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REVIEW ARTICLE
Year : 2011  |  Volume : 2  |  Issue : 4  |  Page : 236-240

The peroxisome proliferator-activated receptor: A family of nuclear receptors role in various diseases


Department of Pharmacology, ISF College of Pharmacy, Moga, Punjab, India

Correspondence Address:
Sandeep Tyagi
Department of Pharmacology, ISF College of Pharmacy, Moga, Punjab - 142 001
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2231-4040.90879

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Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors of nuclear hormone receptor superfamily comprising of the following three subtypes: PPARα, PPARγ, and PPARβ/δ. Activation of PPAR-α reduces triglyceride level and is involved in regulation of energy homeostasis. Activation of PPAR-γ causes insulin sensitization and enhances glucose metabolism, whereas activation of PPAR- β/δ enhances fatty acids metabolism. Thus, PPAR family of nuclear receptors plays a major regulatory role in energy homeostasis and metabolic function. The present review critically analyzes the protective and detrimental effect of PPAR agonists in dyslipidemia, diabetes, adipocyte differentiation, inflammation, cancer, lung diseases, neurodegenerative disorders, fertility or reproduction, pain, and obesity.


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