|
| REVIEW ARTICLE |
|
| Year : 2010 | Volume
: 1
| Issue : 3 | Page : 283-290 |
 |
|
Microsponges: A novel strategy for drug delivery system
Santanu Kaity1, Sabyasachi Maiti1, Ashoke Kumar Ghosh2, Dilipkumar Pal2, Animesh Ghosh3, Subham Banerjee2
1 Department of Pharmaceutics, Gupta College of Technological Sciences, Ashram More, G.T.Road, Asansol-713 301, West Bengal, India
2 Department of Pharmaceutics, College of Pharmacy, Institute of Foreign Trade and Management, Lodhipur Rajput, Delhi Road, Moradabad - 244 001, Uttar Pradesh, India
3 Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi - 835 215, Jharkhand, India
| Date of Web Publication | 10-Nov-2010 |
Correspondence Address:
Santanu Kaity
Department of Pharmaceutics,Gupta College of Technological Sciences, Ashram More, G.T. Road, Asansol - 713 301, West Bengal
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0110-5558.72416
 Abstract | | |
Microsponges are polymeric delivery systems composed of porous microspheres. They are tiny sponge-like spherical particles with a large porous surface. Moreover, they may enhance stability, reduce side effects and modify drug release favorably. Microsponge technology has many favorable characteristics, which make it a versatile drug delivery vehicle. Microsponge Systems are based on microscopic, polymer-based microspheres that can suspend or entrap a wide variety of substances, and can then be incorporated into a formulated product such as a gel, cream, liquid or powder. The outer surface is typically porous, allowing a sustained flow of substances out of the sphere. Microsponges are porous, polymeric microspheres that are used mostly for topical use and have recently been used for oral administration. Microsponges are designed to deliver a pharmaceutical active ingredient efficiently at the minimum dose and also to enhance stability, reduce side effects, and modify drug release. Keywords: Controlled release, drug delivery, healthcare systems, microsponges
How to cite this article:
Kaity S, Maiti S, Ghosh AK, Pal D, Ghosh A, Banerjee S. Microsponges: A novel strategy for drug delivery system. J Adv Pharm Technol Res 2010;1:283-90 |
How to cite this URL:
Kaity S, Maiti S, Ghosh AK, Pal D, Ghosh A, Banerjee S. Microsponges: A novel strategy for drug delivery system. J Adv Pharm Technol Res [serial online] 2010 [cited 2021 Dec 2];1:283-90. Available from: https://www.japtr.org/text.asp?2010/1/3/283/72416 |
| Introduction | |  |
In recent years, there has been considerable emphasis given to the development of novel microsponge base drug delivery systems, in order to modify and control the release behavior of the drugs. By incorporation into a carrier system, it is possible to alter the therapeutic index and duration of the activity of drugs. The ever-increasing interest among consumers with regard to skin care and skin treatment products has been fostered by the widespread use of ingredients like α-hydroxy acids and vitamins in topical products, which can induce perceivable and demonstrable benefits - especially in aging or photo-damaged skin. Although quite useful, in many instances, these ingredients may produce irritancy; such irritancy can be perceived as burning, stinging or redness and particularly occurs in individuals with sensitive skin. Recognizing this problem, the formulators have attempted to deal with this problem in one of the two methods. They have reduced the concentration of such ingredients, but in the process, sacrificed efficacy. They have also modified the vehicle in order to make the product more emollient or skin-compatible. [1] However, this approach, in many cases, also reduces the beneficial effects of the final product. The expanding arena of emerging drugs, increased sensitivity to clinical outcomes, and healthcare costs are driving the need for alternative drug delivery methods and devices. Drug delivery systems that can precisely control the release rates or target drugs to a specific body site have had an enormous impact on the healthcare system. Several predictable and reliable systems been developed for systemic drugs under the heading of transdermal delivery systems (TDS) using the skin as a portal of entry. [2] It has improved the efficacy and safety of many drugs that may be better administered through skin. However, TDS is not practical for delivery of materials whose final target is the skin itself. Controlled release of drugs onto the epidermis with an assurance that the drug remains primarily localized and does not enter the systemic circulation in significant amounts, is an area of research that has only recently been addressed with success. No efficient vehicles have been developed for controlled and localized delivery of drugs into the stratum corneum and underlying skin layers and not beyond the epidermis. Moreover, the application of topical drugs has many problems, such as, ointments that are often aesthetically unappealing, greasiness, stickiness, and so on, that often results in lack of patient compliance. These vehicles require a high concentrations of active agents for effective therapy because of their low efficiency of delivery system, resulting in irritation and allergic reactions in significant users. Other drawbacks of topical formulations are uncontrolled evaporation of the active ingredient, unpleasant odor, and the potential incompatibility of the drugs with the vehicles. Conventional formulations of topical drugs are intended to work on the outer layers of the skin. Typically, such products release their active ingredients upon application, producing a highly concentrated layer of active ingredient that is rapidly absorbed. Thus the need exists for a system to maximize the amount of time that an active ingredient is present either on the skin surface or within the epidermis, while minimizing its transdermal penetration into the body. Microsponges are microscopic spheres capable of absorbing skin secretions, therefore reducing oiliness and shine from the skin. Spherical particles composed of clusters of even tinier spheres are capable of holding four times their weight in skin secretions. Microsponge particles are extremely small, inert, indestructible spheres that do not pass through the skin. Rather, they collect in the tiny nooks and crannies of the skin and slowly release the entrapped drug, as the skin needs it. The microsponge system can prevent excessive accumulation of ingredients within the epidermis and the dermis. Potentially, the microsponge system can significantly reduce the irritation of effective drugs without reducing their efficacy. The empty spheres are then washed away with the next cleansing. The microsponge delivery system fulfills these requirements and has resulted in a new generation of very well-tolerated and highly efficacious, novel products. These products are typically presented to the consumer in conventional forms like creams, gels or lotions and they contain a relatively high concentration of active ingredients.
Microsponges are patented polymeric delivery systems consisting of porous microspheres that can entrap a wide range of active ingredients such as emollients, fragrances, essential oils, sunscreens, and anti-infective, anti-fungal, and anti-inflammatory agents. [3] Like a true sponge, each microsphere consists of a myriad of interconnecting voids within a non-collapsible structure, with a large porous surface. The microsponge technology was developed by Won in 1987, and the original patents were assigned to Advanced Polymer Systems, Inc. [4] This company developed a large number of variations of the technique and applied those to the cosmetic as well as over-the-counter (OTC) and prescription pharmaceutical products. At the present time, this interesting technology has been licensed to Cardinal Health, Inc., for use in topical products. The size of the microsponges can be varied, usually from 5 - 300 μm in diameter, depending upon the degree of smoothness or after-feel required for the end formula. Although the microsponge size may vary, a typical 25 μm sphere can have up to 250000 pores and an internal pore structure equivalent to 10 ft in length, providing a total pore volume of about 1 ml/g. This results in a large reservoir within each microsponge, which can be loaded with up to its own weight of active agent. The microsponge particles themselves are too large to be absorbed into the skin and this adds a measure of safety to these microsponge materials. Another safety concern is the potential bacterial contamination of the materials entrapped in the microsponge. As the size of the pore diameter is smaller, the bacteria ranging from 0.007 to 0.2 μm cannot penetrate into the tunnel structure of the microsponges [Figure 1]. [3] | Figure 1 :Schematic representation of the distribution of the loaded material (active) on skin
Click here to view |
Potential Advantages of the Microsponge Drug Delivery System
- Microcapsules cannot usually control the release rate of the active pharmaceutical ingredients (API). Once the wall is ruptured the API contained within the microcapsules will be released. Can the MDS can do it, is the question.
- Liposomes suffer from a lower pay load, difficult formulation, limited chemical stability, and microbial instability. Do the MDS have a wide range of chemical stability and are they easy to formulate?
- MDS have stability over a pH range of 1 - 11.
- Stable up to temperature 130 o C.
- Pay load is up to 50 - 60%.
- Free flowing and cost effective.
- Microsponges are microscopic spheres capable of absorbing skin secretions, therefore, reducing oiliness and shine from the skin.
Properties of the Actives for the Entrapment into Microsponges
- It should be either fully miscible in a monomer or capable of being made miscible by the addition of a small amount of a water-immiscible solvent.
- It should be water immiscible or at most only slightly soluble.
- It should be inert to monomers and should not increase the viscosity of the mixture during formulation.
- It should be stable when in contact with the polymerization catalyst and under conditions of polymerization.
- The spherical structure of the microsponges should not collapse.
Methods of Preparation of Microsponges
Liquid-liquid suspension polymerization
In general, a solution is made comprising of monomers and the functional or active ingredients, which are immiscible with water. This phase is then suspended with agitation in an aqueous phase, usually containing additives, such as surfactants and dispersants, to promote suspension. Once the suspension is established with discrete droplets of the desired size, polymerization is effected by activating the monomers either by catalysis, increased temperature or irradiation. As the polymerization process continues, a spherical structure is produced containing thousands of microsponges bunched together like grapes, forming interconnecting reservoirs [Figure 2]. | Figure 2 :Reaction vessel for microsponge preparation by liquid- liquid suspension polymerization
Click here to view |
Once the polymerization is complete the solid particles that result from the process are recovered from the suspension. The particles are then washed and processed until they are substantially ready for use. The microsponge products can be made using styrene and divinylbenzene or methyl methacrylate and ethylene glycol dimethacrylate as starting materials. [5]
Quasi-emulsion solvent diffusion
To prepare the inner organic phase, Eudragit RS 100 is dissolved in ethyl alcohol. Next, the drug is added to the solution and dissolved under ultrasonication at 35 o C. The inner phase is poured into the polyvinyl alcohol solution in water (outer phase). Following 60 minutes of stirring, the mixture is filtered, to separate the microsponges. The microsponges are dried in an air-heated oven at 40 o C for 12 hours [Figure 3]. [6]
Ingredients can be entrapped in microsponge polymers either at the time of synthesis, or if too labile to withstand polymerization conditions, they can be post-loaded after the microsphere structure has been pre-formed. In general, the latter process is the preferred mode, as many cosmetic ingredients, and most pharmaceutical ones, would decompose at the temperatures employed for polymerization. | Figure 3 :Preparation of microsponges by the quasi-emulsion solvent diffusion method
Click here to view |
Hypothetical mechanism of action
The active ingredient is added to the vehicle in an entrapped form. As the microsponge particles have an open structure (i.e., they do not have a continuous membrane surrounding them), the active is free to move in and out from the particles and into the vehicle until equilibrium is reached, when the vehicle becomes saturated. Once the finished product is applied to the skin, the active that is already in the vehicle will be absorbed into the skin, depleting the vehicle, which will become unsaturated, therefore, disturbing the equilibrium. This will start a flow of the active from the microsponge particle into the vehicle, and from it to the skin, until the vehicle is either dried or absorbed. Even after that the microsponge particles retained on the surface of the stratum corneum will continue to gradually release the active to the skin, providing prolonged release over time. This proposed mechanism of action highlights the importance of formulating vehicles for use with microsponge entrapments. If the active is too soluble in the desired vehicle during compounding of the finished products, the products will not provide the desired benefits of gradual release. Instead they will behave as if the active was added to the vehicle in a free form. Therefore, while formulating microsponge entrapments, it is important to design a vehicle that has minimal solubilizing power for the actives. This principle is contrary to the conventional formulation principles usually applied to topical products. For these conventional systems it is normally recommended to maximize the solubility of the active in the vehicle. When using microsponge entrapments, some solubility of the active in the vehicle is acceptable, because the vehicle can provide the initial loading dose of the active until release from the microsponge is activated by the shift in equilibrium from the polymer into the carrier. Another way to avoid undesirable premature leaching of the active from the microsponge polymer is to formulate the product with some free and some entrapped active, so the vehicle is pre-saturated. In this case there will not be any leaching of the active from the polymer during compounding. The rate of active release will ultimately depend not only on the partition coefficient of the active ingredient between the polymer and the vehicle (or the skin), but also on some of the parameters that characterize the beads. Examples of these include surface area and primarily, mean pore diameter. [7] Release can also be controlled through diffusion or other triggers such as moisture, pH, friction or temperature.
Characterization of the microsponge
The microsponges are generally characterized for particle size, shape, pore volume, pore diameter. And so on. Different parameters and evaluation methods for microsponges is given in [Table 1]. | Table 1 :Different parameters and characterization methods for microsponges
Click here to view |
Microsponge-based Delivery Systems for Drug
Triggering
Topical drug delivery using microsponge technology
Microspongic delivery of Benzoyl peroxide was developed using an emulsion solvent diffusion method, by adding an organic internal phase containing benzoyl peroxide, ethyl cellulose, and dichloromethane into a stirred aqueous phase containing polyvinyl alcohol, [23] and by suspension polymerization of styrene and divinyl benzene. [24],[25] The prepared microsponges were dispersed in a gel base and the microspongic gels were evaluated for anti-bacterial and skin irritancy. The entrapped system released the drug at a slower rate than the system containing free BPO. The topical delivery system with reduced irritancy was successfully developed. [26] A new formulation of Hydroquinone (HQ) 4%, with retinol 0.15%, entrapped in microsponge reservoirs, was developed to release HQ gradually, to prolong exposure to treatment and to minimize skin irritation. The safety and efficacy of this product were evaluated in a 12-week, open-label study. In this open-label study, HQ 4% with retinol 0.15% was safe as well as effective. [27] The microspongic system for topical delivery of fluconazole gel was observed to have the potential to extend the release. [28] An MDS system for retinoic acid was developed and tested for drug release and anti-acne efficacy. Statistically significant, greater reductions in inflammatory and non-inflammatory lesions were obtained with tretinoin entrapped in the microsponge. [29] Topical analgesic, anti-inflammatory, and counter-irritant drugs in a microsponge® are used for the management of the musculoskeletal system. [30]
Oral drug delivery using microsponge technology
In oral applications, the microsponge system has been shown to increase the rate of solubilization of poorly water-soluble drugs by entrapping such drugs in the microsponge system's pores. As these pores are very small, the drug is in effect reduced to microscopic particles and the significant increase in the surface area thus greatly increases the rate of solubilization. Controlled oral delivery of ibuprofen microsponges is achieved with an acrylic polymer, eudragit RS, by changing their intraparticle density. [31] Sustained release formulation of chlorpheniramine maleate, using powder-coated microsponges, is prepared by the dry impact blending method, for oral drug delivery. [32] Controlled oral delivery of Ketoprofen prepared by quasi-emulsion solvent diffusion method with Eudragit RS 100 and afterwards tablets of microsponges were prepared by the direct compression method. Results indicated that compressibility was much improved in the physical mixture of the drug and polymer; due to the plastic deformation of the sponge-like microsponge structure, producing mechanically strong tablets. [18] Colon-specific, controlled delivery of flurbiprofen, was conducted by using a commercial Microsponge® 5640 system. In vitro studies exhibited that compression-coated colon-specific tablet formulations started to release the drug at the eighth hour, corresponding to the proximal colon arrival time, due to addition of the enzyme, following a modified release pattern, while the drug release from the colon-specific formulations prepared by pore plugging the microsponges showed an increase at the eighth hour, which was the point of time when the enzyme addition was made. [33]
Microsponge-based Delivery Systems for Bone and Tissue Engineering
Bone-substitute compounds were obtained by mixing pre-polymerized powders of polymethylmethacrylate and liquid methylmethacrylate monomer with two aqueous dispersions of a-tricalcium phosphate grains and calcium-deficient hydroxyapatite powders. The final composites appeared to be porous and acted as microsponges. [34] The basic fibroblast growth factor (bFGF) incorporated in a collagen sponge sheet was sustained released in the mouse sub-cutis according to the biodegradation of the sponge matrix, and exhibited local angiogenic activity in a dose-dependent manner. Intra-muscular injection of collagen microsponges incorporating bFGF, induced a significant increase in the blood flow, in the murine ischemic hind limb, which could never have been attained by the bolus injection of bFGF. These results suggest the significance and therapeutic utility of the type I collagen as a reservoir of bFGF. [35] A biodegradable graft material containing the collagen microsponge was developed for cardiovascular tissue grafting, as it would permit the regeneration of the autologous vessel tissue. [36] A thin biodegradable hybrid mesh of synthetic poly (DL-lactic-co-glycolic acid) (PLGA) and naturally derived collagen was used for a three-dimensional culture of human skin fibroblasts. The hybrid mesh was constructed by forming web-like collagen microsponges in the openings of a PLGA-knitted mesh. [37] A tissue-engineered patch made of our biodegradable polymer and collagen-microsponge provided good in situ regeneration at both the venous and arterial wall, suggesting that this patch could be used as a novel surgical material for the repair of the cardiovascular system. [38]
Potential applications of microsponge systems
Microsponges are used widely to develop drug and cosmetic products for topical administration and recently for oral administration [Table 2]. These are designed to deliver the drug efficiently at the minimum dose and also to enhance stability, reduce side effects, and modify drug release. [40]
Marketed formulation based on microsponge materials
List of marketed products using microsponge drug delivery system are given in [Table 3]. | Table 3 :List of marketed products using microsponge drug delivery system
Click here to view |
Future prospects
Microsponges are one of the novel drug delivery systems, which were originally developed for topical delivery of drugs. They can also be used for tissue engineering and controlled oral delivery of drugs using biodegradable polymers. It provides a wide range of formulating advantages. Liquids can be transformed into free flowing powders. Formulations can be developed with otherwise incompatible ingredients, with prolonged stability, without the use of preservatives. Therefore, microsponges will be an ideal drug delivery system related to formulations like the transdermal delivery system. As it requires vehicles at a higher concentration in order to dissolve the API for effective therapy, it causes irritation and hypersensitivity reactions in significant users. Another demerit of topical formulations is uncontrolled evaporation of the cactive ingredient, unpleasant odor, and the potential incompatibility of drugs with the vehicles. Conventional formulations of topical drugs are intended to work on the outer layers of the skin. Typically, such products release their active ingredients upon application, producing a highly concentrated layer of an active ingredient that is rapidly absorbed. Thus, the need exists for a system to maximize the amount of time that an active ingredient is present either on the skin surface or within the epidermis. Some microsponge-based products are already approved; several others are currently under development and clinical assessment.
| Conclusion | | |
The microsponge delivery system is a unique technology for the controlled release of macroporous beads, loaded with active agent, offering a potential reduction in side effects, while maintaining their therapeutic efficacy. The microsponge drug delivery system offers entrapment of its ingredients and is believed to contribute toward reduced side effects, improved stability, increased elegance, and enhanced formulation flexibility. In addition, numerous studies have confirmed that microsponge systems are non-irritating, non-mutagenic, non-allergenic, and non-toxic. This technology is being used currently in cosmetics, over-the-counter skin care, sunscreens, and prescription products. This kind of drug delivery technology may lead to a better understanding of the healing of several diseases. Hence, the microsponge-based drug delivery technology is likely to become a valuable drug delivery matrix substance for various therapeutic applications in the future.
| References | | |
| 1. | Saxena S, Nacht S. Polymeric porous delivery systems: Polytrap and Microsponge. In: Delivery System Handbook for Personal Care and Cosmetic Products: Technology, Applications and Formulations. New York: William Andrew Publishing; 2005. p. 333-51. 
|
| 2. | Kydonieus AF, Berner B. Transdermal Delivery of Drugs. Boca Raton: CRC Press; 1987.
|
| 3. | Nacht S, Kantz M. The microsponge: A novel topical programmable delivery system. Top Drug Deliv Syst 1992;42:299-325.
|
| 4. | Won R. Method for delivering an active ingredient by controlled time release utilizing a novel delivery vehicle which can be prepared by a process utilizing the active ingredient as a porogen. Patent No. 4690825. US: 1987.
|
| 5. | Hainey P, Huxham IM, Rowatt B, Sherrington DC. Synthesis and ultrastructural studies, of styrene-divinylbenzene polyhipe polymers. Macromolecules 1991;24:117-21.
|
| 6. | Orlu M, Cevher E, Araman A. Design and evaluation of colon specific drug delivery system containing flurbiprofen microsponges. Int J Pharm 2006; 318:103-17.
|
| 7. | Embil K, Nacht S. The Microsponge; delivery system (MDS): A topical delivery system with reduced irritancy incorporating multiple triggering mechanims for the release of actives. J Microencapsul 1996;13:575-88.
|
| 8. | Martin A, Swarbrick J, Cammarrata A. Physical Pharmacy- Physical Chemical Principles in Pharmaceutical Sciences. 3 rd ed. Philadelphia: Lea and Febiger;1991. p. 527.
|
| 9. | Emanuele AD, Dinarvand R. Preparation, Characterization and Drug Release from Thermo responsive Microspheres. Int J Pharmaceutics 1995;118:237-42.
|
| 10. | D souza JI. The Microsponge Drug Delivery System: For Delivering an Active Ingredient by Controlled Time Release. Pharmaoinfo net 2008;6:3.
|
| 11. | Washburn EW. Note on a method of determining the distribution of pore sizes in a porous material. Proc Natl Acad Sci U.S.A. 1921;7:115-6.
|
| 12. | Orr Jr C. Application of mercury penetration to material analysis. Powder Technol 1969;3:117-23.
|
| 13. | Kawashima Y, Niwa T, Takeuchi H, Hino T, Itoh Y, Furuyama S. Characterization of polymorphs of tranilast anhydrate and tranilast monohydrate when crystallized by two solvent change spherical crystallization techniques. J Pharm Sci 1991;81:472-8.
|
| 14. | Bodmeier R, Chen H. Preparation and characterization of microspheres containing the anti-inflammatory agents, indomethacin, ibuprofen, and ketoprofen. J Control Release 1989;10:167-75.
|
| 15. | Jones DS, Pearce KJ. Investigation of the effects of some process variables on, microencapsulation of propranolol HCl by solvent evaporation method. Int J Pharm 1995;118:99-205.
|
| 16. | Juni K, Nakano M. Preparation and evaluation in vitro of polylactic acid microspheres containing local anesthetic. Chem Pharm Bull 1981;29:3363-8.
|
| 17. | Barkai A, Pathak V, Benita S. Polyacrylate (Eudragit retard) microspheres for oral controlled release of nifedipine. I. Formulation design and process optimization. Drug Dev Ind Pharm 1990;16:2057-75.
|
| 18. | Comoπlu T, Gφnόl N, Baykara T. Preparation and in vitro evaluation of modified release ketoprofen microsponge. Farmaco 2003;58:101-6.
|
| 19. | Shah VP. Determination of In-vitro Release from Hydrocortisone Creams. Int J Pharm 1989;53:53-9.
|
| 20. | Sato T, Kanke M, Schroeder G, Deluca P. Porous biodegradable microspheres for controlled drug delivery. I: Assessment of processing conditions and solvent removal techniques. Pharm Res 1988;5:21-30.
|
| 21. | Draize JH, Woodard J, Calvary HO. Methods for the Study of Irritationand Toxicity of Substances Applied Topically to the Skin and Mucous Membranes. J Pharmacol and Exp Ther 1944;82:377-89.
|
| 22. | Franz TJ. Percutaneous absorption. On the relevance of in vitro date. J Invest Dermatol 1975;45:498-503.
|
| 23. | Yazici E, Kas HS, Hincal AA. Microsponges, Farmasotik Bilimler Dergisi (Turkey). 1994;19:121-8.
|
| 24. | Wester R, Patel R, Natch S, Leyden J, Melendres J, Maibach H. Controlled release of benzoyl peroxide from a porous microsphere polymeric system can reduce topical irritancy. J Am Acad Derm 1991;24:720-6.
|
| 25. | D'souza JI, Saboji JK, Killedar SG, More NH. Design and Evaluation of Benzoyl Peroxide Microsponges to Enhance Therapeutic Efficacy in Acne Treatment. 20 th FAPA Congress, Bangkok, Thailand: FAPA Congress; Nov 30 - Dec 3, 2004.
|
| 26. | D'souza JI. In-vitro Antibacterial and Skin Irritation Studies of Microsponges of Benzoyl Peroxide. Indian Drugs 2001;38:23.
|
| 27. | Fincham JE, Karnik KA. Patient Counseling and Derm Therapy. US Pharm 1994;19:56-57, 61-2, 66, 71-2, 74, 77-8, 81-2.
|
| 28. | D'souza JI, Masvekar RR, Pattekari PP, Pudi SR, More HN.Microspongic Delivery of Fluconazole For Topical Application, 1 st Indo-Japanese International Conference On Advances In Pharmaceutical Research And Technology. Mumbai, India: Pharmaceutical Research And Technology; 2005. p. 25-9.
|
| 29. | Grimes PE. A microsponge formulation of hydroquinone 4% and retinol 0.15% in the treatment of melasma and post-inflammatory hyperpigmentation. Cutis 2004;74:362-8.
|
| 30. | Embil VP. OTC External analgesic cream/topical analgesic-anti-inflammatory, counterirritant utilizing the Microsponge Delivery System (MDS) for controlled release of actives. Patent Application No: 0101058.6. UK: 2000.
|
| 31. | Kawashima Y, Niwa T, Takeuchi H, Hino T, Itoh Y. Control of Prolonged Drug Release and Compression Properties of Ibuprofen Microsponges with Acrylic Polymer, Eudragit RS, by changing their Intraparticle Density. Chem Pharm Bull 1992;40:196-201.
|
| 32. | Aritomi H, Yamasaki Y, Yamada K, Honda H, Koshi M. Development of sustained release formulation of chlorpheniramine maleate using powder coated microsponges prepared by dry impact blending method. J Pharm Sci Tech 1996;56:49-56.
|
| 33. | OrluM, Cevher E, Araman A. Design and evaluation of colon specific drug delivery system containing flurbiprofen microsponges. Int J Pharm 2006;318:103-17.
|
| 34. | Chen G, Ushida T, Tateishi T. A Biodegradable Hybrid Sponge Nested With Collagen Microsponges. J Biomed Mater Res 2000;51:273-9.
|
| 35. | Kanematsu A, Marui A, Yamamoto S, Ozeki M, Hirano Y, Yamamoto M, et al. Type I collagen can function as a reservoir of basic fibroblast growth factor. J Control Release 2004;94:281-92.
|
| 36. | Iwai S, Sawa Y, Ichikawa H, Taketani S, Uchimura E, Chen G, et al. Biodegradable polymer with collagen microsponge serves as a new bioengineered cardiovascular prosthesis. J Thorac Cardiovasc Surg 2004;128:472-9.
|
| 37. | Chen G, Sato T, Ohgushi H, Ushida T, Tateishi T, Tanaka J. Culturing of skin fibroblasts in a thin PLGA-collagen hybrid mesh. Biomaterials 2005;26:2559-66.
|
| 38. | Iwai S, Sawa Y, Taketani S, Torikai K, Hirakawa K, Matsuda H. Novel Tissue-Engineered Biodegradable Material for Reconstruction of Vascular Wall. Ann Thorac Surg 2005;80:1821-7.
|
| 39. | Grimee PE, Meraz M. A new microentrapped 4% hydroquinone formulation for treatment of hyperpigmentation. 60 th Annual meeting of American Academy of Dermatology. La Poeter 519. New Orleane: Feb 22-27, 2002.
|
| 40. | Khopade AJ, Jain S, Jain NK. The Microsponge. East Pharm 1996;39:49-53.
|
[Figure 1], [Figure 2], [Figure 3]
[Table 1], [Table 2], [Table 3]
| This article has been cited by | | 1 |
Pleiotropic nature of curcumin in targeting multiple apoptotic-mediated factors and related strategies to treat gastric cancer: A review |
|
| Nandini P. Shetty,Manoj Prabhakaran,Akhileshwar Kumar Srivastava | | Phytotherapy Research. 2021; | | [Pubmed] | [DOI] | | | 2 |
Nano intervention in topical delivery of corticosteroid for psoriasis and atopic dermatitis—a systematic review |
|
| Kshitya Shetty,Atul P. Sherje | | Journal of Materials Science: Materials in Medicine. 2021; 32(8) | | [Pubmed] | [DOI] | | | 3 |
50 Years of Topical Retinoids for Acne: Evolution of Treatment |
|
| Hilary Baldwin,Guy Webster,Linda Stein Gold,Valerie Callender,Fran E. Cook-Bolden,Eric Guenin | | American Journal of Clinical Dermatology. 2021; 22(3): 315 | | [Pubmed] | [DOI] | | | 4 |
Enhanced protective potential of novel citronella essential oil microsponge hydrogel against Anopheles stephensi mosquito |
|
| Nitish Kumar,Sunil Kumar,S.P. Singh,Rekha Rao | | Journal of Asia-Pacific Entomology. 2021; 24(1): 61 | | [Pubmed] | [DOI] | | | 5 |
Sponge particulates for biomedical applications: Biofunctionalization, multi-drug shielding, and theranostic applications |
|
| Huaqing Zhang,Yi Jin,Cheng Chi,Guochen Han,Wenxin Jiang,Zhen Wang,Hao Cheng,Chenshuang Zhang,Gang Wang,Chenhua Sun,Yun Chen,Yilong Xi,Mengting Liu,Xie Gao,Xiujun Lin,Lingyu Lv,Jianping Zhou,Yang Ding | | Biomaterials. 2021; 273: 120824 | | [Pubmed] | [DOI] | | | 6 |
Microsponges for controlled release and enhanced oral bioavailability of carbamazepine |
|
| Karam F. Abdalla,Mohamed A. Osman,Ahmed T. Nouh,Gamal M. El Maghraby | | Journal of Drug Delivery Science and Technology. 2021; 65: 102683 | | [Pubmed] | [DOI] | | | 7 |
Synthesis and Characterization of Polymeric Microspheres Template for a Homogeneous and Porous Monolith |
|
| Nur Faezah Ibadat, Clarence M. Ongkudon, Suryani Saallah, Mailin Misson | | Polymers. 2021; 13(21): 3639 | | [Pubmed] | [DOI] | | | 8 |
Microsponge: An advanced drug delivery system |
|
| Kumari Nidhi,Shubham Verma,Sokindra Kumar | | Journal of Clinical and Scientific Research. 2021; 10(2): 108 | | [Pubmed] | [DOI] | | | 9 |
Microsponge carrier for the safe and effective delivery of mycophenolate mofetil |
|
| Muhammad Zaman,Sundus Qureshi,Maria Abdul Ghafoor Raja,Muhammad Wahab Amjad,Kishwar Sultana,Atta Ur Rehman | | Bioinspired, Biomimetic and Nanobiomaterials. 2020; 9(4): 194 | | [Pubmed] | [DOI] | | | 10 |
Current Insights for the Management of Acne in the Modern Era |
|
| Neha Singh,Apoorva Singh,Kalpana Pandey,Kalpana Nimisha | | Recent Patents on Anti-Infective Drug Discovery. 2020; 15(1): 3 | | [Pubmed] | [DOI] | | | 11 |
As Review on Microsponge Gel as Topical Drug Delivery System |
|
| Pravin Jamnadas Kshatriya,Jitendra V. Shinde,Rajashree S. Chavan | | Journal of Drug Delivery and Therapeutics. 2020; 10(6-s): 125 | | [Pubmed] | [DOI] | | | 12 |
Microsponge Technology for Innovative Drug Delivery System |
|
| Lendave A. S. | | International Journal of Scientific Research in Science and Technology. 2020; : 63 | | [Pubmed] | [DOI] | | | 13 |
5-Fluorouracil, innovative drug delivery systems to enhance bioavailability for topical use |
|
| Beatriz Ewert de Oliveira,Otávio Henrique Junqueira Amorim,Lonetá Lauro Lima,Rodrigo Alvarenga Rezende,Natalia Cammarosano Mestnik,Ediléia Bagatin,Gislaine Ricci Leonardi | | Journal of Drug Delivery Science and Technology. 2020; : 102155 | | [Pubmed] | [DOI] | | | 14 |
Cellulose microsponges based gel of naringenin for atopic dermatitis: Design, optimization, in vitro and in vivo investigation |
|
| Ruchika L. Nagula,Sarika Wairkar | | International Journal of Biological Macromolecules. 2020; 164: 717 | | [Pubmed] | [DOI] | | | 15 |
Eugenyl Methacrylate Microsponges Loaded with Eugenol Incorporated In Situ Gel for Treatment of Periodontitis |
|
| Vinita C. Patole,Shilpa P. Chaudhari | | Journal of Pharmaceutical Innovation. 2020; | | [Pubmed] | [DOI] | | | 16 |
Resveratrol-Loaded Microsponge as a Novel Biodegradable Carrier for Dry Powder Inhaler: A New Strategy in Lung Delivery |
|
| Ashwin J. Mali,Anamika Rokade,Ravindra Kamble,Atmaram Pawar,C. Bothiraja | | BioNanoScience. 2020; | | [Pubmed] | [DOI] | | | 17 |
Diversity of ß-cyclodextrin-based nanosponges for transformation of actives |
|
| Sandip Pawar,Pravin Shende,Francesco Trotta | | International Journal of Pharmaceutics. 2019; | | [Pubmed] | [DOI] | | | 18 |
Starch microsponges for enhanced retention and efficacy of topical sunscreen |
|
| Ronak S. Bhuptani,Vandana B. Patravale | | Materials Science and Engineering: C. 2019; 104: 109882 | | [Pubmed] | [DOI] | | | 19 |
Microsponges enriched gel for enhanced topical delivery of 5-fluorouracil |
|
| Subheet Kumar Jain,Manreet Kaur,Pankaj Kalyani,Anshula Mehra,Navjot Kaur,Neha Panchal | | Journal of Microencapsulation. 2019; : 1 | | [Pubmed] | [DOI] | | | 20 |
Sulpiride Gastro-retentive Floating Microsponges; Analytical study, In vitro Optimization and In vivo Characterization |
|
| Mahmoud A. Younis,Marwa R. El-Zahry,Mahmoud A Tallat,Hesham M. Tawfeek | | Journal of Drug Targeting. 2019; : 1 | | [Pubmed] | [DOI] | | | 21 |
Controlled Shape and Porosity of Polymeric Colloids by Photo-Induced Phase Separation |
|
| Elad Hadad,Eitan Edri,Hagay Shpaisman | | Polymers. 2019; 11(7): 1225 | | [Pubmed] | [DOI] | | | 22 |
Gastroretentive Microsponge as a Promising Tool for Prolonging the Release of Mitiglinide Calcium in Type-2 Diabetes Mellitus: Optimization and Pharmacokinetics Study |
|
| Dina Bahaa El Din Mahmoud,Marwa Hassan Shukr,Aliaa Nabil ElMeshad | | AAPS PharmSciTech. 2018; | | [Pubmed] | [DOI] | | | 23 |
Pharmapolymers in the 21 st Century: Synthetic Polymers in Drug Delivery Applications |
|
| Christoph Englert,Johannes C. Brendel,Tobias C. Majdanski,Turgay Yildirim,Stephanie Schubert,Michael Gottschaldt,Norbert Windhab,Ulrich S. Schubert | | Progress in Polymer Science. 2018; | | [Pubmed] | [DOI] | | | 24 |
Encapsulation and controlled release of retinol from silicone particles for topical delivery |
|
| C. Wyatt Shields,John P. White,Erica G. Osta,Jerishma Patel,Shashank Rajkumar,Nickolas Kirby,Jean-Philippe Therrien,Stefan Zauscher | | Journal of Controlled Release. 2018; | | [Pubmed] | [DOI] | | | 25 |
Microsponge: An emerging drug delivery strategy |
|
| Gautam Singhvi,Prachi Manchanda,Neha Hans,Sunil K. Dubey,Gaurav Gupta | | Drug Development Research. 2018; | | [Pubmed] | [DOI] | | | 26 |
Potential therapeutic effects of curcumin in gastric cancer |
|
| Nastaran Barati,Amir A. Momtazi-Borojeni,Muhammed Majeed,Amirhossein Sahebkar | | Journal of Cellular Physiology. 2018; | | [Pubmed] | [DOI] | | | 27 |
Thermal Instability of a Power-Law Fluid Flowing in a Horizontal Porous Layer with an Open Boundary: A Two-Dimensional Analysis |
|
| M. Celli,A. Barletta,S. Longo,L. Chiapponi,V. Ciriello,V. Di Federico,A. Valiani | | Transport in Porous Media. 2017; 118(3): 449 | | [Pubmed] | [DOI] | | | 28 |
Development and evaluation of silver sulfadiazine loaded microsponge based gel for partial thickness (second degree) burn wounds |
|
| P. Mahesh Kumar,Animesh Ghosh | | European Journal of Pharmaceutical Sciences. 2017; 96: 243 | | [Pubmed] | [DOI] | | | 29 |
Porous Inorganic Drug Delivery Systems—a Review |
|
| E. Sayed,R. Haj-Ahmad,K. Ruparelia,M. S. Arshad,M.-W. Chang,Z. Ahmad | | AAPS PharmSciTech. 2017; | | [Pubmed] | [DOI] | | | 30 |
Implementation of quality by design principles in the development of microsponges as drug delivery carriers: Identification and optimization of critical factors using multivariate statistical analyses and design of experiments studies |
|
| Maja Simonoska Crcarevska,Aneta Dimitrovska,Nadica Sibinovska,Kristina Mladenovska,Renata Slavevska Raicki,Marija Glavas Dodov | | International Journal of Pharmaceutics. 2015; | | [Pubmed] | [DOI] | | | 31 |
Development and evaluation of metronidazole loaded microsponge based gel for superficial surgical wound infections |
|
| P. Mahesh Kumar,Animesh Ghosh | | Journal of Drug Delivery Science and Technology. 2015; 30: 15 | | [Pubmed] | [DOI] | | | 32 |
Assessing the viability of microsponges as gastro retentive drug delivery system of curcumin: Optimization and pharmacokinetics |
|
| Priyanka Arya,Kamla Pathak | | International Journal of Pharmaceutics. 2013; | | [Pubmed] | [DOI] | | | 33 |
Microsponges: a futuristic approach for oral drug delivery |
|
| Rishabh Srivastava and Kamla Pathak | | Expert Opinion on Drug Delivery. 2012; 9(7): 863-878 | | [Pubmed] | | | 34 |
Microsponges: a futuristic approach for oral drug delivery |
|
| Rishabh Srivastava,Kamla Pathak | | Expert Opinion on Drug Delivery. 2012; 9(7): 863 | | [Pubmed] | [DOI] | | | 35 |
A look at emerging delivery systems for topical drug products |
|
| SHARON FIREMAN,OFER TOLEDANO,KARINE NEIMANN,NATALIA LOBODA,NAVA DAYAN | | Dermatologic Therapy. 2011; 24(5): 477 | | [Pubmed] | [DOI] | | | 36 |
A study to assess the patient’s knowledge on medical insurance in a selected hospital with the view to develop a self instructional module |
|
| Ruth Raju Allada | | . ; | | [Pubmed] | |
|
 |
|
|
|
