| ORIGINAL ARTICLE |
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| Year : 2017 | Volume
: 8
| Issue : 1 | Page : 2-7 |
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A study of the formation of magnetically active solid dispersions of phenacetin using atomic and magnetic force microscopy
Liana Stanislavovna Usmanova1, Marat Akhmedovich Ziganshin1, Valery Vilenovich Gorbatchuk1, Sufia Askhatovna Ziganshina2, Dmitry Anatolevich Bizyaev2, Anastas Akhmetovich Bukharaev2, Timur Anvarovich Mukhametzyanov1, Alexander Vladimirovich Gerasimov1
1 Department of Physical Chemistry, Butlerov Institute of Chemistry, Kazan Federal University, Kazan, Russia
2 Kazan Scientific Center, E. K. Zavoisky Physical Technical Institute, Russian Academy of Sciences, Kazan, Russia
Correspondence Address:
Alexander Vladimirovich Gerasimov
Department of Physical Chemistry, Butlerov Institute of Chemistry, Kazan Federal University, Kremlevskaya 18, Kazan 420008
Russia
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/2231-4040.197331
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A lot of pharmaceutical substances have a poor solubility that limits their absorption and distribution to the targeted sites to elicit the desired action without causing untoward effects on healthy cells or tissues. For such drugs, new modes of delivery have to be developed for efficient and effective delivery of the drug to the target site. Formation of magnetically active solid dispersion of such drugs could be a useful approach to addressing this problem because they combine targeted delivery and good solubility. In this work, the distribution of superparamagnetic nanoparticles in the solid dispersion of polyethylene glycol with average molecular weight 950-1050 g/mol and phenacetin was studied using atomic force and magnetic force microscopy. The distribution of nanoparticles was found to be uniform in studied composites. Magnetically active solid dispersions may find application in the production of the capsulated drug delivery systems with enhanced solubility parameters. |
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