| ORIGINAL ARTICLE |
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| Year : 2017 | Volume
: 8
| Issue : 4 | Page : 150-155 |
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Novel biorelevant dissolution medium as a prognostic tool for polysaccharide-based colon-targeted drug delivery system
Ankit Kumar Yadav1, Manik Sadora1, Sachin Kumar Singh1, Monica Gulati1, Peddi Maharshi1, Abhinav Sharma1, Bimlesh Kumar1, Harish Rathee1, Deepak Ghai1, Adil Hussain Malik1, Varun Garg1, K Gowthamrajan2
1 Department of Pharmaceutics, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India
2 Department of Pharmaceutics, J.S.S. College of Pharmacy, Ooty, Tamil Nadu, India
Correspondence Address:
Monica Gulati
Department of Pharmaceutics, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab - 144 402
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/japtr.JAPTR_70_17
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To overcome the limitations of the conventionally used methods for evaluation of orally administered colon-targeted delivery systems, a novel dissolution method using probiotics has been recently reported. In the present study, universal suitability of this medium composed of five different probiotics is established. Different delivery systems – mini tablets, liquisolid compacts, and microspheres coated with different polysaccharides – were prepared and subjected to sequential dissolution testing in medium with and without microbiota. The results obtained from fluid thioglycollate medium (FTM)-based probiotic medium for all the polysaccharide-based formulations showed statistically similar dissolution profile to that in the rat and goat cecal content media. Hence, it can be concluded that the developed FTM-based probiotic medium, once established, may eliminate the need for further animal sacrifice in the dissolution testing of polysaccharide-based colon-targeted delivery system. |
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