| ORIGINAL ARTICLE |
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| Year : 2016 | Volume
: 7
| Issue : 3 | Page : 87-90 |
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Effects of Cr3+ ions on electrophysiological parameters of isolated skin of toad Pleurodema thaul
Luis Guzman Jofre1, Ricardo I Castro Cepeda2
1 Department of Clinical Biochemistry and Immunohematology, Faculty of Health Sciences, University of Talca, Talca, Chile
2 Institute of Chemistry and Natural Resources, University of Talca, Talca, Chile
Correspondence Address:
Ricardo I Castro Cepeda
Institute of Chemistry and Natural Resources, Universidad de Talca, Talca
Chile
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/2231-4040.184587
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In view of the toxicity of chromium (Cr3+) ions, it was explored the damaging effects that this ion could induce in cell membranes. The measurement of the effects induced by Cr3+ ions on electrophysiological parameters of short-circuit current and on the potential difference were investigated using the outer side (mucosal) and the inner side (serosal) of toad Pleurodema thaul skin. The results showed a decreased on electrophysiological parameters when it were administered concentrations of 33, 100 and 200 μM of Cr3+, the results also suggest that the administration of Cr3+ inhibits the ion transport in toad skin by the interaction of Cr3+ with lipid bilayers or protein constituents of membrane, and not by an inhibition of the active transport of ions across Na+ channels. |
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