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Year : 2022  |  Volume : 13  |  Issue : 4  |  Page : 291-295

Evaluation of adverse drug reaction in patients warfarin therapy

1 Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor, Indonesia
2 Department of Biology Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor, Indonesia
3 Department of Cardiovascular, Faculty of Medicine, Universitas Padjadjaran, Jatinangor, Indonesia
4 Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Indonesia

Correspondence Address:
Prot. apt. Taofik Rusdiana
Ph.D, Raya Bandung Sumedang Road Km. 21, Hegarmanah, West Java 45363 Bandung
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/japtr.japtr_439_22

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This research aimed to understand the adverse drug reaction (ADR) in heart disease outpatients who were administered warfarin at a hospital in Bandung city. The research was conducted using a cross-sectional design with an observational approach. Subsequently, data were collected from 74 patients who met the inclusion criteria. The causality assessment was made by the Naranjo Algorithm and the incidence of bleeding was classified based on the Bleedscore™. The result showed that the most common ADR were nausea, dizziness, stomach ache, ecchymosis, petechiae, bleeding in the mouth, melena, etc. Furthermore, the INR value was the most significant factor in the incidence of ADR. It was 6.445 using a value of P = 0.001 or a confidence interval of 95%. The most common side effect of warfarin in cardiac outpatients was superficial bleeding, followed by internal bleeding (melena). The INR value is the most significant factor in measuring the incidence of ADR.

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