Journal of Advanced Pharmaceutical Technology & Research

ORIGINAL ARTICLE
Year
: 2012  |  Volume : 3  |  Issue : 3  |  Page : 193--198

Cardioprotective potential of simvastatin in the hyperhomocysteinemic rat heart


Ankur Rohilla1, MU Khan2, Razia Khanam3 
1 Department of Pharmacy, NIMS University, Shobha Nagar, Jaipur, Rajasthan, India
2 Department of Pharmaceutical Sciences, Sri Sai College of Pharmacy, Badhani, Pathankot, Punjab, India
3 Department of Pharmacology, Facutly of Pharmacy, Jamia Hamdard University, Delhi, India

Correspondence Address:
Ankur Rohilla
Department of Pharmacy, NIMS University, Shobha Nagar, Jaipur - 303121, Rajasthan
India

The present study investigated the probable role of simvastatin, 3-hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase inhibitor, in abrogated cardioprotection in hyperhomocysteinemic (Hhcy) rat hearts. Isolated Langendorff«SQ»s perfused normal and Hhcy rat hearts were subjected to 30-min global ischemia (I) followed by 120-min reperfusion (R). Assessment of myocardial damage was done by measuring infarct size and analyzing the release of lactate dehydrogenase (LDH) and creatine kinase (CK-MB) in coronary effluent. In addition, the oxidative stress in the heart was assessed by measuring lipid peroxidation and superoxide anion generation. I/R produced myocardial injury in normal and Hhcy rat hearts by increasing myocardial infarct size, LDH and CK in coronary effluent and oxidative stress. Hhcy rat hearts showed enhanced myocardial injury and high oxidative stress as compared to normal hearts. Treatment with Simvastatin (10 μMol) afforded cardioprotection against I/R-induced myocardial injury in normal and hyperhomocysteinemic rat hearts as assessed in terms of reductions in myocardial infarct size, LDH and CK levels in coronary effluent and oxidative stress. The reductions in the high degree of oxidative stress may be responsible for the observed cardioprotection afforded by simvastatin against I/R-induced myocardial injury in normal and hyperhomocysteinemic rat hearts.


How to cite this article:
Rohilla A, Khan M U, Khanam R. Cardioprotective potential of simvastatin in the hyperhomocysteinemic rat heart.J Adv Pharm Technol Res 2012;3:193-198


How to cite this URL:
Rohilla A, Khan M U, Khanam R. Cardioprotective potential of simvastatin in the hyperhomocysteinemic rat heart. J Adv Pharm Technol Res [serial online] 2012 [cited 2021 Sep 23 ];3:193-198
Available from: https://www.japtr.org/article.asp?issn=2231-4040;year=2012;volume=3;issue=3;spage=193;epage=198;aulast=Rohilla;type=0