| ORIGINAL ARTICLE |
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| Year : 2021 | Volume
: 12
| Issue : 4 | Page : 425-429 |
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Cytotoxic activity of flavonoid from local plant Eriocaulon cinereum R.B against MCF-7 breast cancer cells
Arde Toga Nugraha1, Arba Pramundita Ramadani2, Sista Werdyani3, Isnaini Adinda Pratiwi4, Topan Juniardy4, Sita Arfadila4, Muhammad Reza Putra Mahardhika4
1 Department of Pharmacy, Microbiology and Parasitology Laboratory, Universitas Islam Indonesia, Yogyakarta, Indonesia
2 Department of Pharmacy, Pharmacology Laboratory, Universitas Islam Indonesia, Yogyakarta, Indonesia
3 Department of Pharmacy, Pharmaceutical Chemistry Laboratory, Universitas Islam Indonesia, Yogyakarta, Indonesia
4 Department of Pharmacy, Universitas Islam Indonesia, Yogyakarta, Indonesia
Correspondence Address:
Dr. Arde Toga Nugraha
Department of Pharmacy, Microbiology and Parasitology Laboratory, Universitas Islam Indonesia, Yogyakarta
Indonesia
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/japtr.japtr_69_21
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Eriocaulon cinereum R. Br is used as traditional medicine by the local community in Bangka Belitung Island, Indonesia. The plant is processed as an infusion for fever, boosts the immune system, and treats tumor cells. However, scientific research on this species is still limited. The aims of this study were to determine the cytotoxic of E. cinereum against MCF-7 cells. The results suggested that one of the compounds has a good cytotoxic activity. Therefore, it is quite promising in the effort of cancer drug discovery. The active compound has a flavonoid, which plays a role in several anticancer mechanisms. This study provided scientific evidence regarding the utilization of E. cinereum by the local community for cancer therapy. The plant can be further developed as an alternative agent to treat cancer or as cancer adjuvant therapy.
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