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Year : 2011  |  Volume : 2  |  Issue : 1  |  Page : 39-42

Antidiarrheal activity of Capparis zeylanica leaf extracts

1 Department of Pharmaceutical Chemistry, Grace College of Pharmacy, Palakkad, India
2 Department of Pharmaceutical Sciences, BIT, Mesra, Ranchi, India
3 Department of Pharmaceutical Sciences,KMCH College of Pharmacy, Coimbatore, India

Correspondence Address:
Karanayil R Sini
'Punarjani', Ponkattparamb Kalekkad, Palakkad, Kerala - 678015
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2231-4040.79803

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The antidiarrheal activity of the methanolic extract of the leaves of Capparis zeylanica (Capparidaceae) was investigated by castor oil-induced diarrhea and small intestine transit method on mice. Like loperamide (3 mg/kg body weight), C. zeylanica methanolic extract (100,150,200 mg/kg body weight) produced a significant decrease in the severity of diarrhea. The percentage protection in extract-treated animals showing diarrhea was compared with castor oil-treated and loperamide-treated animals. The activity was found to be dose-dependant. Its effect when evaluated on intestinal transit produced a decrease in intestinal transit (75.97%).The results revealed that the methanolic extract significantly reduced diarrhea in mice with reduction in weight of stools.

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