Home  |  About JAPTR |  Editorial board  |  Search |  Ahead of print  |  Current issue  |  Archives |  Submit article  |  Instructions  |  Subscribe  |  Advertise  |  Contacts  |Login 
Users Online: 5065   Home Print this page Email this page Small font sizeDefault font sizeIncrease font size
     

 Table of Contents  
EDITORIAL
Year : 2018  |  Volume : 9  |  Issue : 2  |  Page : 43  

Pharmaceutical applications of liquisolid technique


Editor, Journal of Advanced Pharmaceutical, Technology and Research, Editor-in-Chief, SPER Times, Secretary, Society of Pharmaceutical Education and Research, 22-C, Jawahar Colony, Gwalior - 474 001, Madhya Pradesh, India

Date of Web Publication25-Jul-2018

Correspondence Address:
Dr. Upendra Nagaich
Editor, Journal of Advanced Pharmaceutical, Technology and Research, Editor-in-Chief, SPER Times, Secretary, Society of Pharmaceutical Education and Research, 22-C, Jawahar Colony, Gwalior - 474 001, Madhya Pradesh
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/japtr.JAPTR_236_18

Rights and Permissions

How to cite this article:
Nagaich U. Pharmaceutical applications of liquisolid technique. J Adv Pharm Technol Res 2018;9:43

How to cite this URL:
Nagaich U. Pharmaceutical applications of liquisolid technique. J Adv Pharm Technol Res [serial online] 2018 [cited 2021 Oct 25];9:43. Available from: https://www.japtr.org/text.asp?2018/9/2/43/237517


The majority of recently discovered active moieties are poorly water-soluble and hydrophobic in nature. Therefore, a big challenge for dissolution and bioavailability enhancement of these drugs had developed. Liquisolid technique is a novel approach toward the development of dry, nonadherent, free-flowing, and compressible powder from the drug in liquid state. Merits of this approach include low costing, simple processing for the formulation of oily liquid drugs, great potentials in industrial production, possess enhanced in vitro drug release as compared to capsules dosage form. Furthermore, it also retards the drug release, i.e., sustained or controlled release can be effectively achieved. The concept behind this approach is adsorption and absorption both. When drug dissolved in liquid carrier is poured onto a porous carrier material, liquid gets absorbed in its internal structure, and after saturation, adsorption on external surface occurs. The porous material having high adsorptive properties gives desirable flow characteristics to the liquisolid system. Moreover, this technique has been explored as an instrument to reduce the pH variation effect on drug release. Liquisolid technique has been classified on the basis of liquid active moieties, viz., powdered drug solutions, powdered drug suspensions, and powdered liquid drugs, and on the basis of formulation technique, viz., liquisolid compacts and liquisolid microsystems. There are numerous applications, viz., enhancement of bioavailability of water-insoluble drugs, sustained and rapid release formulations, and improvement in solubility and dissolution, flowability, and compressibility.






 

Top
 
 
  Search
 
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

 
  In this article

 Article Access Statistics
    Viewed2915    
    Printed51    
    Emailed0    
    PDF Downloaded322    
    Comments [Add]    

Recommend this journal