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Year : 2010  |  Volume : 1  |  Issue : 3  |  Page : 342-347

Synthesis, characterization, and analgesic activity of novel schiff base of isatin derivatives

1 Department of Pharmaceutical Chemistry, D.C.R.M. Pharmacy College, Inkollu - 523 167 (A.P), India
2 Kamalakshi Pandurangan College of Pharmacy, Ayyampalayam, Thiruvannamalai, (T.N), India
3 Department of Medicinal Chemistry, Medicinal Chemistry Research Laboratory, Bapatla College of Pharmacy, Bapatla - 522 101, (A.P), India

Correspondence Address:
Rajaram Prakash Chinnasamy
Department of Pharmaceutical Chemistry, D.C.R.M. Pharmacy College, Inkollu - 523 167, (A.P)
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0110-5558.72428

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In the present study, a series of novel Schiff bases of isatin [5a-5l] were synthesized by condensation of imesatin with different aromatic aldehydes. The imesatins were synthesized by the reaction of isatin with p-phenylenediamine. The chemical structures of the synthesized compounds were confirmed by means of Infrared (IR), Mass spectroscopy, and Elemental analysis. These compounds were screened for the analgesic activity by the tail-immersion method at a dose of 200 mg/kg body weight. Among the tested compounds 3-(4-(4-hydroxy-3-methoxylbenzylideneamino) phenylimino) indoline-2-one (5i) exhibited better analgesic activity when compared to standard pentazocine. From the above-mentioned results it may be concluded that compounds containing electron-donating groups exhibit better analgesic activity than the electron-withdrawing groups.

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