Journal of Advanced Pharmaceutical Technology & Research

ORIGINAL ARTICLE
Year
: 2013  |  Volume : 4  |  Issue : 1  |  Page : 18--24

In vitro dissolution study of atorvastatin binary solid dispersion


Rahat Jahan1, Md. Saiful Islam1, Ahmad Tanwir2, Jakir Ahmed Chowdhury1 
1 Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka, Dhaka, Bangladesh
2 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka, Bangladesh

Correspondence Address:
Md. Saiful Islam
Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka, Khondokar Mokarram H. Science Building (Ground Floor), Dhaka - 1000
Bangladesh

The aim of the present study was to improve the solubility and dissolution rate of atorvastatin (ATV), a slight water-soluble drug, by solid dispersion (SD) technique using a hydrophilic carrier Poloxamer 188 (POL188). Physical mixing (PM) and solvent evaporation (SE) method were used to prepare ATV-SD where different drug-carrier ratios were used. Prepared formulations were characterized in their solid state by solubility study; differential scanning calorimetry, scanning electron microscopy, and Fourier transform infrared spectroscopy which demonstrated changes in the formulations supporting the improved solubility. Percent content of POL188 in the SD matrix was found to play the pivotal role in the improvement of dissolution property of ATV. In case of PM, highest enhancement in drug release was found for 1:3 ratio (P < 0.05, ANOVA Single factor) whereas in case of SE, 3:0.5 ratio of ATV-POL188 resulted the maximum enhancement in ATV release (P < 0.05, ANOVA Single factor). Analysis of dissolution data of optimized formula indicated the best fitting with Peppas-Korsmeyer model and the drug release kinetics was fickian diffusion. In conclusion, binary SD prepared by both PM and SE technique using POL188 could be considered as a simple, efficient method to prepare ATV solid dispersions with significant improvement in the dissolution rate.


How to cite this article:
Jahan R, Islam M, Tanwir A, Chowdhury JA. In vitro dissolution study of atorvastatin binary solid dispersion.J Adv Pharm Technol Res 2013;4:18-24


How to cite this URL:
Jahan R, Islam M, Tanwir A, Chowdhury JA. In vitro dissolution study of atorvastatin binary solid dispersion. J Adv Pharm Technol Res [serial online] 2013 [cited 2022 Oct 3 ];4:18-24
Available from: https://www.japtr.org/article.asp?issn=2231-4040;year=2013;volume=4;issue=1;spage=18;epage=24;aulast=Jahan;type=0