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Year : 2022  |  Volume : 13  |  Issue : 2  |  Page : 83-88

Antihyperlipidemic, anti-inflammatory, analgesic, and antipyretic activities of “dimethyl dimethoxy biphenyl dicarboxylate” in male Wistar rats

1 Department of Pharmacology, Division of Medical Sciences, National Research Centre, Dokki, Giza, Egypt
2 Department of Pharmacology and Toxicology, Pharmacy College, Jazan University, Jazan, Saudi Arabia

Correspondence Address:
Dr. Yousra A Nomier
Department of Pharmacology and Toxicology, Pharmacy College, Jazan University, P O Box 114, Jizan 45142
Saudi Arabia
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/japtr.japtr_292_21

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Dimethyl dimethoxy biphenyl (DDB) dicarboxylate has been applied as a therapeutic modality for curing liver diseases, particularly hepatitis virus. The objective of this study was to assess the protective potential against Triton X-100 induced abnormal fat metabolism in addition to anti-inflammatory, analgesic, and antipyretic effects of DDB. The anti-inflammatory, antinociceptive, and antipyretic of DDB were investigated through induction of paw edema, pain, and fever in experimental rats. DDB decreased cholesterol and triglyceride contents. DDB resulted in inhibition of inflammation, nociception, and fever in the experimental models. DDB improved lipid profile, as evidence of hypolipidemic potential. It also showed anti-inflammatory, analgesic, and antipyretic properties.

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