Home  |  About JAPTR |  Editorial board  |  Search |  Ahead of print  |  Current issue  |  Archives |  Submit article  |  Instructions  |  Subscribe  |  Advertise  |  Contacts  |Login 
Users Online: 459   Home Print this page Email this page Small font sizeDefault font sizeIncrease font size
Year : 2010  |  Volume : 1  |  Issue : 2  |  Page : 245-252

In vitro cytotoxicity study of agave Americana, strychnos Nuxvomica and Areca catechu extracts using MCF-7 cell line

1 Department of Pharmaceutics, Bhagwan Mahavir College of Pharmacy, Bharthana Vesu, Surat, Gujarat, India
2 Department of Pharmaceutical Biotechnology, S. K. Patel College of Pharmaceutical Education and Research, Kherva, Dist. Mehsana, Ganpat Vidyanagar, Gujarat, India
3 Department of Pharmacognosy, Babaria Institute of Pharmacy, Vadodara, Gujarat, India

Correspondence Address:
Chetan C Anajwala
Department of Pharmaceutics, Bhagwan Mahavir College of Pharmacy, Bharthana Vesu, Surat, Gujarat
Login to access the Email id

Source of Support: None, Conflict of Interest: None

PMID: 22247852

Rights and PermissionsRights and Permissions

Research is focusing on the search for new types of natural chemotherapeutic agent that is plant based medicines which are proving to be excellent sources of new compounds. In present research study, an attempt was made to prove cytotoxicity activity of various parts of medicinal plants such as Agave americana, Strychnos nux­vomica and Areca catechu using MCF-7 and Vero cell line. Various parts of the medicinal plants were extracted by soxhlet apparatus using solvents likes methanol and water. By trypan blue dye exclusion method, Viability of MCF-7 and Vero cell lines were 85.50 and 81.13%, respectively. IC 50 value of methanol extract of Agave americana leaves and aqueous extract of Afeca catechu fruits were found to be 545.9 & 826.1 μg/ml by SRB assay and 775.1 & 1461pg/ml by MTT assay, respectively, against MCF­7 cell line. From cytotoxicity study data by SRB and MTT assay, it revealed that methanol extract of Agave americana and aqueous extract of Areca catechu are potent cytotoxic.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded588    
    Comments [Add]    
    Cited by others 1    

Recommend this journal