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Year : 2010  |  Volume : 1  |  Issue : 4  |  Page : 396-400

Synthesis and biological evaluation of formazan derivatives

1 Department of Medicinal Chemistry, Himalayan Pharmacy Institute, E. Sikkim, India
2 Central Drug Research Institute, Lucknow, Uttar Pradesh, India

Correspondence Address:
Gurusamy Mariappan
Department of Medicinal Chemistry, Himalayan Pharmacy Institute, E. Sikkim-737136
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0110-5558.76438

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The formazan derivatives (FM1-FM5) were synthesized by the reaction of benzaldehyde phenylhydrazone with substituted aromatic and hetero aromatic amines. The structures of the synthesized compounds were then elucidated using UV, IR, 1 H NMR and mass spectral data. The synthesized derivatives were screened for anticonvulsant, antibacterial and antiviral activities. All the compounds showed remarkable antibacterial activity at 250 μg/ml, but FM4 and FM3 did not show any inhibition on Staphylococcus aureus and Vibriocholera, respectively. All the compounds showed significant anticonvulsant effect at 100 mg/kg p.o. and the experimental data were statistically significant at P<0.001 level. But none of the compounds was effective against Japanese encephalitis virus.

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