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Year : 2010  |  Volume : 1  |  Issue : 1  |  Page : 41-48

Antidiarrhoeal activity of leaf extract of Celosia Argentea in experimentally induced diarrhoea in rats

1 College of Pharmacy, IPS Academy, Indore, India
2 Veerayatan Institute of Pharmacy, Kutch, Gujarat, India
3 Vinayaka College of Pharmacy, Kullu, Himachal Pradesh, India
4 Department of Pharmaceutical Sciences, Lovely Professional University, Punjab, India

Correspondence Address:
Praveen Sharma
College of Pharmacy, IPS Academy, Indore
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Source of Support: None, Conflict of Interest: None

PMID: 22247831

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In order to scientifically apprise some of the anecdotal, folkloric, ethno medical uses of celosia argentea, the present study was undertaken to examine the antidiarrhoeal properties of alcoholic extract of leaves of Celosia argentea on diarrhoea by using different experimental models. Anti-diarrhoeal effect was evaluated by castor oil induced diarrhoea, charcoal meal test and PGE 2 induced diarrhoea. Loperamide (2 mg/kg) and atropine (0.1mg/kg) were used as standard drugs. Extract was used in 100 and 200 mg/kg dose. It produced dose related anti-diarrhoeal effect. Results suggest that it may act centrally and may inhibit the PGE2 to give anti-diarrhoeal effects. Result of charcoal meal test also suggests its anti-muscarinic activity.

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