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ORIGINAL ARTICLE
Year : 2011  |  Volume : 2  |  Issue : 1  |  Page : 43-46

Synthesis of novel 3-benzyl-2-phenyl-4(5H)-(substituted phenylhydrazino)-1, 3-oxazolidines and their antihyperglycemic activity


Department of Pharmaceutical Chemistry, Srinivas College of Pharmacy, Valachil, Mangalore, Karnataka, India

Correspondence Address:
T Panneerselvam
Department of Pharmaceutical Chemistry, Srinivas College of Pharmacy, Valachil, Mangalore- 574143, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2231-4040.79804

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A number of 3-benzyl-2-phenyl-4(5H)-(substituted phenylhydrazino)-1, 3-oxazolidines 6a-f derivatives were synthesized and their antihyperglycemic activity was evaluated by streptozotocin (STZ) and sucrose-loaded model. Many of oxazolidine derivatives as well as their corresponding substituted phenylhydrazine showed significant reduction in blood glucose level in STZ and sucrose-loaded rat models.


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