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ORIGINAL ARTICLE
Year : 2017  |  Volume : 8  |  Issue : 3  |  Page : 97-101

Leptocarpus disjunctus prolongs sleeping time and increases nonrapid eye movement sleep with additional anxiolytic capacity


1 Public Health Sciences Program, College of Public Health Sciences, Chulalongkorn University, Bangkok 10330, Thailand
2 Department of Pharmacognosy and Pharmacology, Faculty of Pharmacy, Rangsit University, Pathum Thani 12000, Thailand
3 Department of Pharmacology, Faculty of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin 150000, China
4 Public Health Sciences Program, College of Public Health Sciences, Chulalongkorn University, Bangkok 10330; Department of Pharmacognosy and Pharmacology, Faculty of Pharmacy, Rangsit University, Pathum Thani 12000, Thailand

Correspondence Address:
Nijsiri Ruangrungsi
College of Public Health Sciences, Chulalongkorn University, Bangkok 10330
Thailand
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/japtr.JAPTR_185_16

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Leptocarpus disjunctus Mast. (Restionaceae) is an edible plant which has indigenous warnings regarding its side effects which can manifest as dizziness. This study investigated hypnotic and anxiolytic properties using several animal models. Anxiolytic activities were evaluated using locomotor determination by elevated plus-maze test, open-field test, and rotarod performance test. Hypnotic activities were performed using pentobarbital sodium-induced sleeping time test. Sleep architecture and quality were obtained from sleep–wake analysis and nonrapid eye movement (NREM) delta activity using electroencephalography. An ethanolic extract of L. disjunctus indicated effective potencies for hypnotic test, locomotor activities, and sleep–wake analysis. Ethanolic extract showed a dose relationship with sleeping time for pentobarbital-induced sleeping time test (P < 0.01) and also an antagonistic effect on shortening in sleep time induced by flumazenil. The consort significantly decreased locomotor activities among animals undergoing elevated plus-maze test, open-field test, and rotarod performance test, whereas sleep–wake analysis showed that sleeping time and NREM sleep increased. Ethanolic extract of L. disjunctus was shown to be anxiolytic, with the possibly of benzodiazepine-like hypnotic activity.


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