Journal of Advanced Pharmaceutical Technology & Research

ORIGINAL ARTICLE
Year
: 2012  |  Volume : 3  |  Issue : 1  |  Page : 68--74

Chitosan-alginate microcapsules of amoxicillin for gastric stability and mucoadhesion


Saahil Arora, RD Budhiraja 
 Department of Pharmaceutics, Nanomedicine Research Centre, I. S. F. College of Pharmacy, Moga (Punjab), India

Correspondence Address:
Saahil Arora
Department of Pharmaceutics, Nanomedicine Research Centre, I. S. F. College of Pharmacy, Moga (Punjab)
India

Amoxicillin-loaded microcapsules were prepared by ionotropic gelation of sodium alginate (ALG) with chitosan (CS) in presence of calcium chloride as gastroretentive delivery system. The effect of pH, concentration of ALG, CS and calcium chloride, and drug : ALG ratio were optimized in this study for minimizing the degradation of drug in acidic environment and increasing the loading efficacy and mucoadhesive efficiency of microcapsules. The optimum condition for prepared CS-ALG microcapsules was 2%w/v ALG, 0.75%w/v CS (pH5.0), and 1.0% w/v calcium chloride. The resulting microcapsules had drug entrapment efficiency of 84% and average size of 840 mm. CS concentration significantly influenced particle size and encapsulation efficiency of CS-ALG microcapsules (P<0.05). Decrease in the drug: ALG ratio resulted in an increased release of amoxicillin in acidic media. The relative decomposition of drug after encapsulation in CS-ALG microcapsules was decreased to 20.7%, 41.9%, and 83.3% in 2, 4, and 8 hours, respectively.


How to cite this article:
Arora S, Budhiraja R D. Chitosan-alginate microcapsules of amoxicillin for gastric stability and mucoadhesion.J Adv Pharm Technol Res 2012;3:68-74


How to cite this URL:
Arora S, Budhiraja R D. Chitosan-alginate microcapsules of amoxicillin for gastric stability and mucoadhesion. J Adv Pharm Technol Res [serial online] 2012 [cited 2022 Jul 1 ];3:68-74
Available from: https://www.japtr.org/article.asp?issn=2231-4040;year=2012;volume=3;issue=1;spage=68;epage=74;aulast=Arora;type=0