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ORIGINAL ARTICLE
Year : 2011  |  Volume : 2  |  Issue : 1  |  Page : 51-55

Gastroretentive microballoons of metformin: Formulation development and characterization


Department of Pharmaceutics, College of Pharmacy, IPS Academy, Knowledge Village, A. B. Road, Rajendra Nagar, Indore, Madhya Pradesh, India

Correspondence Address:
Akash Yadav
Department of Pharmaceutics, College of Pharmacy, IPS Academy, Rajendra Nagar, Indore - 452 012, Madhya Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2231-4040.79806

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The present study involves preparation and evaluation of floating microballoons with metformin as model drug for prolongation of gastric residence time. The microballoons were prepared by the solvent evaporation method using polymers hydroxypropylmethyl cellulose and ethyl cellulose. The shape and surface morphology of prepared microballoons were characterized by optical and scanning electron microscopy, respectively. In vitro drug release studies were performed and drug release kinetics was evaluated using the linear regression method. Effects of stirring rate during preparation, polymer concentration, solvent composition and dissolution medium on the size of microballoons, and drug release were also observed. The prepared microballoons exhibited prolonged drug release (8 hours) and remained buoyant for >10 hours. The mean particle size increased and the drug release rate decreased at higher polymer concentration. No significant effect of the stirring rate during preparation on drug release was observed. In vitro studies demonstrated diffusion-controlled drug release from the microballoons.


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