Journal of Advanced Pharmaceutical Technology & Research

ORIGINAL ARTICLE
Year
: 2012  |  Volume : 3  |  Issue : 1  |  Page : 30--40

Response surface methodology and process optimization of sustained release pellets using Taguchi orthogonal array design and central composite design


Gurinder Singh, Roopa S Pai, V Kusum Devi 
 Department of Pharmaceutics, Faculty of Pharmacy, Al-Ameen College of Pharmacy, Bangalore, Karnataka, India

Correspondence Address:
Roopa S Pai
Professor, Department of Pharmaceutics, Al-Ameen College of Pharmacy, Near Lal Bagh Main Gate, Hosur Road, Bangalore - 560 027, Karnataka
India

Furosemide is a powerful diuretic and antihypertensive drug which has low bioavailability due to hepatic first pass metabolism and has a short half-life of 2 hours. To overcome the above drawback, the present study was carried out to formulate and evaluate sustained release (SR) pellets of furosemide for oral administration prepared by extrusion/spheronization. Drug Coat L-100 was used within the pellet core along with microcrystalline cellulose as the diluent and concentration of selected binder was optimized to be 1.2%. The formulation was prepared with drug to polymer ratio 1:3. It was optimized using Design of Experiments by employing a 3 2 central composite design that was used to systematically optimize the process parameters combined with response surface methodology. Dissolution studies were carried out with USP apparatus Type I (basket type) in both simulated gastric and intestinal pH. The statistical technique, i.e., the two-tailed paired t test and one-way ANOVA of in vitro data has proposed that there was very significant ( P≤0.05) difference in dissolution profile of furosemide SR pellets when compared with pure drug and commercial product. Validation of the process optimization study indicated an extremely high degree of prognostic ability. The study effectively undertook the development of optimized process parameters of pelletization of furosemide pellets with tremendous SR characteristics.


How to cite this article:
Singh G, Pai RS, Devi V K. Response surface methodology and process optimization of sustained release pellets using Taguchi orthogonal array design and central composite design.J Adv Pharm Technol Res 2012;3:30-40


How to cite this URL:
Singh G, Pai RS, Devi V K. Response surface methodology and process optimization of sustained release pellets using Taguchi orthogonal array design and central composite design. J Adv Pharm Technol Res [serial online] 2012 [cited 2022 Dec 7 ];3:30-40
Available from: https://www.japtr.org/article.asp?issn=2231-4040;year=2012;volume=3;issue=1;spage=30;epage=40;aulast=Singh;type=0