Home  |  About JAPTR |  Editorial board  |  Search |  Ahead of print  |  Current issue  |  Archives |  Submit article  |  Instructions  |  Subscribe  |  Advertise  |  Contacts  |Login 
Users Online: 423   Home Print this page Email this page Small font sizeDefault font sizeIncrease font size
Year : 2010  |  Volume : 1  |  Issue : 2  |  Page : 199-206

Formulation and evaluation of S-(-)-Amlodipine besylate and nebivolol hydrochloride tablets

1 Jeevanjyoti Pharmaceutical, Aurangabad, Maharastra, India
2 Kamla Nehru College of Pharmacy, Aurangabad, Maharastra, India
3 Government College of Pharmacy, Aurangabad, Maharastra, India
4 Mulana Azad College of Arts and Science, Aurangabad, Maharastra, India

Correspondence Address:
S A Shaikh
Jeevanjyoti Pharmaceutical, Aurangabad, Maharastra
Login to access the Email id

Source of Support: None, Conflict of Interest: None

PMID: 22247846

Rights and PermissionsRights and Permissions

The objective of the present study was to develop a tablet formulation of S-(-)­amlodipine besylate chiral separation drug and nebivolol hydrochloride for better management of hypertension, while reducing or avoiding undesirable adverse effects, which are often associated with administration of a racemic mixture of amlodipine. The composition containing the optically pure S-(-)- isomer of amlodipine 2.5 mg has calcium channel blocking activity and, nebivolol hydrochloride 5 mg has beta-receptor blocking activity. The study was also carried out to design a suitable dissolution medium for S-(-) - amlodipine besylate and nebivolol hydrochloride. Amlodipine besylate and nebivolol hydrochloride had maximum solubility in pH 1.2 and thus pH 1.2 was selected as the most suitable media for S-(-) - amlodipine besylate and nebivolol hydrochloride dissolution studies. The RSD below 2% indicated insignificant batch-to-batch variation. The accelerated stability study of the optimized formulation was performed as the ICH guidelines. The results indicated no change in optical rotation of S-(-) - amlodipine besylate. Hence, combination of two drugs can be formulated into the tablet by wet granulation technique having satisfactory release profile.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded727    
    Comments [Add]    
    Cited by others 1    

Recommend this journal