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| REVIEW ARTICLE |
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| Year : 2010 | Volume
: 1
| Issue : 4 | Page : 374-380 |
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Niosome: A future of targeted drug delivery systems
Kazi Masud Karim, Asim Sattwa Mandal, Nikhil Biswas, Arijit Guha, Sugata Chatterjee, Mamata Behera, Ketousetuo Kuotsu
Department of Pharmaceutical Technology, Jadavpur University, Kolkata - 700 032, West Bengal, India
| Date of Web Publication | 3-Feb-2011 |
Correspondence Address:
Ketousetuo Kuotsu
Department of Pharmaceutical Technology, Jadavpur University, Kolkata - 700 032, West Bengal, Kolkata
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0110-5558.76435
 Abstract | | |
Over the past several years, treatment of infectious diseases and immunisation has undergone a revolutionary shift. With the advancement of biotechnology and genetic engineering, not only a large number of disease-specific biological have been developed, but also emphasis has been made to effectively deliver these biologicals. Niosomes are vesicles composed of non-ionic surfactants, which are biodegradable, relatively nontoxic, more stable and inexpensive, an alternative to liposomes. This article reviews the current deepening and widening of interest of niosomes in many scientific disciplines and, particularly its application in medicine. This article also presents an overview of the techniques of preparation of niosome, types of niosomes, characterisation and their applications. Keywords: Bilayer, drug entrapment, lamellar, niosomes, surfactants
How to cite this article:
Karim KM, Mandal AS, Biswas N, Guha A, Chatterjee S, Behera M, Kuotsu K. Niosome: A future of targeted drug delivery systems. J Adv Pharm Technol Res 2010;1:374-80 |
How to cite this URL:
Karim KM, Mandal AS, Biswas N, Guha A, Chatterjee S, Behera M, Kuotsu K. Niosome: A future of targeted drug delivery systems. J Adv Pharm Technol Res [serial online] 2010 [cited 2022 Nov 30];1:374-80. Available from: https://www.japtr.org/text.asp?2010/1/4/374/76435 |
| Introduction | |  |
The concept of targeted drug delivery is designed for attempting to concentrate the drug in the tissues of interest while reducing the relative concentration of the medication in the remaining tissues. As a result, drug is localised on the targeted site. Hence, surrounding tissues are not affected by the drug. In addition, loss of drug does not happen due to localisation of drug, leading to get maximum efficacy of the medication. Different carriers have been used for targeting of drug, such as immunoglobulin, serum proteins, synthetic polymers, liposome, microspheres, erythrocytes and niosomes. [1]
Niosomes are one of the best among these carriers. The self-assembly of non-ionic surfactants into vesicles was first reported in the 70s by researchers in the cosmetic industry. Niosomes (non-ionic surfactant vesicles) obtained on hydration are microscopic lamellar structures formed upon combining non-ionic surfactant of the alkyl or dialkyl polyglycerol ether class with cholesterol. [2] The non-ionic surfactants form a closed bilayer vesicle in aqueous media based on its amphiphilic nature using some energy for instance heat, physical agitation to form this structure. In the bilayer structure, hydrophobic parts are oriented away from the aqueous solvent, whereas the hydrophilic heads remain in contact with the aqueous solvent. The properties of the vesicles can be changed by varying the composition of the vesicles, size, lamellarity, tapped volume, surface charge and concentration. Various forces act inside the vesicle, eg, van der Waals forces among surfactant molecules, repulsive forces emerging from the electrostatic interactions among charged groups of surfactant molecules, entropic repulsive forces of the head groups of surfactants, short-acting repulsive forces, etc. These forces are responsible for maintaining the vesicular structure of niosomes. But, the stability of niosomes are affected by type of surfactant, nature of encapsulated drug, storage temperature, detergents, use of membrane spanning lipids, the interfacial polymerisation of surfactant monomers in situ, inclusion of charged molecule. Due to presence of hydrophilic, amphiphilic and lipophilic moieties in the structure, these can accommodate drug molecules with a wide range of solubility. [3] These may act as a depot, releasing the drug in a controlled manner. The therapeutic performance of the drug molecules can also be improved by delayed clearance from the circulation, protecting the drug from biological environment and restricting effects to target cells. [4] Noisome made of alpha , omega-hexadecyl-bis-(1-aza-18-crown-6) (Bola-surfactant)-Span 80-cholesterol (2:3:1 molar ratio) is named as Bola-Surfactant containing noisome. [5] The surfactants used in niosome preparation should be biodegradable, biocompatible and non-immunogenic. A dry product known as proniosomes may be hydrated immediately before use to yield aqueous niosome dispersions. The problems of niosomes such as aggregation, fusion and leaking, and provide additional convenience in transportation, distribution, storage, and dosing. [6]
Niosomes behave in vivo like liposomes, prolonging the circulation of entrapped drug and altering its organ distribution and metabolic stability. [7] As with liposomes, the properties of niosomes depend on the composition of the bilayer as well as method of their production. It is reported that the intercalation of cholesterol in the bilayers decreases the entrapment volume during formulation, and thus entrapment efficiency. [8]
However, differences in characteristics exist between liposomes and niosomes, especially since niosomes are prepared from uncharged single-chain surfactant and cholesterol, whereas liposomes are prepared from double-chain phospholipids (neutral or charged). The concentration of cholesterol in liposomes is much more than that in niosomes. As a result, drug entrapment efficiency of liposomes becomes lesser than niosomes. Besides, liposomes are expensive, and its ingredients, such as phospholipids, are chemically unstable because of their predisposition to oxidative degradation; moreover, these require special storage and handling and purity of natural phospholipids is variable.
Niosomal drug delivery is potentially applicable to many pharmacological agents for their action against various diseases. It can also be used as vehicle for poorly absorbable drugs to design the novel drug delivery system. It enhances the bioavailability by crossing the anatomical barrier of gastrointestinal tract via transcytosis of M cells of Peyer's patches in the intestinal lymphatic tissues. [9] The niosomal vesicles are taken up by reticulo-endothelial system. Such localised drug accumulation is used in treatment of diseases, such as leishmaniasis, in which parasites invade cells of liver and spleen. [10],[11] Some non-reticulo-endothelial systems like immunoglobulins also recognise lipid surface of this delivery system. [2],[3],[4],[5],[6],[7],[8],[10],[11],[12] Encapsulation of various anti-neoplastic agents in this carrier vesicle has minimised drug-induced toxic side effects while maintaining, or in some instances, increasing the anti-tumour efficacy. [13] Doxorubicin, the anthracycline antibiotic with broad-spectrum anti-tumour activity, shows a dose-dependent irreversible cardio-toxic effect. [14],[15] Niosomal delivery of this drug to mice bearing S-180 tumour increased their life span and decreased the rate of proliferation of sarcoma. Intravenous administration of methotrexate entrapped in niosomes to S-180 tumour bearing mice resulted in total regression of tumour and also higher plasma level and slower elimination. It has good control over the release rate of drug, particularly for treating brain malignant cancer. [16] Niosomes have been used for studying the nature of the immune response provoked by antigens. [17] Niosomes can be used as a carrier for haemoglobin. [18],[19] Vesicles are permeable to oxygen and haemoglobin dissociation curve can be modified similarly to non-encapsulated haemoglobin. Slow penetration of drug through skin is the major drawback of transdermal route of delivery. [20] Certain anti-inflammatory drugs like flurbiprofen and piroxicam and sex hormones like estradiol and levonorgestrel are frequently administered through niosome via transdermal route to improve the therapeutic efficacy of these drugs. This vesicular system also provides better drug concentration at the site of action administered by oral, parenteral and topical routes. Sustained release action of niosomes can be applied to drugs with low therapeutic index and low water solubility. Drug delivery through niosomes is one of the approaches to achieve localised drug action in regard to their size and low penetrability through epithelium and connective tissue, which keeps the drug localised at the site of administration. Localised drug action enhances efficacy of potency of the drug and, at the same time, reduces its systemic toxic effects, eg, antimonials encapsulated within niosomes are taken up by mononuclear cells, resulting in localisation of drug, increase in potency, and hence decrease in dose as well as toxicity. [13] The evolution of niosomal drug delivery technology is still at the stage of infancy, but this type of drug delivery system has shown promise in cancer chemotherapy and anti-leishmanial therapy.
| Various Types of Niosome | | |
Based on the vesicle size, niosomes can be divided into three groups. These are small unilamellar vesicles (SUV, size=0.025-0.05 μm), multilamellar vesicles (MLV, size=>0.05 μm), and large unilamellar vesicles (LUV, size=>0.10 μm).
Methods of Preparation
Niosomes are prepared by different methods based on the sizes of the vesicles and their distribution, number of double layers, entrapment efficiency of the aqueous phase and permeability of vesicle membrane.
Preparation of small unilamellar vesicles
Sonication
The aqueous phase containing drug is added to the mixture of surfactant and cholesterol in a scintillation vial. [11] The mixture is homogenised using a sonic probe at 60°C for 3 minutes. The vesicles are small and uniform in size.
Micro fluidisation
Two fluidised streams move forward through precisely defined micro channel and interact at ultra-high velocities within the interaction chamber. [21] Here, a common gateway is arranged such that the energy supplied to the system remains within the area of niosomes formation. The result is a greater uniformity, smaller size and better reproducibility.
Preparation of multilamellar vesicles
Hand shaking method (Thin film hydration technique)
In the hand shaking method, surfactant and cholesterol are dissolved in a volatile organic solvent such as diethyl ether, chloroform or methanol in a rotary evaporator, leaving a thin layer of solid mixture deposited on the wall of the flask. [11] The dried layer is hydrated with aqueous phase containing drug at normal temperature with gentle agitation.
Trans-membrane pH gradient (inside acidic) drug uptake process (remote Loading)
Surfactant and cholesterol are dissolved in chloroform. [22] The solvent is then evaporated under reduced pressure to obtain a thin film on the wall of the round-bottom flask. The film is hydrated with 300 mM citric acid (pH 4.0) by vortex mixing. The multilamellar vesicles are frozen and thawed three times and later sonicated. To this niosomal suspension, aqueous solution containing 10 mg/ml of drug is added and vortexed. The pH of the sample is then raised to 7.0-7.2 with 1M disodium phosphate. This mixture is later heated at 60°C for 10 minutes to produce the desired multilamellar vesicles.
Preparation of large unilamellar vesicles
Reverse phase evaporation technique (REV)
In this method, cholesterol and surfactant are dissolved in a mixture of ether and chloroform. [23] An aqueous phase containing drug is added to this and the resulting two phases are sonicated at 4-5°C. The clear gel formed is further sonicated after the addition of a small amount of phosphate buffered saline. The organic phase is removed at 40°C under low pressure. The resulting viscous niosome suspension is diluted with phosphate-buffered saline and heated in a water bath at 60°C for 10 min to yield niosomes.
Ether injection method
The ether injection method is essentially based on slow injection of niosomal ingredients in ether through a 14-gauge needle at the rate of approximately 0.25 ml/min into a preheated aqueous phase maintained at 60°C. [11],[24] The probable reason behind the formation of larger unilamellar vesicles is that the slow vapourisation of solvent results in an ether gradient extending towards the interface of aqueous-nonaqueous interface. The former may be responsible for the formation of the bilayer structure. The disadvantages of this method are that a small amount of ether is frequently present in the vesicles suspension and is difficult to remove.
Miscellaneous
Multiple membrane extrusion method
A mixture of surfactant, cholesterol, and diacetyl phosphate in chloroform is made into thin film by evaporation. [20] The film is hydrated with aqueous drug solution and the resultant suspension extruded through polycarbonate membranes, which are placed in a series for up to eight passages. This is a good method for controlling niosome size.
Niosome preparation using polyoxyethylene alkyl ether
The size and number of bilayer of vesicles consisting of polyoxyethylene alkyl ether and cholesterol can be changed using an alternative method. [25] Temperature rise above 60°C transforms small unilamellar vesicles to large multilamellar vesicles (>1 μm), while vigorous shaking at room temperature shows the opposite effect, ie, transformation of multilamellar vesicles into unilamellar ones. The transformation from unilamellar to multilamellar vesicles at higher temperature might be the characteristic for polyoxyethylene alkyl ether (ester) surfactant, since it is known that polyethylene glycol (PEG) and water remix at higher temperature due to breakdown of hydrogen bonds between water and PEG moieties. Generally, free drug is removed from the encapsulated drug by gel permeation chromatography dialysis method or centrifugation method. Often, density differences between niosomes and the external phase are smaller than that of liposomes, which make separation by centrifugation very difficult. Addition of protamine to the vesicle suspension facilitates separation during centrifugation.
Emulsion method
The oil in water (o/w) emulsion is prepared from an organic solution of surfactant, cholesterol, and an aqueous solution of the drug. [26],[27] The organic solvent is then evaporated, leaving niosomes dispersed in the aqueous phase.
Lipid injection method
This method does not require expensive organic phase. Here, the mixture of lipids and surfactant is first melted and then injected into a highly agitated heated aqueous phase containing dissolved drug. Here, the drug can be dissolved in molten lipid and the mixture will be injected into agitated, heated aqueous phase containing surfactant.
Niosome preparation using Micelle
Niosomes may also be formed from a mixed micellar solution by the use of enzymes. A mixed micellar solution of C16 G2, dicalcium hydrogen phosphate, polyoxyethylene cholesteryl sebacetate diester (PCSD) converts to a niosome dispersion when incubated with esterases. PCSD is cleaved by the esterases to yield polyoxyethylene, sebacic acid and cholesterol. Cholesterol in combination with C16 G2 and DCP then yields C16 G2 niosomes.
Characterisation of niosomes
Size
Shape of niosomal vesicles is assumed to be spherical, and their mean diameter can be determined by using laser light scattering method. [28] Also, diameter of these vesicles can be determined by using electron microscopy, molecular sieve chromatography, ultracentrifugation, photon correlation microscopy and optical microscopy [29],[30] and freeze fracture electron microscopy. Freeze thawing of niosomes increases the vesicle diameter, which might be attributed to a fusion of vesicles during the cycle.
Bilayer formation
Assembly of non-ionic surfactants to form a bilayer vesicle is characterised by an X-cross formation under light polarisation microscopy. [31]
Number of lamellae
This is determined by using nuclear magnetic resonance (NMR) spectroscopy, small angle X-ray scattering and electron microscopy. [29]
Membrane rigidity
Membrane rigidity can be measured by means of mobility of fluorescence probe as a function of temperature. [31]
Entrapment efficiency
After preparing niosomal dispersion, unentrapped drug is separated and the drug remained entrapped in niosomes is determined by complete vesicle disruption using 50% n-propanol or 0.1% Triton X-100 and analysing the resultant solution by appropriate assay method for the drug. [32] It can be represented as:
Entrapment efficiency (EF) = (Amount entrapped / total amount) Χ 100
In vitro Release Study
A method of in vitro release rate study was reported with the help of dialysis tubing. [33] A dialysis sac was washed and soaked in distilled water. The vesicle suspension was pipetted into a bag made up of the tubing and sealed. The bag containing the vesicles was then placed in 200 ml buffer solution in a 250 ml beaker with constant shaking at 25°C or 37°C. At various time intervals, the buffer was analysed for the drug content by an appropriate assay method. In another method, isoniazid-encapsulated niosomes were separated by gel filtration on Sephadex G- 50 powder kept in double distilled water for 48 h for swelling. [34] At first, 1 ml of prepared niosome suspension was placed on the top of the column and elution was carried out using normal saline. Niosomes encapsulated isoniazid elutes out first as a slightly dense, white opalescent suspension followed by free drug. Separated niosomes were filled in a dialysis tube to which a sigma dialysis sac was attached to one end. The dialysis tube was suspended in phosphate buffer of pH (7.4), stirred with a magnetic stirrer, and samples were withdrawn at specific time intervals and analysed using high-performance liquid chromatography (HPLC) method.
In vivo Release Study
Albino rats were used for this study. These rats were subdivided with groups. Niosomal suspension used for
in vivo study was injected intravenously (through tail vein) using appropriate disposal syringe.
Factors Affecting Physico-Chemical Properties of Niosomes
Various factors that affect the physico-chemical properties of niosomes are discussed further.
Choice of surfactants and main additives
A surfactant used for preparation of niosomes must have a hydrophilic head and a hydrophobic tail. The hydrophobic tail may consist of one or two alkyl or perfluoroalkyl groups or, in some cases, a single steroidal group. [35] The ether-type surfactants with single-chain alkyl tail is more toxic than corresponding dialkyl ether chain. The ester-type surfactants are chemically less stable than ether-type surfactants and the former is less toxic than the latter due to ester-linked surfactant degraded by esterases to triglycerides and fatty acid in vivo.[36] The surfactants with alkyl chain length from C12 to C18 are suitable for preparation of noisome. Span series surfactants having HLB number between 4 and 8 can form vesicles. [37] Different types of non-ionic surfactants with examples are given in [Table 1]. [38]
The stable niosomes can be prepared with addition of different additives along with surfactants and drugs. The niosomes formed have a number of morphologies and their permeability and stability properties can be altered by manipulating membrane characteristics by different additives. In case of polyhedral niosomes formed from C16G2, the shape of these polyhedral niosomes remains unaffected by adding low amount of solulan C24 (cholesteryl poly-24-oxyethylene ether), which prevents aggregation due to development of steric hindrance. In contrast, addition of C16G2:cholesterol:solulan (49:49:2) results in formation of spherical niosomes. [39] The mean size of niosomes is influenced by membrane composition. Addition of cholesterol molecule to niosomal system makes the membrane rigid and reduces leakage of drug from the noisome. [40]
Temperature of hydration
Hydration temperature influences the shape and size of the niosome. For ideal condition, it should be above the gel to liquid phase transition temperature of system. Temperature change in the niosomal system affects assembly of surfactants into vesicles and also induces vesicle shape transformation. [35],[39] A polyhedral vesicle formed by C16G2:solulan C24 (91:9) at 25°C, on heating, transforms into spherical vesicle at 48°C, but on cooling from 55°C, the vesicle produces a cluster of smaller spherical niosomes at 49°C before changing into polyhedral structures at 35°C. In contrast, the vesicle formed by C16G2:cholesterol:solulan C24 (49:49:2) shows no shape transformation on heating or cooling. [27] Along with the above-mentioned factors, the volume of hydration medium and time of hydration of niosomes are also critical factors. Improper selection of these factors may result in the formation of fragile niosomes or creation of drug leakage problems.
Nature of encapsulated drug
The physico-chemical properties of encapsulated drug influence charge and rigidity of the niosome bilayer. The drug interacts with surfactant head groups and develops the charge that creates mutual repulsion between surfactant bilayers, and hence increases vesicle size. [29] The aggregation of vesicles is prevented due to the charge development on bilayer. The effect of the nature of drug on formation vesicle is given in [Table 2].
Factors affecting vesicles size, entrapment efficiency, and release characteristics
Drug
Entrapment of drug in niosomes increases vesicle size, probably by interaction of solute with surfactant head groups, increasing the charge and mutual repulsion of the surfactant bilayers, thereby increasing vesicle size. In polyoxyethylene glycol (PEG)-coated vesicles, some drug is entrapped in the long PEG chains, thus reducing the tendency to increase the size. The hydrophilic lipophilic balance of the drug affects the degree of entrapment.
Amount and type of surfactant
The mean size of niosomes increases proportionally with increase in the hydrophilic-lipophilic balance (HLB) of surfactants such as Span 85 (HLB 1.8) to Span 20 (HLB 8.6) because the surface free energy decreases with an increase in hydrophobicity of surfactants. [41] The bilayers of the vesicles are either in the so-called liquid state or in gel state, depending on the temperature, the type of lipid or surfactant and the presence of other components such as cholesterol. In the gel state, alkyl chains are present in a well ordered structure, and in the liquid state, the structure of the bilayers is more disordered. The surfactants and lipids are characterised by the gel-liquid phase transition temperature (TC). Phase transition temperature (TC) of surfactants also affects entrapment efficiency, ie, Span 60 having higher TC provides better entrapment.
Cholesterol content and charge
Inclusion of cholesterol in niosomes increases its hydrodynamic diameter and entrapment efficiency. In general, the action of cholesterol is twofold. On one hand, cholesterol increases the chain order of liquid state bilayers, and, on the other, it decreases the chain order of gel state bilayers. At a high cholesterol concentration, the gel state is transformed to a liquid-ordered phase. An increase in cholesterol content of the bilayers resulted in a decrease in the release rate of encapsulated material, and therefore an increase in the rigidity of the resulting bilayers. The presence of charge tends to increase the interlamellar distance between successive bilayers in multilamellar vesicle structure and leads to greater overall entrapped volume. [41]
Methods of Preparation
Hand shaking method forms vesicles with greater diameter (0.35-13 nm) compared to the ether injection method (50-1,000 nm). Small-sized niosomes can be produced by Reverse Phase Evaporation (REV) method. Microfluidisation method gives greater uniformity and small-sized vesicles.
Resistance to osmotic stress
Addition of a hypertonic salt solution to a suspension of niosomes brings about reduction in diameter. In hypotonic salt solution, there is initial slow release with slight swelling of vesicles, probably due to inhibition of eluting fluid from vesicles, followed by faster release, which may be due to mechanical loosening of vesicles structure under osmotic stress. [2],[42]
[Table 3] lists drugs that have been used in animal study through different routes.
| Conclusion | | |
Recent advancements in the field of scientific research have resulted in the endorsement of small molecules such as proteins and vaccines as a major class of therapeutic agents. These, however, pose numerous drug-associated challenges such as poor bioavailability, suitable route of drug delivery, physical and chemical instability and potentially serious side effects. Opinions of the usefulness of niosomes in the delivery of proteins and biologicals can be unsubstantiated with a wide scope in encapsulating toxic drugs such as anti-AIDS drugs, anti-cancer drugs, and anti-viral drugs. It provides a promising carrier system in comparison with ionic drug carriers, which are relatively toxic and unsuitable. However, the technology utilised in niosomes is still in its infancy. Hence, researches are going on to develop a suitable technology for large production because it is a promising targeted drug delivery system.
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[Table 1], [Table 2], [Table 3]
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Lecithin sensitized thermo-sensitive niosome using NIR-carbon dots for breast cancer combined chemo-photothermal therapy |
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Emerging Trends in the Delivery of Resveratrol by Nanostructures: Applications of Nanotechnology in Life Sciences |
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Augmented in vitro and in vivo Profiles of Brimonidine Tartrate Using Gelatinized-Core Liposomes |
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Protective Effects of N-acetylcysteine Niosome Nanoparticles on Paraquatinduced
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FORMULATION AND DEVELOPMENT OF PRONIOSOMAL GEL FOR TOPICAL DELIVERY OF AMPHOTERICIN B |
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Nanocarrier-based approaches to combat chronic obstructive pulmonary disease |
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Cationically modified inhalable nintedanib niosomes: enhancing therapeutic activity against non-small-cell lung cancer |
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Nano-emulsion system consisting of non-ionic surfactant, silicone, and polyol |
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An Overview of Nanotechnologies for Drug Delivery to the Brain |
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Development of Cyclodextrin-Functionalized Transethoniosomes of 6-Gingerol: Statistical Optimization, In Vitro Characterization and Assessment of Cytotoxic and Anti-Inflammatory Effects |
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A Comprehensive Review of the Evolution of Insulin Development and Its Delivery Method |
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Lipomics: A Potential Carrier for the Intravenous Delivery of Lipophilic and Hydrophilic Drugs |
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Erythromycin Formulations—A Journey to Advanced Drug Delivery |
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Ion-Triggered In Situ Gelling Intranasal Spray of Dronedarone Hydrochloride Nanocarriers: In Vitro Optimization and In Vivo Pharmacokinetic Appraisal |
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A Review on the Delivery of Plant-Based Antidiabetic Agents Using Nanocarriers: Current Status and Their Role in Combatting Hyperglycaemia |
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DOE based Formulation development and Evaluation of Niosomal dispersion of Pregabalin |
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Significant of injectable brucine PEGylated niosomes in treatment of MDA cancer cells |
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Niosomes as cutting edge nanocarrier for controlled and targeted delivery of essential oils and biomolecules |
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Continuous supercritical CO2 assisted process for the production of nano-niosomes loaded with a second-generation antibiotic for ocular therapy |
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A Machine Learning Framework for Predicting Entrapment Efficiency in Niosomal Particles |
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GANE can Improve Lung Fibrosis by Reducing Inflammation via Promoting p38MAPK/TGF-ß1/NF-?B Signaling Pathway Downregulation |
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Effects of Imipenem-containing Niosome nanoparticles against high prevalence methicillin-resistant Staphylococcus Epidermidis biofilm formed |
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Menthol augmented niosomes for enhanced intestinal absorption of lopinavir |
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Application of encapsulated nano materials as feed additive in livestock and poultry: a review |
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Niosomes: a novel targeted drug delivery system for cancer |
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Oral administration of nano-tyrosol reversed the diabetes-induced liver damage in streptozotocin-induced diabetic rats |
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Schistosomiasis mansoni: A new therapeutic target for ubiquinol, a natural inhibitor of neutral magnesium-dependent sphingomyelinase in murine model. |
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Preparation and Evaluation of Physicochemical Properties and Anti-leishmanial Activity of Zirconium/Tioxolone Niosomes Against Leishmania major |
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Novel spirooxindole based benzimidazole scaffold: In vitro, nanoformulation and in vivo studies on anticancer and antimetastatic activity of breast adenocarcinoma |
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Emerging Trends of Nanotechnology In Advanced Cosmetics |
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Functionalized niosomes as a smart delivery device in cancer and fungal infection |
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Recent progress in polymeric non-invasive insulin delivery |
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Improving temozolomide biopharmaceutical properties in glioblastoma multiforme (GBM) treatment using GBM-targeting nanocarriers |
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Delivery of small interfering RNAs by nanovesicles for cancer therapy |
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Emerging nanoformulation strategies for phytocompounds and applications from drug delivery to phototherapy to imaging |
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Contact in-vivo larvicidal toxicity and histological studies of Indian herb essential oils loaded niosomes against Aedes aegypti and Culex quinquefasciatus (Diptera: Culicidae) |
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A comprehensive review on possibilities of treating psoriasis using dermal cyclosporine |
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New Approach to Formulate Methotrexate-Loaded Niosomes: In Vitro Characterization and Cellular Effectiveness |
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Lipid-Based Vesicles: a Non-invasive Tool for Transdermal Drug Delivery |
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Nanophytochemicals for the treatment of type II diabetes mellitus: a review |
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Why do few drug delivery systems to combat neglected tropical diseases reach the market? An analysis from the technology’s stages |
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Effects of cefazolin-containing niosome nanoparticles against methicillin-resistant Staphylococcus aureus biofilm formed on chronic wounds |
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Nanotechnology in cosmetics pros and cons |
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Solubility enhancement, formulation development and antifungal activity of luliconazole niosomal gel-based system |
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Preparation of Anisotropic Multiscale Micro-Hydrogels Via Two-Photon Continuous Flow Lithography |
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Development of niosomes for encapsulating captopril-quercetin prodrug to combat hypertension |
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Niosomes formation using a continuous supercritical CO2 assisted process |
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Copper Nanoparticles in Membrane Mimicking Vesicles-Synthesis and Catalytic Activity |
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Role of nanotechnology in the world of cosmetology: A review |
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Preparation, Optimization, and transcorneal permeability study of Lutein-loaded Solid Lipid Nanoparticles |
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An Overview on Niosomes: As an Auspesious Drug Delivery System on the Bases of Application |
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Experimental research in topical psoriasis therapy (Review) |
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Developing Actively Targeted Nanoparticles to Fight Cancer: Focus on Italian Research |
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Emerging Treatment Strategies for Diabetes Mellitus and Associated Complications: An Update |
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Intranasal Zolmitriptan-Loaded Bilosomes with Extended Nasal Mucociliary Transit Time for Direct Nose to Brain Delivery |
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Skin Care Formulations and Lipid Carriers as Skin Moisturizing Agents |
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| Panagoula Pavlou,Angeliki Siamidi,Athanasia Varvaresou,Marilena Vlachou | | Cosmetics. 2021; 8(3): 89 | | [Pubmed] | [DOI] | | | 82 |
Thin-layer hydration method to prepare a green tea extract niosomal gel and its antioxidant performance |
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| U. Chasanah,N. Mahmintari,F. Hidayah,F.A. El Maghfiroh,D. Rahmasari,R. Weka Nugraheni | | European Pharmaceutical Journal. 2021; 68(1): 126 | | [Pubmed] | [DOI] | | | 83 |
Phytoniosomes: An Emergent Strategy for Herbal Drug Delivery System |
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| Priya Kumari, Shaweta Sharma, Pramod Kumar Sharma, Mohd Aftab Alam | | Current Nanomedicine. 2021; 11(3): 149 | | [Pubmed] | [DOI] | | | 84 |
A Critical Review of the Use of Surfactant-Coated Nanoparticles in Nanomedicine and Food Nanotechnology |
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| Taiki Miyazawa,Mayuko Itaya,Gregor C Burdeos,Kiyotaka Nakagawa,Teruo Miyazawa | | International Journal of Nanomedicine. 2021; Volume 16: 3937 | | [Pubmed] | [DOI] | | | 85 |
Oral Bioavailability Improvement of Tailored Rosuvastatin Loaded Niosomal Nanocarriers to Manage Ischemic Heart Disease: Optimization, Ex Vivo and In Vivo Studies |
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| Qiang Liu,Jing Xu,Kun Liao,Na Tang | | AAPS PharmSciTech. 2021; 22(2) | | [Pubmed] | [DOI] | | | 86 |
Evaluation of Natural Bioactive-Derived Punicalagin Niosomes in Skin-Aging Processes Accelerated by Oxidant and Ultraviolet Radiation |
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| Ebtesam A Mohamad,Aya A Aly,Aya A Khalaf,Mona I Ahmed,Reham M Kamel,Sherouk M Abdelnaby,Yasmine H Abdelzaher,Marize G Sedrak,Shaker A Mousa | | Drug Design, Development and Therapy. 2021; Volume 15: 3151 | | [Pubmed] | [DOI] | | | 87 |
The Challenge of Nanovesicles for Selective Topical Delivery for Acne Treatment: Enhancing Absorption Whilst Avoiding Toxicity |
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| Antonia Mancuso,Maria Chiara Cristiano,Massimo Fresta,Donatella Paolino | | International Journal of Nanomedicine. 2020; Volume 15: 9197 | | [Pubmed] | [DOI] | | | 88 |
In vitro Characterization and Release Studies of Combined Nonionic Surfactant-Based Vesicles for the Prolonged Delivery of an Immunosuppressant Model Drug |
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| Akhtar Rasul,Muhammad Imran Khan,Mujeeb Rehman,Ghulam Abbas,Nosheen Aslam,Shabbir Ahmad,Khizar Abbas,Pervaiz Akhtar Shah,Muhammad Iqbal,Ali Mohammed Ahmed Al Subari,Talal Shaheer,Shahid Shah | | International Journal of Nanomedicine. 2020; Volume 15: 7937 | | [Pubmed] | [DOI] | | | 89 |
Assessment of a New Ginsenoside Rh2 Nanoniosomal Formulation for Enhanced Antitumor Efficacy on Prostate Cancer: An in vitro Study |
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| Hadi Zare-Zardini,Ashraf Alemi,Asghar Taheri-Kafrani,Seyed Ahmad Hosseini,Hossein Soltaninejad,Amir Ali Hamidieh,Mojtaba Haghi Karamallah,Majid Farrokhifar,Mohammad Farrokhifar | | Drug Design, Development and Therapy. 2020; Volume 14: 3315 | | [Pubmed] | [DOI] | | | 90 |
Formulation of Nanospanlastics as a Promising Approach for ?Improving the Topical Delivery of a Natural Leukotriene Inhibitor (3-?Acetyl-11-Keto-ß-Boswellic Acid): Statistical Optimization, in vitro ?Characterization, and ex vivo Permeation Study |
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| Farid Badria,Eman Mazyed | | Drug Design, Development and Therapy. 2020; Volume 14: 3697 | | [Pubmed] | [DOI] | | | 91 |
Formulation, Characterization and In-vitro and In-vivo Evaluation of Capecitabine Loaded Niosomes |
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| Parth Patel,Tejas Barot,Pratik Kulkarni | | Current Drug Delivery. 2020; 17(3): 257 | | [Pubmed] | [DOI] | | | 92 |
The Scope and Challenges of Vesicular Carrier-Mediated Delivery of Docetaxel for the Management of Cancer |
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| Charu Misra,Kaisar Raza,Amit Kumar Goyal | | Current Drug Delivery. 2020; 17(10): 874 | | [Pubmed] | [DOI] | | | 93 |
Current Insights for the Management of Acne in the Modern Era |
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| Neha Singh,Apoorva Singh,Kalpana Pandey,Kalpana Nimisha | | Recent Patents on Anti-Infective Drug Discovery. 2020; 15(1): 3 | | [Pubmed] | [DOI] | | | 94 |
Development of Provesicular Nanodelivery System of Curcumin as a Safe and Effective Antiviral Agent: Statistical Optimization, In Vitro Characterization, and Antiviral Effectiveness |
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| Farid A. Badria,Abdelaziz E. Abdelaziz,Amira H. Hassan,Abdullah A. Elgazar,Eman A. Mazyed | | Molecules. 2020; 25(23): 5668 | | [Pubmed] | [DOI] | | | 95 |
Topical Administration of Terpenes Encapsulated in Nanostructured Lipid-Based Systems |
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| Elwira Lason | | Molecules. 2020; 25(23): 5758 | | [Pubmed] | [DOI] | | | 96 |
Nanomaterials for Skin Delivery of Cosmeceuticals and Pharmaceuticals |
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| Eliana B. Souto,Ana Rita Fernandes,Carlos Martins-Gomes,Tiago E. Coutinho,Alessandra Durazzo,Massimo Lucarini,Selma B. Souto,Amélia M. Silva,Antonello Santini | | Applied Sciences. 2020; 10(5): 1594 | | [Pubmed] | [DOI] | | | 97 |
Emerging Nanopharmaceuticals and Nanonutraceuticals in Cancer Management |
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| Lavinia Salama,Elizabeth R. Pastor,Tyler Stone,Shaker A. Mousa | | Biomedicines. 2020; 8(9): 347 | | [Pubmed] | [DOI] | | | 98 |
New Insights on Unique Features and Role of Nanostructured Materials in Cosmetics |
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| Muhammad Bilal,Hafiz M. N. Iqbal | | Cosmetics. 2020; 7(2): 24 | | [Pubmed] | [DOI] | | | 99 |
Niosomal Drug Delivery Systems for Ocular Disease—Recent Advances and Future Prospects |
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| Saliha Durak,Monireh Esmaeili Rad,Abuzer Alp Yetisgin,Hande Eda Sutova,Ozlem Kutlu,Sibel Cetinel,Ali Zarrabi | | Nanomaterials. 2020; 10(6): 1191 | | [Pubmed] | [DOI] | | | 100 |
Design and development of a proniosomal transdermal drug delivery system of caffeine for management of migraine: In vitro characterization, 131I-radiolabeling and in vivo biodistribution studies |
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| Mohamed H. Aboumanei,Ashgan. F. Mahmoud | | Process Biochemistry. 2020; 97: 201 | | [Pubmed] | [DOI] | | | 101 |
A new formulation of hydrophobin-coated niosome as a drug carrier to cancer cells |
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| Mahmood Barani,Mohammad Mirzaei,Masoud Torkzadeh-Mahani,Azadeh Lohrasbi-Nejad,Mohammad Hadi Nematollahi | | Materials Science and Engineering: C. 2020; : 110975 | | [Pubmed] | [DOI] | | | 102 |
Development of dental implant coating with minocycline-loaded niosome for antibacterial application |
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| Nattarat Wongsuwan,Anupma Dwivedi,Salunya Tancharoen,Norased Nasongkla | | Journal of Drug Delivery Science and Technology. 2020; : 101555 | | [Pubmed] | [DOI] | | | 103 |
Niosomes: A review on niosomal research in the last decade |
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| Peeyush Bhardwaj,Purnima Tripathi,Rishikesh Gupta,Sonia Pandey | | Journal of Drug Delivery Science and Technology. 2020; 56: 101581 | | [Pubmed] | [DOI] | | | 104 |
Innovation of testosome as a green formulation for the transdermal delivery of testosterone enanthate |
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| Mahgol Tajbakhsh,Majid Saeedi,Katayoun Morteza-Semnani,Jafar Akbari,Ali Nokhodchi | | Journal of Drug Delivery Science and Technology. 2020; 57: 101685 | | [Pubmed] | [DOI] | | | 105 |
Letrozole-loaded nonionic surfactant vesicles prepared via a slurry-based proniosome technology: Formulation development and characterization |
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| Nada Khudair,Abdelali Agouni,Mohamed A. Elrayess,Mohammad Najlah,Husam M. Younes,Abdelbary Elhissi | | Journal of Drug Delivery Science and Technology. 2020; : 101721 | | [Pubmed] | [DOI] | | | 106 |
Formulation optimization and in vitro characterization of rifampicin and ceftriaxone dual drug loaded niosomes with high energy probe sonication technique |
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| Daulat Haleem Khan,Sajid Bashir,Muhammad Imran Khan,Patrícia Figueiredo,Hélder A. Santos,Leena Peltonen | | Journal of Drug Delivery Science and Technology. 2020; : 101763 | | [Pubmed] | [DOI] | | | 107 |
Niosomes for nose-to-brain delivery of bromocriptine: Formulation development, efficacy evaluation and toxicity profiling |
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| V.G. Sita,Dhananjay Jadhav,Pradeep Vavia | | Journal of Drug Delivery Science and Technology. 2020; 58: 101791 | | [Pubmed] | [DOI] | | | 108 |
Tailoring Solulan C24 based Niosomes for Transdermal Delivery of Donepezil: In vitro characterization, Evaluation of pH sensitivity, and Microneedle-assisted Ex vivo Permeation Studies |
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| Archana S. Nayak,Srivani Chodisetti,Shivaprasad Gadag,Usha Yogendra Nayak,Srinikethan Govindan,Keyur Raval | | Journal of Drug Delivery Science and Technology. 2020; : 101945 | | [Pubmed] | [DOI] | | | 109 |
Niosome-based hydrogel as a potential drug delivery system for topical and transdermal applications |
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| Fiammetta Nigro,Cristal dos Santos Cerqueira Pinto,Elisabete Pereira dos Santos,Claudia Regina Elias Mansur | | International Journal of Polymeric Materials and Polymeric Biomaterials. 2020; : 1 | | [Pubmed] | [DOI] | | | 110 |
Proniosomes as a carrier system for transdermal delivery of clozapine |
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| Fahad Khan Tareen,Kifayat Ullah Shah,Naveed Ahmad,Naveed Asim.ur.Rehman,Shefaat Ullah Shah,Naseem Ullah | | Drug Development and Industrial Pharmacy. 2020; : 1 | | [Pubmed] | [DOI] | | | 111 |
An Overview of Properties and Analytical Methods for Lycopene in Organic Nanocarriers |
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| Gabriela Corrêa Carvalho,Rafael Miguel Sábio,Marlus Chorilli | | Critical Reviews in Analytical Chemistry. 2020; : 1 | | [Pubmed] | [DOI] | | | 112 |
Chitosan-based particulate systems for drug and vaccine delivery in the treatment and prevention of neglected tropical diseases |
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| Sevda Senel,Selin Yüksel | | Drug Delivery and Translational Research. 2020; | | [Pubmed] | [DOI] | | | 113 |
Curcumin Loaded in Niosomal Nanoparticles Improved the Anti-tumor Effects of Free Curcumin on Glioblastoma Stem-like Cells: an In Vitro Study |
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| Sajad Sahab-Negah,Fatemeh Ariakia,Mohammad Jalili-Nik,Amir R. Afshari,Sahar Salehi,Fariborz Samini,Ghadir Rajabzadeh,Ali Gorji | | Molecular Neurobiology. 2020; | | [Pubmed] | [DOI] | | | 114 |
Synthesis and biocompatibility of self-assembling multi-tailed resorcinarene-based supramolecular amphiphile |
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| Imdad Ali,Salim Saifullah,Muhammed Imran,Jan Nisar,Ibrahim Javed,Muhammad Raza Shah | | Colloid and Polymer Science. 2020; | | [Pubmed] | [DOI] | | | 115 |
Nanomedicine Approaches to Negotiate Local Biobarriers for Topical Drug Delivery |
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| Salman Ahmad Mustfa,Eleonora Maurizi,John McGrath,Ciro Chiappini | | Advanced Therapeutics. 2020; : 2000160 | | [Pubmed] | [DOI] | | | 116 |
Synthesis and Characterization of Sulfanilamide-Based Nonionic Surfactants and Evaluation of Their Nano-Vesicular Drug Loading Application |
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| Imdad Ali,Salim Saifullah,Babiker M. El-Haj,Heyam Saad Ali,Saira Yasmeen,Muhammad Imran,Jan Nisar,Muhammad Raza Shah | | Journal of Surfactants and Detergents. 2020; | | [Pubmed] | [DOI] | | | 117 |
Nanoparticles for topical drug delivery: Potential for skin cancer |
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| Vinu Krishnan,Samir Mitragotri | | Advanced Drug Delivery Reviews. 2020; | | [Pubmed] | [DOI] | | | 118 |
Noninvasive transdermal delivery of liposomes by weak electric current |
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| Mahadi Hasan,Anowara Khatun,Tatsuya Fukuta,Kentaro Kogure | | Advanced Drug Delivery Reviews. 2020; | | [Pubmed] | [DOI] | | | 119 |
Lipid-based nanoparticle technologies for liver targeting |
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| Roland Böttger,Griffin Pauli,Po-Han Chao,Nojoud Al-Fayez,Lukas Hohenwarter,Shyh-Dar Li | | Advanced Drug Delivery Reviews. 2020; | | [Pubmed] | [DOI] | | | 120 |
Niosomal formulation of amphotericin B alone and in combination with glucantime: In vitro and in vivo leishmanicidal effects |
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| Mahshid Mostafavi,Iraj Sharifi,Saeedeh Farajzadeh,Payam Khazaeli,Hamid Sharifi,Elnaz Pourseyedi,Sina Kakooei,Mehdi Bamorovat,Alireza Keyhani,Maryam Hakimi Parizi,Ahmad Khosravi,Ali Khamesipour | | Biomedicine & Pharmacotherapy. 2019; 116: 108942 | | [Pubmed] | [DOI] | | | 121 |
Oligonucleotide therapy: An emerging focus area for drug delivery in chronic inflammatory respiratory diseases |
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| Meenu Mehta,Meenu Deeksha,Devesh Tewari,Gaurav Gupta,Rajendra Awasthi,Harjeet Singh,Parijat Pandey,Dinesh Kumar Chellappan,Ridhima Wadhwa,Trudi Collet,Philip M. Hansbro,S Rajesh Kumar,Lakshmi Thangavelu,Poonam Negi,Kamal Dua,Saurabh Satija | | Chemico-Biological Interactions. 2019; 308: 206 | | [Pubmed] | [DOI] | | | 122 |
Topical film prepared with Rhus verniciflua
extract-loaded pullulan hydrogel for atopic dermatitis treatment |
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| Ji Heun Jeong,Seung Keun Back,Jong Hun An,Nam-Seob Lee,Do-Kyung Kim,Chun Soo Na,Young-Gil Jeong,Seung Yun Han | | Journal of Biomedical Materials Research Part B: Applied Biomaterials. 2019; | | [Pubmed] | [DOI] | | | 123 |
Nanomedicines towards targeting intracellular
Mtb
for the treatment of tuberculosis |
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| Samantha Donnellan,Marco Giardiello | | Journal of Interdisciplinary Nanomedicine. 2019; | | [Pubmed] | [DOI] | | | 124 |
Synthesis of Biocompatible Double-Tailed Nonionic Surfactants and Their Investigation for Niosomal Drug-Loading Applications |
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| Imdad Ali,Muhammad Raza Shah,Said Nadeem,Heyam Saad Ali,Salim Saifullah,Farid Ahmed,Muhammad Imran | | Journal of Surfactants and Detergents. 2019; | | [Pubmed] | [DOI] | | | 125 |
A Review on Bioengineering Approaches to Insulin Delivery: A Pharmaceutical and Engineering Perspective |
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| Zahra Baghban Taraghdari,Rana Imani,Fatemeh Mohabatpour | | Macromolecular Bioscience. 2019; : 1800458 | | [Pubmed] | [DOI] | | | 126 |
Antileishmanial activity and immune modulatory effects of benzoxonium chloride and its entrapped forms in niosome on Leishmania tropica |
|
| Maryam Hakimi Parizi,Abbas Pardakhty,Iraj sharifi,Saeedeh Farajzadeh,Mohammad Hossein Daie Parizi,Hamid Sharifi,Ali Reza Keyhani,Mahshid Mostafavi,Mehdi Bamorovat,Daryoush Ghaffari | | Journal of Parasitic Diseases. 2019; | | [Pubmed] | [DOI] | | | 127 |
Do niosomes have a place in the field of drug delivery? |
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| Rita Muzzalupo,Elisabetta Mazzotta | | Expert Opinion on Drug Delivery. 2019; : 1 | | [Pubmed] | [DOI] | | | 128 |
Formulation and optimisation of novel transfersomes for sustained release of local anaesthetic |
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| Ruba Bnyan,Iftikhar Khan,Touraj Ehtezazi,Imran Saleem,Sarah Gordon,Francis O’Neill,Matthew Roberts | | Journal of Pharmacy and Pharmacology. 2019; | | [Pubmed] | [DOI] | | | 129 |
Nanostructured Lipid Carriers of Pioglitazone Loaded Collagen/Chitosan Composite Scaffold for Diabetic Wound Healing |
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| Jawahar Natarajan,Bharat Kumar Reddy Sanapalli,Mehjabeen Bano,Sachin Kumar Singh,Monica Gulati,Veera Venkata Satyanarayana Reddy Karri | | Advances in Wound Care. 2019; | | [Pubmed] | [DOI] | | | 130 |
Microbial biosurfactants: current trends and applications in agricultural and biomedical industries |
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Enhanced nuclear translocation and activation of aryl hydrocarbon receptor (AhR) in THP-1 monocytic cell line by a novel niosomal formulation of indole-3-carbinol |
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| Neda Abbaspour Sani,Mahsa Hasani,Anvarsadat Kianmehr,Saeed Mohammadi,Mehdi Sheikh Arabi,Yaghoub Yazdani | | Journal of Liposome Research. 2019; : 1 | | [Pubmed] | [DOI] | | | 132 |
Preparation and evaluation of transdermal naproxen niosomes: formulation optimization to preclinical anti-inflammatory assessment on murine model |
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| Dibyalochan Mohanty,Miriyala Jhansi Rani,M. Akiful Haque,Vasudha Bakshi,Mohammed Asadullah Jahangir,Syed Sarim Imam,Sadaf Jamal Gilani | | Journal of Liposome Research. 2019; : 1 | | [Pubmed] | [DOI] | | | 133 |
Process optimization of ecological probe sonication technique for production of rifampicin loaded niosomes |
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| Daulat Haleem Khan,Sajid Bashir,Patrícia Figueiredo,Hélder A. Santos,Muhammad Imran Khan,Leena Peltonen | | Journal of Drug Delivery Science and Technology. 2019; 50: 27 | | [Pubmed] | [DOI] | | | 134 |
A novel plier-like gemini cationic niosome for nucleic acid delivery |
|
| Supusson Pengnam,Prasopchai Patrojanasophon,Theerasak Rojanarata,Tanasait Ngawhirunpat,Boon-ek Yingyongnarongkul,Widchaya Radchatawedchakoon,Praneet Opanasopit | | Journal of Drug Delivery Science and Technology. 2019; | | [Pubmed] | [DOI] | | | 135 |
Nanotechnological breakthroughs in the development of topical phytocompounds-based formulations |
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| Ana Cláudia Santos,Dora Rodrigues,Joana A.D. Sequeira,Irina Pereira,Ana Simões,Diana Costa,Diana Peixoto,Gustavo Costa,Francisco Veiga | | International Journal of Pharmaceutics. 2019; : 118787 | | [Pubmed] | [DOI] | | | 136 |
PEGylated Plier-Like Cationic Niosomes on Gene Delivery in HeLa Cells |
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| Supusson Pengnam,Samarwadee Plianwong,Kanokwan Singpanna,Nattisa Ni-yomtham,Widchaya Radchatawedchakoon,Boon Ek Yingyongnarongkul,Praneet Opanasopit | | Key Engineering Materials. 2019; 819: 151 | | [Pubmed] | [DOI] | | | 137 |
Cationic Niosomes as Non-Viral Vehicles for Nucleic Acids: Challenges and Opportunities in Gene Delivery |
|
| Santiago Grijalvo,Gustavo Puras,Jon Zárate,Myriam Sainz-Ramos,Nuseibah A. L. Qtaish,Tania López,Mohamed Mashal,Noha Attia,David Díaz,Ramon Pons,Eduardo Fernández,José Luis Pedraz,Ramon Eritja | | Pharmaceutics. 2019; 11(2): 50 | | [Pubmed] | [DOI] | | | 138 |
Synthesis of Nitrogen Containing Biocompatible Non-ionic Surfactants and Investigation for Their Self-Assembly Based Nano-Scale Vesicles |
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| Imdad Ali,Hiba Manzoor,Muhamad Imran,Muhamad Shafiulah,Muhammad Raza Shah | | Tenside Surfactants Detergents. 2019; 56(1): 35 | | [Pubmed] | [DOI] | | | 139 |
Antileishmanial Activity of Niosomal Combination Forms of Tioxolone along with Benzoxonium Chloride against Leishmania tropica |
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| Maryam Hakimi Parizi,Saeedeh Farajzadeh,Iraj Sharifi,Abbas Pardakhty,Mohammad Hossein Daie Parizi,Hamid Sharifi,Ehsan Salarkia,Saeid Hassanzadeh | | The Korean Journal of Parasitology. 2019; 57(4): 359 | | [Pubmed] | [DOI] | | | 140 |
In Vitro Release Test of Nano-drug Delivery Systems Based on Analytical and Technological Perspectives |
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| Emirhan Nemutlu,Ipek Eroglu,Hakan Eroglu,Sedef Kir | | Current Analytical Chemistry. 2019; 15(4): 373 | | [Pubmed] | [DOI] | | | 141 |
Lipid-Based Nanocarriers for Lymphatic Transportation |
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| Nikhar Vishwakarma,Anamika Jain,Rajeev Sharma,Nishi Mody,Sonal Vyas,Suresh P. Vyas | | AAPS PharmSciTech. 2019; 20(2) | | [Pubmed] | [DOI] | | | 142 |
Nanotechnology: Revolutionizing the Science of Drug Delivery |
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| Mohini Mishra,Pramod Kumar,Jitendra Singh Rajawat,Ruchi Malik,Gitanjali Sharma,Amit Modgil | | Current Pharmaceutical Design. 2019; 24(43): 5086 | | [Pubmed] | [DOI] | | | 143 |
Nanotechnology Advanced Strategies for the Management of Diabetes Mellitus |
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| Amira Mohamed Mohsen | | Current Drug Targets. 2019; 20(10): 995 | | [Pubmed] | [DOI] | | | 144 |
Niosomes: a review of their structure, properties, methods of preparation, and medical applications |
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| Pei Ling Yeo,Chooi Ling Lim,Soi Moi Chye,Anna Pick Kiong Ling,Rhun Yian Koh | | Asian Biomedicine. 2018; 11(4): 301 | | [Pubmed] | [DOI] | | | 145 |
Role of Nanotechnology in Cosmeceuticals: A Review of Recent Advances |
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| Shreya Kaul,Neha Gulati,Deepali Verma,Siddhartha Mukherjee,Upendra Nagaich | | Journal of Pharmaceutics. 2018; 2018: 1 | | [Pubmed] | [DOI] | | | 146 |
Brief Effect of a Small Hydrophobic Drug (Cinnarizine) on the Physicochemical Characterisation of Niosomes Produced by Thin-Film Hydration and Microfluidic Methods |
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| Li Yeo,Temidayo Olusanya,Cheng Chaw,Amal Elkordy | | Pharmaceutics. 2018; 10(4): 185 | | [Pubmed] | [DOI] | | | 147 |
Use of Curcumin, a Natural Polyphenol for Targeting Molecular Pathways in Treating Age-Related Neurodegenerative Diseases |
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| Panchanan Maiti,Gary Dunbar | | International Journal of Molecular Sciences. 2018; 19(6): 1637 | | [Pubmed] | [DOI] | | | 148 |
Micro-/nano-sized delivery systems of ginsenosides for improved systemic bioavailability |
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| Hyeongmin Kim,Jong Hyuk Lee,Jee Eun Kim,Young Su Kim,Choong Ho Ryu,Hong Joo Lee,Hye Min Kim,Hyojin Jeon,Hyo-Joong Won,Ji-Yun Lee,Jaehwi Lee | | Journal of Ginseng Research. 2018; | | [Pubmed] | [DOI] | | | 149 |
Surfactant Effects on Lipid-Based Vesicles Properties |
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| Ruba Bnyan,Iftikhar Khan,Touraj Ehtezazi,Imran Saleem,Sarah Gordon,Francis OæNeill,Matthew Roberts | | Journal of Pharmaceutical Sciences. 2018; | | [Pubmed] | [DOI] | | | 150 |
A Road to Bring Brij52 Back to Attention: Shear Stress Sensitive Brij52 Niosomal Carriers for Targeted Drug Delivery to Obstructed Blood Vessels |
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| Shokouh Arjmand,Abbas Pardakhty,Hamid Forootanfar,Payam Khazaeli | | Medical Hypotheses. 2018; | | [Pubmed] | [DOI] | | | 151 |
Influence of serum on DNA protection ability and transfection efficiency of cationic lipid-based nanoparticles for gene delivery |
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| Supusson Pengnam,Lalita Leksantikul,Prasopchai Tonglairoum,Praneet Opanasopit,Nattisa Ni-yomtham,Boon-Ek Yingyongnarongkul,Samarwadee Plianwong,C. Hamontree | | MATEC Web of Conferences. 2018; 192: 01025 | | [Pubmed] | [DOI] | | | 152 |
Propolis-based niosomes as oromuco-adhesive films: A randomized clinical trial of a therapeutic drug delivery platform for the treatment of oral recurrent aphthous ulcers |
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| Mona G. Arafa,Dalia Ghalwash,Dina M. El-Kersh,M. M. Elmazar | | Scientific Reports. 2018; 8(1) | | [Pubmed] | [DOI] | | | 153 |
Rapid on-Chip Assembly of Niosomes: Batch versus Continuous Flow Reactors |
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| Sara Garcia-Salinas,Erico Himawan,Gracia Mendoza,Manuel Arruebo,Victor Sebastian | | ACS Applied Materials & Interfaces. 2018; | | [Pubmed] | [DOI] | | | 154 |
Application of different nanocarriers for encapsulation of curcumin |
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Thymoquinone-based nanotechnology for cancer therapy: promises and challenges |
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Encapsulation of oils and fragrances by core-in-shell structures from silica particles, polymers and surfactants: The brick-and-mortar concept |
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| Gergana M. Radulova,Tatiana G. Slavova,Peter A. Kralchevsky,Elka S. Basheva,Krastanka G. Marinova,Krassimir D. Danov | | Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2018; 559: 351 | | [Pubmed] | [DOI] | | | 157 |
Embelin-loaded oral niosomes ameliorate streptozotocin-induced diabetes in Wistar rats |
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| Md. Shamsir Alam,Abdul Ahad,Lubna Abidin,Mohd. Aqil,Showkat Rasool Mir,Mohd Mujeeb | | Biomedicine & Pharmacotherapy. 2018; 97: 1514 | | [Pubmed] | [DOI] | | | 158 |
Multi-drug resistant Mycobacterium tuberculosis & oxidative stress complexity: Emerging need for novel drug delivery approaches |
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Magnetic delivery of antitumor carboplatin by using PEGylated-Niosomes |
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| Fereshteh Davarpanah,Aliakbar Khalili Yazdi,Mahmood Barani,Mohammad Mirzaei,Masoud Torkzadeh-Mahani | | DARU Journal of Pharmaceutical Sciences. 2018; | | [Pubmed] | [DOI] | | | 160 |
Nanoparticulate-based drug delivery systems for small molecule anti-diabetic drugs: An emerging paradigm for effective therapy |
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Ocular delivery of proteins and peptides: Challenges and novel formulation approaches |
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| Abhirup Mandal,Dhananjay Pal,Vibhuti Agrahari,Hoang My Trinh,Mary Joseph,Ashim K. Mitra | | Advanced Drug Delivery Reviews. 2018; | | [Pubmed] | [DOI] | | | 162 |
Formulation and optimization of lacidipine loaded niosomal gel for transdermal delivery: In-vitro characterization and in-vivo activity |
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Nanotechnology based approaches for anti-diabetic drugs delivery |
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| Prashant Kesharwani,Bapi Gorain,Siew Yeng Low,Siew Ann Tan,Emily Chai Siaw Ling,Yin Khai Lim,Chuan Ming Chin,Pei Yee Lee,Chun Mey Lee,Chun Haw Ooi,Hira Choudhury,Manisha Pandey | | Diabetes Research and Clinical Practice. 2017; | | [Pubmed] | [DOI] | | | 164 |
Synthesis of Sulfur-Based Biocompatible Nonionic Surfactants and Their Nano-Vesicle Drug Delivery |
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| Imdad Ali,Muhammad Raza Shah,Muhammad Imran,Muhammad Shafiullah | | Journal of Surfactants and Detergents. 2017; | | [Pubmed] | [DOI] | | | 165 |
In vitro and in vivo investigation for optimization of niosomal ability for sustainment and bioavailability enhancement of diltiazem after nasal administration |
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| H. O. Ammar,M. Haider,M. Ibrahim,N. M. El Hoffy | | Drug Delivery. 2017; 24(1): 414 | | [Pubmed] | [DOI] | | | 166 |
Anti-CD123 antibody-modified niosomes for targeted delivery of daunorubicin against acute myeloid leukemia |
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DOE Optimization of Nano-based Carrier of Pregabalin as Hydrogel: New Therapeutic & Chemometric Approaches for Controlled Drug Delivery Systems |
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| Mona G. Arafa,Bassam M. Ayoub | | Scientific Reports. 2017; 7: 41503 | | [Pubmed] | [DOI] | | | 168 |
pH-sensitive pHLIP® coated niosomes |
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| Mohan C. Pereira,Monica Pianella,Da Wei,Anna Moshnikova,Carlotta Marianecci,Maria Carafa,Oleg A. Andreev,Yana K. Reshetnyak | | Molecular Membrane Biology. 2017; : 1 | | [Pubmed] | [DOI] | | | 169 |
Anti-biofilm activity of a sophorolipid-amphotericin B niosomal formulation against Candida albicans |
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| Farazul Haque,Mohammad Sajid,Swaranjit Singh Cameotra,Mani Shankar Battacharyya | | Biofouling. 2017; : 1 | | [Pubmed] | [DOI] | | | 170 |
Enhanced oral bioavailability and sustained delivery of glimepiride via niosomal encapsulation: in-vitro characterization and in-vivo evaluation |
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| Amira Mohamed Mohsen,Mona Mahmoud AbouSamra,Shaimaa Ahmed ElShebiney | | Drug Development and Industrial Pharmacy. 2017; : 1 | | [Pubmed] | [DOI] | | | 171 |
Stem cell-based gene delivery mediated by cationic niosomes for bone regeneration |
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| Noha Attia,Mohamed Mashal,Santiago Grijalvo,Ramon Eritja,Jon Zárate,Gustavo Puras,José Luis Pedraz | | Nanomedicine: Nanotechnology, Biology and Medicine. 2017; | | [Pubmed] | [DOI] | | | 172 |
Retinal gene delivery enhancement by lycopene incorporation into cationic niosomes based on DOTMA and polysorbate 60 |
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| Mohamed Mashal,Noha Attia,Gustavo Puras,Gema Martínez-Navarrete,Eduardo Fernández,Jose Luis Pedraz | | Journal of Controlled Release. 2017; 254: 55 | | [Pubmed] | [DOI] | | | 173 |
Novel carters and targeted approaches: Way out for rheumatoid arthritis quandrum |
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| Shikha Srivastava,Deependra Singh,Satish Patel,Arun K.S. Parihar,Manju R. Singh | | Journal of Drug Delivery Science and Technology. 2017; 40: 125 | | [Pubmed] | [DOI] | | | 174 |
Potential enhancement and targeting strategies of polymeric and lipid-based nanocarriers in dermal drug delivery |
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| Emine Kahraman,Sevgi Güngör,Yildiz Özsoy | | Therapeutic Delivery. 2017; 8(11): 967 | | [Pubmed] | [DOI] | | | 175 |
Nanotechnology-Based Approach in Tuberculosis Treatment |
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| Mohammad Nasiruddin,Md. Kausar Neyaz,Shilpi Das | | Tuberculosis Research and Treatment. 2017; 2017: 1 | | [Pubmed] | [DOI] | | | 176 |
Topical Delivery of Fenoprofen Calcium via Elastic Nano-vesicular Spanlastics: Optimization Using Experimental Design and In Vivo Evaluation |
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| Dalia Ali Farghaly,Ahmed A. Aboelwafa,Manal Y. Hamza,Magdy I. Mohamed | | AAPS PharmSciTech. 2017; | | [Pubmed] | [DOI] | | | 177 |
Nghiên c?u bào ch? niosome metformin |
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| Lê Thùy Dung, Lê Thanh Phu?c, Lê Tr?ng Nghi | | Can Tho University Journal of Science. 2016; 43: 10 | | [Pubmed] | [DOI] | | | 178 |
Recent advances in amphiphilic polymers for simultaneous delivery of hydrophobic and hydrophilic drugs |
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Exploring the use of nanocarrier systems to deliver the magical molecule; Curcumin and its derivatives |
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| Mina Mehanny,Rania M. Hathout,Ahmed S. Geneidi,Samar Mansour | | Journal of Controlled Release. 2016; 225: 1 | | [Pubmed] | [DOI] | | | 180 |
Advances in psoriasis physiopathology and treatments: Up to date of mechanistic insights and perspectives of novel therapies based on innovative skin drug delivery systems (ISDDS) |
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| M. Sala,A. Elaissari,H. Fessi | | Journal of Controlled Release. 2016; | | [Pubmed] | [DOI] | | | 181 |
Preparation and evaluation of niosome gel containing acyclovir for enhanced dermal deposition |
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A single intravenous dose of novel flurbiprofen-loaded proniosome formulations provides prolonged systemic exposure and anti-inflammatory effect |
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| Preeti Verma,Sunil Kumar Prajapati,Rajbharan Yadav,Danielle Senyschyn,Peter R Shea,Natalie L Trevaskis | | Molecular Pharmaceutics. 2016; | | [Pubmed] | [DOI] | | | 183 |
Niosomes: a potential tool for novel drug delivery |
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| Rizwana Khan,Raghuveer Irchhaiya | | Journal of Pharmaceutical Investigation. 2016; 46(3): 195 | | [Pubmed] | [DOI] | | | 184 |
A review of solute encapsulating nanoparticles used as delivery systems with emphasis on branched amphipathic peptide capsules |
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| Sheila M. Barros,Susan K. Whitaker,Pinakin Sukthankar,L. Adriana Avila,Sushanth Gudlur,Matt Warner,Eduardo I.C. Beltrão,John M. Tomich | | Archives of Biochemistry and Biophysics. 2016; 596: 22 | | [Pubmed] | [DOI] | | | 185 |
Development and in-vitro characterization of sorbitan monolaurate and poloxamer 184 based niosomes for oral delivery of diacerein |
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| Muhammad Imran Khan,Asadullah Madni,Leena Peltonen | | European Journal of Pharmaceutical Sciences. 2016; | | [Pubmed] | [DOI] | | | 186 |
Engineering of a hybrid polymer-lipid nanocarrier for the nasal delivery of tenofovir disoproxil fumarate: Physicochemical, molecular, microstructural, and stability evaluation |
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| Varsha B Pokharkar,Mallika R Jolly,Dipak D Kumbhar | | European Journal of Pharmaceutical Sciences. 2015; | | [Pubmed] | [DOI] | | | 187 |
Development, Characterization, andIn VitroBiological Performance of Fluconazole-Loaded Microemulsions for the Topical Treatment of Cutaneous Leishmaniasis |
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| Marcela Brito Oliveira,Giovana Calixto,Márcia Graminha,Hugo Cerecetto,Mercedes González,Marlus Chorilli | | BioMed Research International. 2015; 2015: 1 | | [Pubmed] | [DOI] | | | 188 |
Design and optimization of topical methotrexate loaded niosomes for enhanced management of psoriasis: Application of Box–Behnken design, in-vitro evaluation and in-vivo skin deposition study |
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| Aly A. Abdelbary,Mohamed H.H. AbouGhaly | | International Journal of Pharmaceutics. 2015; 485(1-2): 235 | | [Pubmed] | [DOI] | | | 189 |
Effect of polycaprolactone on in vitro release of melatonin encapsulated niosomes in artificial and whole saliva |
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| C. Nukulkit,A. Priprem,T. Damrongrungruang,E. Benjavongkulchai,N. Pratheepawanit Johns | | Journal of Drug Delivery Science and Technology. 2014; 24(2): 153 | | [Pubmed] | [DOI] | | | 190 |
Nanotechnology-Applied Curcumin for Different Diseases Therapy |
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| Negar Ghalandarlaki,Ali Mohammad Alizadeh,Soheil Ashkani-Esfahani | | BioMed Research International. 2014; 2014: 1 | | [Pubmed] | [DOI] | | | 191 |
Statistically designed nonionic surfactant vesicles for dermal delivery of itraconazole: Characterization and in vivo evaluation using a standardized Tinea pedis infection model |
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| Neeraj Kumar,Shishu Goindi | | International Journal of Pharmaceutics. 2014; 472(1-2): 224 | | [Pubmed] | [DOI] | | | 192 |
Branched amphiphilic peptide capsules: Cellular uptake and retention of encapsulated solutes |
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Quantiosomes as a Multimodal Nanocarrier for Integrating Bioimaging and Carboplatin Delivery |
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Polymer Micro- and Nanocapsules as Biological Carriers with Multifunctional Properties |
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Formulation of tretinoin-loaded topical proniosomes for treatment of acne:in-vitrocharacterization, skin irritation test and comparative clinical study |
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Colloidal drug delivery system: amplify the ocular delivery |
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Vesicular system: Versatile carrier for transdermal delivery of bioactives |
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Formulation and evaluation of metformin hydrochloride-loaded niosomes as controlled release drug delivery system |
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Vesicular systems in treatment of rheumatoid arthritis |
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Exploring the fluorescence switching phenomenon of curcumin encapsulated niosomes: In vitro real time monitoring of curcumin release to cancer cells |
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Nanotechnology in corneal neovascularization therapy - A review |
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Formulation and evaluation of metformin hydrochloride-loaded niosomes as controlled release drug delivery system |
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| Hasan AA, Madkor H, Wageh S. | | Drug Delivery. 2013; 20((3-4)): 120-126 | | [Pubmed] | | | 203 |
Construction of hyaluronic acid noisome as functional transdermal nanocarrier for tumor therapy |
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Construction of hyaluronic acid noisome as functional transdermal nanocarrier for tumor therapy |
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Niosomes from 80s to present: The state of the art |
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Nanotechnology in Corneal Neovascularization Therapy—A Review |
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Exploring the fluorescence switching phenomenon of curcumin encapsulated niosomes: in vitro real time monitoring of curcumin release to cancer cells |
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| Nagaprasad Puvvada,Shashi Rajput,B. N. Prashanth Kumar,Mahitosh Mandal,Amita Pathak | | RSC Advances. 2013; 3(8): 2553 | | [Pubmed] | [DOI] | | | 208 |
Niosomes: Novel sustained release nonionic stable vesicular systems — An overview |
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Development of novel lipid carrier systems for ocular drug delivery |
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Recent Trends in Niosome as Vesicular Drug Delivery System |
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| Anchal Sankhyan, Pravin Pawar | | Journal of Applied Pharmaceutical Science. 2012; 2(6): 20-32 | | [Pubmed] | | | 211 |
Niosomes: Novel sustained release nonionic stable vesicular systems - An overview |
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| Mahale NB, Thakkar PD, Mali RG, Walunj DR, Chaudhari SR. | | Advances in Colloid and Interface Science. 2012; : 46-54 | | [Pubmed] | | | 212 |
Preparation and evaluation of niosomes containing autoclaved Leishmania major: A preliminary study |
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| Pardakhty A, Shakibaie M, Daneshvar H, Khamesipour A, Mohammadi-Khorsand T, Forootanfar H. | | Journal of Microencapsulation. 2012; 29(3): 219-224 | | [Pubmed] | | | 213 |
Preparation and evaluation of niosomes containing autoclavedLeishmania major: a preliminary study |
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| Abbas Pardakhty,Mojtaba Shakibaie,Hamid Daneshvar,Ali Khamesipour,Tayebe Mohammadi-Khorsand,Hamid Forootanfar | | Journal of Microencapsulation. 2012; 29(3): 219 | | [Pubmed] | [DOI] | | | 214 |
Nonionic surfactant vesicular systems for effective drug delivery—an overview |
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| Kumar GP, Rajeshwarrao P | | Acta Pharmaceutica Sinica B. 2011; 1(4): 208-219 | | [Pubmed] | | | 215 |
Provesicular niosomes gel: A novel absorption modulator for transdermal delivery |
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| Litha T, Shoma J, John GS, Viswanad V. | | International Journal of Drug Development and Research. 2011; 3(3): 58-69 | | [Pubmed] | | | 216 |
Nonionic surfactant vesicular systems for effective drug delivery—an overview |
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