| ORIGINAL ARTICLE |
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| Year : 2010 | Volume
: 1
| Issue : 4 | Page : 396-400 |
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Synthesis and biological evaluation of formazan derivatives
Gurusamy Mariappan1, Rejaul Korim1, Nand Madhwa Joshi2, Faruk Alam1, Rajib Hazarika1, Deepak Kumar1, Tiewlasubon Uriah1
1 Department of Medicinal Chemistry, Himalayan Pharmacy Institute, E. Sikkim, India
2 Central Drug Research Institute, Lucknow, Uttar Pradesh, India
Correspondence Address:
Gurusamy Mariappan
Department of Medicinal Chemistry, Himalayan Pharmacy Institute, E. Sikkim-737136
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0110-5558.76438
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The formazan derivatives (FM1-FM5) were synthesized by the reaction of benzaldehyde phenylhydrazone with substituted aromatic and hetero aromatic amines. The structures of the synthesized compounds were then elucidated using UV, IR, 1 H NMR and mass spectral data. The synthesized derivatives were screened for anticonvulsant, antibacterial and antiviral activities. All the compounds showed remarkable antibacterial activity at 250 μg/ml, but FM4 and FM3 did not show any inhibition on Staphylococcus aureus and Vibriocholera, respectively. All the compounds showed significant anticonvulsant effect at 100 mg/kg p.o. and the experimental data were statistically significant at P<0.001 level. But none of the compounds was effective against Japanese encephalitis virus. |
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