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ORIGINAL ARTICLE
Year : 2022  |  Volume : 13  |  Issue : 2  |  Page : 106-110

Antidiabetic and antihyperlipidemic effects of Premna spinosa bark in experimental animal models


1 Indira Gandhi Institute of Pharmaceutical Sciences, Bhubaneswar, Odisha, India
2 Gracious College of Pharmacy, Raipur, Chhatisgarh, India
3 Tetri Chandravansi Pharmacy College, Nawadihkala, Bisrampur, Palamu, Jharkhand, India
4 Centurion University of Technology and Management, Bhubaneswar, Odisha, India
5 West Bengal Medical Services Corporation Ltd., Salt Lake City, Kolkata, West Bengal, India
6 School of Pharmaceutical Sciences, Siksha O Anusandhan Deemed to be University, Bhubaneswar, Odisha, India

Correspondence Address:
Dr. Biswakanth Kar
School of Pharmaceutical Sciences, Siksha O Anusandhan Deemed to be University, Bhubaneswar - 751 030, Odisha
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/japtr.japtr_300_21

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The purpose of the study is to evaluate the antidiabetic and hyperlipidemic potential of stem bark extract of Premna spinosa (Lamiaceae), by using streptozotocin (STZ)-nicotinamide (NA)-induced diabetic and triton-induced hyperlipidemic models in albino rats. The blood glucose, total cholesterol, and triglyceride levels were determined in STZ-NA-induced diabetic and triton-induced hyperlipidemic rats, as per the respective protocols. It was found that there is the dose dependent and significant reduction in foregoing parameters on the administration of extract from Premna spinosa stem bark at the doses of 200, 400, and 800 mg/kg body weight to diabetic and hyperlipidemic rats. From these observed results it may be inferred that the stem bark of Premna spinosa possesses remarkable antidiabetic and antihyperlipidemic properties.


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