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 Table of Contents  
Year : 2021  |  Volume : 12  |  Issue : 4  |  Page : 340-344  

Prospects for using Origanum Syriacum (L.) as a source of antimicrobial agents

Department of General Pharmaceutical and Biomedical Technology, Institute of Medicine, Peoples' Friendship University of Russia (RUDN University), Moscow, Russia

Date of Submission22-Apr-2021
Date of Decision17-Jun-2021
Date of Acceptance19-Jul-2021
Date of Web Publication20-Oct-2021

Correspondence Address:
Mrs. Ranim Mohamad
Department of General Pharmaceutical and Biomedical Technology, Institute of Medicine, Peoples' Friendship University of Russia (RUDN University), 6, Miklukho-Maklaya Street, Moscow 117198, Russian Federation
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/japtr.japtr_106_21

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Origanum syriacum (O. syriacum) (L.) belongs to Group B of the genus Origanum from (Lamiaceae), which is rich in essential oils that exhibit antimicrobial efficacy, anti-inflammatory efficacy, antioxidant activity, and antitumor efficacy. These processing activities are because of its richness in carvacrol and Thymol. In this article, we will focus on O. syriacum, discussing the antimicrobial efficacy for its essential oil and extracts, in addition, cast light on mechanism of essential oil antimicrobial action. This study was conducted from March 2019 to February 2021. We have analyzed the results of studies on antimicrobial efficacy of a plant O. syriacum in the PubMed, Google Scholar, Elsevier over the past 15 years using keywords. O. syriacum essential oil and its extracts have an extensive antimicrobial efficacy give it a great importance in pharmaceutical and medical purposes.

Keywords: Antimicrobial effectiveness, carvacrol, essential oils, Origanum Syriacum (L.), thymol

How to cite this article:
Mohamad R, Mussa R, Suslina SN. Prospects for using Origanum Syriacum (L.) as a source of antimicrobial agents. J Adv Pharm Technol Res 2021;12:340-4

How to cite this URL:
Mohamad R, Mussa R, Suslina SN. Prospects for using Origanum Syriacum (L.) as a source of antimicrobial agents. J Adv Pharm Technol Res [serial online] 2021 [cited 2023 Mar 30];12:340-4. Available from: https://www.japtr.org/text.asp?2021/12/4/340/328623

  Introduction Top

Antibiotic resistance is one of the most difficult problems facing the world today; there is currently a shortage of effective antibiotics, which requires the development of new antibiotics and to search for alternative solutions.[1],[2] The efficacy of thousands of plants against bacteria has known since ancient times. However, few extracts have been studied on humans and animals to ensure their safety and effectiveness.[3] This study sheds light on Origanum syriacum (Lamiaceae) plant belongs to Group B of the genus Origanum grows in the Mediterranean region.[4],[5],[6] Estimated plant height 30–90 cm, leaves ovate, acute or obtuse, the veins are visible at the bottom surface of the leaf, the leaves are covered with glandular popper, Corolla white, the plant blooms in spring.[7] O. syriacum is used in alternative medicine for processing respiratory diseases: a cough remedy, antispasmodic, carminative, painkiller, anthelmintic, treat respiratory infections, and other bacterial, fungal, and viral diseases.[8],[9] Recent studies have also proven its antioxidant effect, anticancer, antibacterial, antifungal, and anti-acetylcholine oxidant.[3],[10],[11],[12],[13],[14],[15],[16],[17],[18] Efficacy against colon cancer and breast cancer was also confirmed.[19] These medicinal properties are because of its richness in carvacrol (it can be up to79.8% from the content of essential oils) and Thymol (it can be up to 83, 8%).[20] Moreover, 11 flavonoids were detected in the plant. Many studies recently have confirmed its antibacterial effectiveness.[21] We found that most of the studies were done on essential oil, and very few were on alcoholic extracts, we will present the types of bacteria fungicide and viruses that O. syriacum has shown to be effective against them, with mention of the plant's parts used in these studies and focus on the mechanism of essential oil antimicrobial action.

  Materials and Methods Top

We have analyzed the results of microbial laboratory studies on antimicrobial efficacy of a plant O. syriacum in the PubMed database, Google Scholar and Elsevier over the past 10 years using keywords (O. syriacum (L.), essential oils, O. syriacum antimicrobial activity, Origanum, Origanum antibacterial activity) and also studied the literature data for the last 15 on the uses of the plant in folk medicine. This study was conducted from March 2019 to February 2021.

  Results Top

Antibacterial activity

The antimicrobial efficacy of the essential oils is caused by phenolic and monoterpene components, the most important of them are carvacrol and thymol and carvacrol has been reported to be one of the most effective antimicrobials.[22],[23] The antimicrobial efficacy of these oils is because of their hydrophobic structure and chemical composition, as hydrophobic properties facilitate the penetration of these substances into the bacterial cell membrane, which leads to a change in the arrangement of lipids and the cytoplasmic membrane, it leads to a change in the cell membrane, which, in turn, leads to alter in the chemical and physical properties of the cell membrane, an increasing of proton passive flux across the cell membrane, electron flow in the cell, active transport, and coagulation in the cell contents.[23],[24],[25] Importance of hydroxyl group and its effective role in the antimicrobial activity return to these two compounds was also proved.[26] A delocalized electron system allowing hydroxyl group to release proton.[18] Moreover, many studies confirmed the synergistic effect between essential oil components.[24],[27] O. syriacum effects on many kinds of Gram-positive and Gram-negative bacteria, most of the studies were done on essential oil and very few studies used alcoholic extracts.[28],[29] [Table 1] shows the types of bacteria that O. syriacum proved to be effective on them, the plant part that was used in the study, the extract or the essential oil.
Table 1: Antibacterial activity, origanum syriacum, with activity against many types of bacteria

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Antifungal activity

O. syriacum essential oil is used in traditional medicine to treat skin fungus.[35] Its essential oil and ethanol extracts showed efficacy against a large number of fungi[12],[14],[36],[37] [Table 2]. Several studies confirmed that the cytotoxic nature of essential oils is due to their lipophilic nature that enables them to penetrate the cell wall and cell membrane. Membranes damage mitochondria ceased the formation of acetyl-CoA, which leads to inhibition of aflatoxin biosynthesis and coagulate the cytoplasm, thus damage to the cellular organelles and they also strongly negatively affect the membrane by interacting with cellular ions or active sites of enzymes that depleting the ATP pool.[38],[39] Effect mechanism that essential oil works on fungal strains appears to be similar to the way it works against bacteria where the treatment of A. flavus fungus with Mentha entate essential oil led to leakage calcium, magnesium, and potassium ions, the occurrence of damaged fungal cell structure and reduced ergosterol content of the cell membrane has a strong role in maintaining the durability of the fungal cell membrane.[40]
Table 2: The essential oils and ethanol extracts from origanum syriacum showed efficacy against many types of fungi

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Antiviral activity

O. syriacum has been used against colds and influenza since ancient times. However, evidence and studies proving its anti-viral effectiveness are still scarce.[41] O. syriacum essential oils showed anti-herpes effectiveness against Type I.[42] In other studies, ethanol extracts of O. syriacum showed anti-HSV-1.[43]

  Discussion Top

Many studies have confirmed that most antibiotics, especially aminoglycosides, have efficacy against many bacteria in vitro, and they are not effective against the intracellular pathogens, Activity of thymol on Salmonella typhimurium has explained in vivo because thymol action fights bacteria is through crossing the cell membrane.[22],[23],[26] Thymol is able to protect macrophages from death due to oxidative stress.[26] Thymol and carvacrol act in various roles against many bacteria species, thymol more toxic against Staphylococcus aureus than carvacol, but carvacrol is the most toxic against Escherichia coli.[23] It is important to remember that there are two types of the plant: one contains mainly carvacrol whereas the other contains mainly thymol.[44] Studies have confirmed the importance of harvest time, type of soil, and the effect of climate on the quantity and quality of the essential oil[45],[46]

  Conclusion Top

We can suggest that O. syriacum essential oil and its extracts have an extensive antimicrobial efficacy give it a great importance in pharmaceutical and medical purposes.


This article has been supported by the RUDN University Strategic Academic Leadership Program.

Financial support and sponsorship


Conflicts of interest

There are no conflicts of interest.

  References Top

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  [Table 1], [Table 2]


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