Home  |  About JAPTR |  Editorial board  |  Search |  Ahead of print  |  Current issue  |  Archives |  Submit article  |  Instructions  |  Subscribe  |  Advertise  |  Contacts  |Login 
Users Online: 470   Home Print this page Email this page Small font sizeDefault font sizeIncrease font size
Year : 2010  |  Volume : 1  |  Issue : 3  |  Page : 330-333

Assessment of the antidiabetic potential of Cassia grandis using an in vivo model

1 Department of Pharmaceutical Chemistry, Maliba Pharmacy College, Gopal Vidyanagar, Tarsadi, Gujarat, India
2 Department of Pharmaceutical Chemistry, Modern College of Pharmacy (for ladies), Moshi, Pune, Maharashtra, India

Correspondence Address:
Sandesh R Lodha
Maliba Pharmacy College, Gopal Vidyanagar, Tarsadi - 394 350, Gujarat
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0110-5558.72429

Rights and Permissions

The aqueous and ethanolic extracts of C. grandis (Family: Leguminosae) were evaluated for antidiabetic activity by a glucose tolerance test, in normal rats and alloxan-induced diabetic rats. The aqueous and ethanolic extracts showed that they significantly lowered the blood glucose levels to normal in the glucose tolerance test. In alloxan-induced diabetic rats the maximum reduction in blood glucose was observed after three hours, at a dose level of 150 mg/kg of body weight. The percentage of protection given by the aqueous and ethanolic extracts was 32.72 and 46.42%, respectively. In the long-term treatment of alloxan-induced diabetic rats, the degree of protection was determined by measuring the blood glucose, cholesterol, and triglycerides on the tenth day. Both the extracts showed a significant antidiabetic activity comparable to that of glibenclamide. These results showed that the Cassia grandis possessed significant antidiabetic activity.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded618    
    Comments [Add]    
    Cited by others 15    

Recommend this journal