|
REVIEW ARTICLE |
|
Year : 2010 | Volume
: 1
| Issue : 3 | Page : 274-282 |
|
|
Therapeutic and cosmeceutical potential of ethosomes: An overview
Poonam Verma, K Pathak
Department of Pharmaceutics, Rajiv Academy for Pharmacy, Mathura, Uttar Pradesh - 281 001, India
Date of Web Publication | 10-Nov-2010 |
Correspondence Address: Poonam Verma Department of Pharmaceutics, Rajiv Academy for Pharmacy, Mathura, Uttar Pradesh - 281 001 India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0110-5558.72415
Abstract | | |
The main disadvantage of transdermal drug delivery is the poor penetration of most compounds into the human skin. The main barrier of the skin is located within its uppermost layer, the stratum corneum (SC). Several approaches have been developed to weaken this skin barrier. One of the approaches for increasing the skin penetration of drugs and many cosmetic chemicals is the use of vesicular systems, such as, liposomes and ethosomes. Ethosomes are phospholipid-based elastic nanovesicles containing a high content of ethanol (20-45%). Ethanol is known as an efficient permeation enhancer and has been added in the vesicular systems to prepare elastic nanovesicles. It can interact with the polar head group region of the lipid molecules, resulting in the reduction of the melting point of the stratum corneum lipid, thereby increasing lipid fluidity and cell membrane permeability. The high flexibility of vesicular membranes from the added ethanol permits the elastic vesicles to squeeze themselves through the pores, which are much smaller than their diameters. Ethosomal systems are much more efficient in delivering substances to the skin in the terms of quantity and depth, than either conventional liposomes or hydroalcoholic solutions. The scope of this small review is to introduce the novel concept of ethosomes and to describe some approaches and mechanisms of stimulating topical and transdermal products with ethosomes. Keywords: Ethosomes, liposomes, novel drug delivery, penetration enhancer, Percutaneous absorption
How to cite this article: Verma P, Pathak K. Therapeutic and cosmeceutical potential of ethosomes: An overview. J Adv Pharm Technol Res 2010;1:274-82 |
How to cite this URL: Verma P, Pathak K. Therapeutic and cosmeceutical potential of ethosomes: An overview. J Adv Pharm Technol Res [serial online] 2010 [cited 2023 Feb 9];1:274-82. Available from: https://www.japtr.org/text.asp?2010/1/3/274/72415 |
Introduction | |  |
Human skin is an effective, selective barrier to chemical permeation, although the skin as a route for delivery can offer many advantages, including avoidance of first-pass metabolism, lower fluctuations in plasma drug levels, targeting of the active ingredient for a local effect, and good patient compliance. [1] Water soluble molecules and drugs are normally not able to cross the skin as the skin is a natural barrier to water. The stratum corneum is composed of insoluble bundled keratins surrounded by a cell envelope, stabilized by cross-linked proteins and covalently bound lipids as shown in [Figure 1].
In general, the epidermis (specifically the stratum corneum) provides the major control element; most small, water-soluble, and non-electrolytes diffuse into the systemic circulation a thousand times more rapidly when the horny layer is present. [2] Thus, to maximise the flux of the drug, the barrier hinderance is reduced by various approaches. Several technological advances have been made in the recent decades to overcome skin barrier properties. Examples include physical means such as iontophoresis, sonophoresis, microneedles, and chemical means, using penetration enhancers and biochemical means, such as, liposomal vesicles and enzyme inhibition. The physical means like iontophoresis, microneedles, and sonophoresis are relatively complicated to use, and will affect patient compliance. [3] The use of chemical enhancers such as surfactants and organic solvents induce irritation, cause damage, and reduce skin barrier function, therefore, it is desirable to deliver the therapeutic agents that maintain the normal skin barrier function without the aid of a chemical enhancer. [4] One such approach is the use of vesicular systems. In the past decade, topical delivery of drugs by liposomal formulation has evoked considerable interest. Deformable liposomes [5] and transferosomes were the first generation of elastic vesicles introduced by Ceve and Blume, in 1992, and were reported to penetrate intact skin while carrying a therapeutic concentration of drugs, when applied under nonoccluded conditions. [6] The drug, encapsulated in lipid vesicles, prepared from phospholipids and nonionic surfactants is known to be transported into and across the skin. The lipids present in the skin contribute to the barrier properties of the skin and prevent the systemic absorption of drugs. Due to the amphiphilic nature, lipid vesicles may serve as non-toxic penetration enhancers for drugs. [7] In addition, the vesicles can be used for encapsulating hydrophilic and lipophilic as well as low and high molecular weight drugs. Therefore, these lipid rich vesicles are hypothesized to carry a significant quantity of drugs across the skin, thus enhancing the systemic absorption of drugs. [8] The use of lipid vesicles in the delivery system for skin treatment has attracted increasing attention in recent years, however, it is generally agreed that classic liposomes are of little or no value as carriers for drug delivery, because they do not penetrate the skin deeply, but rather remain confined to the upper layer of the stratum corneum; only specifically designed vesicles are shown to enhance permeation into the stratum corneum barrier. It has been investigated and reported that lipid vesicular systems embodying ethanol in relatively high concentrations, called ethosomes, are very efficient at enhancing the skin permeation of a number of drugs. [9]
Ethosomes | |  |
Ethosomes were developed by Touitou et al.,1997, as additional novel lipid carriers composed of ethanol, phospholipids, and water. They are reported to improve the skin delivery of various drugs. [10] Ethanol is an efficient permeation enhancer that is believed to act by affecting the intercellular region of the stratum corneum. Ethosomes are soft malleable vesicles composed mainly of phospholipids, ethanol (relatively high concentration), and water. These soft vesicles represent novel vesicles carriers for enhanced delivery through the skin. The size of the ethosomes vesicles can be modulated from tens of nanometers to microns as shown in [Figure 2].
Ethosomes are non-invasive delivery carriers that enable drugs to reach the deep skin layers and / or the systemic circulation. The high concentration of ethanol makes the ethosomes unique, as ethanol is known for its disturbance of skin lipid bilayer organization. Therefore, when integrated into a vesicles membrane; it gives the vesicle the ability to penetrate the stratum corneum. Also, because of their high ethanol concentration, the lipid membrane is packed less tightly than the conventional vesicles, although it has equivalent stability, allowing a more malleable structure and improves the drug distribution ability in the stratum corneum lipids.
Ethosomes as Carriers for Dermal and Transdermal Drug Delivery
Ethosomes were reported to be effective at delivering molecules to and through the skin to the systemic circulation. The ethosomal carrier was previously tested for dermal delivery of the antiviral drug acylovir. The authors in the study reported a two-armed, double-blinded, randomized clinical trial, and demonstrated the efficiency of the ethosomal 5% acylovir system, compared to a 5% acylovir cream (Zovirax, ZC) for the topical treatment of herpetic infection. [5]
Enhanced delivery of chemicals from the ethosomal carrier was observed in permeation experiments with fluorescent probes. The amphiphillic flourescent probe D-289 was used to study skin penetration from trihexphenyl HCl ethosomes into nude mouse skin, after the non-occulusive application (Dayan and Touitou 2000) results showed that classic liposomes did not facilitate probe penetration into this skin, rather, resulted in only a small reservoir in the upper layers of skin. Using hydroethanolic solutions, a relatively deep penetration, but of relatively very low fluorescent activity was observed. The use of the ethosomal system resulted in increase in both depth and fluorescent activity. Ethosmes have also been reported to improve in vivo and in vitro skin delivery of many drugs both under occlusive and non-occlusive conditions. [11]
Mechanism of Action of the Ethosomal Drug Delivery System
A synergistic mechanism was suggested between ethanol, vesicles, and skin lipids. [12] The enhanced delivery of actives using ethosomes over liposomes can be ascribed to an interaction between ethosomes and skin lipids. A possible mechanism for this interaction has been proposed.
From [Figure 3], it is thought that the first part of the mechanism is due to the ethanol effect, where ethanol interacts with the lipid molecules in the polar head group region resulting in a reduction in the transition temperature of the lipids in the stratum corneum, increasing their fluidity and decreasing the density of the lipid multilayer. This is followed by the 'ethosome effect,' which includes lipid penetration and permeation by the opening of new pathways, due to the malleability and fusion of ethosomes with skin lipids, resulting in the release of the drug into the deep layers of the skin. Ethanol may also provide vesicles with soft flexible characteristics, which allow them to penetrate more easily into the deeper layers of the skin. The release of the drug in the deep layers of the skin and its transdermal absorption could then be the result of a fusion of ethosomes, with skin lipids and drug release at various points along the penetration pathway. [13] | Figure 3 :Proposed mechanism of penetration of ethosomal drug delivery system
Click here to view |
Commercial Products Powered by Ethosomes bringing Novelty in the World Market
The commercialization of ethosome technology began in 2000, and it is a rapidly evolving field. There are now two companies exclusively devoted to product development, using ethosomes. Many large pharmaceutical houses and cosmetic firms are also engaged in active research and development. The list of some commercial products based on ethosomal technology are listed in [Table 1].
Advantages of Ethosomal Drug Delivery
In comparison to other transdermal and dermal delivery systems,
- Ethosomes enhance permeation of the drug through skin transdermal and dermal delivery.
- Ethosomes are platforms for the delivery of large and diverse groups of drugs (peptides, protein molecules).
- Ethosomal systems are much more efficient at delivering a fluorescent probe (quantum dots) to the skin in terms of quantity and depth.
- Low risk profile - The technology has no large-scale drug development risk, as the toxicological profiles of the ethosome components are well-documented in the scientific literature.
- High patient compliance-The ethosome drugs are administrated in a semisolid form (gel or cream), producing high patient compliance. In contrast, iontophoresis and phonophoresis are relatively complicated to use, which will affect patient compliance.
- High market attractiveness for products with proprietary technology. Relatively simple to manufacture with no complicated technical investments required for the production of ethosomes.
- The ethosomes system is passive, non-passive, and available for immediate commercialization.
- Various applications in the pharmaceutical, veterinary, and cosmetic fields.
Methods of Preparation of Ethosomes
The literature reports various methods for the preparation of ethosomes and some commonly used methods have been compiled in the preceeding text.
Hot method
The drug is dissolved in a mixture of ethanol and propylene glycol and the mixture is added to the phospholipid dispersion in water at 40ºC. After mixing for five minutes the preparation is sonicated at 4ºC for three cycles of five minutes, with a rest of five minutes between each cycle, using the Probe Sonicator. The formulation is then homogenized at 15,000 psi pressure, in three cycles, using a high pressure homogenizer to get nano-sized ethosomes. [14]
Cold method
This is the most common and widely used method for ethosomal preparation. The phospholipids, drug, and other lipid materials are dissolved in ethanol, in a covered vessel, at room temperature, with vigorous stirring. The mixture is heated up to 30ºC in a water bath. The water is heated to 30ºC in separate vessel, and added to the above mixture and then stirred for five minutes in a covered vessel. The vesicle size of the ethosomal formulation can be decreased if desired, to extend using the sonication or extrusion. Finally the formulation must be properly stored under refrigeration.
Classic Mechanical Dispersion Method
Soya phosphotidylcholine is dissolved in a mixture of chloroform: methanol (3:1) in round bottom flask. The organic solvents are removed using rotary vacuum evaporator above lipid transition temperature to form of a thin lipid film on wall of the flask. Finally, traces of solvent mixture are removed from the deposited lipid film by leaving the contents under vaccum overnight. Hydration is done with different concentration of hydroethanolic mixture containing drug by rotating the flask at suitable temperature. [15],[16]
Classic method
The phospholipid and drug are dissolved in ethanol and heated to 30ºC±1ºC in a water bath. Double distilled water is added in a fine stream to the lipid mixture, with constant stirring at 700 rpm, in a closed vessel. The resulting vesicle suspension is homogenized by passing through a polycarbonate membrane using a hand extruder for three cycles. [17]
Various Methods for Characterization of Ethosomes
The vesicle shape can be easily visualized by using a photomicgrograph, or transmission electron microscopy (TEM) and scanning electron microscopy (SEM) micrographs. [18],[19] The vesicle size and zeta potential of the formulation can be measured with the Zeta meter. [20] The size of the ethosomes range between tens of nanometers to microns and it is influenced by the composition of the formulation. Various factors affect the size and zeta potential of the ethosomes. Reduction in mean vesicle diameter is due to the presence of ethanol, as it causes a modification of the net charge of the system and confers it some degree of stearic stabilization that may finally lead to a decrease in the mean vesicle size, [21] while the size of the vesicles increase with increasing the phospholipid concentration. This can be explained in terms of the tendency of lipid coalesces at high lipid concentration. [22],[23]
The transition temperature of the vesicular lipid systems can be determined by using differential scanning calorimetry, which also detects ethanol-skin phospholipid interaction, a characteristic attributed to the fluidizing effect of ethanol on the phospholipid bilayers. [24]
The entrapment efficiency of ethosomes can be measured by the ultracentrifugation technique. The ability of ethosomes to efficiently entrap lipophilic and hydrophilic drugs can be explained by the high degree of lamellarity and the presence of ethanol in the vesicles. In addition, ethosomal formulations possess greater entrapment capability than liposomes. [25]
The ability of the ethosomal preparation to penetrate into the skin layers can be determined by using confocal laser scanning microscopy. In vitro and in vivo skin permeation studies have demonstrated the ability of the ethosomal formulation to enhance permeation of both hydrophobic and hydrophilic molecules as compared to conventional liposomes. Different workers have reported a 5 - 10 fold better skin permeation of drugs formulated in ethosomes, as compared to the conventional liposomal formulation. [26],[27]
Therapeutic Applications of Ethosomes
Mishra et al., 2007, reported ethosomes for transcutaneous immunization, and antigen-loaded ethosomes for transcutaneous immunization against Hepatitis B were prepared and characterized, which showed greater entrapment efficiency, optimal size range, and a unilamellar, spherical shape in comparision to conventional liposomes. Spectral bio imaging and flow cytometric studies showed an efficient uptake of HBsAg-loaded ethosomes by murine dendritic cells in vitro, reaching a peak by 180 minutes. The transcutaneous delivery potential of the antigen-loaded antigen system, using human cadaver skin, demonstrated a much higher skin permeation of the antigen in comparision to the conventional liposomes and soluble antigen preparation. The topically applied HBsAg-loaded ethosomes in mice showed a robust systemic and mucosal humoral immune response compared to the intramuscularly administered alum-adsorbed HBsAg suspension, the topically applied plain HBsAg solution, and the hydroethanolic (25%) HBsAg solution. HBSAg-loaded ethosomes are able to generate a protective immune response and their ability to transverse and target the immunological milieu of the skin finds a potential application in the development of a transcutaneous vaccine against Hepatitis B virus. [28]
Oral administration of hormones is associated with complications like high first pass metabolism, low oral bioavailability, and several dose-dependent side effects such as virilization, acne, and gynecomastia. In addition along with these side effects, oral hormonal preparations rely highly on patient compliance. The risk of failure of treatment is known to increase with each pill missed. Touitou et al., 2000, [29] compared the skin permeation potential of testosterone ethosomes (Testosome) across rabbit pinna skin, with the marketed transdermal patch of testosterone (Testoderm® patch, Alza corporation, California). The authors observed nearly 30 times higher skin permeation of testosterone from the ethosomal formulation as compared to the marketed formulation. The AUC and Cmax of testosterone significantly improved after the application of Testosome as compared to Testoderm® . Hence, both in vitro and in vivo studies demonstrated improved skin permeation and bioavailability of testosterone from the ethosomal formulation. This group, in their further study, designed a testosterone non-patch formulation to reduce the area of application. They found that with ethosomal testosterone formulation, the area of application required to produce the effective plasma concentration was 10 times less than that required by the commercial gel (AndroG, US) formulation.
Lodzki et al., 2003, [30] prepared the CBD-ethosomal formulation for transdermal delivery of cannabiol for the treatment of rheumatoid arthritis. Results of the skin deposition study showed significant accumulation of Cannabidiol (CBD) in the skin, and underlying muscles after application of CBD-ethosomal formulation to the abdomen of Mice. A plasma concentration study showed that a steady state level was reached in 24 hours, which was maintained through 72 hours. A significant increase in biological anti-inflammatory activity of CBD-ethosomal formulation was observed when tested by using the carrageenan-induced rat paw edema model. Finally, it was concluded that encapsulation of CBD in ethosomes significantly increased its skin permeation, accumulation, and hence, its biological activity.
In another study, Dayan and Touitou, 2001, prepared ethosomal formulation of the psychoactive drug trihexyphenidyl hydrochloride (THP) and compared its delivery with that with the classical liposomal formulation for the treatment of parkinsons disease. THP is an M1 muscarinic receptors antagonist and used in the treatment of Parkinson disease. THP has a short biological half-life (3 hours) and its oral administration is difficult due to motor disorders and neurogical manifestations associated with parkinsonian syndrome. THP ethosomal formulation, when visualized under transmission and scanning electron microscopes, were viewed as small phospholipid vesicles. The value of the transdermal flux of THP through nude mouse skin from ethosomes was 87-, 51-, and 4.5-times higher than that from liposome, phosphate buffer, and hydroethanolic solution, respectively. The quantity of THP remaining in the skin at the end of 18 hours was significantly higher after the application of ethosomes than after the application of liposome or hydroethanolic solution (control). These results indicated the better skin permeation potential of ethosomal-THP formulation and its use for the better management of Parkinson disease.
Yet another report on methotrexate an anti-psoriatic, anti-neoplastic, highly hydrosoluble agent with limited transdermal permeation was researched by Dubey et al. 2007. The authors developed optimized ethosomes-loaded methotrexate and the skin permeation profile of the developed formulation revealed an enhanced permeation of rhodamine red loaded formulation to the deeper layers of the skin. The formulation retained its penetration power after storage and the vesicle skin interaction study also highlighted the penetration enhancing effect of ethosomes, with some visual penetration pathways and corneocyte swelling.
In addition to improved transdermal delivery by ethosomes, investigations on dermal delivery have also been cited in literature. Paolino et al., 2005, [31] investigated the potential application of ethosomes for dermal delivery of ammonium glycyrrhizinate. Ammonium is useful for the treatment of various inflammatory based skin diseases. In vitro skin permeation experiments have shown that a significantly higher cumulative amount of drug has permeated from ethosomes (63.2%) than from the hydroalcoholic solution (22.3%) and aqueous solution (8.9%) of ammonium glycyrrhizinate. Ethosomal formulation showed a very good skin tolerability in human volunteers for 48-hour application. Biological anti-edema activity was also significantly enhanced in case of ethosomal formulation as compared to ethanolic or aqueous solution of the drug.
Maiden et al., 2004, prepared and evaluated the minoxidil ethosomal formulation. Minoxidil is a lipid-soluble drug used topically on the scalp for the treatment of baldness. The conventional topical formulation has very poor skin permeation and retention properties. It was found that the quantity of minoxidil accumulated into nude mice skin after application of its ethosomal formulation was 2.0-, 7.0-, and 5.0-fold higher when compared to ethanolic phospholipid dispersion, hydroethanolic solution, and ethanolic solution of the drug, each containing 0.5% of the drug. These results showed the possibility of using ethosomes for pilosebaceous targeting of minoxidil to achieve better clinical efficacy.
Many environmental pathogens attempt to enter the body through the skin. Skin has, therefore, evolved into an excellent protective barrier, which is also immunologically active and able to express the gene. On the basis of the above-mentioned facts another important application of ethosomes, is to use them for topical delivery of DNA molecules, to express genes in the skin cells. Touitou et al., 2003, in their study, encapsulated the GFP-CMV-driven transfecting construct into the ethosomal formulation. They applied this formulation to the dorsal skin of five-week-old, male CD-1 nude mice for 48 hours. After 48 hours, the treated skin was removed and penetration of green fluorescent protein (GFP) formulation was observed by Confocal laser scanning microscopy (CLSM). It was observed that the topically applied ethosome-GFP-CMV-driven transfecting construct enabled efficient delivery and expression of genes in the skin cells. It was suggested that ethosomes could be used as carriers for gene therapy applications that required transient expression of genes. These results also showed the possibility of using ethosomes for effective transdermal immunization. Gupta et al., 2004, [32] recently reported the immunization potential of using transfersomal formulation. Hence, better skin permeation ability of ethosomes opens the possibility of using these dosage forms for the delivery of immunizing agents. [Table 2] is a short compilation of research reports on ethosomes as a carrier for a variety of drugs researched of late. | Table 2 :A compilation of research reports on ethosomes as a carrier for topical and transdermal delivery of drugs
Click here to view |
Cosmeceutical Applications of Ethosomes
The advantage of applying ethosomes in cosmeceuticals is not only to increase the stability of the cosmetic chemicals and decrease skin irritation from the irritating cosmetic chemicals, but also for transdermal permeation enhancement, especially in the elastic forms. [37] However, the compositions and sizes of the vesicles are the main factors to be considered to obtain these advantages of the elastic vesicles for cosmeceutical applications. Topical administration of many antioxidants is one of the several approaches to diminish oxidative injury in the skin for cosmetic and cosmeceutical applications. However, antioxidants are usually not stable and can be degraded by exposing to light. These antioxidants include vitamin E, vitamin C, and flavonoids. Vitamin E is one of the major exogenous lipophilic antioxidants, which is usually found in tissues. Its topical application can enhance the skin protection from exogenous oxidants. When vitamin E is added to cosmetics and many dermatological products, it is found to decrease the production of lipid peroxides in the epidermis as well as to protect against UV exposure and some destructive chemicals and physical agents. In order to deliver vitamin E into the deeper layer of SC, Koli et al., 2008, have formulated 'Anti-oxidant Ethosomes for Topical Delivery Utilizing the Synergistic Properties of Vitamin A Palmitate, Vitamin E, and Vitamin C,' and the findings have revealed that the synergistic interaction of Vitamin C in the aqueous core and Vitamin A and E in the lipid bilayer, provide complete protection from the oxidation of the ethosome formulations. This has suggested that although elastic and non-elastic liposomes are not beneficial for the delivery of α-tocopherol through the skin, the entrapment of the vitamin either in elastic or non-elastic liposomes can increase its photo-stability under UVB irradiation.[36]
In a study by Esposito et al., 2004, [38] ethosomes and liposomes of azelaic acid (Anti-keratinizing agent used in the treatment of acne) were prepared as a topical vehicle (gel) and the result demonstrated that ETHOS 40 could be responsible for a higher azelaic acid, with respect to ETHOS 20 and liposomes.
A USA company, Osmotics Inc., reported new cellulite cream called lipoduction, which used ethosome technology that penetrated the skin lipid barrier and delivered ingredients directly into the fat cells. Ingredients in lipoduction improved the appearance of cellulite by up to 80% in less than 60 days.
Stability of ethosomes
Stability of the formulations was evaluated in terms of the entrapment capacity and the particle size for a specified period. Basically, the proper choice of the lipid composition appeared to be an important factor in obtaining stable ethosomes dispersions with optimum pharmaceutical and therapeutic characteristics. In case of liposomes, upon storage, many different changes could occur. Liposomes tend to fuse and grow into bigger vesicles and this fusion and breakage of liposomes on storage pose an important problem of drug leakage from the vesicles. The absence of electrostatic repulsion is likely to account for the tendency of the neutral liposome to aggregate, but in case of ethosomes, ethanol causes a modification of the net charge of the system and confers it some degree of steric stabilization leading to increased stability of the dispersion against agglomeration that may also lead to a decrease in the mean vesicle size. Increasing the concentration of ethanol from 15 to 45% increases the entrapment efficiency owing to an increase in the fluidity of the membranes. However, a further increase in the ethanol concentration (> 45%) probably makes the vesicle membrane more leaky, thus leading to a decrease in entrapment efficiency. Therefore, it causes destabilization of the ethosomes.
The lipid portion of the ethosomes is derived from natural and / or synthetic phospholipid sources. Phospholipids containing unsaturated fatty acids are known to undergo oxidative reactions. The reaction products can cause permeability changes in the ethosomes bilayers. Oxidative degradation of the lipids in general can be minimized by protecting the lipid preparation from light, by adding antioxidants such as α-tocopherol. Furthermore, hydrolysis of lipids leads to the formation of lyso-PC. The presence of lyso-PC enhances the permeability of ethosomes, and thus, it is essential to keep its level to a minimum in a given preparation.[39],[40]
Future perspectives
Introduction of ethosomes has initiated a new area in vesicular research for transdermal drug delivery. Different reports show a promising future of ethosomes in making transdermal delivery of various agents more effective. Further research in this area will allow better control over drug release in vivo, allowing the physician to make the therapy more effective. Ethosomes offers a good opportunity for the non-invasive delivery of small-, medium-, and large-sized drug molecules. The results of the first clinical study of the acyclovir-ethosomal formulation support this conclusion. Studies will continue to further improve the skin delivery of drugs using lipid vesicles. Special emphasis seems to be given to the skin delivery of proteins and other macromolecules and for transcutaneous immunization. The near future also holds the emergence of new commercial ethosome-based topical products. NTT, Novel Therapeutic Technology Inc., is a biopharmaceutical company with a portfolio of pharmaceutical formulations based on ethosome technology including formulations for the treatment of alopecia, deep skin infection, herpes, hormone deficiencies, inflammation, postoperative nausea, atopic dermatitis, and erectile dysfunction.
Conclusion | |  |
The last decade has shown a huge growth in the application of ethosomal technology to monitor skin permeability. The previously proposed mechanism of penetration enhancement with the ethosomal system suggested that the intercalation of ethanol into the polar head group environment results in increased membrane permeability. The understanding of the mechanisms of absorption and enhancement has improved and different determinants at a molecular level are beginning to be understood. With this it should be possible to achieve bioavailabilities comparable to those expected in oral drug delivery. As far as stability is concerned, ethosomes are much more stable than liposomes because of the presence of ethanol, which provides a net negative surface charge, which avoids aggregation of vesicles due to electrostatic repulsion. Ethosomes have also been proved to be interesting delivery systems for pharmaceutical and cosmetic products; topically applied ethosomes can increase the residence time of drugs or cosmetic chemicals in the stratum corneun and epidermis and reduce the systemic absorption of drugs or cosmetic chemicals, these properties allow them to penetrate easily into the deeper layers of the skin and circulation. However, the exact mode and nature of deformable vesicle transport into and possibly across the skin is not yet fully understood. Especially the degree of intact vesicle permeation across the stratum corneum and the partitioning of intact vesicles into the viable epidermis remains to be elucidated in more detail. In this respect, there are still inconsistencies in the results. This might be due to differences in vesicle composition, vesicle preparation, or in the skin structure of different species. The optimized developed elastic vesicular formulations, by adjusting their compositions and sizes, can be a promising means for not only cosmeceutical applications, but also for the topical non-invasive treatment of local and systemic disorders of many pharmaceuticals as well. With this possibility, developing safe and effective dermal and transdermal delivery systems should be far more successful.
References | |  |
1. | Barry BW. Novel mechanisms and devices to enable successful transdermal drug delivery. Eur J Pharm Sci 2001;14:101-14.  [PUBMED] [FULLTEXT] |
2. | Hadgraft J. Passive enhancement strategies in topical and transdermal drug delivery. Int J Pharm 1999;184:1-6.  [PUBMED] [FULLTEXT] |
3. | Thong HY, Zhai H, Maibach HI. Percutaneous enhancers: An overview. J Skin Pharmacol Physiol 2007;2:1-12.  |
4. | Shim J, Kang HS, Park WS, Han SH. Transdermal delivery of minoxidil with ethanolic liposomes. J Cont Rel 2003;97:477-84.  |
5. | Essa AE, Bonner MC, Barry BW. Electroporation and ultradeformable liposomes; Human skin barrier repair by phospholipids. J Cont Rel 2003;92:163-72.  |
6. | Nguyen PL, Bowstra JA. Vesicles as a tool for transdermal and dermal delivery. Drug Disc Tec 2005;2:67-74.  |
7. | Biju S, Talegoankar S, Mishra P, Khar RK. Vesicular systems An overview. Ind J Pharm Sci. 2006;5:141-50.  |
8. | Ceve G. Lipids vesicles and other colloids as drug carrier on the skin. Adv Drug Del Rev 2004;56:675-711.  |
9. | Touitou E, Dayan N, Bergelson L, Godin B, Eliaz M. Ethosomes-novel vesicular carriers for enhanced delivery: Characterization and skin penetration properties. J Control Release 1999;65:403-18.  |
10. | Bendas ER, Tadros MI. Enhanced transdermal delivery of sulbutamol sulfate via ethosomes. AAPS Pharm Sci Tech 2007;8:1-7.  |
11. | Godin B, Touitou E. Mechanism of bacitracin permeation enhancement through the skin and cellular membranes from an ethosomal carrier. J Control Release 2003;94:365-79.  |
12. | Touitou E, Godin B, Dayan N. Intracellular delivery mediated by ethosomal carrier. Biomaterials 2001;22:3055-9.  |
13. | Elsayed MA, Abdallah YO, Naggar FV, Khalafallah NM. Lipids vesicles for skin delivery of drugs: Reviewing three decades of research. Int J Pharm 2006;332:1-16.  |
14. | Bhalaria MK, Naik S, Mishra AN. Ethosomes: A novel system for antifungal drugs in the treatment of topical fungal disease. Ind J Exp Biol 2009;47:368-75.  |
15. | Dubey V, Mishra D, Jain NK. Melatonin loaded ethanolic liposomes: Physicochemical characterization and enhanced transdermal delivery. Eur J Pharm Biopharm 2007;67:398-405.  [PUBMED] [FULLTEXT] |
16. | Dubey V, Mishra D, Dutta T, Nahar M, Saraf DK, Jain NK. Dermal and transdermal delivery of an anti-psoriatic agent via ethanolic liposomes. J Control Release 2007;123:148-54 .  [PUBMED] [FULLTEXT] |
17. | Jain S, Tiwary AK, Sapra B, Jain NK. Formulation and evaluation of ethosomes for transdermal delivery of lamivudine. AAPS Pharm Sci Tech 2007;8:1-9.  |
18. | Fang YP, Tsai YH, Wu PC, Huang YB. Comparision of 5-aminolevulinic acid-encapsulated liposomes versus ethosomes for skin delivery for photodynamic therapy. Int J Pharm 2008;356:144-52.  [PUBMED] [FULLTEXT] |
19. | Godin B, Touitou E. Erythromycin ethosomal systems: Physicochemical characterization and enhanced antibacterial activity. Curr Drug Del 2005;2:269-75.  |
20. | Rao Y, Zheng F, Gao J. In vitro percutaneous permeation and skin accumulation finasteride using vesicular ethosomal carrier. AAPS Pharm Sci Tech 2009;9:860-5.  |
21. | Fang JY, Hwang TL, Leu HY. Effect of enhancers and retarders on percutaneous absorption of flurbiprofen from hydrogel. Int J Pharm 2003;250:313-25.  |
22. | Lopez-Pinto JM, Gonzalez-Rodriguez ML, Rabasco AM. Effect of cholesterol and ethanol on dermal delivery from DPPC liposomes. Int J Pharm 2005;298:1-12.  |
23. | Maghraby M, Campbell M, Finnin BC. Mechanism of action of novel skin penetration enhancers phospholipids versus skin lipids liposomes. Int J Pharm 2005;305:90-104.  |
24. | Hu G, Liu J. Advances in studies of phospholipids as carriers in skin topical application. J Nanjug Med Univ 2007;21:349-53.  |
25. | Godin B, Touitou E, Rubinstein E, Athamna A, Athamna M. A new approach for treatment of deep skin infection by an ethosomal antibiotic preparation: An In vivo study. J Antimicro Chemother 2005;55:989-94.  |
26. | Verma DD, Verma S, Blume G, Fahr A. Ethosomes increases skin penetration of entrapped and non-entrapped hydrophilic substances into human skin: A skin penetration and confocal laser scanning microscopy studies. Eur J Pharm Biopharm 2003;55:271-7.  |
27. | Vivek D, Dhirendra K. Ethosomes for enhanced transdermal drug delivery of aceclofenac. Int J Drug Del 2010;2:81-92.  |
28. | Mishra D, Mishra PK, Dubey V, Nahar M, Jain NK. Systemic and mucosal immune response induced by transcutaneous immunization using Hepatitis B surface antigen-loaded modified liposomes. J Control Release 2007;33:424-33.  |
29. | Ainbinder D, Touitou E. Testosterone ethosomes for enhanced transdermal delivery. Drug Del 2000;12:297-303.  |
30. | Lodzki M, Godin B, Rakou L, Mechoulam R, Gallily R, Touitou E. Cannabiol-transdermal delivery and anti-inflammatory effect in a murine model. J Control Release 2003;93:377-87.  [PUBMED] [FULLTEXT] |
31. | Paolino D, Lucania G, Mardente D, Alhaique F, Fresta M. Ethosomes for skin delivery of ammonium glycyrrhizinate: In vitro percutaneous permeation through human skin and in vivo anti-inflammatory activity on human volunteers. J Control Release 2005;106:99-110.  [PUBMED] [FULLTEXT] |
32. | Gupta P, Singh P, Mishra V, Jain S. Topical immunization: Mechanistic insight and novel delivery system. Ind J Bio 2004;3:9-21.  |
33. | Jain S, Umamaheshwari RB, Bhadra D, Jain NK. Ethosomes: A novel vesicular carriers for enhanced transdermal delivery of an anti HIV agent. Ind J Pharm Sci 2004;66:72-81.  |
34. | Presa P, Rued T, Hernando A. Gold nanoparticles generated in ethosomes bilayers, revealed by cryo electron tomography. J Phys Chem 2009;113:3051-7.  |
35. | Singh HP, Utreja P, Tiwary AK, Jain S. Elastic liposomal formulations for sustained delivery of Colchicine: In vitro characterization and In vivo evaluation of anti gout activity. AAPS Pharm Sci Tec 2008;11:54-64.  |
36. | Koli JR, Lin S. Development of anti oxidant ethosomes for topical delivery utilizing the synergistic properties of Vit A palmitate, Vit E and Vit C. AAPS Pharm Sci Tec 2009;11:1-8.  |
37. | Manosrai A, Jantrawut P, Khositsuntiwong N, Manosroi W, Manosroi J. Novel Elastic Nanovesicles for Cosmeceutical and Pharmaceutical Applications. Chiang Mai J Sci 2009;36:168-78.  |
38. | Esposito E, Menegatti E, Cortesi R. Ethosomes and liposomes as topical vehicles for azeliac acid: A preformulation study. J Cosmet Sci 2004;55:253-64.  [PUBMED] |
39. | Rao LS. Preparation of liposomes on the industrial scale: Problems and perspectives. In: Gregoriadis G, editor. Liposome technology, Vol. 1. Florida: CRC Press; 1984.  |
40. | New RRC. Preparation of liposomes. In: New RRC, editor. Liposomes-a practical approach. Oxford: Oxford University Press; 1990.  |
[Figure 1], [Figure 2], [Figure 3]
[Table 1], [Table 2]
This article has been cited by | 1 |
Ethosomes and their monotonous effects on Skin cancer disruption |
|
| Prafull Shinde, Amit Page, Sankha Bhattacharya | | Frontiers in Nanotechnology. 2023; 5 | | [Pubmed] | [DOI] | | 2 |
Fisetin in Cancer: Attributes, Developmental Aspects, and Nanotherapeutics |
|
| Rachna M. Kumar, Hitesh Kumar, Tanvi Bhatt, Rupshee Jain, Kanan Panchal, Akash Chaurasiya, Vikas Jain | | Pharmaceuticals. 2023; 16(2): 196 | | [Pubmed] | [DOI] | | 3 |
Quality by Design Assisted Optimization and Risk Assessment of Black Cohosh Loaded Ethosomal Gel for Menopause: Investigating Different Formulation and Process Variables |
|
| Sradhanjali Mohapatra, Mohd. Aamir Mirza, Sayeed Ahmad, Uzma Farooq, Mohammad Javed Ansari, Kanchan Kohli, Zeenat Iqbal | | Pharmaceutics. 2023; 15(2): 465 | | [Pubmed] | [DOI] | | 4 |
Polysaccharide-Based Transdermal Drug Delivery |
|
| Jingyuan Li, Hong Xiang, Qian Zhang, Xiaoqing Miao | | Pharmaceuticals. 2022; 15(5): 602 | | [Pubmed] | [DOI] | | 5 |
Development and Evaluation of Ethosomes Loaded with Zingiber zerumbet Linn Rhizome Extract for Antifungal Skin Infection in Deep Layer Skin |
|
| Kampanart Huanbutta, Napapat Rattanachitthawat, Kunlathida Luangpraditkun, Pornsak Sriamornsak, Vivek Puri, Inderbir Singh, Tanikan Sangnim | | Pharmaceutics. 2022; 14(12): 2765 | | [Pubmed] | [DOI] | | 6 |
Ethosomal (-)-epigallocatechin-3-gallate as a novel approach to enhance antioxidant, anti-collagenase and anti-elastase effects |
|
| Çigdem Yücel, Gökçe Seker Karatoprak, Sena Yalçintas, Tugba Eren Böncü | | Beilstein Journal of Nanotechnology. 2022; 13: 491 | | [Pubmed] | [DOI] | | 7 |
Transethosomes: A Breakthrough System for Transdermal and Topical Drug Delivery |
|
| Jawad Ali, Reesha Raza, Sibgha Ameen, Anam Arshad, Fauzia Karim, Muhammad Waseem Akram, Lubna Shakir | | Pakistan BioMedical Journal. 2022; | | [Pubmed] | [DOI] | | 8 |
Nanodelivery of Dietary Polyphenols for Therapeutic Applications |
|
| Mithun Rudrapal, Ashwini K. Mishra, Laxmi Rani, Khomendra K. Sarwa, James H. Zothantluanga, Johra Khan, Mehnaz Kamal, Santwana Palai, Atul R. Bendale, Swati G. Talele, Vasim T. Pathan, Laxmikant B. Borse, Vishnu S. Neharkar, Pravat K. Sahoo | | Molecules. 2022; 27(24): 8706 | | [Pubmed] | [DOI] | | 9 |
Nanotechnology in Cosmetics and Cosmeceuticals—A Review of Latest Advancements |
|
| Vaibhav Gupta, Sradhanjali Mohapatra, Harshita Mishra, Uzma Farooq, Keshav Kumar, Mohammad Javed Ansari, Mohammed F. Aldawsari, Ahmed S. Alalaiwe, Mohd Aamir Mirza, Zeenat Iqbal | | Gels. 2022; 8(3): 173 | | [Pubmed] | [DOI] | | 10 |
Nanostructured Ethosomal Gel Loaded with Arctostaphylosuva-Ursi
Extract; In-Vitro/In-Vivo Evaluation as a Cosmeceutical Product for Skin
Rejuvenation |
|
| Nayla Javed, Shakeel Ijaz, Naveed Akhtar, Haji Muhammad Shoaib Khan | | Current Drug Delivery. 2022; 19(6): 706 | | [Pubmed] | [DOI] | | 11 |
Lipid-Based Drug Delivery System (LBDDS): An Emerging Paradigm to Enhance Oral Bioavailability of Poorly Soluble Drugs |
|
| Roohi Kesharwani, Pankaj Jaiswal, Dilip Kumar Patel, Pankaj Kumar Yadav | | Biomedical Materials & Devices. 2022; | | [Pubmed] | [DOI] | | 12 |
Emerging Trends of Nanotechnology In Advanced Cosmetics |
|
| Sunil Kumar Dubey, Anuradha Dey, Gautam Singhvi, Murali Manohar Pandey, Vanshikha Singh, Prashant Kesharwani | | Colloids and Surfaces B: Biointerfaces. 2022; : 112440 | | [Pubmed] | [DOI] | | 13 |
Metformin-loaded ethosomes with promoted anti-proliferative activity in melanoma cell line B16, and wound healing aptitude: Development, characterization and in vivo evaluation |
|
| Shrouk Magdy, Eman Alaaeldin, Zeinab Fathalla, Rania Alaaeldin, Mahmoud Elrehany, Entesar Ali Saber, Rasha TA Abdel-Aziz, Heba F. Mansour | | International Journal of Pharmaceutics. 2022; : 121781 | | [Pubmed] | [DOI] | | 14 |
Niosomal and ethosomal gels: A comparative in vitro and ex Vivo evaluation for repurposing of spironolactone |
|
| Heba M. Abdallah, Nagia A. El-Megrab, Gehan F. Balata, Noura G. Eissa | | Journal of Drug Delivery Science and Technology. 2022; : 103583 | | [Pubmed] | [DOI] | | 15 |
Polymeric Ethosomal Gel Loaded with Nimodipine: Optimisation, Pharmacokinetic and Histopathological Analysis |
|
| Jamal Moideen Muthu Mohamed, Barkat A Khan, Vijaya Rajendran, Mohamed El-Sherbiny, Gamal Othman, Abdulrahman Bashir Ahmed Hussamuldin, Rasha Hamed Al-Serwi | | Saudi Pharmaceutical Journal. 2022; | | [Pubmed] | [DOI] | | 16 |
Novel nanotechnological approaches for treatment of skin-aging |
|
| Ashmita Sharma, Anurag Kuhad, Ranjana Bhandari | | Journal of Tissue Viability. 2022; | | [Pubmed] | [DOI] | | 17 |
Lipid-based nanoparticulate delivery systems for HER2-positive breast cancer immunotherapy |
|
| Nima Behravan, Fatemeh Zahedipour, Mahmoud Reza Jaafari, Thomas P. Johnston, Amirhossein Sahebkar | | Life Sciences. 2022; 291: 120294 | | [Pubmed] | [DOI] | | 18 |
Gemini Surfactant Mediated Catansomes for Enhanced Singlet Oxygen Generation of Rose Bengal and Their Phototoxicity against Cancer Cells |
|
| Bunty Sharma, Mario Samperi, Akhil Jain, Ganga Ram Chaudhary, Gurpreet Kaur, Lluďsa Pérez-García | | ACS Biomaterials Science & Engineering. 2022; | | [Pubmed] | [DOI] | | 19 |
Exploiting Recent Trends in the Treatment of Androgenic Alopecia through Topical Nanocarriers of Minoxidil |
|
| Khushbakht Saleem, Bazla Siddiqui, Asim .ur.Rehman, Malik Mumtaz Taqi, Naveed Ahmed | | AAPS PharmSciTech. 2022; 23(8) | | [Pubmed] | [DOI] | | 20 |
Delivery systems in nanocosmeceuticals |
|
| Santos-Adriana Martel-Estrada, Andrea-Isabel Morales-Cardona, Claudia-Lucía Vargas-Requena, Juan-Antonio Rubio-Lara, Carlos-Alberto Martínez-Pérez, Florinda Jimenez-Vega | | REVIEWS ON ADVANCED MATERIALS SCIENCE. 2022; 61(1): 901 | | [Pubmed] | [DOI] | | 21 |
Central composite design for the development of carvedilol-loaded transdermal ethosomal hydrogel for extended and enhanced anti-hypertensive effect |
|
| Padmanabha Rao Amarachinta,Garima Sharma,Noufel Samed,Ananda Kumar Chettupalli,Madhusudhan Alle,Jin-Chul Kim | | Journal of Nanobiotechnology. 2021; 19(1) | | [Pubmed] | [DOI] | | 22 |
Intranasal In Situ Gel of Apixaban-Loaded Nanoethosomes: Preparation, Optimization, and In Vivo Evaluation |
|
| Ahmed A. El-Shenawy,Reda A. Mahmoud,Essam A. Mahmoud,Mohamed S. Mohamed | | AAPS PharmSciTech. 2021; 22(4) | | [Pubmed] | [DOI] | | 23 |
Brucine-Loaded Ethosomal Gel: Design, Optimization, and Anti-inflammatory Activity |
|
| Marwa H. Abdallah, Amr S. Abu Lila, Rahamat Unissa, Heba S. Elsewedy, Hanaa A. Elghamry, Mahmoud S. Soliman | | AAPS PharmSciTech. 2021; 22(8) | | [Pubmed] | [DOI] | | 24 |
Lipid-based nanoparticles for psoriasis treatment: a review on conventional treatments, recent works, and future prospects |
|
| Ummu Umaimah Mohd Nordin,Noraini Ahmad,Norazlinaliza Salim,Nor Saadah Mohd Yusof | | RSC Advances. 2021; 11(46): 29080 | | [Pubmed] | [DOI] | | 25 |
Design, formulation and optimization of topical ethosomes using full factorial design: in-vitro and ex-vivo characterization |
|
| Hadeer A. El-Hashemy | | Journal of Liposome Research. 2021; : 1 | | [Pubmed] | [DOI] | | 26 |
Nanoformulations-based advancement in the delivery of phytopharmaceuticals for skin cancer management |
|
| Yasmine K. Yasmeen,Mohammad Kashif Iqubal,Mohd Ashif Khan,Nidhi B. Agarwal,Javed Ali,Sanjula Baboota | | Journal of Drug Delivery Science and Technology. 2021; : 102912 | | [Pubmed] | [DOI] | | 27 |
Lipid-Based Vesicles: a Non-invasive Tool for Transdermal Drug Delivery |
|
| Alan Raj,Sarath Chandran C.,Anoop Narayanan V.,Aparna Ivon,Nazeera Farzana N. M.,Neethu Narayan P. P. | | Journal of Pharmaceutical Innovation. 2021; | | [Pubmed] | [DOI] | | 28 |
Topical nanocarriers for management of Rheumatoid Arthritis: A review |
|
| Chando Anita,Momin Munira,Quadros Mural,Lalka Shaily | | Biomedicine & Pharmacotherapy. 2021; 141: 111880 | | [Pubmed] | [DOI] | | 29 |
Lipid Based Nanocarriers: Promising Drug Delivery System for Topical Application |
|
| Darshana Patel,Brijesh Patel,Hetal Thakkar | | European Journal of Lipid Science and Technology. 2021; : 2000264 | | [Pubmed] | [DOI] | | 30 |
Ethosomes as Nanocarriers for the Development of Skin Delivery Formulations |
|
| Ana Cláudia Paiva-Santos,Ana Luísa Silva,Catarina Guerra,Diana Peixoto,Miguel Pereira-Silva,Mahdi Zeinali,Filipa Mascarenhas-Melo,Ricardo Castro,Francisco Veiga | | Pharmaceutical Research. 2021; | | [Pubmed] | [DOI] | | 31 |
Elastic and Ultradeformable Liposomes for Transdermal Delivery of Active Pharmaceutical Ingredients (APIs) |
|
| Eliana B. Souto,Ana S. Macedo,Joăo Dias-Ferreira,Amanda Cano,Aleksandra Zielinska,Carla M. Matos | | International Journal of Molecular Sciences. 2021; 22(18): 9743 | | [Pubmed] | [DOI] | | 32 |
Applications of Nanosized-Lipid-Based Drug Delivery Systems in Wound Care |
|
| Andreea-Mariana Matei,Constantin Caruntu,Mircea Tampa,Simona Roxana Georgescu,Clara Matei,Maria Magdalena Constantin,Traian Vasile Constantin,Daniela Calina,Diana Alina Ciubotaru,Ioana Anca Badarau,Cristian Scheau,Ana Caruntu | | Applied Sciences. 2021; 11(11): 4915 | | [Pubmed] | [DOI] | | 33 |
Positively Charged Lipid as Potential Tool to Influence the Fate of Ethosomes |
|
| Antonia Mancuso,Maria Chiara Cristiano,Massimo Fresta,Daniele Torella,Donatella Paolino | | Applied Sciences. 2021; 11(15): 7060 | | [Pubmed] | [DOI] | | 34 |
Recent Advances in Nanomaterials for Dermal and Transdermal Applications |
|
| Amani Zoabi,Elka Touitou,Katherine Margulis | | Colloids and Interfaces. 2021; 5(1): 18 | | [Pubmed] | [DOI] | | 35 |
Ultraflexible Liposome Nanocargo as a Dermal and Transdermal Drug Delivery System |
|
| Kalvatala Sudhakar,Shivkanya Fuloria,Vetriselvan Subramaniyan,Kathiresan V. Sathasivam,Abul Kalam Azad,Shasank S. Swain,Mahendran Sekar,Sundram Karupiah,Omji Porwal,Alaka Sahoo,Dhanalekshmi Unnikrishnan Meenakshi,Vipin Kumar Sharma,Sanjay Jain,R. Narayana Charyulu,Neeraj Kumar Fuloria | | Nanomaterials. 2021; 11(10): 2557 | | [Pubmed] | [DOI] | | 36 |
Site-Specific Vesicular Drug Delivery System for Skin Cancer: A Novel Approach for Targeting |
|
| Manisha Pandey, Hira Choudhury, Bapi Gorain, Shao Qin Tiong, Grace Yee Seen Wong, Kai Xin Chan, Xuan They, Wei Shen Chieu | | Gels. 2021; 7(4): 218 | | [Pubmed] | [DOI] | | 37 |
Quality by Design for Development, Optimization and Characterization of Brucine Ethosomal Gel for Skin Cancer Delivery |
|
| Tamer A. Ismail,Tamer M. Shehata,Dalia I. Mohamed,Heba S. Elsewedy,Wafaa E. Soliman | | Molecules. 2021; 26(11): 3454 | | [Pubmed] | [DOI] | | 38 |
The Topical Nanodelivery of Vismodegib Enhances Its Skin Penetration and Performance In Vitro While Reducing Its Toxicity In Vivo |
|
| Maria Natalia Calienni,Daniela Maza Vega,C. Facundo Temprana,María Cecilia Izquierdo,David E. Ybarra,Ezequiel Bernabeu,Marcela Moretton,Fernando C. Alvira,Diego Chiappetta,Silvia del Valle Alonso,María Jimena Prieto,Jorge Montanari | | Pharmaceutics. 2021; 13(2): 186 | | [Pubmed] | [DOI] | | 39 |
Challenges in the Physical Characterization of Lipid Nanoparticles |
|
| Supandeep Singh Hallan,Maddalena Sguizzato,Elisabetta Esposito,Rita Cortesi | | Pharmaceutics. 2021; 13(4): 549 | | [Pubmed] | [DOI] | | 40 |
Electrospun Nanofiber and Cryogel of Polyvinyl Alcohol Transdermal Patch Containing Diclofenac Sodium: Preparation, Characterization and In Vitro Release Studies |
|
| Shafizah Sa’adon, Mohamed Nainar Mohamed Ansari, Saiful Izwan Abd Razak, Abdul Halim Mohd Yusof, Ahmad Athif Mohd Faudzi, Suresh Sagadevan, Nadirul Hasraf Mat Nayan, Joseph Sahaya Anand, Khairul Anuar Mat Amin | | Pharmaceutics. 2021; 13(11): 1900 | | [Pubmed] | [DOI] | | 41 |
Experimental research in topical psoriasis therapy (Review) |
|
| Diana Ni?escu,Alina Mu?etescu,Maria Ni?escu,Monica Costescu,Oana-Andreia Coman | | Experimental and Therapeutic Medicine. 2021; 22(3) | | [Pubmed] | [DOI] | | 42 |
Plumbagin-Loaded Glycerosome Gel as Topical Delivery System for Skin Cancer Therapy |
|
| Shadab Md,Nabil A. Alhakamy,Hibah M. Aldawsari,Mohammad Husain,Nazia Khan,Mohamed A. Alfaleh,Hani Z. Asfour,Yassine Riadi,Anwar L. Bilgrami,Md Habban Akhter | | Polymers. 2021; 13(6): 923 | | [Pubmed] | [DOI] | | 43 |
The Scope and Challenges of Vesicular Carrier-Mediated Delivery of Docetaxel for the Management of Cancer |
|
| Charu Misra,Kaisar Raza,Amit Kumar Goyal | | Current Drug Delivery. 2020; 17(10): 874 | | [Pubmed] | [DOI] | | 44 |
Biocompatible Nanovesicular Drug Delivery Systems with Targeting Potential for Autoimmune Diseases |
|
| Yub Raj Neupane,Asiya Mahtab,Lubna Siddiqui,Archu Singh,Namrata Gautam,Syed Arman Rabbani,Honey Goel,Sushama Talegaonkar | | Current Pharmaceutical Design. 2020; 26(42): 5488 | | [Pubmed] | [DOI] | | 45 |
Current Insights for the Management of Acne in the Modern Era |
|
| Neha Singh,Apoorva Singh,Kalpana Pandey,Kalpana Nimisha | | Recent Patents on Anti-Infective Drug Discovery. 2020; 15(1): 3 | | [Pubmed] | [DOI] | | 46 |
Polyvinyl Alcohol/Hydroxyethylcellulose Containing Ethosomes as a Scaffold for Transdermal Drug Delivery Applications |
|
| Gomaa El Fawal,Huoyan Hong,Xinran Song,Jinglei Wu,Meiqi Sun,Lin Zhang,Chuanglong He,Xiumei Mo,Hongsheng Wang | | Applied Biochemistry and Biotechnology. 2020; | | [Pubmed] | [DOI] | | 47 |
Naringin nano-ethosomal novel sunscreen creams: Development and performance evaluation |
|
| Hemanth Gollavilli,Aswathi R. Hegde,Renuka S. Managuli,K. Vijay Bhaskar,Swapnil Dengale,Meka Sreenivasa Reddy,Guruprasad Kalthur,Srinivas Mutalik | | Colloids and Surfaces B: Biointerfaces. 2020; : 111122 | | [Pubmed] | [DOI] | | 48 |
Revitalizing the local anesthetic effect of Mebeverine hydrochloride via encapsulation within ethosomal vesicular system |
|
| Azza A. Hasan,Rasha M. Samir,Samir S. Abu-Zaid,Amr S. Abu Lila | | Colloids and Surfaces B: Biointerfaces. 2020; : 111208 | | [Pubmed] | [DOI] | | 49 |
Lipid vesicles: A versatile drug delivery platform for dermal and transdermal applications |
|
| Indhu A. Chacko,Vivek M. Ghate,Leonna Dsouza,Shaila A. Lewis | | Colloids and Surfaces B: Biointerfaces. 2020; 195: 111262 | | [Pubmed] | [DOI] | | 50 |
Background and different treatment modalities for melasma: Conventional and nanotechnology-based approaches |
|
| Shymaa Hatem,Nada M. El Hoffy,Reham S. Elezaby,Maha Nasr,Amany O. Kamel,Seham A. Elkheshen | | Journal of Drug Delivery Science and Technology. 2020; 60: 101984 | | [Pubmed] | [DOI] | | 51 |
Drug delivery systems integrated with conventional and advanced treatment approaches toward cellulite reduction |
|
| Sara A. Abosabaa,Mona G. Arafa,Aliaa Nabil ElMeshad | | Journal of Drug Delivery Science and Technology. 2020; : 102084 | | [Pubmed] | [DOI] | | 52 |
5-Fluorouracil, innovative drug delivery systems to enhance bioavailability for topical use |
|
| Beatriz Ewert de Oliveira,Otávio Henrique Junqueira Amorim,Lonetá Lauro Lima,Rodrigo Alvarenga Rezende,Natalia Cammarosano Mestnik,Ediléia Bagatin,Gislaine Ricci Leonardi | | Journal of Drug Delivery Science and Technology. 2020; : 102155 | | [Pubmed] | [DOI] | | 53 |
Transdermal delivery systems in cosmetics |
|
| Byel Kim,Hang-Eui Cho,Sun He Moon,Hyun-Jung Ahn,Seunghee Bae,Hyun-Dae Cho,Sungkwan An | | Biomedical Dermatology. 2020; 4(1) | | [Pubmed] | [DOI] | | 54 |
An evaluation of tocotrienol ethosomes for transdermal delivery using Strat-M® membrane and excised human skin |
|
| Rajesh Sreedharan Nair,Nashiru Billa,Chee-Onn Leong,Andrew P. Morris | | Pharmaceutical Development and Technology. 2020; : 1 | | [Pubmed] | [DOI] | | 55 |
Trends in nanotechnology-based delivery systems for dermal targeting of drugs: an enticing approach to offset psoriasis |
|
| Sadaf Saleem,Mohammad Kashif Iqubal,Sanjay Garg,Javed Ali,Sanjula Baboota | | Expert Opinion on Drug Delivery. 2020; : 1 | | [Pubmed] | [DOI] | | 56 |
Therapeutic Strategies for Erectile Dysfunction With Emphasis on Recent Approaches in Nanomedicine |
|
| Hussein O. Ammar,Mina I. Tadros,Nahla M. Salama,Amira M. Ghoneim | | IEEE Transactions on NanoBioscience. 2020; 19(1): 11 | | [Pubmed] | [DOI] | | 57 |
Nanotechnological interventions in dermatophytosis: from oral to topical, a fresh perspective |
|
| Riya Bangia,Gajanand Sharma,Sunil Dogra,Om Prakash Katare | | Expert Opinion on Drug Delivery. 2019; 16(4): 377 | | [Pubmed] | [DOI] | | 58 |
A brief overview on nano-sized materials used in the topical treatment of skin and soft tissue bacterial infections |
|
| Sara Salatin,Farzaneh Lotfipour,Mitra Jelvehgari | | Expert Opinion on Drug Delivery. 2019; : 1 | | [Pubmed] | [DOI] | | 59 |
Innovative nanocompounds for cutaneous administration of classical antifungal drugs: a systematic review |
|
| Rafael Silva Santos,Kahynna Cavalcante Loureiro,Polyana Santos Rezende,Luciana Nalone Andrade,Raquel de Melo Barbosa,Antonello Santini,Ana Cláudia Santos,Classius Ferreira da Silva,Eliana Barbosa Souto,Damiăo Pergentino de Sousa,Ricardo Guimarăes Amaral,Patrícia Severino | | Journal of Dermatological Treatment. 2019; : 1 | | [Pubmed] | [DOI] | | 60 |
Preparation and evaluation of optimized zolmitriptan niosomal emulgel |
|
| Magdy Ibrahim Mohamed,Aly Ahmed Abdelbary,Soha Mohamed Kandil,Tamer Mohamed Mahmoud | | Drug Development and Industrial Pharmacy. 2019; : 1 | | [Pubmed] | [DOI] | | 61 |
Neuroprotective effects of novel nanosystems simultaneously loaded with vinpocetine and piracetam after intranasal administration |
|
| Maha Nasr,Sara A. Wahdan | | Life Sciences. 2019; 226: 117 | | [Pubmed] | [DOI] | | 62 |
Formulation development of ethosomes containing indomethacin for transdermal delivery |
|
| Pajaree Sakdiset,Thanaporn Amnuaikit,Wiwat Pichayakorn,Sirirat Pinsuwan | | Journal of Drug Delivery Science and Technology. 2019; 52: 760 | | [Pubmed] | [DOI] | | 63 |
Nanotechnological breakthroughs in the development of topical phytocompounds-based formulations |
|
| Ana Cláudia Santos,Dora Rodrigues,Joana A.D. Sequeira,Irina Pereira,Ana Simőes,Diana Costa,Diana Peixoto,Gustavo Costa,Francisco Veiga | | International Journal of Pharmaceutics. 2019; : 118787 | | [Pubmed] | [DOI] | | 64 |
Formulation approaches for improved retinoids delivery in the treatment of several pathologies |
|
| Antónia Gonçalves,Berta N. Estevinho,Fernando Rocha | | European Journal of Pharmaceutics and Biopharmaceutics. 2019; | | [Pubmed] | [DOI] | | 65 |
Colloidal (-)-epigallocatechin-3-gallate vesicular systems for prevention and treatment of skin cancer: A comprehensive experimental study with preclinical investigation |
|
| Maha El-Kayal,Maha Nasr,Seham Elkheshen,Nahed Mortada | | European Journal of Pharmaceutical Sciences. 2019; 137: 104972 | | [Pubmed] | [DOI] | | 66 |
A novel transdermal nanoethosomal gel of lercanidipine HCl for treatment of hypertension: optimization using Box-Benkhen design, in vitro and in vivo characterization |
|
| Heba F. Salem,Shahira F. El-Menshawe,Rasha A. Khallaf,Yasmine K. Rabea | | Drug Delivery and Translational Research. 2019; | | [Pubmed] | [DOI] | | 67 |
Development of Topical Gel of Methotrexate Incorporated Ethosomes and Salicylic Acid for the Treatment of Psoriasis |
|
| Akhilesh Chandra,Geeta Aggarwal,Satish Manchanda,Akshay Narula | | Pharmaceutical Nanotechnology. 2019; 7(5): 362 | | [Pubmed] | [DOI] | | 68 |
New Strategies for the Delivery of Some Natural Anti-oxidants with Therapeutic Properties |
|
| Elisabetta Esposito,Markus Drechsler,Carmelo Puglia,Rita Cortesi | | Mini-Reviews in Medicinal Chemistry. 2019; 19(13): 1030 | | [Pubmed] | [DOI] | | 69 |
Nanotechnology: Revolutionizing the Science of Drug Delivery |
|
| Mohini Mishra,Pramod Kumar,Jitendra Singh Rajawat,Ruchi Malik,Gitanjali Sharma,Amit Modgil | | Current Pharmaceutical Design. 2019; 24(43): 5086 | | [Pubmed] | [DOI] | | 70 |
Drug/Vehicle Impacts and Formulation Centered Stratagems for Enhanced Transdermal Drug Permeation, Controlled Release and Safety: Unparalleled Past and Recent Innovations-An Overview |
|
| Balamurugan Manickam,Rajesh Sreedharan,Kumarappan Chidambaram | | Current Drug Therapy. 2019; 14(3): 192 | | [Pubmed] | [DOI] | | 71 |
Design of Prototype Formulations for In Vitro Dermal Delivery of the Natural Antioxidant Ferulic Acid Based on Ethosomal Colloidal Systems |
|
| Cesar Londońo,John Rojas,Cristhian Yarce,Constain Salamanca | | Cosmetics. 2019; 6(1): 5 | | [Pubmed] | [DOI] | | 72 |
Trends in Atopic Dermatitis—From Standard Pharmacotherapy to Novel Drug Delivery Systems |
|
| Eliana B. Souto,Joăo Dias-Ferreira,Jéssica Oliveira,Elena Sanchez-Lopez,Ana Lopez-Machado,Marta Espina,Maria L. Garcia,Selma B. Souto,Carlos Martins-Gomes,Amélia M. Silva | | International Journal of Molecular Sciences. 2019; 20(22): 5659 | | [Pubmed] | [DOI] | | 73 |
TOPICAL DELIVERY OF DRUGS USING ETHOSOMES: A REVIEW |
|
| V Sankar, V. Wilson, K. Siram, A. Karuppaiah, S Hariharan, A. Justin | | INDIAN DRUGS. 2019; 56(08): 7 | | [Pubmed] | [DOI] | | 74 |
The Effect of Alkyl Chain Number in Sucrose Surfactant on the Physical Properties of Quercetin-Loaded Deformable Nanoliposome and Its Effect on In Vitro Human Skin Penetration |
|
| In Ki Hong,Ji Hoon Ha,Sangkeun Han,Hakhee Kang,Soo Nam Park | | Nanomaterials. 2018; 8(8): 622 | | [Pubmed] | [DOI] | | 75 |
Insights on the Use of Nanocarriers for Acne Alleviation |
|
| Sandra Sherif Amer,Maha Nasr,Wael Mamdouh,Omaima Sammour | | Current Drug Delivery. 2018; 16(1): 18 | | [Pubmed] | [DOI] | | 76 |
Development, Characterization and Transdermal Delivery of Dapsone and an Antibiotic Entrapped in Ethanolic Liposomal Gel for the Treatment of Lapromatous Leprosy |
|
| Ruchi Tiwari,Gaurav Tiwari,Pranay Wal,Ankita Wal,Priyanka Maurya | | The Open Nanomedicine Journal. 2018; 5(1): 1 | | [Pubmed] | [DOI] | | 77 |
Nanoparticulate-based drug delivery systems for small molecule anti-diabetic drugs: An emerging paradigm for effective therapy |
|
| Siddharth Uppal,Kishan S. Italiya,Deepak Chitkara,Anupama Mittal | | Acta Biomaterialia. 2018; | | [Pubmed] | [DOI] | | 78 |
Advanced Inorganic Nanosystems for Skin Drug Delivery |
|
| E. Carazo,A. Borrego-Sánchez,F. García-Villén,R. Sánchez-Espejo,P. Cerezo,C. Aguzzi,C. Viseras | | The Chemical Record. 2018; | | [Pubmed] | [DOI] | | 79 |
A practical framework for implementing Quality by Design to the development of topical drug products: Nanosystem-based dosage forms |
|
| Ana Simőes,Francisco Veiga,Ana Figueiras,Carla Vitorino | | International Journal of Pharmaceutics. 2018; 548(1): 385 | | [Pubmed] | [DOI] | | 80 |
Factorial design based curcumin ethosomal nanocarriers for the skin cancer delivery: in vitro evaluation |
|
| Malleswara Rao Peram,Sunil Jalalpure,Vijay Kumbar,Sachin Patil,Sumit Joshi,Kishore Bhat,Prakash Diwan | | Journal of Liposome Research. 2018; : 1 | | [Pubmed] | [DOI] | | 81 |
Surfactant Effects on Lipid-Based Vesicles Properties |
|
| Ruba Bnyan,Iftikhar Khan,Touraj Ehtezazi,Imran Saleem,Sarah Gordon,Francis OćNeill,Matthew Roberts | | Journal of Pharmaceutical Sciences. 2018; | | [Pubmed] | [DOI] | | 82 |
Development of ethosomal gel of ranolazine for improved topical delivery: In vitro and ex vivo evaluation |
|
| Deepak Bisht,Devina Verma,Mohd. Aamir Mirza,Md. Khalid Anwer,Zeenat Iqbal | | Journal of Molecular Liquids. 2017; 225: 475 | | [Pubmed] | [DOI] | | 83 |
Delivery systems for cosmetics - From manufacturing to the skin of natural antioxidants |
|
| Raquel Costa,Lúcia Santos | | Powder Technology. 2017; | | [Pubmed] | [DOI] | | 84 |
Ethosomes of Phenylethyl Resorcinol as Vesicular Delivery System for Skin Lightening Applications |
|
| Tunyaluk Limsuwan,Prapaporn Boonme,Pasarat Khongkow,Thanaporn Amnuaikit | | BioMed Research International. 2017; 2017: 1 | | [Pubmed] | [DOI] | | 85 |
Development and evaluation of finasteride loaded ethosomes for targeting to the pilosebaceous unit |
|
| Vinny Wilson,Karthik Siram,Selvakumar Rajendran,Veintramuthu Sankar | | Artificial Cells, Nanomedicine, and Biotechnology. 2017; : 1 | | [Pubmed] | [DOI] | | 86 |
Ibuprofen loaded nano-ethanolic liposomes carbopol gel system: in vitro characterization and anti-inflammatory efficacy assessment in Wistar rats |
|
| Atefeh Afshar Moghaddam,Abdul Ahad,Mohd. Aqil,Farhan J. Ahmad,Yasmin Sultana,Asgar Ali | | Journal of Polymer Engineering. 2017; 0(0) | | [Pubmed] | [DOI] | | 87 |
Nanoparticles as safe and effective delivery systems of antifungal agents: Achievements and challenges |
|
| Ghareb M. Soliman | | International Journal of Pharmaceutics. 2017; 523(1): 15 | | [Pubmed] | [DOI] | | 88 |
Improvement of skin whitening agents efficiency through encapsulation: Current state of knowledge |
|
| Elissa Ephrem,Hamid Elaissari,Hélčne Greige-Gerges | | International Journal of Pharmaceutics. 2017; 526(1-2): 50 | | [Pubmed] | [DOI] | | 89 |
Broad overview of engineering of functional nanosystems for skin delivery |
|
| Ana Henriques Mota,Patrícia Rijo,Jesús Molpeceres,Catarina Pinto Reis | | International Journal of Pharmaceutics. 2017; | | [Pubmed] | [DOI] | | 90 |
Nanomaterials for transdermal drug delivery: beyond the state of the art of liposomal structures |
|
| Roxana Jijie,Alexandre Barras,Rabah Boukherroub,Sabine Szunerits | | Journal of Materials Chemistry B. 2017; | | [Pubmed] | [DOI] | | 91 |
Spotlight on Biomimetic Systems Based on Lyotropic Liquid Crystal |
|
| Juliana de Souza,Katiusca Pontes,Thais Alves,Venâncio Amaral,Márcia Rebelo,Moema Hausen,Marco Chaud | | Molecules. 2017; 22(3): 419 | | [Pubmed] | [DOI] | | 92 |
Potential enhancement and targeting strategies of polymeric and lipid-based nanocarriers in dermal drug delivery |
|
| Emine Kahraman,Sevgi Güngör,Yildiz Özsoy | | Therapeutic Delivery. 2017; 8(11): 967 | | [Pubmed] | [DOI] | | 93 |
Noninvasive approach for enhancing small interfering RNA delivery percutaneously |
|
| Ibrahim A. Aljuffali,Yin-Ku Lin,Jia-You Fang | | Expert Opinion on Drug Delivery. 2016; 13(2): 265 | | [Pubmed] | [DOI] | | 94 |
(-)-Epigallocatechin gallate (EGCG)-nanoethosomes as a transdermal delivery system for docetaxel to treat implanted human melanoma cell tumors in mice |
|
| Bingwu Liao,Hao Ying,Chenhuan Yu,Zhaoyang Fan,Weihua Zhang,John Shi,Huazhong Ying,Nagaiya Ravichandran,Yongquan Xu,Junfeng Yin,Yongwen Jiang,Qizhen Du | | International Journal of Pharmaceutics. 2016; 512(1): 22 | | [Pubmed] | [DOI] | | 95 |
Enhancement of 8-methoxypsoralen topical delivery via nanosized niosomal vesicles: Formulation development, in vitro and in vivo evaluation of skin deposition |
|
| Ahmed Alaa Kassem,Sameh Hosam Abd El-Alim,Marwa Hasanein Asfour | | International Journal of Pharmaceutics. 2016; | | [Pubmed] | [DOI] | | 96 |
In vitro models for evaluating safety and efficacy of novel technologies for skin drug delivery |
|
| Viktoria Planz,Claus-Michael Lehr,Maike Windbergs | | Journal of Controlled Release. 2016; | | [Pubmed] | [DOI] | | 97 |
Ethosomes and organogels for cutaneous administration of crocin |
|
| Elisabetta Esposito,Markus Drechsler,Nicolas Huang,Gabriella Pavoni,Rita Cortesi,Debora Santonocito,Carmelo Puglia | | Biomedical Microdevices. 2016; 18(6) | | [Pubmed] | [DOI] | | 98 |
In vitro drug release and percutaneous behavior of poloxamer-based hydrogel formulation containing traditional Chinese medicine |
|
| Wenyi Wang,Patrick C.L. Hui,Elaine Wat,Frency S.F. Ng,Chi-Wai Kan,Xiaowen Wang,Eric C.W. Wong,Huawen Hu,Ben Chan,Clara B.S. Lau,Ping-Chung Leung | | Colloids and Surfaces B: Biointerfaces. 2016; 148: 526 | | [Pubmed] | [DOI] | | 99 |
Topically applied lipid- and surfactant-based nanoparticles in the treatment of skin disorders |
|
| Eline Desmet,Mireille Van Gele,Jo Lambert | | Expert Opinion on Drug Delivery. 2016; : 1 | | [Pubmed] | [DOI] | | 100 |
Recent Advances in Lipid-Based Vesicles and Particulate Carriers for Topical and Transdermal Application |
|
| Shashank Jain,Niketkumar Patel,Mansi K. Shah,Pinak Khatri,Namrata Vora | | Journal of Pharmaceutical Sciences. 2016; | | [Pubmed] | [DOI] | | 101 |
Lipid-based nanovesicles for nanomedicine |
|
| N. Grimaldi,F. Andrade,N. Segovia,L. Ferrer-Tasies,S. Sala,J. Veciana,N. Ventosa | | Chem. Soc. Rev.. 2016; | | [Pubmed] | [DOI] | | 102 |
Pharmaceutical liposomal drug delivery: a review of new delivery systems and a look at the regulatory landscape |
|
| Claudia Zylberberg,Sandro Matosevic | | Drug Delivery. 2016; : 1 | | [Pubmed] | [DOI] | | 103 |
Preparation of intravenous cholesterol tracer using current good manufacturing practices |
|
| Xiaobo Lin,Lina Ma,Susan B. Racette,William P. Swaney,Richard E. Ostlund | | Journal of Lipid Research. 2015; 56(12): 2393 | | [Pubmed] | [DOI] | | 104 |
Advanced formulations for improving therapies with anti-inflammatory or anaesthetic drugs: A review |
|
| Francesca Maestrelli,Marco Bragagni,Paola Mura | | Journal of Drug Delivery Science and Technology. 2015; | | [Pubmed] | [DOI] | | 105 |
Transdermal delivery of tadalafil using a novel formulation |
|
| Jong-Suep Baek,Cheong-Weon Cho | | Drug Delivery. 2015; : 1 | | [Pubmed] | [DOI] | | 106 |
Nano vesicular lipid carriers of angiotensin II receptor blocker: Anti-hypertensive and skin toxicity study in focus |
|
| Abdul Ahad,Mohd. Aqil,Kanchan Kohli,Yasmin Sultana,Mohd. Mujeeb | | Artificial Cells, Nanomedicine, and Biotechnology. 2015; : 1 | | [Pubmed] | [DOI] | | 107 |
In vitroand preclinical assessment of factorial design based nanoethosomes transgel formulation of an opioid analgesic |
|
| Shakeeb Ahmed,Syed Sarim Imam,Ameeduz Zafar,Asgar Ali,Mohammed Aqil,Azka Gull | | Artificial Cells, Nanomedicine, and Biotechnology. 2015; : 1 | | [Pubmed] | [DOI] | | 108 |
Current and emerging lipid-based systems for transdermal drug delivery |
|
| Sumeet K Singla,Vishal Sachdeva | | Therapeutic Delivery. 2015; 6(9): 1063 | | [Pubmed] | [DOI] | | 109 |
High-efficient nano-carrier gel systems for testosterone propionate skin delivery |
|
| Shu Meng,Zaixing Chen,Liqun Yang,Xiaowei Zhang,Jing Guo,Miao Li,Jianxin Li | | Pharmaceutical Development and Technology. 2014; : 1 | | [Pubmed] | [DOI] | | 110 |
Oro-dental mucoadhesive proniosomal gel formulation loaded with lornoxicam for management of dental pain |
|
| Ghada Ahmed Abdelbary,Mona Hassan Aburahma | | Journal of Liposome Research. 2014; : 1 | | [Pubmed] | [DOI] | | 111 |
Enhanced anti-inflammatory activity of carbopol loaded meloxicam nanoethosomes gel |
|
| Abdul Ahad,Mohammad Raish,Abdullah M. Al-Mohizea,Fahad I. Al-Jenoobi,Mohd Aftab Alam | | International Journal of Biological Macromolecules. 2014; 67: 99 | | [Pubmed] | [DOI] | | 112 |
Comparison of ethosomes and liposomes for skin delivery of psoralen for psoriasis therapy |
|
| Yong-Tai Zhang,Li-Na Shen,Zhong-Hua Wu,Ji-Hui Zhao,Nian-Ping Feng | | International Journal of Pharmaceutics. 2014; | | [Pubmed] | [DOI] | | 113 |
Nanovesicular carriers as alternative drug delivery systems: ethosomes in focus |
|
| Chukwuemeka C Mbah,Philip F Builders,Anthony A Attama | | Expert Opinion on Drug Delivery. 2014; 11(1): 45 | | [Pubmed] | [DOI] | | 114 |
Formulation and in vitro evaluation of pH-responsive ethosomes for vaginal delivery of metronidazole |
|
| C. Mbah,P. Builders,I. Nzekwe,O. Kunle,M. Adikwu,A. Attama | | Journal of Drug Delivery Science and Technology. 2014; 24(6): 565 | | [Pubmed] | [DOI] | | 115 |
Lipoidal soft hybrid biocarriers in pharmacotherapeutics |
|
| Meenu Sharma,Mohammed Yusuf,Vijay Sharma,Kamla Pathak | | Pharmaceutical Patent Analyst. 2013; 2(4): 539 | | [Pubmed] | [DOI] | | 116 |
Ethogel topical formulation for increasing the local bioavailability of 5-fluorouracil |
|
| Richa Puri,Subheet Jain | | Anti-Cancer Drugs. 2012; : 1 | | [Pubmed] | [DOI] | | 117 |
Ethosomes for transdermal and topical drug delivery |
|
| Rakesh, R. and Anoop, K.R. | | International Journal of Pharmacy and Pharmaceutical Sciences. 2012; 4(SUPPL.3): 17-24 | | [Pubmed] | | 118 |
Preclinical and clinical aspects of antimicrobial drugs delivered through ethosomal vesicles |
|
| Akhtar, N. and Pathak, K. | | Anti-Infective Agents. 2012; 10(1): 15-25 | | [Pubmed] | | 119 |
Novel drug delivery approaches on antiviral and antiretroviral agents |
|
| Arora, S. and Chawla, A. and Pawar, P. and Sharma, P. | | Journal of Advanced Pharmaceutical Technology and Research. 2012; 3(3): 147-159 | | [Pubmed] | | 120 |
Ethogel topical formulation for increasing the local bioavailability of 5-fluorouracil: a mechanistic study |
|
| Puri, Richa; Jain, Subheet | | Anti Cancer Drugs. 2012; | | [Pubmed] | |
|
 |
 |
|