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GUEST EDITORIAL
Year : 2012  |  Volume : 3  |  Issue : 4  |  Page : 200-201  

Natural products derived from plants as a source of drugs

Ciddi Veeresham
Department of Pharmacy, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Andhra Pradesh, India

Date of Web Publication14-Dec-2012

Correspondence Address:
Ciddi Veeresham
Department of Pharmacy, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Andhra Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2231-4040.104709

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How to cite this article:
Veeresham C. Natural products derived from plants as a source of drugs. J Adv Pharm Technol Res 2012;3:200-1

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Veeresham C. Natural products derived from plants as a source of drugs. J Adv Pharm Technol Res [serial online] 2012 [cited 2023 Feb 9];3:200-1. Available from: https://www.japtr.org/text.asp?2012/3/4/200/104709

Nature, the master of craftsman of molecules created almost an inexhaustible array of molecular entities. It stands as an infinite resource for drug development, novel chemotypes and pharmacophores, and scaffolds for amplification into efficacious drugs for a multitude of disease indications and other valuable bioactive agents. Since time immemorial, natural products have been the backbone of traditional system of healing throughout the globe, and have also been an integral part of history and culture. Although the use of bioactive natural products as herbal drug preparations dates back hundreds, even thousands, of years ago, their application as isolated and characterized compounds to modern drug discovery and development started only in the 19 th century. It has been well documented that natural products played critical roles in modern drug development, especially for antibacterial and antitumor agents. Even though popularity of the synthetic products increased due to its production cost, time effectiveness, easy quality control, stringent regulation and quick effects, but their safety and efficacy was always remained questionable, resulting in the dependence on the natural products by more than 80% of the total population in the developing world, because of its time tested safety and efficacy. A huge number of natural product-derived compounds in various stages of clinical development highlighted the existing viability and significance of the use of natural products as sources of new drug candidates.

Until recently, plants were an important source of novel pharmacologically active compounds with many blockbuster drugs being derived directly or indirectly from plants. Despite the current preoccupation with synthetic chemistry as a vehicle to discover and manufacture drugs, the contribution of plants to disease treatment and prevention is still enormous. Even at the dawn of 21 st century, 11% of the 252 drugs considered as basic and essential by the WHO were exclusively of flowering plant origin.

Obviously natural products will continue to be extremely important as sources of medicinal agents. In addition to the natural products which have found direct medicinal application as drug entities, many others can serve as chemical models or templates for the design, synthesis, and semi synthesis of novel substances for treating humankind's diseases. Although there are some new approaches to drug discovery, such as combinatorial chemistry and computer-based molecular modeling design, and many drugs are made by synthetic chemistry, none of them can replaced the important role of natural products in drug discovery and development as most of the core structures or scaffolds for synthetic chemicals are based upon natural products.

According to Newman and Cragg 2012, the utility of natural products as sources of novel structures is still alive and well. Up to 50% the approved drugs during the last 30 years are from either directly or indirectly from natural products and in the area of cancer, over the time frame from around the 1940s to date, of the 175 small molecules 85 actually being either natural products or directly derived there from.

The use of plants as medicines has a long history in the treatment of various diseases. The plant-derived compounds have a long history of clinical use, better patient tolerance and acceptance. To date, 35,000-70,000 plant species have been screened for their medicinal use. Plants especially those with ethnopharmacological uses have been the primary sources of medicine for early drug discovery. Fabricant and Farnsworth, (2001) reported that, 80% of 122 plant derived drugs were related to their original ethnopharmacological purposes. Current drug discovery from plants mainly relied on bioactivity-guided fractionation and led to isolation of many important anticancer drugs such as paclitaxel, camptothecin etc.

The first commercial pure natural product introduced for therapeutic use is morphine marketed by Merck in 1826, and the first semi-synthetic pure drug aspirin, based on a natural product salicin isolated from Salix alba, was introduced by Bayer in 1899. This led to the isolation of early drugs such as cocaine, codeine, digitoxin, quinine and pilocarpine, of which some are still in use and several other recent plant derived compounds, which have undergone development and have been marketed as drugs which include Paclitaxel from Taxus brevifolia for lung, ovarian and breast cancer, Artemisinin from traditional Chinese plant Artemisia annua to combat multidrug resistant malaria, Silymarin extracted from the seeds of Silybum marianum for the treatment of liver diseases.

There is growing evidence that the old molecules are finding new applications through better understanding of molecular biology and clinical observations. For instance, the alkaloid, forskolin from Coleus forskohlii and phytochemicals from Stephania glabra, are now being rediscovered as adenylate cyclase and nitric oxide activators, which may help in preventing conditions including obesity and atherosclerosis.

During the last decade few plant derived drugs have been launched include Arteether, endoperoxide sesquiterpene lactone and semisynthetic natural product derived from Artemisinin used in malarial treatment, Nitisinone derived from natural product Leptospermone (Callistemon citrinus) is used in treatment of antityrosinaemia, galantamine is a natural alkaloid (obtained from Galanthus nivalis) for Alzhemer's, apomorphine is a semisynthetic compound derived from morphine (Papaver somniferum) used in Parkinson's disease, Tiotropium a derivative of atropine from Atropa belladonna in chronic obstructive pulmonary disease, Dronabinol and Cannabidiol obtained from cannabis plant (Cannabis sativa) and Capsaicin active compound from Capsicum annuum are used as pain relievers.

Natural products discovered so far have played a vital role in improving the human health and have been the drugs of choice despite facing a tough competition from compounds derived from computational and combinatorial chemistry, due to their safety and efficacy. The most striking feature of natural products in connection to their long lasting importance in drug discovery is their structural diversity that is still largely untapped.

Revitalization of the natural products is bringing newer challenges with respect to quality control and standardization along with cost effectiveness. The renewed interest in the development of natural products requires the confluence of the modern techniques and harmonization of regulations related to their research and development between various fields of science.

 
   Authors Top

Prof. (Dr.) Ciddi Veeresham



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64 Molecular mechanism of Ferula Asafoetida for the treatment of asthma: Network pharmacology and molecular docking approach
Muhammad Qasim, Muhammad Abdullah, Usman Ali Ashfaq, Fatima Noor, Nazia Nahid, Ahmad Alzamami, Norah A Alturki, Mohsin Khurshid
Saudi Journal of Biological Sciences. 2022; : 103527
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65 Inhibition of Inflammation Associated Corneal Neovascularization by Dalbergia sissoo and Catharanthus roseus Leaves Extracts in Animal Model
Munir Ahmed, Muhammad Umar Khayam Sahibzada, Hafiz Majid Rasheed, Taous Khan, Fazli Wahid, Umar Farooq, Ameer Khusro, Jalal Uddin, Sher Afzal, Ajmal Khan, Ahmed Al-Harrasi
South African Journal of Botany. 2022;
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66 Seasonality impact on the anti-inflammatory, antiproliferative potential and the lignan composition of Bursera microphylla
Heriberto Torres-Moreno, Julio César López-Romero, Max Vidal-Gutiérrez, Karen Lillian Rodríguez-Martínez, Ramón Enrique Robles-Zepeda, Wagner Vilegas, Gloria Mariana Velarde-Rodríguez
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67 An overview of some important deliberations to promote medicinal plants cultivation
Preet Amol Singh, Neha Bajwa, Sampath Chinnam, Arun Chandan, Ashish Baldi
Journal of Applied Research on Medicinal and Aromatic Plants. 2022; : 100400
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68 Evaluation of the antibacterial and antifungal potentials of peptide-rich extracts from selected Nigerian plants
Emmanuel A. Agbebi, Olumuyiwa S. Alabi, Abraham O. Nkrumah, Omonike O. Ogbole
European Journal of Integrative Medicine. 2022; : 102163
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69 Bioprospecting Dodonaea viscosa Jacq.; a traditional medicinal plant for antioxidant, cytotoxic, antidiabetic and antimicrobial potential
Marya Nawaz Malik, Ihsan ul-Haq, Humaira Fatima, Madiha Ahmad, Iffat Naz, Bushra Mirza, Nosheen Kanwal
Arabian Journal of Chemistry. 2022; : 103688
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70 Identification of secondary metabolites from Crescentia cujete as promising antibacterial therapeutics targeting type 2A topoisomerases through molecular dynamics simulation
Jamiu Olaseni Aribisala, Rukayat Abiola Abdulsalam, Yamkela Dweba, Khumbulani Madonsela, Saheed Sabiu
Computers in Biology and Medicine. 2022; 145: 105432
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71 In vitro and in silico perspectives to explain anticancer activity of a novel syringic acid analog ((4-(1H-1, 3-benzodiazol-2-yl)-2, 6-dimethoxy phenol)) through apoptosis activation and NFkB inhibition in K562 leukemia cells
Srinivasulu Cheemanapalli, Chandrasekaran Palaniappan, Yeshwanth Mahesh, Yuvaraj Iyyappan, Suresh Yarrappagaari, Sekar Kanagaraj
Computers in Biology and Medicine. 2022; : 106349
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72 Pharmacological effect of Heritiera fomes on Long Evans rats against Postprandial Hyperglycemia and $${\left(\varvec{C}{\varvec{H}}_{2}\varvec{O}\right)}_{\varvec{n}}$$ adsorption in vitro
Md. Iqbal Hossain Nayan, Md. Mohibul Alam, Md. Abrar Jamil, Md. Ismail Hossain, Iqramul Haq, J.M.A. Hannan
Journal of Diabetes & Metabolic Disorders. 2022;
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73 Investigating the ability of Securigera securidaca extract in biological synthesis of selenium nanoparticles, pancreatic a-amylase inhibition, antioxidant and phenolic capacity and in vivo studying the anti-diabetic effects of extract on pseudo-diabetic r
Fariba Mollania, Hossein Sahabi
Nanotechnology for Environmental Engineering. 2022; 7(1)
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74 Ciliatoside A, isolated from Peristrophe japonica, inhibits HBsAg expression and cccDNA transcription by inducing autophagy
Ren Fang, Tan Ming, Jerome P.L. Ng, Wu An Guo, Yuan Si Yu, Zhang Hui, Ren Ji Hua, Cheng Sheng Tao, Zhang Juan, Lo Hang Hong, Vincent Kam Wai Wong, Betty Yuen Kwan Law, Chen Juan
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75 Comparative Content, Biological and Anticancer Activities of Heracleum humile Extracts Obtained by Ultrasound-Assisted Extraction Method
Mustafa Ocal, Yasemin Celik Altunoglu, Simone Angeloni, Ahmed M. Mustafa, Giovanni Caprioli, Gokhan Zengin, Mehmet Yavuz Paksoy, Mehmet Cengiz Baloglu
Chemistry & Biodiversity. 2022;
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76 Anti-Inflammatory Potential of Compounds Isolated from Tunisian Lichens Species
Mohamed Mendili, Ayda Khadhri, Jouda Mediouni-Ben Jemâa, Anna Andolfi, Immacolata Tufano, Samira Aschi-Smiti, Marina DellaGreca
Chemistry & Biodiversity. 2022;
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77 Total Bioactive Contents, Metabolic Profiling, Docking Studies, Antioxidant and Enzyme Inhibition Activities of Convolvulus Arvensis L. and Multivariate Analysis to Unravel a Potential Herb as Natural Resource for Phar
Muhammad Imran Tousif, Mamona Nazir, Muhammad Saleem, Saba Tauseef, Reaz Uddin, Gokhan Zengin, Mohamad Fawzi Mahomoodally, Zaheer Abbas
Chemistry & Biodiversity. 2022;
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78 Antiviral activity of triptolide on herpes simplex virus in vitro
Nasrin Aliabadi, Marzieh Jamalidoust, Gholamreza Pouladfar, Atoosa Ziyaeyan, Mazyar Ziyaeyan
Immunity, Inflammation and Disease. 2022; 10(7)
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79 Isolation and Characterization of Werneria Chromene and Dihydroxyacidissimol from Burkillanthus malaccensis (Ridl.) Swingle
Masyitah Zulkipli, Nuzum Mahbub, Ayesha Fatima, Stefanie Lim Wan-Lin, Teng-Jin Khoo, Tooba Mahboob, Mogana Rajagopal, Chandramathi Samudi, Gheetanjali Kathirvalu, Nor Hayati Abdullah, Ana Rita Pinho, Sonia M. R. Oliveira, Maria de Lourdes Pereira, Mohammed Rahmatullah, Anamul Hasan, Alok K. Paul, Mark S. Butler, Muhammad Nawaz, Polrat Wilairatana, Veeranoot Nissapatorn, Christophe Wiart
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80 Plant Pyranocoumarins: Description, Biosynthesis, Application
Maria T. Khandy, Anastasia K. Sofronova, Tatiana Y. Gorpenchenko, Nadezhda K. Chirikova
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81 Screening of phytochemicals, toxicities, and activities of three Dillenia species
Pornnarong Siripiyasing, Kittiya Silawong, Tikumporn Thooptianrat, Runglawan Sudmoon, Nelly Babayan, Lusine Khondkaryan, Lilit Apresyan, Tawatchai Tanee, Arunrat Chaveerach
Journal of Herbmed Pharmacology. 2022; 11(3): 339
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82 Bioassay standardization of drug dosage form prepared from hydroalcoholic extract of Dracocephalum kotschyi
Hassan Sadraei, Amir Hossein Rasouli-Amirabadi, Afsaneh Yekdaneh, Naser Tavakoli
Journal of Herbmed Pharmacology. 2022; 11(3): 435
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83 Advanced Analytical Approaches for the Analysis of Polyphenols in Plants Matrices—A Review
Elena Roxana Chiriac,Carmen Lidia Chitescu,Elisabeta-Irina Geana,Cerasela Elena Gird,Radu Petre Socoteanu,Rica Boscencu
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84 Analytical Separation of Carcinogenic and Genotoxic Alkenylbenzenes in Foods and Related Products (2010–2020)
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85 In-vitro Comparative study on blood clotting time of some Plants Extracts and Heparin when Infected with Snakebite
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86 Pharmacognostical Investigation of Trapa natans L Leaves
Chandana Majee,Rupa Mazumder,Alka N. Choudhary
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87 Quality assessment of frequently available mother tinctures in the market by employing standard values
Malik Mahrukh,Hussain Shahzad,Arshad Malik Javeria,Adil Asia,Nazir Sara,Usman Gondal Muhammad
African Journal of Pharmacy and Pharmacology. 2021; 15(4): 61
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88 Eight key rules for successful data-dependent acquisition in mass spectrometry-based metabolomics
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89 Prospects and Challenges of Developing Plant-Derived Snake Antivenin Natural Products: A Focus on West Africa
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90 Computational screening of natural compounds from Salvia plebeia R. Br. for inhibition of SARS-CoV-2 main protease
Afraa Aqeel Zackria, Ramya Pattabiraman, T. P. Krishna Murthy, S. Birendra Kumar, Blessy Baby Mathew, Vinai George Biju
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91 Non-toxic nature of chebulinic acid on biochemical, hematological and histopathological analysis in normal Sprague Dawley rats
Khurram Aamir,Vaisnevee Sugumar,Hidayat Ullah Khan,Chung Yeng Looi,Rajesh Juneja,Muhammad Waqas,Aditya Arya
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92 Anti-Leishmania Effects of Volatile Oils and Their Isolates
Patrícia Fampa,Melissa Florencio,Raissa Couto Santana,Dayana Rosa,Deivid Costa Soares,Herbert Leonel de Matos Guedes,Anabela Cordeiro da Silva,Douglas Siqueira A. Chaves,Lucia H. Pinto-da-Silva
Revista Brasileira de Farmacognosia. 2021;
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93 Coumarins as Potential Antiprotozoal Agents: Biological Activities and Mechanism of Action
Elkin Jose Torres Sierra,Cleydson Finotti Cordeiro,Livia de Figueiredo Diniz,Ivo Santana Caldas,Jamie Anthony Hawkes,Diogo Teixeira Carvalho
Revista Brasileira de Farmacognosia. 2021;
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94 Natural Bioactive Compounds as Potential Browning Agents in White Adipose Tissue
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95 In Vitro Anthelmintic Efficacy of Sesbania sesban var. bicolor, Cyperus compressus and Asparagus racemosus Against Gastrothylax crumenifer (Trematoda)
Amar Deep Soren,Arun Kumar Yadav
Proceedings of the Zoological Society. 2021;
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96 Emerging nanoformulation strategies for phytocompounds and applications from drug delivery to phototherapy to imaging
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97 Optimization of ultrasound-assisted, microwave-assisted and Soxhlet extraction of bioactive compounds from Lagenaria siceraria: A comparative analysis
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98 Challenges and recent trends with the development of hydrogel fiber for biomedical applications
Reema Ansar,Sidra Saqib,Ahmad Mukhtar,Muhammad Bilal Khan Niazi,Muhammad Shahid,Zaib Jahan,Salik Javed Kakar,Bushra Uzair,Muhammad Mubashir,Sami Ullah,Kuan Shiong Khoo,Hooi Ren Lim,Pau Loke Show
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99 Therapeutic effects of medicinal plants on isoproterenol-induced heart failure in rats
Faeze Keihanian,Mohsen Moohebati,Amin Saeidinia,Seyed Ahmad Mohajeri,Saeid Madaeni
Biomedicine & Pharmacotherapy. 2021; 134: 111101
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100 Ex vivo and in vivo chemoprotective activity and potential mechanism of Martynoside against 5-fluorouracil-induced bone marrow cytotoxicity
Mengying Hong, Dongdong Chen, Zhuping Hong, Kejun Tang, Yuanyuan Yao, Liubo Chen, Tingting Ye, Jing Qian, Yushen Du, Ren Sun
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101 Chitosan-tripolyphosphate nanoparticles designed to encapsulate polyphenolic compounds for biomedical and pharmaceutical applications - A review
Mariana Carolina Di Santo,Cecilia Luciana D’ Antoni,Ana Paula Domínguez Rubio,Agustina Alaimo,Oscar Edgardo Pérez
Biomedicine & Pharmacotherapy. 2021; 142: 111970
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102 Camptothecinæs Journey from Discovery to WHO Essential Medicine: Fifty Years of Promise
Noura Khaiwa,Noor R. Maarouf,Mhd H. Darwish,Dima W.M. Alhamad,Anusha Sebastian,Mohamad Hamad,Hany A. Omar,Gorka Orive,Taleb H. Al-Tel
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103 Combination of docosahexaenoic acid and Ginko biloba extract improves cognitive function and hippocampal tissue damages in a mouse model of Alzheimer’s disease
Nabila E. Abdelmeguid,Mahmoud I.M. Khalil,Rasha Elhabet,Ahmed S. Sultan,Sherine Abdel Salam
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104 Alkaloidal extract from Carica papaya seeds ameliorates CCl4-induced hepatocellular carcinoma in rats
Isaac Kyei-Barffour,Roselind Kyei Baah Kwarkoh,Desmond Omane Acheampong,Augustine Suurinobah Brah,Samuel Addo Akwetey,Benjamin Aboagye
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105 An insight into Verbascum bombyciferum extracts: Different extraction methodologies, biological abilities and chemical profiles
Simone Angeloni,Gokhan Zengin,Kouadio Ibrahim Sinan,Gunes Ak,Filippo Maggi,Giovanni Caprioli,Alevcan Kaplan,Muammer Bahsi,Ugur Çakilcioglu,Abdelhakim Bouyahya,Sharmeen Jugreet,Mohamad Fawzi Mahomoodally
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106 Acute and sub-acute oral toxicity Lagerstroemia speciosa in Sprague-Dawley rats
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Saudi Journal of Biological Sciences. 2021;
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107 Electrospun nanocarriers for delivering natural products for cancer therapy
Reza Mohammadinejad,Vijay Sagar Madamsetty,Anuj Kumar,Mohammad Varzandeh,Ali Dehshahri,Ali Zarrabi,Fariba Sharififar,Mehdi Mohammadi,Amir Fahimipour,Seeram Ramakrishna
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108 Molecular docking and network pharmacology-based approaches to explore the potential of terpenoids for Mycobacterium tuberculosis
K. Kalaimathi,G. Thiyagarajan,S. Vijayakumar,K. Bhavani,K. Karthikeyan,J. Maria Jancyrani,K. Doss,J. Sureshkumar,S. Prabhu
Pharmacological Research - Modern Chinese Medicine. 2021; : 100002
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109 Antiglycation and enzyme inhibitory potential of salicylalazine isolated from Micromeria biflora (Buch.-Ham.ex D.Don) Benth
Abdur Rauf,Saud Bawazeer,Umer Rashid,Mohamed A. El-Esawi,Muhammad Humayun Khan,Syed Uzair Ali Shah,Mohammad S. Mubarak,Kannan RR Rengasamy
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110 Red laser-mediated alterations in seed germination, growth, pigments and withanolide content of Ashwagandha [Withania somnifera (L.) Dunal]
Sachin Ashok Thorat,Poornima Poojari,Arya Kaniyassery,Kodsara Ramachandra Kiran,Kapaettu Satyamoorthy,Krishna Kishore Mahato,Annamalai Muthusamy
Journal of Photochemistry and Photobiology B: Biology. 2021; : 112144
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111 Evaluation of the antiulcerogenic activity of hydromethanol extracts of Solanum incanum L. (Solanaceae) leaves and roots in mice; single and repeated dose study
Yaschilal Muche Belayneh,Gedefaw Getnet Amare,Birhanu Geta Meharie,Zemene Demelash Kifle
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112 Antiplasmodial diterpenoid alkaloid from Aconitum heterophyllum Wall. ex Royle: Isolation, characterization, and UHPLC-DAD based quantification
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113 Molecular pharming to support human life on the moon, mars, and beyond
Matthew J. McNulty,Yongao (Mary) Xiong,Kevin Yates,Kalimuthu Karuppanan,Jacob M. Hilzinger,Aaron J. Berliner,Jesse Delzio,Adam P. Arkin,Nancy E. Lane,Somen Nandi,Karen A. McDonald
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114 Resveratrol impairs acquisition, reinstatement and precipitates extinction of alcohol-induced place preference in mice
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Neurological Research. 2021; : 1
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115 Linalool attenuates acquisition and reinstatement and accelerates the extinction of nicotine-induced conditioned place preference in male mice
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116 A Study on the Effect of Valeric Acid in Alzheimer's Induced Rats by the Estimation of Aß 1-42 Biomarker
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Journal of Health and Allied Sciences NU. 2021;
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117 Glycine betaine-based ionic liquids and their influence on bacteria, fungi, insects and plants
Damian Krystian Kaczmarek,Daniela Gwiazdowska,Krzysztof Jus,Tomasz Klejdysz,Marta Wojcieszak,Katarzyna Materna,Juliusz Pernak
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118 In-silico screening and identification of phytochemicals from Centella asiatica as potential inhibitors of sodium-glucose co-transporter 2 for treating diabetes
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119 Herbal antioxidants in dialysis patients: a review of potential mechanisms and medical implications
Masoumeh Asgharpour,Amirhesam Alirezaei
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120 Recent development in biological activities and safety concerns of perillaldehyde from perilla plants: A review
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121 Nutraceuticals: unlocking newer paradigms in the mitigation of inflammatory lung diseases
Yinghan Chan,Venkata Sita Rama Raju Allam,Keshav Raj Paudel,Sachin K. Singh,Monica Gulati,Muralikrishnan Dhanasekaran,Piyush Kumar Gupta,Niraj Kumar Jha,Hari Prasad Devkota,Gaurav Gupta,Philip M Hansbro,Brian Gregory George Oliver,Dinesh Kumar Chellappan,Kamal Dua
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122 New 3-O-substituted xanthone derivatives as promising acetylcholinesterase inhibitors
Zi Han Loh,Huey Chong Kwong,Kok Wai Lam,Soek Sin Teh,Gwendoline Cheng Lian Ee,Ching Kheng Quah,Anthony Siong Hock Ho,Siau Hui Mah
Journal of Enzyme Inhibition and Medicinal Chemistry. 2021; 36(1): 627
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123 A Review on Pharmacological, Anti-oxidant Activities and Phytochemical Constituents of a Novel Lichen Parmotrema Species
Saparja Saha,Amrita Pal,Santanu Paul
Journal of Biologically Active Products from Nature. 2021; 11(3): 190
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124 Pharmacological profile of Shiva Gutika: an uncharted and versatilepolyherbal drug
V. H. Pushpa, M. K. Jayanthi, Shashank M. Patil, Ramith Ramu
All Life. 2021; 14(1): 215
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125 Hesperidin-An Emerging Bioactive Compound against Metabolic Diseases and Its Potential Biosynthesis Pathway in Microorganism.
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126 Aerosol-based Pulmonary Delivery of Therapeutic Molecules from Food Sources: Delivery Mechanism, Research Trends, and the Way Forward
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127 PHARMACOGNOSTICAL STUDIES OF LEAVES OF ACACIA ETBAICA SUBSPECIES UNCINATA
Michael D. SALEH KASSEM ALGFRI
Asian Journal of Pharmaceutical and Clinical Research. 2021; : 76
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128 Antioxidant, Anti-Inflammatory and Cytotoxic Properties of Centaurea africana Lamk var. [Bonnet] M
Sabrina Hadjira, Amira Mansour, Caglar Berkel, Ramdane Seghiri, Ahmed Menad, Fadila Benayache, Samir Benayache, Ercan Cacan, Souad Ameddah
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry. 2021; 20(1): 89
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129 Phytochemistry, Traditional Uses and Pharmacological Properties of Enhydra fluctuans Lour: a Comprehensive Review
Antica Barua, Muhammad S. Alam, Md. Junaid, Yeasmin Akter, Syeda S. Afrose, Tania Sharmin, Rasheda Akter, S.M. Zahid Hosen
Current Pharmaceutical Biotechnology. 2021; 22(8): 1061
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130 Current Knowledge Regarding Pharmacological Profile and Chemical Constituents of Gynura procumbens
Ehfazul Haque, Mir Shahriar Kamal, Md. Rafat Tahsin, Raju Ahmed, Jakir Ahmed Choudhury, Abu Asad Choudhury, Shaila Kabir, Md. Shah Amran, Md. Sahab Uddin
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131 Alkaloidal Extract From Carica papaya Seeds Ameliorates CCl 4-Induced Hepatocellular Carcinoma in Rats
Isaac Kyei-Barffour,Roselind Kyei Baah Kwarkoh,Desmond Omane Acheampong,Augustine Suurinobah Brah,Samuel Akwetey Addo,Benjamin Benjamin Aboagye,Alex Boye
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132 Green synthesis of silver nanoparticles using Tropaeolum majus: Phytochemical screening and antibacterial studies
Saud Bawazeer,Abdur Rauf,Syed Uzair Ali Shah,Ahmed M. Shawky,Yahya S. Al-Awthan,Omar Salem Bahattab,Ghias Uddin,Javeria Sabir,Mohamed A. El-Esawi
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133 Thymoquinone and its derivatives against breast cancer with HER2 positive: in silico studies of ADMET, docking and QSPR
Adinda Adelia Wulandari,Achmad Aziz Choiri,Achmad Aziz Fitria,Tri Widiandani
Journal of Basic and Clinical Physiology and Pharmacology. 2021; 32(4): 393
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134 Toxicological evaluations of betulinic acid and ursolic acid; common constituents of Houttuynia cordata used as an anthelmintic by the Naga tribes in North-east India
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Future Journal of Pharmaceutical Sciences. 2021; 7(1)
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135 The neuroprotective attribution of Ocimum basilicum: a review on the prevention and management of neurodegenerative disorders
Mohamed Ali Seyed,Siddiqua Ayesha,Norazrina Azmi,Fahad Mohamed Al-Rabae,Adel Ibrahim Al-Alawy,Othman Rashed Al-Zahrani,Yousef Hawsawi
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136 Sub-Acute Oral Toxicity Study of Ethanol Extract of Oroxylum Indicum Leafin C57BL/6 Mice
Mohd Farhan Hanif Reduan,Mohammad Rasul Arif Mastika,Fathin Faahimaah Abdul Hamid,Noramalina Noralidin,Nur Athirah Abd Manaf,Rumaizi Shaari,Intan Noor Aina Kamaruzaman,Muhammad Luqman Nordin
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137 COVID-19: Challenges, Preventive Measures and Remediation
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138 Isolation, Characterization of Active Constituent and Evaluation of Hepatoprotective Activity of Inula Racemosa Hook. F. Roots
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139 An in vitro study of an Artocarpus heterophyllus substance as a hepatitis C antiviral and its combination with current anti-HCV drugs
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140 Transferring Ethnopharmacological Results Back to Traditional Healers in Rural Indigenous Communities – The Ugandan Greater Mpigi Region Example
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141 Therapeutic potential and pharmacological activities of ß-eudesmol
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142 Evaluation of the Hypoglycemic Potential of Leaves Extract of Spondias pinnata (L.f.) Kurz. from Nepal
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143 Traditional Medicinal Vegetables in Northern Uganda: An Ethnobotanical Survey
Rebecca Nakaziba,Maxson Kenneth Anyolitho,Sharon Bright Amanya,Crispin Duncan Sesaazi,Frederick Byarugaba,Jasper Ogwal-Okeng,Paul E. Alele,Severino Matias de Alencar
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144 Antifungal and Antibacterial Activities of Apple Vinegar of Different Cultivars
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145 Evaluation of the Antidiarrheal and Antioxidant Effects of Some Chewing Sticks Commonly Used for Oral Hygiene in Ghana
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146 UPLC-ESI-Q-TOF-MS-Based Metabolite Profiling, Antioxidant and Anti-Inflammatory Properties of Different Organ Extracts of Abeliophyllum distichum
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147 Usnic Acid and Usnea barbata (L.) F.H. Wigg. Dry Extracts Promote Apoptosis and DNA Damage in Human Blood Cells through Enhancing ROS Levels
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148 LC-MS Based Analysis and Biological Properties of Pseudocedrela kotschyi (Schweinf.) Harms Extracts: A Valuable Source of Antioxidant, Antifungal, and Antibacterial Compounds
Kouadio Ibrahime Sinan,Stefano Dall’Acqua,Irene Ferrarese,Adriano Mollica,Azzurra Stefanucci,Jasmina Glamoclija,Marina Sokovic,Marija Nenadic,Abdurrahman Aktumsek,Gokhan Zengin
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149 Synthesis, Characterization and Bioactivity Profiling of Gold Nanoparticles of Trachyspermum ammi Crude Extract
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150 Optimization of PhysicoChemical Parameters for Production of Cytotoxic Secondary Metabolites and Apoptosis Induction Activities in the Culture Extract of a Marine Algal–Derived Endophytic Fungus Aspergillus sp.
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151 Atheroprotective Properties of Costus spicatus (Jacq.) Sw. in Female Rats
Bethânia Rosa Lorençone,Lucas Pires Guarnier,Rhanany Alan Calloi Palozi,Paulo Vitor Moreira Romão,Aline Aparecida Macedo Marques,Lislaine Maria Klider,Roosevelt Isaias Carvalho Souza,Ariany Carvalho dos Santos,Cleide Adriane Signor Tirloni,Nadla Soares Cassemiro,Denise Brentan Silva,Jane Manfron Budel,Arquimedes Gasparotto Junior
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152 Natural Antioxidants from Plant Extracts in Skincare Cosmetics: Recent Applications, Challenges and Perspectives
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153 Deeper Insights on Alchornea cordifolia (Schumach. & Thonn.) Müll.Arg Extracts: Chemical Profiles, Biological Abilities, Network Analysis and Molecular Docking
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154 Evaluation of the Effectiveness of Herbal Components Based on Their Regulatory Signature on Carcinogenic Cancer Cells
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155 Antiviral Properties of Polyphenols from Plants
Katarzyna Chojnacka,Dawid Skrzypczak,Grzegorz Izydorczyk,Katarzyna Mikula,Daniel Szopa,Anna Witek-Krowiak
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156 Adjunctive Nutraceutical Therapies for COVID-19
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157 Cheminformatics-Based Identification of Potential Novel Anti-SARS-CoV-2 Natural Compounds of African Origin
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158 Plant-Derived Anticancer Compounds as New Perspectives in Drug Discovery and Alternative Therapy
Cristina Adriana Dehelean,Iasmina Marcovici,Codruta Soica,Marius Mioc,Dorina Coricovac,Stela Iurciuc,Octavian Marius Cretu,Iulia Pinzaru
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159 Phytochemicals Targeting JAK–STAT Pathways in Inflammatory Bowel Disease: Insights from Animal Models
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160 Natural Xanthine Oxidase Inhibitor 5-O-Caffeoylshikimic Acid Ameliorates Kidney Injury Caused by Hyperuricemia in Mice
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161 SARS-CoV-2 Fears Green: The Chlorophyll Catabolite Pheophorbide A Is a Potent Antiviral
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162 Bryo-Activities: A Review on How Bryophytes Are Contributing to the Arsenal of Natural Bioactive Compounds against Fungi
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163 Selective Anticancer Properties, Proapoptotic and Antibacterial Potential of Three Asplenium Species
Venelin Petkov,Tsvetelina Batsalova,Plamen Stoyanov,Tsvetelina Mladenova,Desislava Kolchakova,Mariana Argirova,Tsvetanka Raycheva,Balik Dzhambazov
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164 Elemental Analysis and In Vitro Evaluation of Antibacterial and Antifungal Activities of Usnea barbata (L.) Weber ex F.H. Wigg from Calimani Mountains, Romania
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165 Lead Compounds in the Context of Extracellular Vesicle Research
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166 Phytochemicals and Enzyme Inhibitory Capacities of the Methanolic Extracts from the Italian Apple Cultivar Mela Rosa dei Monti Sibillini
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167 Chelerythrine Chloride Downregulates ß-Catenin and Inhibits Stem Cell Properties of Non-Small Cell Lung Carcinoma
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168 Untargeted Characterization of Chestnut (Castanea sativa Mill.) Shell Polyphenol Extract: A Valued Bioresource for Prostate Cancer Cell Growth Inhibition
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169 Synthesis and Properties of CurNQ for the Theranostic Application in Ovarian Cancer Intervention
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170 Phytochemicals as Anti-Inflammatory Agents in Animal Models of Prevalent Inflammatory Diseases
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171 Genista tridentata L.: A Rich Source of Flavonoids with Anti-Inflammatory Activity
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172 Investigation of the Biological Activities of Different Extracts from Dipsacus laciniatus Aerial Parts
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173 Immunomodulating potential of Neolamarckia cadamba (Roxb.) Bark extract
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174 Prevention of Oxidative Stress-Induced Pancreatic Beta Cell Damage by Broussonetia kazinoki Siebold Fruit Extract via the ERK-Nox4 Pathway
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175 Assessment of the Pharmacological Properties and Phytochemical Profile of Bruguiera gymnorhiza (L.) Lam Using In Vitro Studies, In Silico Docking, and Multivariate Analysis
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176 Ethnobotanical Description and Biological Activities of Senna alata
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177 In Silico Identification of New Targets for Diagnosis, Vaccine, and Drug Candidates against Trypanosoma cruzi
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178 Inhibitory potential on key enzymes relevant to type II diabetes mellitus and antioxidant properties of the various extracts and phytochemical constituents from Rumex acetosella L
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179 Pharmacological Assessment of the Carvacrol Chemotype Essential Oil FromPlectranthus amboinicusGrowing in Cuba
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180 In vitro antimitotic and cytotoxic potential of plant extracts: a comparative study of Mucuna pruriens, Asteracantha longifolia and Sphaeranthus indicus
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181 Antioxidant and in vivo hepatoprotective effects of Gardenia gummifera L.f. fruit methanol extract
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182 Ethnobotanical survey of the medicinal flora of Harighal, Azad Jammu & Kashmir, Pakistan
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183 RP-HPLC-UV Analysis of the Phenolic Compounds, Antimicrobial Activity Against Multi-Drug Resistant Bacteria and Antioxidant Activity of Fruit and Seed of Diospyros lotus L.ctivity of Fruit and Seed of Diospyros lotus L.
Zeynep AKAR,Aylin KARAKURT,Funda OKUMUS,Sedanur CINEMRE,Azer ÖZAD DÜZGÜN,Bülent AKAR,Zehra CAN
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184 Therapeutic Potential of Medicinal Plant Proteins: Present Status and Future Perspectives
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185 Antioxidant Potential of Glycyrrhiza glabra L. roots: In-Vitro Evidences
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186 Metabolism and Pharmacokinetics of Phytochemicals in the Human Body
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187 Germacrone: A Potent Secondary Metabolite with Therapeutic Potential in Metabolic Diseases, Cancer and Viral Infections
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188 Punica granatum L. (Pomegranate): A Potential Anti-microbial Agent
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189 Traditional and Herbal Medicines: Understanding & Exploration (Part II)
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190 Hepatoprotective and hematological effects of Justicia secunda Vahl leaves on carbon tetrachloride induced toxicity in rats
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191 Antimicrobial activity of Plumbago indica and ligand screening of plumbagin against methicillin-resistant Staphylococcus aureus
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192 Antiproliferative activity of new pentacyclic triterpene and a saponin from Gladiolus segetum Ker-Gawl corms supported by molecular docking study
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193 Dark Classics in Chemical Neuroscience: An Evidence-Based Systematic Review of Belladonna
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194 cis-9-Hexadecenal, a Natural Compound Targeting Cell Wall Organization, Critical Growth Factor, and Virulence of Aspergillus fumigatus
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195 A yeast platform for high-level synthesis of tetrahydroisoquinoline alkaloids
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196 Antioxidant properties of the Lebanese plantIrisxgermanicaL. crude extracts and antagonism of chlorpromazine toxicity onSaccharomyces cerevisiae
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197 Bioassay-guided isolation of antiplasmodial and antimicrobial constituents from the roots of Terminalia albida
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198 Constituents of essential oil of Origanum minutiflorum and its in vitro antioxidant, scolicidal and anticancer activities
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199 Therapeutic potential of sulfur-containing natural products in inflammatory diseases
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200 Anti-diabetic potential of plant alkaloids: Revisiting current findings and future perspectives
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201 Sugiol, a diterpenoid: Therapeutic actions and molecular pathways involved
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202 Davilla elliptica (Dilleniaceae) a. St.-Hil. Ethnomedicinal, phytochemical, and pharmacological aspects: A review
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203 Biochanin A: A novel bioactive multifunctional compound from nature
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204 Hispolon: A natural polyphenol and emerging cancer killer by multiple cellular signaling pathways
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205 Resveratrol encapsulation in high molecular weight chitosan-based nanogels for applications in ocular treatments: Impact on human ARPE-19 culture cells
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206 Nanocapsules Containing Saussurea lappa Essential Oil: Formulation, Characterization, Antidiabetic, Anti-Cholinesterase and Anti-Inflammatory Potentials
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207 Production of plant natural products through engineered Yarrowia lipolytica
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208 Calotropis - A multi-potential plant to humankind: Special focus on its wound healing efficacy
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209 Generation of A Stable GFP-reporter Zika Virus System for High-throughput Screening of Zika Virus Inhibitors
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210 Urolithin A Induces Brown-like Phenotype in 3T3-L1 White Adipocytes via ß3-adrenergic Receptor-p38 MAPK Signaling Pathway
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211 Phytochemicals and biological activities of species from the genus Maytenus
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212 Anti-Cancer and Anti-Inflammatory Activities of Bromo- and Cyano-Substituted Azulene Derivatives
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213 Therapeutic uses of post-partum tissue-derived mesenchymal stromal cell secretome
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214 Factorial design-guided optimization of extraction of therapeutically active furanocoumarin khellin from Ammi majus L. fruits
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215 Effects of Hydroalcoholic Flower Extract of Marigold (Calendula officinalis) on the Biochemical and Histological Parameters in STZ-Induced Diabetic Rats
Esmaeel Ebrahimi,Alireza Kheirollah,Esrafil Mansouri,Hossein Babaahmadi-Razaei,Ghorban Mohammadzadeh
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216 Cytotoxic Potential and Phytochemical Profile of Extracts from Garcinia rubra Merr. Leaves
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219 Essential oil yield estimation by Gas chromatography–mass spectrometry (GC–MS) after Methyl jasmonate (MeJA) elicitation in in vitro cultivated tissues of Coriandrum sativum L.
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221 Status and future scope of plant-based green hydrogels in biomedical engineering
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222 Progress in the discovery of naturally occurring anti-diabetic drugs and in the identification of their molecular targets
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Fitoterapia. 2019; 134: 270
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223 Accessing to the Nicotiana tabacum leaf antimicrobial activity: In-silico and in-vitro investigations
Yanelis Capdesuñer,Jorge García-Brizuela,Hans Peter Mock,Karel Vives Hernández,Martha Hernández de la Torre,Cosme E. Santiesteban-Toca
Plant Physiology and Biochemistry. 2019;
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224 In silico identification of mimicking molecule(s) triggering von Willebrand factor in human: a molecular drug target for regulating coagulation pathway
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Journal of Biomolecular Structure and Dynamics. 2019; : 1
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225 Toward Multi-Targeted Platinum and Ruthenium Drugs—A New Paradigm in Cancer Drug Treatment Regimens?
Reece G. Kenny,Celine J. Marmion
Chemical Reviews. 2019; 119(2): 1058
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226 Medicinal Plant Compounds for Combating the Multi-drug Resistant Pathogenic Bacteria: A Review
Mulugeta Mulat,Archana Pandita,Fazlurrahman Khan
Current Pharmaceutical Biotechnology. 2019; 20(3): 183
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227 Inhibition of Aspergillus fumigatus Biofilm and Cytotoxicity Study of Natural Compound Cis-9-Hexadecenal
Shanu Hoda,Lovely Gupta,Harshita Agarwal,Gaurav Raj,Maansi Vermani,Pooja Vijayaraghavan
Journal of Pure and Applied Microbiology. 2019; 13(2): 1207
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228 Cannabis medicinal, más que una encrucijada legal para el tratamiento de la epilepsia
Diana C. Riveros,Laura E. González-Valenzuela
Revista La Propiedad Inmaterial. 2019; (28): 259
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229 Oral Acute and Repeated-Doses Toxicity Study of Valepotriates from Valeriana glechomifolia (Meyer) in Mice
Tielle Moraes de Almeida,Gilsane Lino von Poser,Liz Girardi Müller,Paula Reis Pereira,Eduardo Cassel,Rubem Mario Figueiro Vargas,Nilson Junior da Silva Nunes,David Driemeier,Eliane Dallegrave,Stella de Faria Valle,Stela Maris Kuze Rates
Current Drug Discovery Technologies. 2019; 16(1): 96
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230 The Promising Role of Plant Tannins as Bioactive Antidiabetic Agents
Mohammed Ajebli,Mohamed Eddouks
Current Medicinal Chemistry. 2019; 26(25): 4852
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231 Use of Natural Components Derived from Oil Seed Plants for Treatment of Inflammatory Skin Diseases
Monika Styrczewska,Magdalena Zuk,Aleksandra Boba,Iwan Zalewski,Anna Kulma
Current Pharmaceutical Design. 2019; 25(20): 2241
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232 Crystal structure and in vitro antimicrobial activity studies of Robustic acid and other Alpinumisoflavones isolated from Millettia thonningii
Jerry Joe E.K. Harrison,Moscoh Daniel Ayine-Tora,Benjamin Appiagyei,Felix C. Mills-Robertson,William A. Asomaning,Daniel G. Achel,Hiroyuki Ishida,Robert Kingsford-Adaboh
Zeitschrift für Kristallographie - Crystalline Materials. 2019; 234(4): 229
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233 Isolation, Characterization and Assessment for Central Nervous System Effects of Novel Phytomolecule from Galphimia glauca Cav. Stems
VAISHNAVI VEERA REDDY,BHARGAVI THALLURI,BABA SHANKAR RAO GARIGE,RAM MOHAN MANDA,VASUDHA BAKSHI
Asian Journal of Chemistry. 2019; 31(6): 1230
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234 Pharmacokinetics of thymoquinone in layer chickens following oral and intravenous administration
Sehrish Iqbal,Aqeel Javeed,Adeel Sattar,Rabia Tanvir
Journal of Veterinary Pharmacology and Therapeutics. 2019;
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235 Morelloflavone as a novel inhibitor of mitotic kinesin Eg5
Tomisin Happy Ogunwa,Kenichi Taii,Kei Sadakane,Yuka Kawata,Shinsaku Maruta,Takayuki Miyanishi
The Journal of Biochemistry. 2019;
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236 Protective Effects of Broussonetia kazinoki Siebold Fruit Extract against Palmitate-Induced Lipotoxicity in Mesangial Cells
Donghee Kim,Hyo-Jin Kim,Seon-Heui Cha,Hee-Sook Jun
Evidence-Based Complementary and Alternative Medicine. 2019; 2019: 1
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237 Pharmacotherapeutics and Molecular Mechanism of Phytochemicals in Alleviating Hormone-Responsive Breast Cancer
Shailima Rampogu,Chanin Park,Doneti Ravinder,Minky Son,Ayoung Baek,Amir Zeb,Rohit Bavi,Raj Kumar,Gihwan Lee,Shraddha Parate,Smita C. Pawar,Yohan Park,Seok Ju Park,Keun Woo Lee
Oxidative Medicine and Cellular Longevity. 2019; 2019: 1
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238 Larrea tridentata Extract Mitigates Oxidative Stress-Induced Cytotoxicity in Human Neuroblastoma SH-SY5Y Cells
Karla Morán-Santibañez,Abimael H. Vasquez,Armando Varela-Ramirez,Veronica Henderson,Janae Sweeney,Valerie Odero-Marah,Karine Fenelon,Rachid Skouta
Antioxidants. 2019; 8(10): 427
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239 Cutting-Edge Search for Safer Opioid Pain Relief: Retrospective Review of Salvinorin A and Its Analogs
Jordan K. Zjawiony,Antônio S. Machado,Ricardo Menegatti,Paulo C. Ghedini,Elson A. Costa,Gustavo R. Pedrino,Scott E. Lukas,Octávio L. Franco,Osmar N. Silva,James O. Fajemiroye
Frontiers in Psychiatry. 2019; 10
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240 Deciphering the Antibacterial Mode of Action of Alpha-Mangostin on Staphylococcus epidermidis RP62A Through an Integrated Transcriptomic and Proteomic Approach
Murugesan Sivaranjani,Katarzyna Leskinen,Chairmandurai Aravindraja,Päivi Saavalainen,Shunmugiah Karutha Pandian,Mikael Skurnik,Arumugam Veera Ravi
Frontiers in Microbiology. 2019; 10
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241 Phenolic Profiling and Biological Potential of Ficus curtipes Corner Leaves and Stem Bark: 5-Lipoxygenase Inhibition and Interference with NO Levels in LPS-Stimulated RAW 264.7 Macrophages
Catarina Andrade,Federico Ferreres,Nelson G. M. Gomes,Sutsawat Duangsrisai,Nattawut Srisombat,Srunya Vajrodaya,David M. Pereira,Angel Gil-Izquierdo,Paula B. Andrade,Patrícia Valentão
Biomolecules. 2019; 9(9): 400
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242 Evaluating Iso-Mukaadial Acetate and Ursolic Acid Acetate as Plasmodium falciparum Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase Inhibitors
Francis Opoku,Penny P. Govender,Ofentse J. Pooe,Mthokozisi B.C. Simelane
Biomolecules. 2019; 9(12): 861
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243 Casticin-Induced Inhibition of Cell Growth and Survival Are Mediated through the Dual Modulation of Akt/mTOR Signaling Cascade
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Cancers. 2019; 11(2): 254
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244 Phytochemical Profiling of Coryphantha macromeris (Cactaceae) Growing in Greenhouse Conditions Using Ultra-High-Performance Liquid Chromatography–Tandem Mass Spectrometry
Emmanuel Cabañas-García,Carlos Areche,Juan Jáuregui-Rincón,Francisco Cruz-Sosa,Eugenio Pérez-Molphe Balch
Molecules. 2019; 24(4): 705
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245 At-Line Monitoring of the Extraction Process of Rosmarini Folium via Wet Chemical Assays, UHPLC Analysis, and Newly Developed Near-Infrared Spectroscopic Analysis Methods
Stefanie Delueg,Christian G. Kirchler,Florian Meischl,Yukihiro Ozaki,Michael A. Popp,Günther K. Bonn,Christian W. Huck
Molecules. 2019; 24(13): 2480
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246 Erythroxylum in Focus: An Interdisciplinary Review of an Overlooked Genus
J.C.A. Restrepo,J.C.A. Saenz,J.C.A. Jara-Muñoz,J.C.A. Calixto-Botía,J.C.A. Rodríguez-Suárez,J.C.A. Zuleta,J.C.A. Chavez,J.C.A. Sanchez,J.C.A. D’Auria
Molecules. 2019; 24(20): 3788
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247 Evaluation of Manganese Chloride’s Effect on Biosynthetic Properties of In Vitro Cultures of Eschscholzia californica Cham.
Andrea Balažová,Júlia Urdová,František Bilka,Ivana Holková,Branislav Horváth,Vladimír Forman,Pavel Mucaji
Molecules. 2018; 23(4): 971
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248 Molecular Targets Modulated by Fangchinoline in Tumor Cells and Preclinical Models
Myriam Mérarchi,Gautam Sethi,Lu Fan,Srishti Mishra,Frank Arfuso,Kwang Ahn
Molecules. 2018; 23(10): 2538
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249 Transcriptional Profiles of Secondary Metabolite Biosynthesis Genes and Cytochromes in the Leaves of Four Papaver Species
Dowan Kim,Myunghee Jung,In Ha,Min Lee,Seok-Geun Lee,Younhee Shin,Sathiyamoorthy Subramaniyam,Jaehyeon Oh
Data. 2018; 3(4): 55
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250 Effects of Mulberry Fruit (Morus alba L.) Consumption on Health Outcomes: A Mini-Review
Hongxia Zhang,Zheng Ma,Xiaoqin Luo,Xinli Li
Antioxidants. 2018; 7(5): 69
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251 Astragalin: A Bioactive Phytochemical with Potential Therapeutic Activities
Ammara Riaz,Azhar Rasul,Ghulam Hussain,Muhammad Kashif Zahoor,Farhat Jabeen,Zinayyera Subhani,Tahira Younis,Muhammad Ali,Iqra Sarfraz,Zeliha Selamoglu
Advances in Pharmacological Sciences. 2018; 2018: 1
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252 Isolation of anticancer constituents from Cucumis prophetarum var. prophetarum through bioassay-guided fractionation
Abdulrhman Alsayari,Lucas Kopel,Mahmoud Salama Ahmed,Hesham S. M. Soliman,Sivakumar Annadurai,Fathi T. Halaweish
BMC Complementary and Alternative Medicine. 2018; 18(1)
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253 Antioxidant activity, antibacterial potential and characterization of active fraction of Dioscorea pentaphylla L. tuber extract collected from Similipal Biosphere Reserve, Odisha, India
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Brazilian Journal of Pharmaceutical Sciences. 2018; 53(4)
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254 Toxicity and Antigenotoxic Effect of Hispolon Derivatives: Role of Structure in Modulating Cellular Redox State and Thioredoxin Reductase
Pogakula Chethna,Shruti S. Iyer,Vishwa V. Gandhi,Amit Kunwar,Beena G. Singh,Atanu Barik,Neduri V. Balaji,Modukuri V. Ramani,Gottumukkala V. Subbaraju,K. Indira Priyadarsini
ACS Omega. 2018; 3(6): 5958
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255 Alkaloid rich fraction of Datura alba Rumph. ex Nees leaves possesses antitumor and antimitotic activity
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South African Journal of Botany. 2018; 117: 282
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256 Recommended Medicinal Plants as Source of Natural Products: A Review
Henry Ivanz A. Boy,Alfred Joshua H. Rutilla,Kimbberly A. Santos,Allister Matthew T. Ty,Alicia I. Yu,Tooba Mahboob,Jitbanjong Tangpoong,Veeranoot Nissapatorn
Digital Chinese Medicine. 2018; 1(2): 131
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257 Toxic effect of Moringa peregrina seeds on histological and biochemical analyses of adult male Albino rats
Heba N.Gad EL-Hak,Abdel Raouf A. Moustafa,Samira R. Mansour
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258 The Medicinal Uses, Toxicities and Anti-inflammatory Activity of Polyalthia Species (Annonaceae)
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Journal of Ethnopharmacology. 2018;
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259 Bioactive Compounds Extracted from Mangrove Plants (Avicennia marina and Rhizophora mucronata): an Overview
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Pathophysiology. 2018;
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260 Evaluation of Boerhavia erecta L. for potential antidiabetic and antihyperlipidemic activities in streptozotocin-induced diabetic Wistar rats
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Future Journal of Pharmaceutical Sciences. 2018;
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261 Optimization of extraction parameters of antioxidant activity of extracts from New Zealand and Chinese Asparagus officinalis L root cultivars
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Industrial Crops and Products. 2018; 119: 191
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262 Lotus aegaeus (Gris.) Boiss and Iberis sempervirens L.: Chemical fingerprints, antioxidant potential, and inhibition activities and docking on key enzymes linked to global health problems
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263 Phytochemical screening, free radical scavenging and antimicrobial potential of Chromolaena odorata leaf extracts against pathogenic bacterium in wound infections– a multispectrum perspective
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Biocatalysis and Agricultural Biotechnology. 2018;
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264 HPLC-DAD profiles and pharmacological insights of Onobrychis argyrea subsp isaurica extracts
Gokalp Ozmen Guler,Gokhan Zengin,Firat Karadag,Adriano Mollica,Carene Marie Nancy Picot,Mohamad Fawzi Mahomoodally
Computational Biology and Chemistry. 2018; 76: 256
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265 Comprehensive review of antimicrobial activities of plant flavonoids
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Phytochemistry Reviews. 2018;
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266 Effect of Synadenium grantii and its isolated compound on dysmenorrhea behavior model in mice
Flávia Werner da Rocha Jesuíno,Jaqueline Pavesi Reis,Juliana Cristina Pereira Whitaker,Adriana Campos,Maria Verônica Dávila Pastor,Valdir Cechinel Filho,Nara Lins Meira Quintão
Inflammopharmacology. 2018;
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267 Natural Products Extraction of the Future—Sustainable Manufacturing Solutions for Societal Needs
Lukas Uhlenbrock,Maximilian Sixt,Martin Tegtmeier,Hartwig Schulz,Hansjörg Hagels,Reinhard Ditz,Jochen Strube
Processes. 2018; 6(10): 177
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268 Cytotoxicity of n-Butanol Extracts of Streptomyces Against Human Breast Cancer Cells
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International Journal of Pharmacology. 2017; 13(8): 969
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269 Therapeutic effect of an alkaloid-rich fraction of Abrus precatorius seed methanol extract on paracetamol-induced liver damage in rats
Chimere Young Ukegbu,Elijah Joshua Parker,Fred Nwodo C. Okwesili,Okechukwu Iroha
African Journal of Biochemistry Research. 2017; 11(11): 72
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270 Constituents of leaves from Bauhinia curvula Benth. exert gastroprotective activity in rodents: role of quercitrin and kaempferol
Ana Paula Beber,Priscila de Souza,Thaise Boeing,Lincon Bordignon Somensi,Luísa Nathália Bolda Mariano,Benhur Judah Cury,Ligia Moura Burci,Cristiane Bezerra da Silva,Euclésio Simionatto,Sérgio Faloni de Andrade,Luísa Mota da Silva
Inflammopharmacology. 2017;
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271 Antidiabetic plant-derived nutraceuticals: a critical review
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European Journal of Nutrition. 2017;
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272 Metal-Free trans -Aziridination of Zerumbone: Synthesis and Biological Evaluation of Aziridine Derivatives of Zerumbone
Greeshma Gopalan,Bhandara Purayil Dhanya,Jayaram Saranya,Thankappan Remadevi Reshmitha,Thekke Veettil Baiju,Murugan Thulasi Meenu,Mangalam S. Nair,Prakasan Nisha,Kokkuvayil Vasu Radhakrishnan
European Journal of Organic Chemistry. 2017; 2017(21): 3072
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273 Euclea undulata Thunb.: Review of its botany, ethnomedicinal uses, phytochemistry and biological activities
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Asian Pacific Journal of Tropical Medicine. 2017;
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274 Exploiting natural variation for accelerating discoveries in plant specialized metabolism
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Phytochemistry Reviews. 2017;
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275 Topical aqueous extract of Ephedra alata can improve wound healing in an animal model
Naim Kittana,Hanood Abu-Rass,Ruba Sabra,Lama Manasra,Hadeel Hanany,Nidal Jaradat,Fatima Hussein,Abdel Naser Zaid
Chinese Journal of Traumatology. 2017;
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276 A Novel DSC Approach for Evaluating Protectant Drugs Efficacy against Dementia
Silviya Abarova,Rumiana Koynova,Lyubka Tancheva,Boris Tenchov
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2017;
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277 Antinociceptive and anti-inflammatory effects of the methanolic stem bark extract of Antrocaryon klaineanum Pierre (Anacardiaceae) in mice and rat
Annie Laure Magne Fongang,Edwige Laure Nguemfo,Yolande Djouatsa Nangue,Calvin Bogning Zangueu,Yannick Fouokeng,Anatole Guy Blaise Azebaze,Eulogio José Llorent-Martínez,Maria Luisa Fernández-de Córdova,Alain Bertrand Dongmo,Wolfgang Vierling
Journal of Ethnopharmacology. 2017; 203: 11
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278 Antibacterial activity of medicinal plants from The Physicians of Myddvai, a 14th century Welsh medical manuscript
Charles Stephen Wagner,Jillian De Gezelle,Maureen Robertson,Keith Robertson,Mickey Wilson,Slavko Komarnytsky
Journal of Ethnopharmacology. 2017; 203: 171
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279 Bioavailability-enhanced Resveramax™ modulates quorum sensing and inhibits biofilm formation in Pseudomonas aeruginosa PAO1
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Microbial Pathogenesis. 2017;
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280 A polyphenolic extract from green tea leaves activates fat browning in high fat diet-induced obese mice
Audrey M. Neyrinck,Laure B. Bindels,Lucie Geurts,Matthias Van Hul,Patrice D. Cani,Nathalie M. Delzenne
The Journal of Nutritional Biochemistry. 2017;
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281 Broadening our perspectives on complementary and alternative medicine for menopause: A narrative review
Dunia Tonob,Melissa K. Melby
Maturitas. 2017; 99: 79
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282 Biological activities of plant extracts from Ficus elastica and Selaginella vogelli : An antimalarial, antitrypanosomal and cytotoxity evaluation
Jean Emmanuel Mbosso Teinkela,Xavier Siwe Noundou,Edwige Laure Nguemfo,Franck Meyer,Rene Wintjens,Michelle Isaacs,Emmanuel Mpondo Mpondo,Heinrich C. Hoppe,Rui Werner Maçedo Krause,Anatole Guy Blaise Azebaze
Saudi Journal of Biological Sciences. 2017;
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283 In vitro antimicrobial activity of the methanol extract and compounds from the wood of Ficus elastica Roxb. ex Hornem. aerial roots
J.E. Mbosso Teinkela,X. Siwe Noundou,S. Fannang,F. Meyer,J.C. Vardamides,E. Mpondo Mpondo,R.W.M. Krause,A.G.B. Azebaze,J.C.A. Nguedia
South African Journal of Botany. 2017; 111: 302
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284 Magnolol inhibits venous remodeling in mice
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Scientific Reports. 2017; 7(1)
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285 Molecular binding mechanism of 5-hydroxy-1-methylpiperidin-2-one with human serum albumin
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Journal of Biomolecular Structure and Dynamics. 2017; : 1
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286 Traditional Chinese herbal medicine and its effects on the quality of life of lung cancer patients: a meta-analysis
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Bioscience Horizons: The International Journal of Student Research. 2017; 10
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287 The role of spices in nutrition and health: a review of three popular spices used in Southern Nigeria
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Food Quality and Safety. 2017;
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288 An integrative in-silico approach for therapeutic target identification in the human pathogen Corynebacterium diphtheriae
Syed Babar Jamal,Syed Shah Hassan,Sandeep Tiwari,Marcus V. Viana,Leandro de Jesus Benevides,Asad Ullah,Adrián G. Turjanski,Debmalya Barh,Preetam Ghosh,Daniela Arruda Costa,Artur Silva,Richard Röttger,Jan Baumbach,Vasco A. C. Azevedo,Alexandre G. de Brevern
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289 Bioactive Steroids and Saponins of the Genus Trillium
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Molecules. 2017; 22(12): 2156
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290 Optimizing the Maximum Recovery of Dihydromyricetin from Chinese Vine Tea, Ampelopsis grossedentata, Using Response Surface Methodology
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291 Phytochemicals as novel agents for the induction of browning in white adipose tissue
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292 Fraxinus xanthoxyloides leaves reduced the level of inflammatory mediators during in vitro and in vivo studies
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BMC Complementary and Alternative Medicine. 2016; 16(1)
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293 Preliminary assessment of free radical scavenging, thrombolytic and membrane stabilizing capabilities of organic fractions of Callistemon citrinus (Curtis.) skeels leaves
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294 Methylferulate from Tamarix aucheriana inhibits growth and enhances chemosensitivity of human colorectal cancer cells: possible mechanism of action
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295 The GenusHeracleum: A Comprehensive Review on Its Phytochemistry, Pharmacology, and Ethnobotanical Values as a Useful Herb
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296 Extraction of bioactive plant materials by simultaneous enzyme treatment and lactic acid fermentation – a mini-review
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297 A reexamination of poneratoxin from the venom of the bullet ant Paraponera clavata
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298 Alzheimeræs disease: An overview of amyloid beta dependent pathogenesis and its therapeutic implications along with in silico approaches emphasizing the role of natural products
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Journal of the Neurological Sciences. 2016; 361: 256
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299 An overview of herb and dietary supplement efficacy, safety and government regulations in the United States with suggested improvements. Part 1 of 5 series
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300 New potential phytotherapeutics obtained from white mulberry (Morus alba L.) leaves
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301 Synthesis and Characterization of Sygyzium cumini Nanoparticles for Its Protective Potential in High Glucose-Induced Cardiac Stress: a Green Approach
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302 In vitro inhibitory effects on a-glucosidase and a-amylase level and antioxidant potential of seeds of Phoenix dactylifera L.
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303 Safety assessment of aqueous acetone extract of Clerodendrum infortunatum L. in Wistar rats
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304 High-throughput sequencing and de novo transcriptome assembly of Swertia japonica to identify genes involved in the biosynthesis of therapeutic metabolites
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305 Picking edible and medicinal plants: exotic “apples” and “pears”
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