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Year : 2020  |  Volume : 11  |  Issue : 3  |  Page : 123-127

Antioxidant and cytotoxic activities of the ethyl acetate extract of Sphagneticola trilobata (L.) J.F. Pruski on MCF-7 breast cancer cell

1 Department of Biology, Samudra University, Kampus Unsam Meurandeh, Langsa, Indonesia
2 Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Sumatera Utara, Medan, Indonesia
3 Department of Chemistry, Faculty of Engineering, Samudra University, Kampus Unsam Meurandeh, Langsa, Indonesia

Correspondence Address:
Prof. Dr. Syafruddin Ilyas
Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Sumatera Utara, Medan 20155
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/japtr.JAPTR_31_20

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Sphagneticola trilobata (L.) J.F. Pruski is the perennial herb distributed at tropical temperature. In this study, the antioxidant and anticancer properties of the ethyl acetate extract from S. trilobata leaves were investigated against MCF-7 breast cancer cells. The antioxidant and anticancer activities were assessed by 1,1-diphenyl-2-picrylhydrazyl free radical scavenging and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay methods, respectively. The extract demonstrated DPPH free radical scavenging effect with IC50value equaling to 127.43 μg/mL. The cytotoxic study was conducted on the concentration range of 1–200 μg/mL, and the results exhibited the strongest inhibitory activity against MCF-7 with the LC50value of 58.143 μg/mL. The cytotoxic activity of the extract was supported by the induction of apoptosis cell which possessed the apoptosis percentage of 78.80%. Thus, the cheap herbal drug treatment might highly be recommended to treat effectively breast cancers as an ideal choice or combinational therapy.

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