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REVIEW ARTICLE
Year : 2011  |  Volume : 2  |  Issue : 4  |  Page : 236-240  

The peroxisome proliferator-activated receptor: A family of nuclear receptors role in various diseases

Sandeep Tyagi, Paras Gupta, Arminder Singh Saini, Chaitnya Kaushal, Saurabh Sharma
Department of Pharmacology, ISF College of Pharmacy, Moga, Punjab, India

Date of Web Publication16-Dec-2011

Correspondence Address:
Sandeep Tyagi
Department of Pharmacology, ISF College of Pharmacy, Moga, Punjab - 142 001
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2231-4040.90879

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   Abstract 

Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors of nuclear hormone receptor superfamily comprising of the following three subtypes: PPARα, PPARγ, and PPARβ/δ. Activation of PPAR-α reduces triglyceride level and is involved in regulation of energy homeostasis. Activation of PPAR-γ causes insulin sensitization and enhances glucose metabolism, whereas activation of PPAR- β/δ enhances fatty acids metabolism. Thus, PPAR family of nuclear receptors plays a major regulatory role in energy homeostasis and metabolic function. The present review critically analyzes the protective and detrimental effect of PPAR agonists in dyslipidemia, diabetes, adipocyte differentiation, inflammation, cancer, lung diseases, neurodegenerative disorders, fertility or reproduction, pain, and obesity.

Keywords: Diabetes, dyslipidemia, peroxisome proliferator-activated receptors


How to cite this article:
Tyagi S, Gupta P, Saini AS, Kaushal C, Sharma S. The peroxisome proliferator-activated receptor: A family of nuclear receptors role in various diseases. J Adv Pharm Technol Res 2011;2:236-40

How to cite this URL:
Tyagi S, Gupta P, Saini AS, Kaushal C, Sharma S. The peroxisome proliferator-activated receptor: A family of nuclear receptors role in various diseases. J Adv Pharm Technol Res [serial online] 2011 [cited 2021 Dec 2];2:236-40. Available from: https://www.japtr.org/text.asp?2011/2/4/236/90879


   Introduction Top


Peroxisomes are subcellular organelles found in most plant and animal cells that perform diverse metabolic functions including H 2 O 2-based respiration, β-oxidation of fatty acids (FAs), and cholesterol metabolism. Peroxisome proliferator-activated receptors (PPARs) proteins belong to superfamily of phylogenetically related protein termed nuclear hormone factor.[1] PPARs were identified in rodents in 1990 and these belong to a nuclear hormone receptor superfamily containing 48 members. But, these agents are associated with no proliferation in the human beings. Structurally, PPARs are similar to steroid or thyroid hormone receptor and are stimulated in response to small lipophilic ligands. In rodents, a large class of structurally related chemicals including herbicides, industrial solvents, and hypolipidemic drugs lead to significant increase in the number and size of peroxisomes in the liver and may cause liver hypertrophy, liver hyperplasia, hepatocarcinogenesis, and transcription of genes encoding proximal enzymes. PPARs mainly exist in three subtypes; α, β/δ, and γ, each of which mediates the physiological actions of a large variety of FAs and FA-derived molecules. Activated PPARs are also capable of transcriptional repression through DNA-independent protein-protein interactions with other transcription factors such as NFκB signal activators and transducers of transcription STAT-1 and AP-1 signaling. [2]


   Structure Top


The PPARs possess the canonical domain structure common to other nuclear receptor family members, including the amino-terminal AF-1 trans activation domain, followed by a DNA-binding domain, and a dimerization and ligand-binding domain with a ligand-dependent trans activation function AF-2 located at the carboxy-terminal region. [3]


   Isoforms of Peroxisome Proliferator-Activated Receptors Top


PPARs are transcription factors that belong to the Superfamily of nuclear receptors. Other members of this family include retinoic acid, estrogen, thyroid, vitamin D, and glucocorticoid receptors, and several other proteins involved in xenobiotic metabolism PPARs act on DNA response elements as heterodimers with the retinoid X receptor (RXR). Their natural activating ligands are lipid-derived substrates. The family of PPARs is represented by the following three members: PPAR-α, PPAR-δ, and PPAR-γ. They play an essential role in energy metabolism; however, they differ in the spectrum of their activity-PPAR-γ regulates energy storage, whereas PPAR-α is expressed predominantly in the liver, and to a lesser extent, in muscle, in the heart, and in bone and PPAR-δ present ubiquitously expressed in whole body regulate energy expenditure; expression of PPAR-γ in endothelial cells, vascular smooth muscle cells. PPAR-γ is further subdivided in four isoforms.[4]

  • γ1 - expressed in virtually all tissues, including heart, muscle, colon, kidney, pancreas, and spleen.
  • γ2 - expressed mainly in adipose tissue (30 amino acids longer).
  • γ3 - expressed in macrophages, large intestine, and white adipose tissue.
  • γ4 - expressed in endothelial cells.



   Mechanism of Action of Peroxisome Proliferator-Activated Receptors Top


PPARs function as heterodimer in association with co- activator complex that binds to DNA sequence termed peroxisome proliferators response elements (PPREs) present in promoter of target genes which leads to transactivation and transrepression of various genes. [1] In the absence of the ligands, these heterodimers are associated with co- repressor complex which block gene transcription. Some of the agonists of various PPARs receptors are given in Balakumar P.2007. [5] Like PPARs, RXR exists as three distinct isoforms: RXR-α, β, and γ, all of which are activated by the endogenous agonist 9-cis retinoic acid. [6] No specific roles have yet been elaborated for these different isoforms within the PPAR: RXR complex. However, synthetic RXR agonists (rexiniids) can activate the complex and thereby obtain antidiabetic outcomes similar to those seen with PPAR agonists in mouse models of type 2 diabetes. [7] The LBD facilitates the heterodimerization of PPARs with RXR and the resultant heterodimer subsequently binds to PPRE with the recruitment of cofactors. [1]

Peroxisome Proliferator-Activated Receptor-Alpha

PPAR-α expression is relatively high in hepatocytes, enterocytes, vascular and immune cell types such as monocytes/macrophages, endothelial cells, smooth muscle cells, lymphocytes, non-neuronal cells like microglia and astroglia.[8],[9] In the liver, it plays a crucial role in FA oxidation, which provides energy for peripheral tissues, elevated mitochondrial and peroxisomal FAs β-oxidation rates, such as liver, heart muscle, kidney, skeletal muscle, retina, and brown adipose tissues, and have a potential role in oxidant/antioxidant pathway. [10],[11] PPAR-α ligands can be both synthetic or endogenous FAs and FA-derived compounds are natural ligands for PPAR-α. [12] Over the last several decades, there have been a number of studies on the physiology, pharmacology, and functional genomics of PPAR-α. In vivo and In vitro studies demonstrate that PPAR-α plays a central role in lipid and lipoprotein metabolism, and thereby decreases dyslipidemia associated with metabolic syndrome.[13],[14],[15] In the fasting state, PPAR-α is activated by adipose-derived FAs, thereby enhancing the generation of ketone bodies through FA oxidation in liver and peripheral blood mononuclear cells.[16]

Peroxisome Proliferator-Activated Receptor-γ

Thiazolidinediones (TZDs) are the most widely studied PPAR-γ ligands. Troglitazone was the first drug approved for this use, followed by rosiglitazone and pioglitazone. The mechanism of action of TZDs was not known until 1995, when Lehmann reported that TZDs were high affinity ligands, for Peroxisome proliferator-activated receptor gamma (PPAR-γ) is a ligand-dependent transcription factor and a member of the nuclear receptor superfamily. Acting as sensors of hormones, vitamins, endogenous metabolites, and xenobiotic compounds, the nuclear receptors control the expression of a very large number of genes. PPAR-γ has been known for some time to regulate adipocyte differentiation, FA storage and glucose metabolism, and is a target of antidiabetic drugs.[17] PPAR-γ agonist improves insulin resistance by opposing the effect of TNF-α in adipocytes.[18] PPAR-γ enhances the expression of a number of genes encoding proteins involved in glucose and lipid metabolism.[19] Various modulator of PPAR-γ agonist is shown in Balakumar P. 2007.[5]

Peroxisome Proliferator-Activated Receptor-β/δ

PPAR-δ/β is expressed in skeletal muscle, adipocytes, macrophages, lungs, brain, and skin. It promotes FA metabolism and suppresses macrophage derived inflammation.[20] Newly synthesized compounds such as GW501516, GW610742, and GW0742X are shown to have high selectivity to PPARδ.[21] PPAR-δ has been noted to reduce the expression of inflammatory mediators and adhesion molecules, suggesting their potential role in attenuating atherogenesis.[22] Few studies have shown that PPAR-δ ligands have the potential to inhibit cardiac hypertrophy due to their inhibitory activity on NFκB, a transcription factor which produces inflammatory cytokines. Various modulator of PPAR-β/δ agonist is shown in Balakumar P. 2007. [5]


   Pharmacological Potentials Top


Obesity

This special issue begins with a review of key observations in human subjects harboring genetic variations in PPARγ and a thorough overview of the metabolic effects of PPARs in genetically modified animal models. The interaction of PPARs with uncoupling proteins regulating energy expenditure is reviewed as recent developments with RXR agonists. A closely related topic addressed is the molecular and physiological functions of PPAR co-activators and co-repressors in relationship to adipocyte energy metabolism. In addition, the potential advantages of selective PPAR agonists are discussed. The intriguing possibility that PPARs may mediate effects of caloric restriction on longevity is also considered. Finally, evidence that PPARs may be interesting therapeutic targets to modulate obesity-induced inflammation is reviewed. [23] PPAR-α ligands such as fibrates have been used for the treatment of dyslipidemia due to their ability to lower plasma triglyceride levels and elevate HDL cholesterol levels. PPAR-α activators have been shown to regulate obesity in rodents by both increasing hepatic FA oxidation and decreasing the levels of circulating triglycerides responsible for adipose cell hypertrophy and hyperplasia. However, these effects of PPAR-α on obesity and lipid metabolism may be exerted with sexual dimorphism and seem to be influenced by estrogen. Estrogen inhibits the actions of PPARα on obesity and lipid metabolism through its effects on PPARα-dependent regulation of target genes. [24]

Inflammation

Inflammatory conditions are mainly characterized by activation of macrophages and monocytes at the injury site which subsequently increase the release of proinflammatory mediators like TNF-α, IL-6, and IL-1β which in turn stimulates the production of COX products. PPAR-α and fenofibrate reduces pain and inflammation and further inhibits the release of several pro-inflammatory and pro-angiogenic enzymes (e.g., iNOS, chymase, and metalloproteinase MMP-9), and mediators (e.g., NO and TNF-α).[25],[26] More recently, PPAR-γ has been recognized as playing a fundamentally important role in the immune response through its ability to inhibit the expression of inflammatory cytokines and to direct the differentiation of immune cells toward anti-inflammatory phenotypes. A feature of PPAR-γ is the structural diversity of its ligands, which encompass endogenous metabolites, dietary compounds, and synthetic drugs. The high and increasing incidence of inflammatory and allergic disease, coupled with encouraging results from recent clinical trials, suggest that natural PPAR-γ agonists found in foods may be beneficial to human health by acting as anti-inflammatory molecules. PPAR-γ is therefore not only a target of the pharmaceutical industry, but also of great potential interest to the food industry, since it is activated by several natural dietary constituents. [27]

Adipocyte Differentiation

Adipogenesis refers to the process of differentiation of the pre-adipocyte precursor cells into adipocytes that are capable of lipid filling, as well as the expression of hormones and cytokines. PPAR-γ regulates the expression of numerous genes involved in lipid metabolism, including aP2, PPCK, acyl-CoA synthase, and LPL. [28] PPAR-γ has also been shown to control expression of FATP-1 and CD36, both involved in lipid uptake into adipocytes. These genes have all been shown to possess PPREs within their regulatory regions. PPAR-γ is mainly involved in the process of cell growth arrest, followed by progression into the fully differentiated adipocyte phenotype.[29] PPAR-γ and PPAR-β have both been implicated in molecular signaling that mediates adipocyte differentiation, whereas the role of PPAR-γ is well established in this process. The specific role of PPAR-γ is less certain. It has been reported that in the presence of standard differentiation medium, PPAR-γ is required for maximal adipocyte differentiation as PPAR-γ null adipocytes exhibit significantly impaired lipid accumulation and expression of adipose differentiate marker mRNAs.[30]

Anti-Cancer Effect

Peroxisome proliferator-activated receptor (PPAR) is a Double-Edged Sword in Cancer Therapy. PPAR-alpha stimulation appears to inhibit proliferation of human colon cancer cell lines and to reduce poly formation in the mouse model of familial adenomatous. PPAR-β (also referred to as PPARδ) in epithelial homeostasis have been described including the regulation of keratinocyte differentiation, apoptosis and cell proliferation, inflammation, and wound healing. [31] PPAR-γ not only controls the expression of genes involved in differentiations but also negatively regulates the cell cycle. [32] TZDs induce the tumor suppressor gene PTEN, which also contributes to their antiproliferative activity. PPAR-γ activation inhibits the proliferation of malignant cells, including those derived from liposarcoma, breast adenocarcinoma,[33] prostate carcinoma, colorectal carcinoma, non-small-cell lung carcinoma, pancreatic carcinoma, bladder cancer, gastric carcinoma, and glial tumors of the brain. [34]

Neurodegenerative Disorder

PPAR-γ agonists have also shown efficacy in Parkinson disease, Alzheimer disease, brain injury, and ALS. They act on microglial cells and inhibit the microglial cells activation. The role of PPARs in modulating lipid and glucose metabolism is well established. More recently, PPARs have been demonstrated to modulate inflammation. For example, PPAR agonists inhibit the production of proinflammatory molecules by peripheral immune cells as well as resident glial cells. Furthermore, PPAR receptor agonists have proven effective in suppressing the development of animal models of CNS inflammatory and neurodegenerative disorders. [35] In vivo oral administration of the PPAR-γ agonist pioglitazone reduced glial activation and the accumulation of Aβ-positive plaques in the hippocampus and cortex. Various neurodegenerative diseases are associated with electron transport chain enzyme activity reductions and increased mitochondrial-generated oxidative stress. [36]


   Peroxisome Proliferator-Activated Receptors in Lung Pathophysiology and Disease Top


This special issue contains a comprehensive group of reviews and original investigations illustrating the pivotal role of PPARs in the regulation of multiple cellular events in lung pathogenesis. Such events include lung morphogenesis, the inhibition of the release of inflammatory mediators from lung immune and stromal/parenchymal cells In vitro, and dampening both inflammation and damage in animal models of acute lung injury (ALI), ischemia-reperfusion injury, and allergic airways inflammation. Also covered are lung tissue remodeling and the fibro-proliferation that occur in chronic airways disease, ALI, pulmonary vascular disease, and pulmonary fibrosis. In addition, activation of key macrophage antimicrobial and reparative responses within the airspace is addressed, also data illuminating the central role of PPAR-γ in the regulation of critical aspects of lung tumor initiation, progression, and metastasis are summarized. [23]

Peroxisome Proliferator-Activated Receptors and Diabetes

The three PPAR subtypes, alpha, gamma, and delta, have distinct expression patterns and regulate glucose homeostasis based on the need of a specific tissue. Although PPAR alpha potentiates FA catabolism in the liver and is the molecular target of the lipid-lowering fibrates, PPAR-gamma is essential for adipocyte differentiation and hypertrophy, and mediates the activity of the insulin-sensitizing TZDs. PPAR-delta may be important in regulating body weight and lipid metabolism in fat tissues. [37]

Peroxisome Proliferator-Activated Receptors and Pain

Synthetic PPAR-α receptor agonists produce broad-spectrum analgesia in a dose-dependent manner.[38] It was recently reported that supraspinal (intracerebroventricular) administration of PPAR-α ligands (perfluorooctanoic acid) reduced peripheral edema and/or inflammatory hyperalgesia [25],[39],[40] and that intrathecal administration of PPARγ ligands, rosiglitazone and 15d-PGJ2, reduced behavioral signs of neuropathic pain.[41] It was recently reported that systemic administration of pioglitazone reduced behavioral signs of neuropathic pain, raising the possibility that this FDA-approved drug can be effective as an analgesic agent. [42]


   Conclusion Top


PPAR are involved in various independent and DNA-dependent molecular and enzymatic pathways in adipose tissue, liver, and skeletal muscles. These pathways are affected in disease condition and cause the metabolic energy imbalance. Thus, intervention of PPAR can provide therapeutic targets for plethora of diseases such as dyslipidemia, diabetes, obesity, inflammation, neurodegenerative disorder, and cancer. Finally, evidence that PPARs may be interesting therapeutic targets to modulate obesity-induced inflammation is reviewed. Since its inception, a little over three years ago, PPAR Research has become a vibrant forum showcasing global effort in this ever-expanding field of research. Then, there is a series of reviews focusing on the potentially beneficial effects of PPAR agonists on the various diseases. Examining the contents of these special issues reveals an intense interest in exploring new physiological roles of the PPARs and in the identification of new and improved PPAR agonist drugs.


   Acknowledgments Top


The authors are thankful to R. D. Budhiraja (director administration) ISF College of Pharmacy, Moga, Punjab for encouragement and valuable advice.

 
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10 Network modeling and inference of peroxisome proliferator-activated receptor pathway in high fat diet-linked obesity
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19 Guggulsterone ameliorates ethidium bromide-induced experimental model of multiple sclerosis via restoration of behavioral, molecular, neurochemical and morphological alterations in rat brain
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32 Endocannabinoid markers in autism spectrum disorder: A scoping review of human studies
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36 Quantitative Chemical Proteomics Reveals Interspecies Variations on Binding Schemes of L-FABP with Perfluorooctanesulfonate
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37 Glitazones Activate PGC-1a Signaling via PPAR-?: A Promising Strategy for Antiparkinsonism Therapeutics
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39 Comparative assessment of antimicrobial, antiradical and cytotoxic activities of cannabidiol and its propyl analogue cannabidivarin
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42 The role of gut microbiome in prevention, diagnosis and treatment of gestational diabetes mellitus
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43 Emerging role of nutritional short-chain fatty acids (SCFAs) against cancer via modulation of hematopoiesis
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45 Transcriptomic Changes and the Roles of Cannabinoid Receptors and PPAR? in Developmental Toxicities Following Exposure to ?9-Tetrahydrocannabinol and Cannabidiol
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46 In vivo brain levels of acetylcholine and 5-hydroxytryptamine after oleoylethanolamide or palmitoylethanolamide administrations are mediated by PPARa engagement
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47 Association between long noncoding RNA taurine-upregulated gene 1 and microRNA-377 in vitiligo
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50 Oral Administration of Germinated, Pigmented, Giant Embryo Rice (Oryza sativa L. cv. Keunnunjami) Extract Improves the Lipid and Glucose Metabolisms in High-Fat Diet-Fed Mice
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54 Sensory Neurons, Neuroimmunity, and Pain Modulation by Sex Hormones
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57 Pharmacological Therapeutics: Current Trends for Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD)
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62 Expression of the Wilms’ tumour gene and its association with PPARß/d in healthy skin and melanoma of horses
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63 Peroxisome-Proliferator Activator Receptor ? in Mouse Model with Meningoencephalitis Caused by Angiostrongylus cantonensis
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67 The Synergy of ADAM17-Induced Myocardial Inflammation and Metabolic Lipids Dysregulation During Acute Stress: New Pathophysiologic Insights Into Takotsubo Cardiomyopathy
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68 The Role of Metabolism in Heart Failure and Regeneration
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69 Placental Gene Co-expression Network for Maternal Plasma Lipids Revealed Enrichment of Inflammatory Response Pathways
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70 Nuclear Receptors in Asthma: Empowering Classical Molecules Against a Contemporary Ailment
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71 Transcriptomic Effects of Healthspan-Promoting Dietary Interventions: Current Evidence and Future Directions
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72 PPAR? Mediates the Anti-Epithelial-Mesenchymal Transition Effects of FGF1?HBS in Chronic Kidney Diseases via Inhibition of TGF-ß1/SMAD3 Signaling
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73 Peroxisome Proliferator-Activated Receptor ?, but Not a or G-Protein Coupled Estrogen Receptor Drives Functioning of Postnatal Boar Testis—Next Generation Sequencing Analysis
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74 Lipotoxic Impairment of Mitochondrial Function in ß-Cells: A Review
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75 Harnessing the Benefits of Endogenous Hydrogen Sulfide to Reduce Cardiovascular Disease
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76 L-Carnosine Stimulation of Coenzyme Q10 Biosynthesis Promotes Improved Mitochondrial Function and Decreases Hepatic Steatosis in Diabetic Conditions
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77 Serum Bilirubin Levels in Overweight and Obese Individuals: The Importance of Anti-Inflammatory and Antioxidant Responses
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78 Protective Effects of Echinacea purpurea Ethanol Extract on Male Reproductive Dysfunction in Obese Rats
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79 Sirtuins-Mediated System-Level Regulation of Mammalian Tissues at the Interface between Metabolism and Cell Cycle: A Systematic Review
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80 The Influence of Anti-Diabetic Drugs on Prostate Cancer
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81 Lipoprotein Lipase Regulates Microglial Lipid Droplet Accumulation
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82 Long-Term Effects of Very Low Dose Particle Radiation on Gene Expression in the Heart: Degenerative Disease Risks
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83 Epigenetic Regulation of Processes Related to High Level of Fibroblast Growth Factor 21 in Obese Subjects
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84 The Role of Lipid Sensing Nuclear Receptors (PPARs and LXR) and Metabolic Lipases in Obesity, Diabetes and NAFLD
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85 Essential Fatty Acids as Biomedicines in Cardiac Health
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86 Novel Therapeutic Targets for the Treatment of Right Ventricular Remodeling: Insights from the Pulmonary Artery Banding Model
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87 Computational Identification of Master Regulators Influencing Trypanotolerance in Cattle
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88 Studies in a Murine Granuloma Model of Instilled Carbon Nanotubes: Relevance to Sarcoidosis
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89 Metabolic Spectrum of Liver Failure in Type 2 Diabetes and Obesity: From NAFLD to NASH to HCC
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90 Human Placental Transcriptome Reveals Critical Alterations in Inflammation and Energy Metabolism with Fetal Sex Differences in Spontaneous Preterm Birth
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91 PPARs as Metabolic Sensors and Therapeutic Targets in Liver Diseases
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92 Exploring the Biological Activity and Mechanism of Xenoestrogens and Phytoestrogens in Cancers: Emerging Methods and Concepts
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93 Elucidating the Neuroprotective Role of PPARs in Parkinson’s Disease: A Neoteric and Prospective Target
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94 Targetable Pathways for Alleviating Mitochondrial Dysfunction in Neurodegeneration of Metabolic and Non-Metabolic Diseases
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95 Nuclear Receptors in Myocardial and Cerebral Ischemia—Mechanisms of Action and Therapeutic Strategies
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96 Role of Peroxisome Proliferator-Activated Receptors (PPARs) in Energy Homeostasis of Dairy Animals: Exploiting Their Modulation through Nutrigenomic Interventions
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97 The Effects of Major Mushroom Bioactive Compounds on Mechanisms That Control Blood Glucose Level
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98 PPARa Modulation-Based Therapy in Central Nervous System Diseases
Deokho Lee, Yohei Tomita, William Allen, Kazuo Tsubota, Kazuno Negishi, Toshihide Kurihara
Life. 2021; 11(11): 1168
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99 Diet and PPARG2 Pro12Ala Polymorphism Interactions in Relation to Cancer Risk: A Systematic Review
Lieu Tran,Gerd Bobe,Gayatri Arani,Yang Zhang,Zhenzhen Zhang,Jackilen Shannon,Yumie Takata
Nutrients. 2021; 13(1): 261
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100 The Nutraceutical N-Palmitoylethanolamide (PEA) Reveals Widespread Molecular Effects Unmasking New Therapeutic Targets in Murine Varicocele
Pietro Antonuccio,Herbert Ryan Marini,Antonio Micali,Carmelo Romeo,Roberta Granese,Annalisa Retto,Antonia Martino,Salvatore Benvenga,Salvatore Cuzzocrea,Daniela Impellizzeri,Rosanna Di Paola,Roberta Fusco,Raimondo Maximilian Cervellione,Letteria Minutoli
Nutrients. 2021; 13(3): 734
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101 Nutrigenomics and Nutrigenetics in Metabolic- (Dysfunction) Associated Fatty Liver Disease: Novel Insights and Future Perspectives
Marcello Dallio,Mario Romeo,Antonietta Gerarda Gravina,Mario Masarone,Tiziana Larussa,Ludovico Abenavoli,Marcello Persico,Carmelina Loguercio,Alessandro Federico
Nutrients. 2021; 13(5): 1679
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102 Beneficial Effects of Exogenous Ketogenic Supplements on Aging Processes and Age-Related Neurodegenerative Diseases
Zsolt Kovács,Brigitta Brunner,Csilla Ari
Nutrients. 2021; 13(7): 2197
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103 Novel Role for Macrophage Galactose-Type Lectin-1 to Regulate Innate Immunity against Mycobacterium tuberculosis
Kubra F. Naqvi,Matthew B. Huante,Tais B. Saito,Mark A. Endsley,Benjamin B. Gelman,Janice J. Endsley
The Journal of Immunology. 2021; 207(1): 221
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104 Ameliorative role of diallyl disulfide against glycerol-induced nephrotoxicity in rats
AshwaniKumar Sharma,Anmoldeep Kaur,Japneet Kaur,Gurpreet Kaur,Apporva Chawla,Mannan Khanna,Harmanpreet Kaur,Harnoor Kaur,Tajpreet Kaur,AmritPal Singh
Journal of Pharmacy And Bioallied Sciences. 2021; 13(1): 129
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105 Association of PPARG rs3856806 C>T polymorphism with body mass index, glycaemia and lipid parameters in Serbian adolescents
Vanja Vidovic,Nela Maksimovic,Stojko Vidovic,Tatjana Damnjanovic,Ivana Novakovic
Scripta Medica. 2021; 52(1): 15
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106 Nontraditional Risk Factors for Obesity in Modern Society
Su-Jin Han,Seung-Hwan Lee
Journal of Obesity & Metabolic Syndrome. 2021; 30(2): 93
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107 Effects of Cajanus cajan (L.) millsp. roots extracts on the antioxidant and anti-inflammatory activities
Thuy-LanThi Vo,Nae-Cherng Yang,Shu-Er Yang,Chien-Lin Chen,Chi-Hao Wu,Tuzz-Ying Song
Chinese Journal of Physiology. 2020; 63(3): 137
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108 The Impact of Dietary Supplementation of Whole Foods and Polyphenols on Atherosclerosis
Abigail E. Cullen,Ann Marie Centner,Riley Deitado,Javier Fernandez,Gloria Salazar
Nutrients. 2020; 12(7): 2069
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109 The Effects of Brown Algae-Derived Monosaccharide L-Fucose on Lipid Metabolism in C57BL/6J Obese Mice
Xiao Yuan,Tomohiko Nakao,Hina Satone,Kazuyuki Ohara,Yuri Kominami,Miho Ito,Teruki Aizawa,Tomoya Ueno,Hideki Ushio
Nutrients. 2020; 12(12): 3798
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110 Marine Algae Polysaccharides - a Promising Means of Pathogenetic Therapy of Infectious Diarrhea
N. N. Besednova,T. A. Kuznetsova,T. S. Zaporozhets,S. P. Kryzhanovsky,L. G. Gusev?,T. N. Zvyagintseva
Antibiotics and Chemotherapy. 2020; 65(7-8): 42
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111 Regulation of the MIE Locus During HCMV Latency and Reactivation
Abigail L. Dooley,Christine M. O’Connor
Pathogens. 2020; 9(11): 869
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112 Relationship between endocrine disruptors and obesity with a focus on bisphenol A: a narrative review
Sofiane Boudalia,Aissam Bousbia,Boualem Boumaaza,Malha Oudir,Marie Chantal Canivenc Lavier
BioImpacts. 2020; 11(4): 289
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113 Is There a Future for PPARs in the Treatment of Neuropsychiatric Disorders?
Michele Tufano,Graziano Pinna
Molecules. 2020; 25(5): 1062
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114 Physalis alkekengi L. Extract Reduces the Oxidative Stress, Inflammation and Apoptosis in Endothelial Vascular Cells Exposed to Hyperglycemia
Laura Gratiela Vicas,Tunde Jurca,Ioana Baldea,Gabriela Adriana Filip,Diana Olteanu,Simona Valeria Clichici,Annamaria Pallag,Eleonora Marian,Otilia Micle,Carmen Bianca Crivii,Tudor Suciu,Izabela Craciun,Felicia Gabriela Gligor,Mariana Muresan
Molecules. 2020; 25(16): 3747
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115 Fatty Acid Synthase: An Emerging Target in Cancer
Chee Wai Fhu,Azhar Ali
Molecules. 2020; 25(17): 3935
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116 PPARa Agonist Oral Therapy in Diabetic Retinopathy
Yohei Tomita,Deokho Lee,Kazuo Tsubota,Toshihide Kurihara
Biomedicines. 2020; 8(10): 433
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117 Leveraging Nuclear Receptors as Targets for Pathological Ocular Vascular Diseases
Pei-Li Yao,Jeremy Peavey,Goldis Malek
International Journal of Molecular Sciences. 2020; 21(8): 2889
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118 Anti-Inflammatory Activity of Extracts and Pure Compounds Derived from Plants via Modulation of Signaling Pathways, Especially PI3K/AKT in Macrophages
Anna Merecz-Sadowska,Przemyslaw Sitarek,Tomasz Sliwinski,Radoslaw Zajdel
International Journal of Molecular Sciences. 2020; 21(24): 9605
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119 Post-Ischaemic Immunological Response in the Brain: Targeting Microglia in Ischaemic Stroke Therapy
Charlotte Rawlinson,Stuart Jenkins,Laura Thei,Mark L. Dallas,Ruoli Chen
Brain Sciences. 2020; 10(3): 159
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120 A-Kinase Anchoring Protein 1: Emerging Roles in Regulating Mitochondrial Form and Function in Health and Disease
Yujia Liu,Ronald A. Merrill,Stefan Strack
Cells. 2020; 9(2): 298
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121 PPAR-Mediated Toxicology and Applied Pharmacology
Yue Xi,Yunhui Zhang,Sirui Zhu,Yuping Luo,Pengfei Xu,Zhiying Huang
Cells. 2020; 9(2): 352
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122 Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments
Mina Wang,Yan Tan,Yifan Shi,Xu Wang,Zehuan Liao,Peng Wei
Frontiers in Endocrinology. 2020; 11
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123 Intrauterine Inflammation Alters the Transcriptome and Metabolome in Placenta
Yu-Chin Lien,Zhe Zhang,Guillermo Barila,Amy Green-Brown,Michal A. Elovitz,Rebecca A. Simmons
Frontiers in Physiology. 2020; 11
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124 Tackling Chronic Inflammation with Withanolide Phytochemicals—A Withaferin A Perspective
Emilie Logie,Wim Vanden Berghe
Antioxidants. 2020; 9(11): 1107
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125 PPAR? Transcription Deficiency Exacerbates High-Fat Diet-Induced Adipocyte Hypertrophy and Insulin Resistance in Mice
Fusheng Guo,Shuangshuang Xu,Yanlin Zhu,Xing Zheng,Yi Lu,Jui Tu,Ying He,Lihua Jin,Yong Li
Frontiers in Pharmacology. 2020; 11
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126 Antioxidant and Anti-Inflammatory Effects of Genus Gynura: A Systematic Review
Jiah Ning Tan,Shamin Mohd Saffian,Fhataheya Buang,Zakiah Jubri,Ibrahim Jantan,Khairana Husain,Norsyahida Mohd Fauzi
Frontiers in Pharmacology. 2020; 11
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127 Matrix Metalloproteinase-12 Is Required for Granuloma Progression
Arjun Mohan,Nicole Neequaye,Anagha Malur,Eman Soliman,Matthew McPeek,Nancy Leffler,David Ogburn,Debra A. Tokarz,Warren Knudson,Sina A. Gharib,Lynn M. Schnapp,Barbara P. Barna,Mary Jane Thomassen
Frontiers in Immunology. 2020; 11
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128 Novel Cinnamic Acid Derivatives as Potential PPARd Agonists for Metabolic Syndrome: Design, Synthesis, Evaluation and Docking Studies
Ajay Chauhan,Ajmer S. Grewal,Deepti Pandita,Viney Lather
Current Drug Discovery Technologies. 2020; 17(3): 338
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129

Anti-Diabetic Effect of Telmisartan Through its Partial PPAR?-Agonistic Activity
Muluken Altaye Ayza,Kaleab Alemayehu Zewdie,Bekalu Amare Tesfaye,Selamawit Tesfamariam Gebrekirstos,Derbew Fikadu Berhe
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 2020; Volume 13: 3627
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130

Gut Microbiota, Peroxisome Proliferator-Activated Receptors, and Hepatocellular Carcinoma
Qiang Yu,Liwei Wu,Jie Ji,Jiao Feng,Weiqi Dai,Jingjing Li,Jianye Wu,Chuanyong Guo
Journal of Hepatocellular Carcinoma. 2020; Volume 7: 271
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131 Transcriptomic profiling of PBDE-exposed HepaRG cells unveils critical lncRNA- PCG pairs involved in intermediary metabolism
Angela Zhang,Cindy Yanfei Li,Edward J. Kelly,Lianne Sheppard,Julia Yue Cui,Matias A. Avila
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132 Whole blood transcriptional responses of very preterm infants during late-onset sepsis
Sherrianne Ng,Tobias Strunk,Amy H. Lee,Erin E. Gill,Reza Falsafi,Tabitha Woodman,Julie Hibbert,Robert E. W. Hancock,Andrew Currie,Francisco J. Esteban
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133 Autosomal dominant polycystic kidney disease and pioglitazone for its therapy: a comprehensive review with an emphasis on the molecular pathogenesis and pharmacological aspects
Aryendu Kumar Saini,Rakesh Saini,Shubham Singh
Molecular Medicine. 2020; 26(1)
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134 Probiotics ameliorate pioglitazone-associated bone loss in diabetic rats
Ahmad Gholami,Mohammad Hossein Dabbaghmanesh,Younes Ghasemi,Pedram Talezadeh,Farhad Koohpeyma,Nima Montazeri-Najafabady
Diabetology & Metabolic Syndrome. 2020; 12(1)
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135 Screening of Some Sulfonamide and Sulfonylurea Derivatives as Anti-Alzheimer’s Agents Targeting BACE1 and PPAR?
Ning Li,Yan Wang,Wensheng Li,Haiyan Li,Liu Yang,Jun Wang,Hazem A. Mahdy,Ahmed B. M. Mehany,Dareen A. Jaiash,Eman Y. Santali,Ibrahim H. Eissa
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136 ß-Sitosterol Protects against Myocardial Ischemia/Reperfusion Injury via Targeting PPAR?/NF-?B Signalling
Fengxia Lin,Luhua Xu,Meizhu Huang,Bin Deng,Weiwei Zhang,Zhicong Zeng,Song Yinzhi
Evidence-Based Complementary and Alternative Medicine. 2020; 2020: 1
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137 PPARs and the Development of Type 1 Diabetes
Laurits J. Holm,Mia Øgaard Mønsted,Martin Haupt-Jorgensen,Karsten Buschard
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138 Free Fatty Acids and Their Inflammatory Derivatives Affect BDNF in Stroke Patients
Dariusz Kotlega,Agnieszka Zembron-Lacny,Barbara Morawin,Monika Golab-Janowska,Przemyslaw Nowacki,Malgorzata Szczuko,Raffaele Capasso
Mediators of Inflammation. 2020; 2020: 1
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139 Role of PPARs in Progression of Anxiety: Literature Analysis and Signaling Pathways Reconstruction
Olga I. Rudko,Artemii V. Tretiakov,Elena A. Naumova,Eugene A. Klimov,Hongbao Cao
PPAR Research. 2020; 2020: 1
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140 Peroxisomal proliferator-activated receptor a-b deficiency induces the reprogramming of nutrient metabolism in zebrafish
Ling-Yu Li,Hong-Bo Lv,Zhe-Yue Jiang,Fang Qiao,Li-Qiao Chen,Mei-Ling Zhang,Zhen-Yu Du
The Journal of Physiology. 2020;
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141 Evolving Role for Pharmacotherapy in NAFLD/NASH
Suzanna L. Attia,Samir Softic,Marialena Mouzaki
Clinical and Translational Science. 2020;
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142 Regulation of the germinal center response by nuclear receptors and implications for autoimmune diseases
William J. Olson,Bojana Jakic,Natascha Hermann-Kleiter
The FEBS Journal. 2020;
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143 Induced Ketosis as a Treatment for Neuroprogressive Disorders: Food for Thought?
Gerwyn Morris,Basant K Puri,Andre Carvalho,Michael Maes,Michael Berk,Anu Ruusunen,Lisa Olive
International Journal of Neuropsychopharmacology. 2020;
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144 Consumption of the Artificial Sweetener Acesulfame Potassium throughout Pregnancy Induces Glucose Intolerance and Adipose Tissue Dysfunction in Mice
Jasmine F Plows,Jacob Morton-Jones,Pania E Bridge-Comer,Anna Ponnampalam,Joanna L Stanley,Mark H Vickers,Clare M Reynolds
The Journal of Nutrition. 2020;
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145 Extracellular Vesicles Attenuate Nitrofen-Mediated Human Pulmonary Artery Endothelial Dysfunction: Implications for Congenital Diaphragmatic Hernia
Siqin Zhaorigetu,Henry Bair,Di Jin,Vikas S. Gupta,Lavannya M. Pandit,Robert M. Bryan,Kevin P. Lally,Scott D. Olson,Charles S. Cox,Matthew T. Harting
Stem Cells and Development. 2020;
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146 The Glitazars Paradox: Cardiotoxicity of the Metabolically Beneficial Dual PPARa and PPAR? Activation
Charikleia Kalliora,Konstantinos Drosatos
Journal of Cardiovascular Pharmacology. 2020; 76(5): 514
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147 Non-hormonal mediators of uterine fibroid growth
Esra Cetin,Ayman Al-Hendy,Michal Ciebiera
Current Opinion in Obstetrics & Gynecology. 2020; 32(5): 361
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148 Evaluation of burst release and sustained release of pioglitazone-loaded fibrous mats on diabetic wound healing: an in vitro and in vivo comparison study
Muhammet Emin Cam,Sila Yildiz,Hussain Alenezi,Sumeyye Cesur,Gul Sinemcan Ozcan,Gokce Erdemir,Ursula Edirisinghe,Dilek Akakin,Durdane Serap Kuruca,Levent Kabasakal,Oguzhan Gunduz,Mohan Edirisinghe
Journal of The Royal Society Interface. 2020; 17(162): 20190712
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149 MDM2 and MDMX promote ferroptosis by PPARa-mediated lipid remodeling
Divya Venkatesh,Nicholas A. OæBrien,Fereshteh Zandkarimi,David R. Tong,Michael E. Stokes,Denise E. Dunn,Everett S. Kengmana,Allegra T. Aron,Alyssa M. Klein,Joleen M. Csuka,Sung-Hwan Moon,Marcus Conrad,Christopher J. Chang,Donald C. Lo,Angelo DæAlessandro,Carol Prives,Brent R. Stockwell
Genes & Development. 2020; 34(7-8): 526
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150 Biochemical investigation of rs1801282 variations in PPAR-? gene and its correlation with risk factors of diabetes mellitus in coronary artery disease
Kanwal Rehman,Komal Jabeen,Fazli Rabbi Awan,Misbah Hussain,Muhammad Asim Saddique,Muhammad Sajid Hamid Akash
Clinical and Experimental Pharmacology and Physiology. 2020;
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151 Comparative genome-wide methylation analysis of longissimus dorsi muscles in Yorkshire and Wannanhua pigs
X.-J. Li,L.-Q. Liu,H. Dong,J.-J. Yang,W.-W. Wang,Q. Zhang,C.-L. Wang,J. Zhou,H.-Q. Cheng
Animal Genetics. 2020;
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152 Transcriptome signature of two lactation stages in Ghezel sheep identifies using RNA-Sequencing
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Animal Biotechnology. 2020; : 1
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153 Dysregulation of Ephrin receptor and PPAR signaling pathways in neural progenitor cells infected by Zika virus
Sathya N. Thulasi Raman,Elyse Latreille,Jun Gao,Wanyue Zhang,Jianguo Wu,Marsha S. Russell,Lisa Walrond,Terry Cyr,Jessie R. Lavoie,David Safronetz,Jingxin Cao,Simon Sauve,Aaron Farnsworth,Wangxue Chen,Pei-Yong Shi,Youchun Wang,Lisheng Wang,Michael Rosu-Myles,Xuguang Li
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154 Comprehensive Review of Bioactive and Molecular Aspects of Moringa Oleifera Lam
Kaushal H. Shah,Manisha J. Oza
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155 Plant polyphenols mechanisms of action on insulin resistance and against the loss of pancreatic beta cells
Camelia Papuc,Gheorghe V. Goran,Corina N. Predescu,Liliana Tudoreanu,Georgeta ?tefan
Critical Reviews in Food Science and Nutrition. 2020; : 1
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156 Integrated anti-hyperlipidemic bioactivity of whole Citrus grandis [L.] osbeck fruits—multi-action mechanism evidenced using animal and cell models
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157 Targeting cancer stem cell pathways for cancer therapy
Liqun Yang,Pengfei Shi,Gaichao Zhao,Jie Xu,Wen Peng,Jiayi Zhang,Guanghui Zhang,Xiaowen Wang,Zhen Dong,Fei Chen,Hongjuan Cui
Signal Transduction and Targeted Therapy. 2020; 5(1)
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158 Fatty acid-binding protein 5 limits ILC2-mediated allergic lung inflammation in a murine asthma model
Shuhei Kobayashi,Shunichi Tayama,Hai The Phung,Yoshiteru Kagawa,Hirofumi Miyazaki,Yu Takahashi,Takashi Maruyama,Naoto Ishii,Yuji Owada
Scientific Reports. 2020; 10(1)
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159 Molecular pathophysiology of diabetes mellitus during pregnancy with antenatal complications
Arthur T. Kopylov,Olga Papysheva,Iveta Gribova,Galina Kotaysch,Lubov Kharitonova,Tatiana Mayatskaya,Ekaterina Sokerina,Anna L. Kaysheva,Sergey G. Morozov
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160 Brief high fat high sugar diet results in altered energy and fat metabolism during pregnancy in mice
Kathleen A. Pennington,Yuanlin Dong,Simone Hernandez Ruano,Nicola van der Walt,Haleh Sangi-Haghpeykar,Chandrasekhar Yallampalli
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161 Pioglitazone Increases Blood–Brain Barrier Expression of Fatty Acid-Binding Protein 5 and Docosahexaenoic Acid Trafficking into the Brain
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162 Lactobacillus pentosus S-PT84 Prevents Low-Grade Chronic Inflammation-Associated Metabolic Disorders in a Lipopolysaccharide and High-Fat Diet C57/BL6J Mouse Model
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163 Effects of Casein, Chicken, and Pork Proteins on the Regulation of Body Fat and Blood Inflammatory Factors and Metabolite Patterns Are Largely Dependent on the Protein Level and Less Attributable to the Protein Source
Shangxin Song,Tianlan Xia,Changqing Zhu,Jingqi Xue,Qingquan Fu,Chun Hua,Guido J. E. J. Hooiveld,Michael Müller,Chunbao Li
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164 Neuroprotection Following Concussion: The Potential Role for Cannabidiol
Jyotpal Singh,John Patrick Neary
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques. 2020; 47(3): 289
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165 The role of lipids in the central nervous system and their pathological implications in amyotrophic lateral sclerosis
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166 Sleep Disruption and Duration are Associated with Variants in Genes Involved in Energy Homeostasis in Adults with HIV/AIDS
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167 PPAR?/PGC1a signaling as a potential therapeutic target for mitochondrial biogenesis in neurodegenerative disorders
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168 Epigenetics and the endocannabinoid system signaling: An intricate interplay modulating neurodevelopment
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169 Phytosterols of marine algae: Insights into the potential health benefits and molecular pharmacology
Md. Abdul Hannan,Abdullah Al Mamun Sohag,Raju Dash,Md. Nazmul Haque,Md. Mohibbullah,Diyah Fatimah Oktaviani,Md. Tahmeed Hossain,Ho Jin Choi,Il Soo Moon
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170 The roles and interaction of FXR and PPARs in the pathogenesis of nonalcoholic fatty liver disease
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171 Crocin attenuates oxidative stress and inflammation in myocardial infarction induced by isoprenaline via PPAR? activation in diabetic rats
Mohammad Badavi,Seyyed Ali Mard,Mahin Dianat,Neda Dashtbozorgi
Journal of Diabetes & Metabolic Disorders. 2020;
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172 The meaning of non-classical estrogen receptors and peroxisome proliferator-activated receptor for boar Leydig cell of immature testis
M. Kotula-Balak,M. Duliban,P. Pawlicki,R. Tuz,B. Bilinska,B.J. Plachno,Z.J. Arent,I. Krakowska,K. Tarasiuk
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173 Gene set enrichment analysis, network pharmacology and in silico docking approach to understand the molecular mechanism of traditional medicines for the treatment of diabetes mellitus
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Journal of Proteins and Proteomics. 2020;
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174 Frequency of PPAR-?, FTO and ABCC8 genetic variation in Pakistani cardiovascular smokers
Kanwal Rehman,Ayesha Tahir,Sania Niaz,Sara Shabbir,Komal Jabeen,Amna Faheem,Muhammad Sajid Hamid Akash
Environmental Science and Pollution Research. 2020;
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175 Adipose tissue, immune aging, and cellular senescence
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176 Virtual screening of potentially endocrine-disrupting chemicals against nuclear receptors and its application to identify PPAR?-bound fatty acids
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177 Role of peroxisome proliferator-activated receptors in stroke prevention and therapy—The best is yet to come?
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178 Human Milk Oligosaccharides Protect against Necrotizing Enterocolitis by Activating Intestinal Cell Differentiation
Bo Li,Richard You Wu,Rachael G. Horne,Abdalla Ahmed,Dorothy Lee,Shaiya C. Robinson,Haitao Zhu,Carol Lee,Marissa Cadete,Kathene C. Johnson-Henry,Eva Landberg,Mashriq Alganabi,Thomas Abrahamsson,Paul Delgado-Olguin,Agostino Pierro,Philip M. Sherman
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179 RvE1 treatment prevents memory loss and neuroinflammation in the Ts65Dn mouse model of Down syndrome
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180 A 3D Self-Assembled In Vitro Model to Simulate Direct and Indirect Interactions between Adipocytes and Skeletal Muscle Cells
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181 Nuclear receptors in the kidney during health and disease
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182 PPAR?: A turning point for irritable bowel syndrome treatment
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183 Changes in erythrocyte membrane epoxyeicosatrienoic, dihydroxyeicosatrienoic, and hydroxyeicosatetraenoic acids during pregnancy
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184 Cold-hearted: A case for cold stress in cancer risk
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185 Pharmacologic Treatment Strategies for Nonalcoholic Steatohepatitis
James Philip G. Esteban,Amon Asgharpour
Gastroenterology Clinics of North America. 2020; 49(1): 105
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186 iTAG-RNA Isolates Cell-Specific Transcriptional Responses to Environmental Stimuli and Identifies an RNA-Based Endocrine Axis
Jonatan Darr,Archana Tomar,Maximilian Lassi,Raffaele Gerlini,Lucia Berti,Annette Hering,Fabienne Scheid,Martin Hrabe de Angelis,Michael Witting,Raffaele Teperino
Cell Reports. 2020; 30(9): 3183
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187 Type II diabetes mellitus: a review on recent drug based therapeutics
Santwana Padhi,Amit Kumar Nayak,Anindita Behera
Biomedicine & Pharmacotherapy. 2020; 131: 110708
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188 Increased risk of acute liver failure by pain killer drugs in NAFLD: Focus on nuclear receptors and their coactivators
Maria Arconzo,Elena Piccinin,Antonio Moschetta
Digestive and Liver Disease. 2020;
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189 Dexmedetomidine inhibits LPS-induced inflammatory responses through peroxisome proliferator-activated receptor gamma (PPAR?) activation following binding to a2 adrenoceptors
Maki Fujimoto,Hitoshi Higuchi,Yuka Honda-Wakasugi,Saki Miyake,Yukiko Nishioka,Akiko Yabuki-Kawase,Shigeru Maeda,Takuya Miyawaki
European Journal of Pharmacology. 2020; : 173733
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190 Keratocytes promote corneal neovascularization through VEGFr3 induced by PPARa-inhibition
Xue Wang,Liying Tang,Zhaoqiang Zhang,Wensheng Li,Yongxiong Chen
Experimental Eye Research. 2020; : 107982
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191 Neurovascular protection by peroxisome proliferator-activated receptor a in ischemic stroke
Austin C. Boese,Jean-Pyo Lee,Milton H. Hamblin
Experimental Neurology. 2020; 331: 113323
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192 Multisystemic alterations in humans induced by bisphenol A and phthalates: experimental, epidemiological and clinical studies reveal the need to change health policies
A. Martínez-Ibarra,L.D. Martínez-Razo,K. MacDonald-Ramos,M. Morales-Pacheco,E.R. Vázquez-Martínez,M. López-López,M. Rodríguez Dorantes,M. Cerbón
Environmental Pollution. 2020; : 116380
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193 Fine particles cause the abnormality of cardiac ATP levels via PPAR?-mediated utilization of fatty acid and glucose using in vivo and in vitro models
Xiaoting Jin,Bin Xue,Rifat Zubair Ahmed,Guobin Ding,Zhuoyu Li
Environmental Pollution. 2019; 249: 286
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194 Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy
Uxía Nogueira-Recalde,Irene Lorenzo-Gómez,Francisco J. Blanco,María I. Loza,Diego Grassi,Valery Shirinsky,Ivan Shirinsky,Martin Lotz,Paul D. Robbins,Eduardo Domínguez,Beatriz Caramés
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195 Role of PPAR receptor in different diseases and their ligands: Physiological importance and clinical implications
Agha Zeeshan Mirza,Ismail I. Althagafi,Hina Shamshad
European Journal of Medicinal Chemistry. 2019;
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196 Fenofibrate induces PPARa and BMP2 expression to stimulate osteoblast differentiation
Yu-Ha Kim,Won-Gu Jang,Sin-Hye Oh,Jung-Woo Kim,Mi Nam Lee,Ju Han Song,Jin-Woo Yang,Yaran Zang,Jeong-Tae Koh
Biochemical and Biophysical Research Communications. 2019;
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197 Hippocampal PPARa is involved in the antidepressant-like effects of venlafaxine in mice
Cheng Chen,Jian-Hong Shen,Hui Xu,Peng Chen,Fei Chen,Yi-Xiang Guan,Bo Jiang,Zhong-Hua Wu
Brain Research Bulletin. 2019;
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198 Pioglitazone-loaded three-dimensional composite polymeric scaffolds: a proof of concept study in wounded diabetic rats
Rabab Kamel,Rasha El-batanony,Abeer Salama
International Journal of Pharmaceutics. 2019; : 118667
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199 Identification of PPAR-activating compounds in herbal and edible plants and fungi from Vietnam
Long Pham Ngoc,Hai-yen Man,Harry Besselink,Ha Dang Thi Cam,Abraham Brouwer,Bart van der Burg
Industrial Crops and Products. 2019; 129: 195
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200 PPAR-d and erucic acid in multiple sclerosis and Alzheimeræs Disease. Likely benefits in terms of immunity and metabolism
Meric A. Altinoz,Aysel Ozpinar
International Immunopharmacology. 2019; 69: 245
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201 Peroxisome proliferator-activated receptors and their agonists in non-alcoholic fatty liver disease (NAFLD)
Narendra Singh Choudhary,Naveen Kumar,Ajay Duseja
Journal of Clinical and Experimental Hepatology. 2019;
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202 PPAR-? agonist, pioglitazone, reduced oxidative and endoplasmic reticulum stress associated with L-NAME-induced hypertension in rats
Eman Soliman,Shereen F. Behairy,Nabila N. El-maraghy,Shimaa M. Elshazly
Life Sciences. 2019; : 117047
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203 Kynurenic acid attenuates pro-inflammatory reactions in lipopolysaccharide-stimulated endothelial cells through the PPARd/HO-1-dependent pathway
Taeseung Lee,Hyung Sub Park,Ji Hoon Jeong,Tae Woo Jung
Molecular and Cellular Endocrinology. 2019; 495: 110510
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204 Drug Development for the Therapy of Mitochondrial Diseases
Volkmar Weissig
Trends in Molecular Medicine. 2019;
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205 Xiexin Tang ameliorates dyslipidemia in high-fat diet-induced obese rats via elevating gut microbiota-derived short chain fatty acids production and adjusting energy metabolism
Suwei Xiao,Zhimiao Zhang,Mengjun Chen,Junfeng Zou,Shu Jiang,Dawei Qian,Jinao Duan
Journal of Ethnopharmacology. 2019; 241: 112032
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206 Molecular determinants as therapeutic targets in cancer chemotherapy: An update
Tanweer Haider,Rahul Tiwari,Suresh Prasad Vyas,Vandana Soni
Pharmacology & Therapeutics. 2019;
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207 Arylierungschemie für die Biokonjugation
Chi Zhang,Ekaterina V. Vinogradova,Alexander M. Spokoyny,Stephen L. Buchwald,Bradley L. Pentelute
Angewandte Chemie. 2019; 131(15): 4860
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208 Arylation Chemistry for Bioconjugation
Chi Zhang,Ekaterina V. Vinogradova,Alexander M. Spokoyny,Stephen L. Buchwald,Bradley L. Pentelute
Angewandte Chemie International Edition. 2019; 58(15): 4810
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209 TGF ß-1 and WNT Signaling Pathways Collaboration Associated with Cochlear Implantation Trauma-Induced Fibrosis
Esperanza Bas,Mir R. Anwar,Thomas R. Van De Water
The Anatomical Record. 2019;
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210 Hesperidin regresses cardiac hypertrophy by virtue of PPAR-? agonistic, anti-inflammatory, antiapoptotic, and antioxidant properties
Poorva Bhargava,Vipin Kumar Verma,Salma Malik,Sana Irfan Khan,Jagriti Bhatia,Dharamvir Singh Arya
Journal of Biochemical and Molecular Toxicology. 2019; : e22283
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211 Aerobic training induces differential expression of genes involved in lipid metabolism in skeletal muscle and white adipose tissues
Letícia Maria de Souza Cordeiro,Érica Guilhen Mario,Carolina Campos Lima Moreira,Angélica Heringer Rodrigues,Samuel Penna Wanner,Danusa Dias Soares,Leida Maria Botion,Adaliene Versiani Matos Ferreira
Journal of Cellular Biochemistry. 2019;
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212 Gene co-regulation and co-expression in the aryl hydrocarbon receptor-mediated transcriptional regulatory network in the mouse liver
Navya Josyula,Melvin E. Andersen,Norbert E. Kaminski,Edward Dere,Timothy R. Zacharewski,Sudin Bhattacharya
Archives of Toxicology. 2019;
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213 Endothelial PPAR? Is Crucial for Averting Age-Related Vascular Dysfunction by Stalling Oxidative Stress and ROCK
Md. Sahab Uddin,Md. Tanvir Kabir,Md. Jakaria,Abdullah Al Mamun,Kamal Niaz,Md. Shah Amran,George E. Barreto,Ghulam Md Ashraf
Neurotoxicity Research. 2019;
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214 Rational Design, Synthesis, and In Vitro Neuroprotective Evaluation of Novel Glitazones for PGC-1a Activation via PPAR-?: a New Therapeutic Strategy for Neurodegenerative Disorders
Antony Justin,Subhankar Mandal,P. Prabitha,S. Dhivya,S. Yuvaraj,Pradeep Kabadi,Satheesh John Sekhar,C. H. Sandhya,Ashish D. Wadhwani,Selvaraj Divakar,Jeyabalan Jeyaram Bharathi,Priya Durai,B. R. Prashantha Kumar
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215 Reversal of NASH fibrosis with pharmacotherapy
Joseph J. Alukal,Paul J. Thuluvath
Hepatology International. 2019;
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216 Polyphenols for diabetes associated neuropathy: Pharmacological targets and clinical perspective
Rozita Naseri,Fatemeh Farzaei,Sajad Fakhri,Fardous F. El-Senduny,Miram Altouhamy,Roodabeh Bahramsoltani,Farnaz Ebrahimi,Roja Rahimi,Mohammad Hosein Farzaei
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217 The ameliorative effect of angiotensin 1-7 on experimentally induced-preeclampsia in rats: Targeting the role of peroxisome proliferator-activated receptors gamma expression & asymmetric dimethylarginine
Mervat H. El-Saka,Nermin M. Madi,Rowida Raafat Ibrahim,Ghada Mahmoud Alghazaly,Shereef Elshwaikh,Manal El-Bermawy
Archives of Biochemistry and Biophysics. 2019; 671: 123
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218 The fate of medium-chain fatty acids in very long-chain acyl-CoA dehydrogenase deficiency (VLCADD): A matter of sex?
Zeinab Wehbe,Khaled Alatibi,Julia Jellusova,Ute Spiekerkoetter,Sara Tucci
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 2019; 1864(11): 1591
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219 PPAR gamma agonist, pioglitazone, rescues liver damage induced by renal ischemia/reperfusion injury
Shimaa Elshazly,Eman Soliman
Toxicology and Applied Pharmacology. 2019; 362: 86
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220 Identification of Secreted Phosphoprotein 1 (SPP1) as a Prognostic Factor in Lower-Grade Gliomas
Jiawei Chen,Chongxian Hou,Zongtai Zheng,Han Lin,Guangzhao Lv,Dong Zhou
World Neurosurgery. 2019;
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221 Remyelination pharmacotherapy investigations highlight diverse mechanisms underlying multiple sclerosis progression
George S Melchor,Tahiyana Khan,Joan Reger,Jeffrey K. Huang
ACS Pharmacology & Translational Science. 2019;
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222 Global Gene Networks in 3D4/31 Porcine Alveolar Macrophages Treated with Antigenic Epitopes of Actinobacillus pleuropneumoniae ApxIA, IIA, and IVA
Suji Kim,Myung Whan Oh,Woo Bin Park,Han Sang Yoo
Scientific Reports. 2019; 9(1)
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223 Prenatal androgen excess alters the uterine peroxisome proliferator-activated receptor (PPAR) system
Silvana R. Ferreira,Leandro M. Vélez,Maria F. Heber,Giselle A. Abruzzese,Alicia B. Motta
Reproduction, Fertility and Development. 2019; 31(8): 1401
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224 Rosiglitazone increases expression of steroidogenic acute regulatory protein and progesterone production through PPAR?–EGFR–ERK1/2 in human cumulus granulosa cells
Kristina Pogrmic-Majkic,Gordana Kosanin,Dragana Samardzija Nenadov,Svetlana Fa,Bojana Stanic,Aleksandra Trninic Pjevic,Nebojsa Andric
Reproduction, Fertility and Development. 2019; 31(11): 1647
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225 Lycopene inhibits hepatic stellate cell activation and modulates cellular lipid storage and signaling
Monique de Barros Elias,Felipe Leite Oliveira,Fatima Costa Rodrigues Guma,Renata Brum Martucci,Radovan Borojevic,Anderson Junger Teodoro
Food & Function. 2019;
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226 Alterations in protein expression patterns of spinal peroxisome proliferator-activated receptors after spinal cord injury
Youngkyung Kim,Kyu-Won Park,Jeonghwa Oh,Junesun Kim,Young Wook Yoon
Neurological Research. 2019; : 1
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227 Pulmonary vascular disease is evident in gene regulation of experimental bronchopulmonary dysplasia
Cecilie Revhaug,Magdalena Zasada,Anne Gro W. Rognlien,Clara-Cecilie Günther,Agnieszka Grabowska,Teofila Ksiazek,Anna Madetko-Talowska,Katarzyna Szewczyk,Mirolaw Bik-Multanowski,Przemko Kwinta,Jacek J. Pietrzyk,Lars O. Baumbusch,Ola D. Saugstad
The Journal of Maternal-Fetal & Neonatal Medicine. 2019; : 1
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228 Impacts of cannabinoid epigenetics on human development: reflections on Murphy et. al. ‘cannabinoid exposure and altered DNA methylation in rat and human sperm’ epigenetics 2018; 13: 1208-1221.
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Epigenetics. 2019; : 1
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229 Glucokinase activation as antidiabetic therapy: effect of nutraceuticals and phytochemicals on glucokinase gene expression and enzymatic activity
Tereso J. Guzmán,Carmen M. Gurrola-Díaz
Archives of Physiology and Biochemistry. 2019; : 1
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230 A Dietary Pattern Derived from Reduced Rank Regression and Fatty Acid Biomarkers Is Associated with Lower Risk of Type 2 Diabetes and Coronary Artery Disease in Chinese Adults
Jowy YH Seah,Choon Nam Ong,Woon-Puay Koh,Jian-Min Yuan,Rob M van Dam
The Journal of Nutrition. 2019;
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231 A locked immunometabolic switch underlies TREM2 R47H loss of function in human iPSC-derived microglia
Thomas M. Piers,Katharina Cosker,Anna Mallach,Gabriel Thomas Johnson,Rita Guerreiro,John Hardy,Jennifer M. Pocock
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232 PPAR-? signalling as a key mediator of human hair follicle physiology and pathology
Yuval Ramot,Marta Bertolini,Maria Boboljova,Yoshikazu Uchida,Ralf Paus
Experimental Dermatology. 2019;
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233 The effects of oleoylethanolamide, an endogenous PPAR-a agonist, on risk factors for NAFLD: A systematic review
Helda Tutunchi,Alireza Ostadrahimi,Maryam Saghafi-Asl,Vahid Maleki
Obesity Reviews. 2019;
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234 Tumor necrosis factor alpha mediates orofacial discomfort in an occlusal dental interference model in rats: The role of trigeminal ganglion inflammation
Paulo Goberlânio de Barros Silva,Joyce Ohana Lima Martins,Raimundo Antonio Lima Praxedes Neto,José Vitor Mota Lemos,Larissa Carvalho Machado,Anna Clara Aragão Matos Carlos,Ana Paula Negreiros Nunes Alves,Ramille Araújo Lima
Journal of Oral Pathology & Medicine. 2019;
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235 TNBG-5602, a novel derivative of quinoxaline, inhibits liver cancer growth via upregulating peroxisome proliferator-activated receptor ? in vitro and in vivo
Xuelian Hu,Chunmei Wan,Zongjie Gan,Rongxing Liu,Yongjie Chen,Jing Wang,Linling Gan,Yuhang Chen,Yingbo Li,Baicheng He,Yu Yu
Journal of Pharmacy and Pharmacology. 2019;
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236 Identification of a metallothionein gene in honey bee Apis mellifera and its expression profile in response to Cd, Cu and Pb exposure
Jelena Purac,Tatjana V. Nikolic,Danijela Kojic,Andelka S. Celic,Jovana J. Plavša,Duško P. Blagojevic,Edward T. Petri
Molecular Ecology. 2019; 28(4): 731
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237 PPAR-? Activation Exerts an Anti-inflammatory Effect by Suppressing the NLRP3 Inflammasome in Spinal Cord-Derived Neurons
Qing-Qi Meng,Zhen-Cheng Feng,Xing-Liang Zhang,Li-Qiong Hu,Min Wang,Hai-Feng Zhang,Si-Ming Li
Mediators of Inflammation. 2019; 2019: 1
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238 Serum Adropin Levels Are Reduced in Adult Patients with Nonalcoholic Fatty Liver Disease
Orkide  Kutlu, Özgür Altun, Okan Dikker, Serife Aktas, Neslihan Özsoy, Yücel Arman, Eylem  Özgün Çil, Mustafa Özcan, Sengül Aydin Yoldemir, Murat Akarsu, Ilkim Deniz Toprak, Kerem Kirna, Yasin Kutlu, Zeki Toprak, Hasan Eruzun, Tufan Tükek
Medical Principles and Practice. 2019; 28(5): 463
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239 TGF-ß in fibrosis by acting as a conductor for contractile properties of myofibroblasts
Alexandre Vallée,Yves Lecarpentier
Cell & Bioscience. 2019; 9(1)
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240 Alterations in tissue microRNA after heat stress in the conscious rat: potential biomarkers of organ-specific injury
Matthew G. Permenter,Bonna C. McDyre,Danielle L. Ippolito,Jonathan D. Stallings
BMC Genomics. 2019; 20(1)
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241 Urinary concentrations of phthalate biomarkers and weight change among postmenopausal women: a prospective cohort study
Mary V. Díaz Santana,Susan E. Hankinson,Carol Bigelow,Susan R. Sturgeon,R. Thomas Zoeller,Lesley Tinker,Jo Ann E. Manson,Antonia M. Calafat,Jaymie R. Meliker,Katherine W. Reeves
Environmental Health. 2019; 18(1)
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242 Lipotoxicity and ß Cell Maintenance in Obesity and Type 2 Diabetes
Risheng Ye,Toshiharu Onodera,Philipp E Scherer
Journal of the Endocrine Society. 2019; 3(3): 617
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243 Amelioration of Oxidative Stress and Neuroinflammation by Saroglitazar, A Dual PPARa/? Agonist in MES Induced Epileptic Rats
Snigdha Rani Panigrahy,Supriya Pradhan,Chandra Sekhar Maharana
Biomedical and Pharmacology Journal. 2019; 12(04): 1985
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244 Activity and molecular targets of pioglitazone via blockade of proliferation, invasiveness and bioenergetics in human NSCLC
Vincenza Ciaramella,Ferdinando Carlo Sasso,Raimondo Di Liello,Carminia Maria Della Corte,Giusi Barra,Giuseppe Viscardi,Giovanna Esposito,Francesca Sparano,Teresa Troiani,Erika Martinelli,Michele Orditura,Ferdinando De Vita,Fortunato Ciardiello,Floriana Morgillo
Journal of Experimental & Clinical Cancer Research. 2019; 38(1)
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245 PPAR?: Potential Therapeutic Target for Ailments Beyond Diabetes and its Natural Agonism
Sana Shafi,Pawan Gupta,Gopal Lal Khatik,Jeena Gupta
Current Drug Targets. 2019; 20(12): 1281
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246 PPAR? Agonistic Activity of Sulphonylureas
Debjani Banerjee,Harnovdeep Singh Bharaj,Moulinath Banerjee
Endocrine, Metabolic & Immune Disorders - Drug Targets. 2019; 19(4): 467
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247 Lead Optimization Resources in Drug Discovery for Diabetes
Pragya Tiwari,Ashish Katyal,Mohd F. Khan,Ghulam Md. Ashraf,Khurshid Ahmad
Endocrine, Metabolic & Immune Disorders - Drug Targets. 2019; 19(6): 754
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248 Crosstalk between Peroxisome Proliferator-Activated Receptors andToll-Like Receptors: A Systematic Review
Nasim Dana,Golnaz Vaseghi,Shaghayegh Haghjooy-Javanmard
Advanced Pharmaceutical Bulletin. 2019; 9(1): 12
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249 Peroxisomes and Oxidative Stress: Their Implications in the Modulation of Cellular Immunity During Mycobacterial Infection
Geetanjali Ganguli,Utsav Mukherjee,Avinash Sonawane
Frontiers in Microbiology. 2019; 10
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250 Flavonoids and Their Anti-Diabetic Effects: Cellular Mechanisms and Effects to Improve Blood Sugar Levels
Dong-Soon AL-Ishaq,Dong-Soon Abotaleb,Dong-Soon Kubatka,Dong-Soon Kajo,Dong-Soon Büsselberg
Biomolecules. 2019; 9(9): 430
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251 Interactions between Host PPARs and Gut Microbiota in Health and Disease
Arif Hasan,Asadur Rahman,Hiroyuki Kobori
International Journal of Molecular Sciences. 2019; 20(2): 387
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252 Nifedipine Modulates Renal Lipogenesis via the AMPK-SREBP Transcriptional Pathway
Yen-Chung Lin,Mai-Szu Wu,Yuh-Feng Lin,Chang-Rong Chen,Chang-Yu Chen,Chang-Jui Chen,Che-Chou Shen,Kuan-Chou Chen,Chiung-Chi Peng
International Journal of Molecular Sciences. 2019; 20(7): 1570
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253 Epigenetic Effects of n-3 LCPUFAs: A Role in Pediatric Metabolic Syndrome
Han Sang Amatruda,Han Sang Ippolito,Han Sang Vizzuso,Han Sang Vizzari,Han Sang Banderali,Han Sang Verduci
International Journal of Molecular Sciences. 2019; 20(9): 2118
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254 The Role of Heme Oxygenase 1 in the Protective Effect of Caloric Restriction against Diabetic Cardiomyopathy
Maayan Waldman,Vadim Nudelman,Asher Shainberg,Romy Zemel,Ran Kornwoski,Dan Aravot,Stephen J. Peterson,Michael Arad,Edith Hochhauser
International Journal of Molecular Sciences. 2019; 20(10): 2427
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255 WY-14643 Regulates CYP1B1 Expression through Peroxisome Proliferator-Activated Receptor a-Mediated Signaling in Human Breast Cancer Cells
Rainer Hwang,Rainer Won,Rainer Jin,Rainer Lee,Rainer Pham,Rainer Choi,Rainer Kang,Rainer Jeong
International Journal of Molecular Sciences. 2019; 20(23): 5928
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256 A Review of Various Antioxidant Compounds and their Potential Utility as Complementary Therapy in Multiple Sclerosis
Elzbieta Dorota Miller,Angela Dziedzic,Joanna Saluk-Bijak,Michal Bijak
Nutrients. 2019; 11(7): 1528
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257 Astaxanthin as a Peroxisome Proliferator-Activated Receptor (PPAR) Modulator: Its Therapeutic Implications
Chang-Ik Choi
Marine Drugs. 2019; 17(4): 242
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258 From Pre-Diabetes to Diabetes: Diagnosis, Treatments and Translational Research
Radia Marium Modhumi Khan,Zoey Jia Yu Chua,Jia Chi Tan,Yingying Yang,Zehuan Liao,Yan Zhao
Medicina. 2019; 55(9): 546
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259 Hepatic Gene Expression During the Perinatal Transition in the Rat
Edward Hurley, Valerie Zabala, Joan M. Boylan, Philip A. Gruppuso, Jennifer A. Sanders
Gene Expression. 2019; 19(1): 1
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260 Neuroprotection mediated by the Wnt/Frizzled signaling pathway in early brain injury induced by subarachnoid hemorrhage
Yang Wang,De-Jun Bao,Bin Xu,Chuan-Dong Cheng,Yong-Fei Dong,Xiang-pin Wei,Chao-Shi Niu
Neural Regeneration Research. 2019; 14(6): 1013
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261 Hepatitis C virus core protein modulates several signaling pathways involved in hepatocellular carcinoma
Shahab Mahmoudvand,Somayeh Shokri,Reza Taherkhani,Fatemeh Farshadpour
World Journal of Gastroenterology. 2019; 25(1): 42
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262 Comprehensive analysis of gene expression profiles provides insight into the pathogenesis of Crohnæs disease
Lumin Bo,Hongyu Fu,Junchi Yang
Molecular Medicine Reports. 2018;
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263 Suppressive Effect of 4-Hydroxy-2-(4-Hydroxyphenethyl) Isoindoline-1,3-Dione on Ovalbumin-Induced Allergic Asthma
Jin Huang,Mingzhi Su,Bo-Kyung Lee,Mee-Jeong Kim,Jee H. Jung,Dong-Soon Im
Biomolecules & Therapeutics. 2018; 26(6): 539
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264 Peroxisome Proliferator-Activated Receptor a Agonist and Its Target Nanog Cooperate to Induce Pluripotency
Jungwoon Lee,Jinhyuk Lee,Yee Cho
Journal of Clinical Medicine. 2018; 7(12): 488
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265 Neuronal Lipid Metabolism: Multiple Pathways Driving Functional Outcomes in Health and Disease
Timothy J. Tracey,Frederik J. Steyn,Ernst J. Wolvetang,Shyuan T. Ngo
Frontiers in Molecular Neuroscience. 2018; 11
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266 Peroxisome Proliferator Activated Receptor Agonists Modulate Transposable Element Expression in Brain and Liver
Laura B. Ferguson,Lingling Zhang,Shi Wang,Courtney Bridges,R. Adron Harris,Igor Ponomarev
Frontiers in Molecular Neuroscience. 2018; 11
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267 Integrative Transcriptomic and microRNAomic Profiling Reveals Immune Mechanism for the Resilience to Soybean Meal Stress in Fish Gut and Liver
Nan Wu,Biao Wang,Zheng-Wei Cui,Xiang-Yang Zhang,Ying-Yin Cheng,Xuan Xu,Xian-Mei Li,Zhao-Xi Wang,Dan-Dan Chen,Yong-An Zhang
Frontiers in Physiology. 2018; 9
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268 Profiling Cellular Processes in Adipose Tissue during Weight Loss Using Time Series Gene Expression
Samar Tareen,Michiel Adriaens,Ilja Arts,Theo de Kok,Roel Vink,Nadia Roumans,Marleen van Baak,Edwin Mariman,Chris Evelo,Martina Kutmon
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269 Pivotal Roles of Peroxisome Proliferator-Activated Receptors (PPARs) and Their Signal Cascade for Cellular and Whole-Body Energy Homeostasis
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International Journal of Molecular Sciences. 2018; 19(4): 949
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270 The Role of PPAR and Its Cross-Talk with CAR and LXR in Obesity and Atherosclerosis
Pengfei Xu,Yonggong Zhai,Jing Wang
International Journal of Molecular Sciences. 2018; 19(4): 1260
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271 Integrating Thyroid Hormone Signaling in Hypothalamic Control of Metabolism: Crosstalk Between Nuclear Receptors
Soumaya Kouidhi,Marie-Stéphanie Clerget-Froidevaux
International Journal of Molecular Sciences. 2018; 19(7): 2017
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272 Comparative Genome-Wide Survey of Single Nucleotide Variation Uncovers the Genetic Diversity and Potential Biomedical Applications among Six Macaca Species
Jing Li,Zhenxin Fan,Tianlin Sun,Changjun Peng,Bisong Yue,Jing Li
International Journal of Molecular Sciences. 2018; 19(10): 3123
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273 Exercise Training-Induced Changes in MicroRNAs: Beneficial Regulatory Effects in Hypertension, Type 2 Diabetes, and Obesity
Alex Improta Caria,Carolina Nonaka,Ciro Pereira,Milena Soares,Simone Macambira,Bruno Souza
International Journal of Molecular Sciences. 2018; 19(11): 3608
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274 Cancer; an induced disease of twentieth century! Induction of tolerance, increased entropy and ‘Dark Energy’: loss of biorhythms (Anabolism v. Catabolism)
Mahin Khatami
Clinical and Translational Medicine. 2018; 7(1)
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275 Research Advances in the Correlation between Peroxisome Proliferator-Activated Receptor-? and Digestive Cancers
Shuqi Xu,Xuanfu Xu
PPAR Research. 2018; 2018: 1
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276 Inhibitory Effects of a Novel PPAR-? Agonist MEKT1 on Pomc Expression/ACTH Secretion in AtT20 Cells
Rehana Parvin,Erika Noro,Akiko Saito-Hakoda,Hiroki Shimada,Susumu Suzuki,Kyoko Shimizu,Hiroyuki Miyachi,Atsushi Yokoyama,Akira Sugawara
PPAR Research. 2018; 2018: 1
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277 Chlorogenic Acid Functions as a Novel Agonist of PPAR?2 during the Differentiation of Mouse 3T3-L1 Preadipocytes
Shu-guang Peng,Yi-lin Pang,Qi Zhu,Jing-he Kang,Ming-xin Liu,Zheng Wang
BioMed Research International. 2018; 2018: 1
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278 Biological Evaluation of Different Extracts of Aerial Parts of Nepeta deflersiana and Standardization of Active Extracts Using 8-Epi-7-Deoxyloganic Acid and Ursolic Acid by Validated HPTLC Method
Raha Orfali,Nasir Ali Siddiqui,Perwez Alam,Tawfeq Abdullah Alhowiriny,Areej Mohammad Al-Taweel,Sami Al-Yahya,Najwa Mohammed Majrashi,Rashad Mehmood,Shabana Iqrar Khan,Shagufta Perveen
Evidence-Based Complementary and Alternative Medicine. 2018; 2018: 1
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279 PPARs: Key Regulators of Airway Inflammation and Potential Therapeutic Targets in Asthma
Asoka Banno,Aravind T. Reddy,Sowmya P. Lakshmi,Raju C. Reddy
Nuclear Receptor Research. 2018; 5
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280 Pre, peri and posttransplant diabetes mellitus
Basset El Essawy,Fouad Kandeel
Current Opinion in Nephrology and Hypertension. 2018; : 1
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281 A Systems Biology Approach to Understanding the Pathophysiology of High-Grade Serous Ovarian Cancer: Focus on Iron and Fatty Acid Metabolism
Anna Konstorum,Miranda L. Lynch,Suzy V. Torti,Frank M. Torti,Reinhard C. Laubenbacher
OMICS: A Journal of Integrative Biology. 2018; 22(7): 502
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282 Supplementation with Resveratrol and Curcumin Does Not Affect the Inflammatory Response to a High-Fat Meal in Older Adults with Abdominal Obesity: A Randomized, Placebo-Controlled Crossover Trial
Cécile Vors,Charles Couillard,Marie-Eve Paradis,Iris Gigleux,Johanne Marin,Marie-Claude Vohl,Patrick Couture,Benoît Lamarche
The Journal of Nutrition. 2018; 148(3): 379
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283 Tetrabromobisphenol-A Promotes Early Adipogenesis and Lipogenesis in 3T3-L1 Cells
Vesna A Chappell,Amanda Janesick,Bruce Blumberg,Suzanne E Fenton
Toxicological Sciences. 2018;
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284 Effects of Resveratrol and Mangiferin on PPAR? and FALDH Gene Expressions in Adipose Tissue of Streptozotocin-Nicotinamide-Induced Diabetes in Rats
Purabi Sarkar,Ananya Bhowmick,Mohan Chandra Kalita,Sofia Banu
Journal of Dietary Supplements. 2018; : 1
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285 Identification and Molecular Characterization of PPARd as a Novel Target for Covalent Modification by 15-deoxy-?12, 14-prostaglandin J2
Aravind T Reddy,Sowmya P Lakshmi,Asoka Banno,Raju C. Reddy
ACS Chemical Biology. 2018;
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286 Design, Synthesis, and Evaluation of a Novel Series of Indole Sulfonamide Peroxisome Proliferator Activated Receptor (PPAR) a/?/d Triple Activators: Discovery of Lanifibranor, a New Antifibrotic Clinical Candidate
Benaïssa Boubia,Olivia Poupardin,Martine Barth,Jean Binet,Philippe Peralba,Laurent Mounier,Elise Jacquier,Emilie Gauthier,Valérie Lepais,Maryline Chatar,Stéphanie Ferry,Anne Thourigny,Fabrice Guillier,Jonathan Llacer,Jérome Amaudrut,Pierre Dodey,Olivier Lacombe,Philippe Masson,Christian Montalbetti,Guillaume Wettstein,Jean-Michel Luccarini,Christiane Legendre,Jean-Louis Junien,Pierre Broqua
Journal of Medicinal Chemistry. 2018;
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287 Peroxisomes and cancer: The role of a metabolic specialist in a disease of aberrant metabolism
Michael S. Dahabieh,Erminia Di Pietro,Maïka Jangal,Christophe Goncalves,Michael Witcher,Nancy E. Braverman,Sonia V. del Rincón
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. 2018; 1870(1): 103
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288 Pioglitazone Reduces Hepatocellular Carcinoma Development in Two Rodent Models of Cirrhosis
Shen Li,Sarani Ghoshal,Mozhdeh Sojoodi,Gunisha Arora,Ricard Masia,Derek J. Erstad,Michael Lanuti,Yujin Hoshida,Thomas F. Baumert,Kenneth K. Tanabe,Bryan C. Fuchs
Journal of Gastrointestinal Surgery. 2018;
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289 Structure-Based Stepwise Screening of PPAR? Antagonists as Potential Competitors with NCOA1 Coactivator Peptide for PPAR? CIS Site
Yi Shen,Hongbo Chi,Jinhu Zhou,Lifei Luo,Qian Tu,Cancan Qi,Zuhua Gao
International Journal of Peptide Research and Therapeutics. 2018;
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290 Effect of supplementing chromium histidinate and picolinate complexes along with biotin on insulin sensitivity and related metabolic indices in rats fed a high-fat diet
Cemal Orhan,Osman Kucuk,Mehmet Tuzcu,Nurhan Sahin,James R. Komorowski,Kazim Sahin
Food Science & Nutrition. 2018;
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291 The nuclear receptor superfamily: A structural perspective
Emily R. Weikum,Xu Liu,Eric A. Ortlund
Protein Science. 2018; 27(11): 1876
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292 Ginsenoside Rf inhibits cyclooxygenase-2 induction via peroxisome proliferator–activated receptor gamma in A549 cells
Heewon Song,Joonwoo Park,KeunOh Choi,Jeonggeun Lee,Jie Chen,Hyun-Ju Park,Byeung-Il Yu,Mitsuru Iida,Mee-Ra Rhyu,YoungJoo Lee
Journal of Ginseng Research. 2018;
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293 Synthesis and evaluation of an orally available “Y”-shaped biaryl peroxisome proliferator-activated receptor d agonist
Dong-Su Kim,Jaehwan Lee,Ashwini M. Londhe,Tara Man Kadayat,Jeongmin Joo,Hayoung Hwang,Kyung-Hee Kim,Ae Nim Pae,Jungwook Chin,Sung Jin Cho,Heonjoong Kang
Bioorganic & Medicinal Chemistry. 2018;
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294 Heme oxygenase-1 induction by rosiglitazone via PKCa/AMPKa/p38 MAPKa/SIRT1/PPAR? pathway suppresses lipopolysaccharide-mediated pulmonary inflammation
Rou-Ling Cho,Wei-Ning Lin,Chen-yu Wang,Chien-Chung Yang,Li-Der Hsiao,Chih-Chung Lin,Chuen-Mao Yang
Biochemical Pharmacology. 2018;
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295 Vascular smooth muscle cell proliferation as a therapeutic target. Part 1: molecular targets and pathways
Dongdong Wang,Pavel Uhrin,Andrei Mocan,Birgit Waltenberger,Johannes M. Breuss,Devesh Tewari,Judit Mihaly-Bison,Lukasz Huminiecki,Rafal R. Starzynski,Nikolay T. Tzvetkov,Jaroslaw Horbanczuk,Atanas G. Atanasov
Biotechnology Advances. 2018;
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296 H 2 S induces Th1/Th2 imbalance with triggered NF-?B pathway to exacerbate LPS-induce chicken pneumonia response
Wei Wang,Menghao Chen,Xi Jin,Xiaojing Li,Zijiang Yang,Hongjin Lin,Shiwen Xu
Chemosphere. 2018; 208: 241
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297 Biotinylated PAMAM G3 dendrimer conjugated with celecoxib and/or Fmoc-l-Leucine and its cytotoxicity for normal and cancer human cell lines
Lukasz Uram,Aleksandra Filipowicz,Maria Misiorek,Natalia Pienkowska,Joanna Markowicz,Elzbieta Walajtys-Rode,Stanislaw Wolowiec
European Journal of Pharmaceutical Sciences. 2018; 124: 1
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298 Saroglitazar reduces obesity and associated inflammatory consequences in murine adipose tissue
Durgesh Kumar,Umesh Kumar Goand,Sanchita Gupta,Kripa Shankar,Salil Varshney,Sujith Rajan,Ankita Srivastava,Abhishek Gupta,Achchhe Lal Vishwakarma,Anurag Kumar Srivastava,Anil N Gaikwad
European Journal of Pharmacology. 2018;
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299 Phytol: A review of biomedical activities
Muhammad Torequl Islam,Eunüs S. Ali,Shaikh J. Uddin,Subrata Shaw,Md Amirul Islam,Md Iqbal Ahmed,Manik Chandra Shill,Utpal Kumar Karmakar,Nagendra Sastry Yarla,Ishaq N. Khan,Md Morsaline Billah,Magdalena D. Pieczynska,Gokhan Zengin,Clemens Malainer,Ferdinando Nicoletti,Diana Gulei,Ioana Berindan-Neagoe,Apostol Apostolov,Maciej Banach,Andy W.K. Yeung,Amr El-Demerdash,Jianbo Xiao,Prasanta Dey,Santosh Yele,Artur Józwik,Nina Strzalkowska,Joanna Marchewka,Kannan R.R. Rengasamy,Jaroslaw Horbanczuk,Mohammad Amjad Kamal,Mohammad S. Mubarak,Siddhartha K. Mishra,Jamil A. Shilpi,Atanas G. Atanasov
Food and Chemical Toxicology. 2018;
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300 Signaling pathways linking inflammation to insulin resistance
Hamid Zand,Nava Morshedzadeh,Farnush Naghashian
Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 2017;
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301 Treatment Strategies for Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis
Pegah Golabi,Haley Bush,Zobair M. Younossi
Clinics in Liver Disease. 2017;
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302 Dose-dependent effects of peroxisome proliferator-activated receptors ß/d agonist on systemic inflammation after haemorrhagic shock
Luxu Yin,Daniel Busch,Zhi Qiao,Martijn van Griensven,Michel Teuben,Frank Hildebrand,Hans-Christoph Pape,Roman Pfeifer
Cytokine. 2017;
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303 Design, synthesis, molecular modeling and anti-hyperglycemic evaluation of novel quinoxaline derivatives as potential PPAR? and SUR agonists
Mohammed K. Ibrahim,Ibrahim H. Eissa,Abdallah E. Abdallah,Ahmed M. Metwaly,M.M. Radwan,M.A. ElSohly
Bioorganic & Medicinal Chemistry. 2017; 25(4): 1496
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304 Ligands of peroxisome proliferator-activated receptor-alpha promote glutamate transporter-1 endocytosis in astrocytes
Hui-Ting Huang,Chih-Kai Liao,Wen-Tai Chiu,Shun-Fen Tzeng
The International Journal of Biochemistry & Cell Biology. 2017; 86: 42
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305 CBMG, a novel derivative of mansonone G suppresses adipocyte differentiation via suppression of PPAR? activity
Hyo Kyeong Kim,Rita Hairani,Hana Jeong,Mi Gyeong Jeong,Warinthorn Chavasiri,Eun Sook Hwang
Chemico-Biological Interactions. 2017; 273: 160
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306 Bazedoxifene and raloxifene protect neocortical neurons undergoing hypoxia via targeting ERa and PPAR-?
J. Rzemieniec,E. Litwa,A. Wnuk,W. Lason,M. Kajta
Molecular and Cellular Endocrinology. 2017;
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307 Of mice and humans through the looking glass: “Reflections” on epigenetics of lipid metabolism
Raffaella Longo,Alessandra Ferrari,Monica Zocchi,Maurizio Crestani
Molecular Aspects of Medicine. 2017;
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308 Bacaba phenolic extract attenuates adipogenesis by down-regulating PPAR? and C/EBPa in 3T3-L1 cells
Judith Lauvai,Monika Schumacher,Fernanda Dias Bartolomeu Abadio Finco,Lutz Graeve
NFS Journal. 2017; 9: 8
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309 The mechanism of skin lipids influencing skin status
Yan Jia,Yao Gan,Congfen He,Zhou Chen,Cheng Zhou
Journal of Dermatological Science. 2017;
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310 Integrated in silico–in vitro screening of ovarian cancer peroxisome proliferator-activated receptor-? agonists against a biogenic compound library
Gui-Lian Zhang,Feng-Ying Liu,Jing Zhang,Li-Ping Wang,Er-Xia Jia,Shi-Ming Lv
Medicinal Chemistry Research. 2017;
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311 Roles of Peroxisome Proliferator-Activated Receptor Gamma on Brain and Peripheral Inflammation
Sonia Villapol
Cellular and Molecular Neurobiology. 2017;
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312 Relationship Between Circulating Fatty Acids and Fatty Acid Ethanolamide Levels After a Single 2-h Dietary Fat Feeding in Male Sprague–Dawley Rats
Anthonia O. Olatinsu,Jyoti Sihag,Peter J. H. Jones
Lipids. 2017;
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313 Identification and comparative analysis of the pearl oyster Pinctada fucata hemocytes microRNAs in response to Vibrio alginolyticus infection
Zhongliang Wang,Bei Wang,Gang Chen,Yishan Lu,Jichang Jian,Zaohe Wu
Genes & Genomics. 2017;
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314 Adiponectin regulates AQP3 via PPARa in human hepatic stellate cells
Matteo Tardelli,Thierry Claudel,Francesca V. Bruschi,Veronica Moreno-Viedma,Michael Trauner
Biochemical and Biophysical Research Communications. 2017; 490(1): 51
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315 Linking cortisol response with gene expression in fish exposed to gold nanoparticles
M. Teles,A.M.V.M. Soares,L. Tort,L. Guimarães,M. Oliveira
Science of The Total Environment. 2017;
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316 Regulation of cell signaling pathways by dietary agents for cancer prevention and treatment
Manoj K. Pandey,Subash C. Gupta,Ali Nabavizadeh,Bharat B. Aggarwal
Seminars in Cancer Biology. 2017;
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317 Transcriptome Analysis of Three Sheep Intestinal Regions reveals Key Pathways and Hub Regulatory Genes of Large Intestinal Lipid Metabolism
Tianle Chao,Guizhi Wang,Zhibin Ji,Zhaohua Liu,Lei Hou,Jin Wang,Jianmin Wang
Scientific Reports. 2017; 7(1)
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318 Association Between Plasma N-Acylethanolamides and High Hemoglobin Concentration in Southern Peruvian Highlanders
Dulce E. Alarcón-Yaquetto,Lidia Caballero,Gustavo F. Gonzales
High Altitude Medicine & Biology. 2017;
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319 Rational screening of peroxisome proliferator-activated receptor-? agonists from natural products: potential therapeutics for heart failure
Rui Chen,Jing Wan,Jing Song,Yan Qian,Yong Liu,Shuiming Gu
Pharmaceutical Biology. 2017; 55(1): 503
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320 Understanding mitochondrial biogenesis through energy sensing pathways and its translation in cardio-metabolic health
Abhijit Nirwane,Anuradha Majumdar
Archives of Physiology and Biochemistry. 2017; : 1
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321 Selenium supplementation through Se-rich dietary matrices can upregulate the anti-inflammatory responses in lipopolysaccharide-stimulated murine macrophages
Noorpreet Inder kaur Dhanjal,Siddharth Sharma,K. Sandeep Prabhu,N. Tejo Prakash
Food and Agricultural Immunology. 2017; : 1
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322 Altered Pathway Analyzer: A gene expression dataset analysis tool for identification and prioritization of differentially regulated and network rewired pathways
Abhinav Kaushik,Shakir Ali,Dinesh Gupta
Scientific Reports. 2017; 7: 40450
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323 The Myofibroblast: TGFß-1, A Conductor which Plays a Key Role in Fibrosis by Regulating the Balance between PPAR? and the Canonical WNT Pathway
Yves Lecarpentier,Olivier Schussler,Victor Claes,Alexandre Vallée
Nuclear Receptor Research. 2017; 4
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324 A systems perspective on brown adipogenesis and metabolic activation
R.N. Pradhan,M. Zachara,B. Deplancke
Obesity Reviews. 2017; 18: 65
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325 Molecular factors involved in the hypolipidemic- and insulin-sensitizing effects of a ginger (Zingiber officinale Roscoe) extract in rats fed a high-fat diet
Natalia de las Heras,María Valero-Muñoz,Beatriz Martín-Fernández,Sandra Ballesteros,Antonio López-Farré,Baltasar Ruiz-Roso,Vicente Lahera
Applied Physiology, Nutrition, and Metabolism. 2017; 42(2): 209
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326 Time-dependent therapeutic roles of nitazoxanide on high-fat diet/streptozotocin-induced diabetes in rats: effects on hepatic peroxisome proliferator-activated receptor-gamma receptors
Samah M. Elaidy,Mona A. Hussain,Mohamed K. El-Kherbetawy
Canadian Journal of Physiology and Pharmacology. 2017; : 1
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327 Increased hepatic mitochondrial FA oxidation reduces plasma and liver TG levels and is associated with regulation of UCPs and APOC-III in rats
Carine Lindquist,Bodil Bjørndal,Christine Renate Rossmann,Deusdedit Tusubira,Asbjørn Svardal,Gro Vatne Røsland,Karl Johan Tronstad,Seth Hallström,Rolf Kristian Berge
Journal of Lipid Research. 2017; 58(7): 1362
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328 Statin therapy causes gut dysbiosis in mice through a PXR-dependent mechanism
Jose A. Caparrós-Martín,Ricky R. Lareu,Joshua P. Ramsay,Jörg Peplies,F. Jerry Reen,Henrietta A. Headlam,Natalie C. Ward,Kevin D. Croft,Philip Newsholme,Jeffery D. Hughes,Fergal O’Gara
Microbiome. 2017; 5(1)
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329 Thermodynamics in cancers: opposing interactions between PPAR gamma and the canonical WNT/beta-catenin pathway
Yves Lecarpentier,Victor Claes,Alexandre Vallée,Jean-Louis Hébert
Clinical and Translational Medicine. 2017; 6(1)
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330 RXR Ligands Negatively Regulate Thrombosis and Hemostasis
Amanda J. Unsworth,Gagan D. Flora,Parvathy Sasikumar,Alexander P. Bye,Tanya Sage,Neline Kriek,Marilena Crescente,Jonathan M. Gibbins
Arteriosclerosis, Thrombosis, and Vascular Biology. 2017; 37(5): 812
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331 Decreased Adiponectin-Mediated Signaling Through the AdipoR2 Pathway Is Associated With Carotid Plaque Instability
Karina Gasbarrino,Huaien Zheng,Anouar Hafiane,John P. Veinot,Chi Lai,Stella S. Daskalopoulou
Stroke. 2017; 48(4): 915
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332 Integrative Comparison of mRNA Expression Patterns in Breast Cancers from Caucasian and Asian Americans with Implications for Precision Medicine
Yanxia Shi,Albert Steppi,Ye Cao,Jianan Wang,Max M. He,Liren Li,Jinfeng Zhang
Cancer Research. 2017; 77(2): 423
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333 Combination of Classifiers Identifies Fungal-Specific Activation of Lysosome Genes in Human Monocytes
João P. Leonor Fernandes Saraiva,Cristina Zubiria-Barrera,Tilman E. Klassert,Maximilian J. Lautenbach,Markus Blaess,Ralf A. Claus,Hortense Slevogt,Rainer König
Frontiers in Microbiology. 2017; 8
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334 KRAS mutant colorectal cancer gene signatures identified angiotensin II receptor blockers as potential therapies
Qing Wen,Philip D. Dunne,Paul G. O’Reilly,Gerald Li,Anthony J. Bjourson,Darragh G. McArt,Peter W. Hamilton,Shu-Dong Zhang
Oncotarget. 2017; 8(2): 3206
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335 Host-mediated effects of phytonutrients in ruminants: A review
J. Oh,E.H. Wall,D.M. Bravo,A.N. Hristov
Journal of Dairy Science. 2017;
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336 Comparative genome-wide methylation analysis of longissimus dorsi muscles between Japanese black (Wagyu) and Chinese Red Steppes cattle
Xibi Fang,Zhihui Zhao,Haibin Yu,Guangpeng Li,Ping Jiang,Yuwei Yang,Runjun Yang,Xianzhong Yu,Sanjay B Jadhao
PLOS ONE. 2017; 12(8): e0182492
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337 Influence of energy exchange genes on lipid metabolism during pregnancy complicated by the development of fetal growth restriction
S. A. Azhibekov,N. V. Putilova,T. B. Tretyakova,L. A. Pestryaeva
Rossiiskii vestnik akushera-ginekologa. 2017; 17(6): 9
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338 Topically administered rhGM-CSF affects PPARß expression in the stasis zone
Gen-Feng Fu,She-Min Tian,Xin-Jian Cha,Hong-Jun Huang,Ji-He Lou,Ying Wei,Cheng-De Xia,Yong-Lin Li,Xi-Hua Niu
Experimental and Therapeutic Medicine. 2017;
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339 Implications of dietary ?-3 and ?-6 polyunsaturated fatty acids in breast cancer (Review)
Oana Zanoaga,Ancuta Jurj,Lajos Raduly,Roxana Cojocneanu-Petric,Enrique Fuentes-Mattei,Oscar Wu,Cornelia Braicu,Claudia Gherman,Ioana Berindan-Neagoe
Experimental and Therapeutic Medicine. 2017;
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340 Anti-Obesity Effect of Pine Cone (Pinus koraiensis) Supercritical Extract in High-Fat Diet-Induced Obese Mice
Dasom Lee,Minhee Lee,Hyesook Kim,Tuk-Rai Jeong,Hyun-Pil Yang,Heo Seok Hyun,Jeongmin Lee
Journal of the Korean Society of Food Science and Nutrition. 2016; 45(12): 1701
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341 Potential effects of curcumin on peroxisome proliferator-activated receptor-?in vitroandin vivo
Mohsen Mazidi,Ehsan Karimi,Mohsen Meydani,Majid Ghayour-Mobarhan,Gordon A Ferns
World Journal of Methodology. 2016; 6(1): 112
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342 Nutrigenomics and Beef Quality: A Review about Lipogenesis
Marcio Ladeira,Jon Schoonmaker,Mateus Gionbelli,Júlio Dias,Tathyane Gionbelli,José Carvalho,Priscilla Teixeira
International Journal of Molecular Sciences. 2016; 17(6): 918
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343 Mechanisms of Body Weight Reduction by Black Tea Polyphenols
Haibo Pan,Ying Gao,Youying Tu
Molecules. 2016; 21(12): 1659
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344 A PROSPECTIVE STUDY OF EFFECT OF TELMISARTAN (ANGIOTENSIN II RECEPTOR BLOCKER) ON METABOLIC PARAMETERS IN HYPERTENSIVE PATIENTS WITH METABOLIC SYNDROME
Somesekhar V,Rajendra Prasad R,Swami K. S. R
Journal of Evidence Based Medicine and Healthcare. 2016; 3(34): 1635
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345 EFFECT OF IRBESARTAN ON BIOCHEMICAL PARAMETERS IN OVERWEIGHT HYPERTENSIVE PATIENTS
Balachandra Rao Naidu M,Ch. Ratna Kumar,Kiranmai Kiranmai
Journal of Evidence Based Medicine and Healthcare. 2016; 3(52): 2668
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346 Novel hepatic microRNAs upregulated in human nonalcoholic fatty liver disease
Jarkko Soronen,Hannele Yki-Järvinen,You Zhou,Sanja Sädevirta,Antti-Pekka Sarin,Marja Leivonen,Ksenia Sevastianova,Julia Perttilä,Pirkka-Pekka Laurila,Alexander Sigruener,Gerd Schmitz,Vesa M. Olkkonen
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347 The Ticking of the Epigenetic Clock: Antipsychotic Drugs in Old Age
Adonis Sfera,Carolina Osorio,Luzmin Inderias,Michael Cummings
Frontiers in Endocrinology. 2016; 7
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348 Endocrine Aspects of Environmental “Obesogen” Pollutants
Francesca Nappi,Luigi Barrea,Carolina Di Somma,Maria Savanelli,Giovanna Muscogiuri,Francesco Orio,Silvia Savastano
International Journal of Environmental Research and Public Health. 2016; 13(8): 765
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349 The increasingly complex regulation of adipocyte differentiation
Sylvia P Poulos,Michael V Dodson,Melinda F Culver,Gary J Hausman
Experimental Biology and Medicine. 2016; 241(5): 449
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350 PPAR Gamma in Neuroblastoma: The Translational Perspectives of Hypoglycemic Drugs
Serena Vella,Pier Giulio Conaldi,Tullio Florio,Aldo Pagano
PPAR Research. 2016; 2016: 1
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351 Pentoxifylline ameliorates non-alcoholic fatty liver disease in hyperglycaemic and dyslipidaemic mice by upregulating fatty acid ß-oxidation
Jia-Hung Ye,Jung Chao,Ming-Ling Chang,Wen-Huang Peng,Hao-Yuan Cheng,Jiunn-Wang Liao,Li-Heng Pao
Scientific Reports. 2016; 6: 33102
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352 Endocrine and metabolic impacts of warming aquatic habitats: differential responses between recently isolated populations of a eurythermal desert pupfish
Sean C. Lema,Michelle I. Chow,Emily J. Resner,Alex A. Westman,Darran May,Andrew H. Dittman,Kristin M. Hardy
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353 Prenatal phthalate exposure: epigenetic changes leading to lifelong impact on steroid formation
D. B. Martinez-Arguelles,V. Papadopoulos
Andrology. 2016; : n/a
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354 Molecular mechanism of lipid-induced cardiac insulin resistance and contractile dysfunction
Yilin Liu,Dietbert Neumann,Jan F.C. Glatz,Joost J.F.P. Luiken
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355 Astragaloside IV, a Natural PPAR? Agonist, Reduces Aß Production in Alzheimer’s Disease Through Inhibition of BACE1
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Molecular Neurobiology. 2016;
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356 Low serum vitamin D-status, air pollution and obesity: A dangerous liaison
Luigi Barrea,Silvia Savastano,Carolina Di Somma,Maria Cristina Savanelli,Francesca Nappi,Lidia Albanese,Francesco Orio,Annamaria Colao
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357 Neurokinin-1 receptor inhibition reverses ischaemic brain injury and dementia in bilateral common carotid artery occluded rats: possible mechanisms
Jaspreet Kaur,Shweta Sharma,Manpreet Sandhu,Saurabh Sharma
Inflammopharmacology. 2016; 24(4): 133
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358 Marine-sulfated polysaccharides extract of Ulva armoricana green algae exhibits an antimicrobial activity and stimulates cytokine expression by intestinal epithelial cells
Mustapha Berri,Cindy Slugocki,Michel Olivier,Emmanuelle Helloin,Isabelle Jacques,Henri Salmon,Hervé Demais,Matthieu Le Goff,Pi Nyvall Collen
Journal of Applied Phycology. 2016;
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359 Use of retinoic acid/aldehyde dehydrogenase pathway as potential targeted therapy against cancer stem cells
Jan S. Moreb,Deniz A. Ucar-Bilyeu,Abdullah Khan
Cancer Chemotherapy and Pharmacology. 2016;
[Pubmed] | [DOI]
360 Nanofiber scaffolds influence organelle structure and function in bone marrow stromal cells
Wojtek Tutak,Giri Jyotsnendu,Peter Bajcsy,Carl G. Simon
Journal of Biomedical Materials Research Part B: Applied Biomaterials. 2016; : n/a
[Pubmed] | [DOI]
361 Nuclear receptor function in skin health and disease: therapeutic opportunities in the orphan and adopted receptor classes
Kelvin Yin,Aaron G. Smith
Cellular and Molecular Life Sciences. 2016;
[Pubmed] | [DOI]
362 Inhibition of hypoxia-induced cyclooxygenase-2 by Korean Red Ginseng is dependent on peroxisome proliferator-activated receptor gamma
Heewon Song,Young Joo Lee
Journal of Ginseng Research. 2016;
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363 Screening and functional analysis of differentially expressed genes in chronic glomerulonephritis by whole genome microarray
Jia-rong Gao,Xiu-juan Qin,Hui Jiang,Ting Wang,Jun-mei Song,Shuang-zhi Xu
Gene. 2016; 589(1): 72
[Pubmed] | [DOI]
364 Instant rice made from white and pigmented giant embryonic rice reduces lipid levels and body weight in high fat diet-fed mice
Soo Im Chung,Catherine W. Rico,Sang Chul Lee,Mi Young Kang
Obesity Research & Clinical Practice. 2016;
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365 Evidence that activation of nuclear peroxisome proliferator-activated receptor alpha (PPARa) modulates sleep homeostasis in rats
Eric Murillo-Rodríguez,Khalil Guzmán,Gloria Arankowsky-Sandoval,Mireille Salas-Crisóstomo,Ramsés Jiménez-Moreno,Oscar Arias-Carrión
Brain Research Bulletin. 2016;
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366 DHA-enriched fish oil upregulates cyclin-dependent kinase inhibitor 2A (P16INK) expression and downregulates telomerase activity without modulating effects of PPAR? Pro12Ala polymorphism in type 2 diabetic patients: A randomized, double-blind, placebo-controlled clinical trial
Omid Toupchian,Gity Sotoudeh,Anahita Mansoori,Shima Abdollahi,Seyyed Ali Keshavarz,Mahmoud Djalali,Ensieh Nasli-Esfahani,Ehsan Alvandi,Reza Chahardoli,Fariba Koohdani
Clinical Nutrition. 2016;
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367 Effects of tetramethylpyrazine from Chinese black vinegar on antioxidant and hypolipidemia activities in HepG2 cells
Jicheng Chen,Jingjing Tian,Huifang Ge,Ruihai Liu,Jianbo Xiao
Food and Chemical Toxicology. 2016;
[Pubmed] | [DOI]
368 Peroxisome proliferator-activated receptor gamma (PPAR?) in brown trout: Interference of estrogenic and androgenic inputs in primary hepatocytes
Célia Lopes,Tânia Vieira Madureira,Nádia Ferreira,Ivone Pinheiro,L. Filipe C. Castro,Eduardo Rocha
Environmental Toxicology and Pharmacology. 2016; 46: 328
[Pubmed] | [DOI]
369 Sleep and neurochemical modulation by the nuclear peroxisome proliferator-activated receptor a (PPAR-a) in rat
Stephanie Mijangos-Moreno,Alwin Poot-Aké,Khalil Guzmán,Gloria Arankowsky-Sandoval,Oscar Arias-Carrión,Jaime Zaldívar-Rae,Andrea Sarro-Ramírez,Eric Murillo-Rodríguez
Neuroscience Research. 2015;
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370 Peroxisome proliferator-activated receptors (PPARs) and PPAR agonists: the ‘future’ in dermatology therapeutics?
Mrinal Gupta,Vikram K. Mahajan,Karaninder S. Mehta,Pushpinder S. Chauhan,Ritu Rawat
Archives of Dermatological Research. 2015; 307(9): 767
[Pubmed] | [DOI]
371 Proliferation and fission of peroxisomes — An update
Michael Schrader,Joseph L. Costello,Luis F. Godinho,Afsoon S. Azadi,Markus Islinger
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 2015;
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372 Expression of metabolic sensing receptors in adipose tissues of periparturient dairy cows with differing extent of negative energy balance
P. Friedrichs,H. Sauerwein,K. Huber,L. F. Locher,J. Rehage,U. Meyer,S. Dänicke,B. Kuhla,M. Mielenz
animal. 2015; : 1
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373 The role of microRNAs in bone remodeling
Dian Jing,Jin Hao,Yu Shen,Ge Tang,Mei-Le Li,Shi-Hu Huang,Zhi-He Zhao
International Journal of Oral Science. 2015; 7(3): 131
[Pubmed] | [DOI]
374 Phosphatidic Acid (PA) can Displace PPARa/LXRa Binding to The EGFR Promoter Causing its Transrepression in Luminal Cancer Cells
Madhu Mahankali,Terry Farkaly,Shimpi Bedi,Heather A. Hostetler,Julian Gomez-Cambronero
Scientific Reports. 2015; 5: 15379
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375 Inactivation of PPARß/d adversely affects satellite cells and reduces postnatal myogenesis
Preeti Chandrashekar,Ravikumar Manickam,Xiaojia Ge,Sabeera Bonala,Craig McFarlane,Mridula Sharma,Walter Wahli,Ravi Kambadur
American Journal of Physiology-Endocrinology and Metabolism. 2015; 309(2): E122
[Pubmed] | [DOI]
376 Systemic PPAR? deletion causes severe disturbance in fluid homeostasis in mice
Li Zhou,Alexandra Panasiuk,Maicy Downton,Daqiang Zhao,Baoxue Yang,Zhanjun Jia,Tianxin Yang
Physiological Genomics. 2015; 47(11): 541
[Pubmed] | [DOI]
377 Critical role of PPAR? in water balance
Ningjun Li
Physiological Genomics. 2015; 47(11): 538
[Pubmed] | [DOI]
378 The role of PPAR?-mediated signalling in skin biology and pathology: new targets and opportunities for clinical dermatology
Yuval Ramot,Arianna Mastrofrancesco,Emanuela Camera,Pierre Desreumaux,Ralf Paus,Mauro Picardo
Experimental Dermatology. 2015; 24(4): 245
[Pubmed] | [DOI]
379 Antidiabetic properties of dietary flavonoids: a cellular mechanism review
Ramachandran Vinayagam,Baojun Xu
Nutrition & Metabolism. 2015; 12(1)
[Pubmed] | [DOI]
380 Potential Epigenetic Mechanism in Non-Alcoholic Fatty Liver Disease
Chao Sun,Jian-Gao Fan,Liang Qiao
International Journal of Molecular Sciences. 2015; 16(3): 5161
[Pubmed] | [DOI]
381 Eicosanoid pathway in colorectal cancer: Recent updates
Sinem Tuncer
World Journal of Gastroenterology. 2015; 21(41): 11748
[Pubmed] | [DOI]
382 Expression of PPAR-? in adipose tissue of rats with polycystic ovary syndrome induced by DHEA
YU-XIA WANG,WEI-JIE ZHU,BAO-GUO XIE
Molecular Medicine Reports. 2014; 9(3): 889
[Pubmed] | [DOI]
383 Role of adipokines and peroxisome proliferator-activated receptors in nonalcoholic fatty liver disease
Vettickattuparambil George Giby,Thekkuttuparambil Ananthanarayanan Ajith
World Journal of Hepatology. 2014; 6(8): 570
[Pubmed] | [DOI]
384 Anti-obesity Effects of African Mango (Irvingia gabonesis, IGOB 131TM) Extract in Leptin-deficient Obese Mice
Minhee Lee,Da-Eun Nam,Ok Kyung Kim,Tae Jin Shim,Ji Hoon Kim,Jeongmin Lee
Journal of the Korean Society of Food Science and Nutrition. 2014; 43(10): 1477
[Pubmed] | [DOI]
385 Deficiency of the Transcriptional Repressor B Cell Lymphoma 6 (Bcl6) Is Accompanied by Dysregulated Lipid Metabolism
Christopher R. LaPensee,Grace Lin,Alexander L. Dent,Jessica Schwartz,Xiaoli Chen
PLoS ONE. 2014; 9(6): e97090
[Pubmed] | [DOI]
386 A new dawn for the use of thiazolidinediones in cancer therapy
Hardik Joshi,Tanushree Pal,CS Ramaa
Expert Opinion on Investigational Drugs. 2014; 23(4): 501
[Pubmed] | [DOI]
387 PPARa Activation Can Help Prevent and Treat Non–Small Cell Lung Cancer
Nataliya Skrypnyk,Xiwu Chen,Wen Hu,Yan Su,Stacey Mont,Shilin Yang,Mahesha Gangadhariah,Shouzuo Wei,John R. Falck,Jawahar Lal Jat,Roy Zent,Jorge H. Capdevila,Ambra Pozzi
Cancer Research. 2014; 74(2): 621
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388 PPAR^|^gamma;
Keiji Yoshikawa
The Japanese Journal of SURGICAL METABOLISM and NUTRITION. 2014; 48(2): 81
[Pubmed] | [DOI]
389 Two butenolides with PPARa agonistic activity from a marine-derived Streptomyces
Yasuhiro Igarashi,Marumi Ikeda,Satoshi Miyanaga,Hiroaki Kasai,Yoshikazu Shizuri,Nobuyasu Matsuura
The Journal of Antibiotics. 2014;
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390 PPARa ligand clofibrate ameliorates blood pressure and vascular reactivity in spontaneously hypertensive rats
Zivar Yousefipour,Mohammad Newaz
Acta Pharmacologica Sinica. 2014;
[Pubmed] | [DOI]
391 AMPK-dependent signaling modulates the suppression of invasion and migration by fenofibrate in CAL 27 oral cancer cells through NF-?B pathway
Shih-Chang Tsai,Ming-Hsui Tsai,Chang-Fang Chiu,Chi-Cheng Lu,Sheng-Chu Kuo,Nai-Wen Chang,Jai-Sing Yang
Environmental Toxicology. 2014; : n/a
[Pubmed] | [DOI]
392 MicroRNAs as key regulators of xenobiotic biotransformation and drug response
Jennifer Bolleyn,Joery De Kock,Robim Marcelino Rodrigues,Mathieu Vinken,Vera Rogiers,Tamara Vanhaecke
Archives of Toxicology. 2014;
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393 Polymorphism of FABP2 and PPARG2 genes in risk prediction of cataract among North Indian population
Shania Abbas,Syed Tasleem Raza,Anu Chandra,Luxmi Singh,Saliha Rizvi,Ale eba,Faisal Ahmed,Farzana Mahdi
Meta Gene. 2014; 2: 307
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394 Mindin/Spondin 2 inhibits hepatic steatosis, insulin resistance, and obesity via interaction with peroxisome proliferator-activated receptor a in mice
Li-Hua Zhu,Aibing Wang,Pengcheng Luo,Xinan Wang,Ding-Sheng Jiang,Wei Deng,Xiaofei Zhang,Tao Wang,Yi Liu,Lu Gao,Shumin Zhang,Xiaodong Zhang,Jie Zhang,Hongliang Li
Journal of Hepatology. 2014;
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395 PPAR-? inhibits IL-13-induced collagen production in mouse airway fibroblasts
Jiamei Lu,Lu Liu,Yanting Zhu,Yonghong Zhang,Yuanyuan Wu,Guizuo Wang,Dexin Zhang,Jing Xu,Xinming Xie,Rui Ke,Dong Han,Shaojun Li,Wei Feng,Mei Xie,Yun Liu,Ping Fang,Hongyang Shi,Ping He,Yuan Liu,Xiuzhen Sun,Manxiang Li
European Journal of Pharmacology. 2014; 737: 133
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396 Energy and metabolic sensing G protein-coupled receptors during lactation-induced changes in energy balance
P. Friedrichs,B. Saremi,S. Winand,J. Rehage,S. Dänicke,H. Sauerwein,M. Mielenz
Domestic Animal Endocrinology. 2014;
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397 L-165,041, troglitazone and their combination treatment to attenuate high glucose-induced receptor for advanced glycation end products (RAGE) expression
Yao-Jen Liang,Jhin-Hao Jian,Chao-Yi Chen,Chia-Yu Hsu,Chin-Yu Shih,Jyh-Gang Leu
European Journal of Pharmacology. 2013; 715(1-3): 33
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398 Peroxisome proliferator-activated receptor targets for the treatment of metabolic diseases
Monsalve, F.A. and Pyarasani, R.D. and Delgado-Lopez, F. and Moore-Carrasco, R.
Mediators of Inflammation. 2013; 2013(549627)
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399 Therapeutic implications of targeting energy metabolism in breast cancer
Sakharkar MK, Shashni B, Sharma K, Dhillon SK, Ranjekar PR, Sakharkar KR.
PPAR Research. 2013; (Art )
[Pubmed]
400 Interferon regulatory factor 9 protects against hepatic insulin resistance and steatosis in male mice
Xin-An Wang,Ran Zhang,Dingsheng Jiang,Wei Deng,Shumin Zhang,Shan Deng,Jinfeng Zhong,Tao Wang,Li-Hua Zhu,Li Yang,Shufen Hong,Sen Guo,Ke Chen,Xiao-Fei Zhang,Zhigang She,Yingjie Chen,Qinglin Yang,Xiao-Dong Zhang,Hongliang Li
Hepatology. 2013; 58(2): 603
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401 SERPINA3K induces apoptosis in human colorectal cancer cells via activating the Fas/FasL/caspase-8 signaling pathway
Yao, Y. and Li, L. and Huang, X. and Gu, X. and Xu, Z. and Zhang, Y. and Huang, L. and Li, S. and Dai, Z. and Li, C. and Zhou, T. and Cai, W. and Yang, Z. and Gao, G. and Yang, X.
FEBS Journal. 2013; 280(14): 3244-3255
[Pubmed]
402 Molecular evidence for the involvement of PPAR-δ and PPAR-γ in anti-inflammatory and neuroprotective activities of palmitoylethanolamide after spinal cord trauma
Paterniti, I. and Impellizzeri, D. and Crupi, R. and Morabito, R. and Campolo, M. and Esposito, E. and Cuzzocrea, S.
Journal of Neuroinflammation. 2013; 10(20)
[Pubmed]
403 Hepatitis C virus nonstructural protein 5A favors upregulation of gluconeogenic and lipogenic gene expression leading towards insulin resistance: a metabolic syndrome
Fahed Parvaiz,Sobia Manzoor,Jawed Iqbal,Steven McRae,Farrakh Javed,Qazi Laeeque Ahmed,Gulam Waris
Archives of Virology. 2013;
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404 Fatty acids regulation of inflammatory and metabolic genes
Laureane N. Masi,Alice C. Rodrigues,Rui Curi
Current Opinion in Clinical Nutrition and Metabolic Care. 2013; : 1
[Pubmed] | [DOI]
405 Molecular evidence for the involvement of PPAR-d and PPAR-? in anti-inflammatory and neuroprotective activities of palmitoylethanolamide after spinal cord trauma
Irene Paterniti,Daniela Impellizzeri,Rosalia Crupi,Rossana Morabito,Michela Campolo,Emanuela Esposito,Salvatore Cuzzocrea
Journal of Neuroinflammation. 2013; 10(1): 20
[Pubmed] | [DOI]
406 The G32E Functional Variant Reduces Activity of PPARD by Nuclear Export and Post-Translational Modification in Pigs
Yanyu Duan,Bertram Brenig,Xiaohui Wu,Jun Ren,Lusheng Huang,Marinus FW. te. Pas
PLoS ONE. 2013; 8(9): e75925
[Pubmed] | [DOI]
407 SERPINA3K induces apoptosis in human colorectal cancer cells via activating the Fas/FasL/caspase-8 signaling pathway
Yachao Yao,Lei Li,Xuan Huang,Xiaoqiong Gu,Zumin Xu,Yang Zhang,Lijun Huang,Shuai Li,Zhiyu Dai,Cen Li,Ti Zhou,Weibin Cai,Zhonghan Yang,Guoquan Gao,Xia Yang
FEBS Journal. 2013; 280(14): 3244
[Pubmed] | [DOI]
408 Liver damage is not reversed during the lean period in diet-induced weight cycling in mice
Sandra Barbosa-da-Silva,Natalia C. da Silva,Marcia B. Aguila,Carlos A. Mandarim-de-Lacerda
Hepatology Research. 2013; : n/a
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409 Therapeutic Implications of Targeting Energy Metabolism in Breast Cancer
Meena K. Sakharkar,Babita Shashni,Karun Sharma,Sarinder K. Dhillon,Prabhakar R. Ranjekar,Kishore R. Sakharkar
PPAR Research. 2013; 2013: 1
[Pubmed] | [DOI]
410 Peroxisome Proliferator-Activated Receptor Targets for the Treatment of Metabolic Diseases
Francisco A. Monsalve,Radha D. Pyarasani,Fernando Delgado-Lopez,Rodrigo Moore-Carrasco
Mediators of Inflammation. 2013; 2013: 1
[Pubmed] | [DOI]
411 Induction of Thymic Stromal Lymphopoietin Production by Nonanoic Acid and Exacerbation of Allergic Inflammation in Mice
Saori Yamashita,Ryosuke Segawa,Nozomi Satou,Masahiro Hiratsuka,Warren J Leonard,Noriyasu Hirasawa
Allergology International. 2013; 62(4): 463
[Pubmed] | [DOI]
412 PPARs: Interference with Warburg’ Effect and Clinical Anticancer Trials
Joseph Vamecq,Jean-Marie Colet,Jean Jacques Vanden Eynde,Gilbert Briand,Nicole Porchet,Stéphane Rocchi
PPAR Research. 2012; 2012: 1
[Pubmed] | [DOI]
413 PPARG Epigenetic Deregulation and Its Role in Colorectal Tumorigenesis
Lina Sabatino,Alessandra Fucci,Massimo Pancione,Vittorio Colantuoni
PPAR Research. 2012; 2012: 1
[Pubmed] | [DOI]
414 Identification of a Molecular Signature Underlying Inhibition of Mammary Carcinoma Growth by Dietary N-3 Fatty Acids
Weiqin Jiang,Zongjian Zhu,John N. McGinley,Karam El Bayoumy,Andrea Manni,Henry J. Thompson
Cancer Research. 2012; 72(15): 3795
[Pubmed] | [DOI]
415 Anti-angiogenic treatment strategies for the therapy of endometriosis
M. W. Laschke,M. D. Menger
Human Reproduction Update. 2012; 18(6): 682
[Pubmed] | [DOI]
416 PPARG Epigenetic Deregulation and Its Role in Colorectal Tumorigenesis
Lina Sabatino, Alessandra Fucci, Massimo Pancione, and Vittorio Colantuoni
PPAR Research. 2012; : Art-687492
[Pubmed]
417 Anti-angiogenic treatment strategies for the therapy of endometriosis
Laschke MW, Menger MD
European Society of Human Reproduction and Embryology. 2012; 18(6): 682-702
[Pubmed]
418 Identification of a Molecular Signature Underlying Inhibition of Mammary Carcinoma Growth by Dietary N-3 Fatty Acids
Weiqin Jiang, Zongjian Zhu, John N. McGinley, Karam El Bayoumy, Andrea Manni, Henry J. Thompson
Cancer Research. 2012; 72(15): 3795-3806
[Pubmed]
419 “PPARs: Interference with Warburg’ Effect and Clinical Anticancer Trials,”
Joseph Vamecq, Jean-Marie Colet, Jean Jacques Vanden Eynde, Gilbert Briand, Nicole Porchet, Stéphane Rocchi,
PPAR Research. 2012; : Art-304760
[Pubmed]



 
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