of some novel benzimidazole derivatives.J Adv Pharm Technol Res 2014;5:21-27


How to cite this URL:
Krishnanjaneyulu IS, Saravanan G, Vamsi J, Supriya P, Bhavana JU, Sunil Kumar MV. Synthesis, characterization and antimicrobial activity of some novel benzimidazole derivatives. J Adv Pharm Technol Res [serial online] 2014 [cited 2022 May 16 ];5:21-27
Available from: https://www.japtr.org/article.asp?issn=2231-4040;year=2014;volume=5;issue=1;spage=21;epage=27;aulast=Krishnanjaneyulu;type=0