Home  |  About JAPTR |  Editorial board  |  Search |  Ahead of print  |  Current issue  |  Archives |  Submit article  |  Instructions  |  Subscribe  |  Advertise  |  Contacts  |Login 
Users Online: 430   Home Print this page Email this page Small font sizeDefault font sizeIncrease font size
Year : 2015  |  Volume : 6  |  Issue : 3  |  Page : 103-107

Evaluation of wound healing activity of Thunbergia laurifolia supercritical carbon dioxide extract in rats with second-degree burn wounds

1 Interdisciplinary Program of Pharmacology, Graduate School, Chulalongkorn University, Bangkok 10330, Thailand
2 Department of Pharmacology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand

Correspondence Address:
Wacharee Limpanasithikul
Department of Pharmacology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330
Login to access the Email id

Source of Support: A grant from the 90th Anniversary of Chulalongkorn University Fund, Conflict of Interest: None

DOI: 10.4103/2231-4040.157984

Rights and Permissions

Thunbergia laurifolia Lindl (TL) has been traditionally used as an antidote, anti-inflammatory, and anti-drug addiction. This study investigated the burn wound healing activity of TL leaf extract (TLL) from supercritical CO 2 extraction in rats. The extract was prepared to 2.5%, 5%, and 10% gel (TLL gel). Rats were induced to second-degree burn wounds. They were randomly divided into six groups (six rats/group), which five groups were topically applied gel base, 1% silver sulfadiazine gel, 2.5%, 5%, and 10% TLL gel, respectively, for 14 days. Six untreated burn rats were used as the control group. The rats in each group were evaluated for wound healing rate, histological parameters, and wound collagen content. Rats treated with 10% TLL gel had a higher wound healing rate than rats in the control and untreated groups. An increase in collagen content, which indicates good regeneration of wound skin, was observed in the TLL treated rats from a pathological study by Masson's trichrome and collagen content assay. The results from this study suggest that T. laurifolia leaf extract obtained by supercritical CO 2 extraction promotes the recovery of wound skin by shortening the inflammation phase, increasing collagen content, and stimulating fibroblasts proliferation and migration in wound healing.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded657    
    Comments [Add]    
    Cited by others 6    

Recommend this journal