Synthesis and antimalarial evaluation of some 4-quinazolinone derivatives based on febrifugine

Debanjan Sen; Anirban Banerjee; Ashoke Kumar Ghosh; Tapan Kumar Chatterjee

doi:10.4103/0110-5558.76439

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ORIGINAL ARTICLE

Year : 2010 | Volume : 1 | Issue : 4 | Page : 401-405

Synthesis and antimalarial evaluation of some 4-quinazolinone derivatives based on febrifugine

Debanjan Sen¹, Anirban Banerjee², Ashoke Kumar Ghosh³, Tapan Kumar Chatterjee⁴
¹ Bengal Institute of Pharmaceutical Sciences, Kalyani, Nadia, West Bengal, India
² IT consultant, Schrödinger LCC, Moradabad, Uttar Pradesh - 244001, India
³ Pharmacy College, IFTM, Lodhipur Rajput, Moradabad, Uttar Pradesh - 244001, India
⁴ Division of Pharmacology, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal, India

Correspondence Address:
Debanjan Sen
Bengal institute of Pharmaceutical Sciences SPLPM campus, Kalyani, Nadia, West Bengal
India

Source of Support: Bengal Institute of Pharmaceutical Sciences, Kalyani and Jadavpur University, Kolkata, Conflict of Interest: None

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DOI: 10.4103/0110-5558.76439

A series of 2-substituted and 2,3-substituted quinazolin -4(3H)-one derivatives were designed and synthesized based on the structure of febrifugine. The structures of the new compounds were confirmed by spectral analysis. The in vivo biological activity test results indicated that those compounds exhibited antimalarial activities against Plasmodium berghei in mice, at a dose of 5 mg/kg. Compared to Chloroquine and Artemisinin, these compounds have the advantages of shorter synthetic routes and consequently are highly cost effective in nature.

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