Journal of Advanced Pharmaceutical Technology & Research

ORIGINAL ARTICLE
Year
: 2013  |  Volume : 4  |  Issue : 4  |  Page : 210--216

Effect of formulation factors on in vitro transcorneal permeation of voriconazole from aqueous drops


Biswaranjan Mohanty1, Sagar Kumar Mishra2, Dipak K Majumdar3 
1 Department of Pharmaceutics, Seemanta Institute of Pharmaceutical Sciences, Jharpokharia, Mayurbhanj, Orissa, India
2 Department of Pharmaceutical Sciences, Utkal University, Bhubaneswar, Orissa, India
3 Department of Pharmaceutics, Delhi Institute of Pharmaceutical Sciences and Research, Formerly College of Pharmacy, University of Delhi, New Delhi, India

Correspondence Address:
Dipak K Majumdar
Department of Pharmaceutics, Delhi Institute of Pharmaceutical Sciences and Research, Formerly College of Pharmacy, University of Delhi, Pushp Vihar, Sector III, New Delhi - 110 017
India

The purpose of this research was to evaluate the effect the formulation factors on in vitro permeation of voriconazole through freshly isolated goat and sheep corneas. An increase in the pH of the drops from 4.0 to 8.0 resulted in significant (P < 0.05) increase drug permeation. Raising concentration of the drops from 0.05% to 0.2% (w/v) significantly, (P < 0.05) increased drug permeation, but decreased the percent permeation. Corneal transport of voriconazole is both pH and concentration dependent. Eye drops containing disodium edetate (ethylenediaminetetraacetic acid) alone or combination with benzalkonium chloride showed significantly (P < 0.05) higher permeation as compared with control formulation. Addition of beta-cyclodextrin to the formulation enhanced corneal permeation of voriconazole. Compared with control formulation, voriconazole 0.2% (w/v) drop containing viscosity modifier produced significant (P < 0.05) decrease in permeation. Most of the formulations showed higher zone of inhibition against Candida albicans.


How to cite this article:
Mohanty B, Mishra SK, Majumdar DK. Effect of formulation factors on in vitro transcorneal permeation of voriconazole from aqueous drops.J Adv Pharm Technol Res 2013;4:210-216


How to cite this URL:
Mohanty B, Mishra SK, Majumdar DK. Effect of formulation factors on in vitro transcorneal permeation of voriconazole from aqueous drops. J Adv Pharm Technol Res [serial online] 2013 [cited 2021 Dec 2 ];4:210-216
Available from: https://www.japtr.org/article.asp?issn=2231-4040;year=2013;volume=4;issue=4;spage=210;epage=216;aulast=Mohanty;type=0