ORIGINAL ARTICLE
Year : 2011 | Volume
: 2 | Issue : 2 | Page : 115--120
Preparation and evaluation of mucoadhesive cefdinir microcapsules
Prabhakar Reddy Veerareddy, Swathi Tedla, Srinivas Reddy Banda, Suresh Bandari, Raju Jukanti
Department of Pharmaceutics, St. Peter's Institute of Pharmaceutical Sciences, Vidyanagar, Hanamkonda, Warangal, Andhra Pradesh, India
Correspondence Address:
Prabhakar Reddy Veerareddy
Department of Pharmaceutics, St. Peter«SQ»s Institute of Pharmaceutical Sciences, Warangal - 506 001, Andhra Pradesh
India
The mucoadhesive microcapsules were prepared by using various concentrations of three different mucoadhesive polymers, namely, chitosan, Carbopol 934P, and methyl cellulose as wall materials and cefdinir as the core material employing orificeionic gelation method. The prepared microcapsules were characterized by scanning electron microscope (SEM) and Fourier transform infrared spectrometry (FT-IR). The prepared microcapsules were found to be spherical with particle size ranging from 765±20 to 985±10 μm and encapsulation efficiencies in the range of 55%-92%. The formulation containing Carbopol 934P as mucoadhesive polymer was found to be best with particle size 946±10 μm. The ex vivo wash-off test showed that the mucoadhesion after 1 h was 80% and the in vitro drug release was extended for more than 12 h. FT-IR spectra indicate that there was no interaction between drug and the polymers used in the formulation. Cefdinir is better absorbed from the upper part of the gastrointestinal tract, it suffers from low oral bioavailability (20-30%), shorter biological half-life (1-2 h), and less transit time. Thus, it can be concluded that microcapsules prepared using Carbopol 934P have promising properties for use as mucoadhesive carrier to increase the residence time of cefdinir.
How to cite this article:
Veerareddy PR, Tedla S, Banda SR, Bandari S, Jukanti R. Preparation and evaluation of mucoadhesive cefdinir microcapsules.J Adv Pharm Technol Res 2011;2:115-120
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How to cite this URL:
Veerareddy PR, Tedla S, Banda SR, Bandari S, Jukanti R. Preparation and evaluation of mucoadhesive cefdinir microcapsules. J Adv Pharm Technol Res [serial online] 2011 [cited 2023 Mar 29 ];2:115-120
Available from: https://www.japtr.org/article.asp?issn=2231-4040;year=2011;volume=2;issue=2;spage=115;epage=120;aulast=Veerareddy;type=0 |
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